• The Korean Journal of Pain
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• 제37권3호
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• pp.211-217
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• 2024

Background: Tolerance to the analgesic effects of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) is a major concern for relieving pain. Thus, it is highly valuable to find new pharmacological strategies for prolonged therapeutic procedures. Biguanide-type drugs such as metformin (MET) are effective for neuroprotection and can be beneficial for addressing opioid tolerance in the treatment of chronic pain. It has been proposed that analgesic tolerance to NSAIDs is mediated by the endogenous opioid system. According to the cross-tolerance between NSAIDs, especially sodium salicylate (SS), and opiates, especially morphine, the objective of this study was to investigate whether MET administration can reduce tolerance to the anti-nociceptive effects of SS. Methods: Fifty-six male Wistar rats were used in this research (weight 200-250 g). For induction of tolerance, SS (300 mg/kg) was injected intraperitoneally for 7 days. During the examination period, animals received MET at doses of 50, 75, or 100 mg/kg for 7 days to evaluate the development of tolerance to the analgesic effect of SS. The hot plate test was used to evaluate the drugs' anti-nociceptive properties. Results: Salicylate injection significantly increased hot plate latency as compared to the control group, but the total analgesic effect of co-treatment with SS + Met50 was stronger than the SS group. Furthermore, the effect of this combination undergoes less analgesic tolerance over time. Conclusions: It can be concluded that MET can reduce the analgesic tolerance that is induced by repeated intraperitoneal injections of SS in Wister rats.

• 약학회지
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• 제51권6호
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• pp.508-516
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• 2007

Thymus magnus is an endemic (Ulleung Island) species in Korea. This plant is used as diaphoretics and carminatives in traditional medicine. In the literature, few scientific assays were realized on this species, such as antibiotic (Streptococcus pneumoniae, Staphylococcus aureus, Salmonella enteritidis, and S. typhimurium) and antifungal activities. In order to clarify whether essential oil of T. magnus have pharmacological effects, anti-inflammatory, sedative, anti-depressant, analgesic, and sleep-prolonged effects were investigated using animal models. From this study, the following conclusions were attained; 1) Essential oil of T. magnus did not show any acute toxicity on mice when orally administered at the dose of 2-3 g/kg body weight. 2) Essential oil of T. magnus possessed strong anti-inflammatory activity, similar to that of a positive control prednisolone. 3) Essential oil of T. magnus had excellent analgesic activity, comparable to that of aspirin. 4) The essential oil of T. magnus possessed strong sleep-prolonged effect on pentobarbital induced-sleep test in mice model. 5) In the hot plate test, the essential oil of T. magnus had moderate effect. 6) And the essential oil of T. magnus had no significant effects in forced-swimming test and open-field test.

• 동력기계공학회지
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• 제5권1호
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• pp.21-26
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• 2001

This paper represents the turbulent intensity, the turbulent kinetic energy and Reynolds shear stress in the X-Y plane of cone type swirl gas burner measured by using X-probe from the hot-wire anemometer system. The experiment is carried out at flowrate 350 and $450{\ell}/min$ respectively in the test section of subsonic wind tunnel. The turbulent intensity and the turbulent kinetic energy show that the maximum value is formed in the narrow slits distributed radially on the edge of a cone type swirl burner, hence, the combustion reaction is anticipated to occur actively near this region. And the turbulent intensities ${\upsilon}\;and\;{\omega}$ are disappeared faster than the turbulent intensity u due to the inclined flow velocity ejecting from the swirl vanes of a cone type baffle plate of burner. Moreover, the Reynolds shear stress $u{\upsilon}$ is distributed about three times as large as the Reynolds shear stress $u{\omega}$ in the outer region of the cone type gas burner.

• 소성∙가공
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• 제15권2호
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• pp.118-125
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• 2006

API steel is used for line-pipe to transport the oil and natural gas. As the recent trends in the development of API steel are towards the use of larger diameter and thicker plate, many researches have been studied to achieve higher strength, higher toughness and lower yield ratio in API steel. However, the strength of API steel after pipe forming is changed depending on the competition of the Bauschinger effect and work hardening which are affected by the strain history during pipe forming process. So, the purpose of this study is to investigate the influence of microstructure on the Bauschinger effect for API steel. To change the microstructure of API steel we have changed the hot rolling condition and the amounts of V and Cu addition. The compression-tensile test and the microstructure observation by OM and TEM were conducted to investigate the yield strength drop and the correlation between the Bauschinger effect and microstructure of API steel. The experimental results show that the increase of polygonal ferrites volume fraction increases the Baushcinger effect due to the back stress which comes from the increase of mobile dislocation density at polygonal ferrite interior during the compressive deformation. The hot rolling condition was more effective on the Bauschinger effect in API steel than the small amount of V and Cu addition.

• 환경생물
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• 제17권3호
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• pp.249-255
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• 1999

Poly(3-hydroxybutyrate)의 표면 형태가 생분해성에 미치는 영향을 조사하였다. 용융 상태의 PHB를 서냉 ($-0.5^{\circ}C$/min)시켰을 때 PHB의 결정화도는 액체질소 속으로 급냉한 후 $90^{\circ}C$에서 2시간 동안 숙성한 PHB의 결정화도보다 높게 나타났으나 전자의 PHB 시료는 미세 균열의 존재로 인하여 후자의 PHB 시료보다 더 빠르게 생분해되었다. 거친 표면을 가진 평판 위에서 hot press하여 표면을 거칠게 만든 PHB film의 생분해는 표면이 평활한 film보다 훨씬 더 빠르게 진행되었다.

• 동력기계공학회지
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• 제4권4호
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• pp.25-31
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• 2000

This paper represents the vector fields and three dimensional mean velocities in the X-Y plane of cone type swirl gas burner measured by using X-probe from the hot-wire anemometer system. This experiment is carried out at flowrate 350 and $450{\ell}/min$ respectively in the test section of subsonic wind tunnel. The vector plot shows that the maximum axial mean velocity component is focused in the narrow slits distributed radially on the edge of a cone type swirl burner, for that reason, there is some entrainment of ambient air in the outer region of the burner and the rotational flow can be shown in the inner region of the burner because mean velocity W is distributed about twice as large as mean velocity V due to inclined flow velocity ejecting from the swirl vanes of a cone type baffle plate of burner. Moreover, the mean velocities are largely distributed near the outer region of burner within $X/R{\fallingdotseq}1.5$, hence, the turbulent characteristics are anticipated to be distributed largely in the center of this region due to the large inclination of mean velocity and swirl effect.

• ETRI Journal
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• 제29권5호
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• pp.667-669
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• 2007

This letter presents a smart integrated microfluidic device which can be applied to actively immobilize proteins on demand. The active component in the device is a temperature-controllable microelectrode array with a smart polymer film, poly(N-isopropylacrylamide) (PNIPAAm) which can be thermally switched between hydrophilic and hydrophobic states. It is integrated into a micro hot diaphragm having an integrated micro heater and temperature sensors on a 2-micrometer-thick silicon oxide/silicon nitride/silicon oxide (O/N/O) template. Only 36 mW is required to heat the large template area of 2 mm${\times}$16 mm to $40^{\circ}C$ within 1 second. To relay the stimulus-response activity to the microelectrode surface, the interface is modified with a smart polymer. For a model biomolecular affinity test, an anti-6-(2, 4-dinitrophenyl) aminohexanoic acid (DNP) antibody protein immobilization on the microelectrodes is demonstrated by fluorescence patterns.

• Journal of Welding and Joining
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• 제32권6호
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• pp.75-81
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• 2014

Usage of heavy metal element (Pb, Hg and Cd etc.) in electronic devices have been restricted due to the environmental banning of the European Union, such as WEEE and RoHS. Therefore, it is needed to develop the Pb-free solder plated ribbon in photovoltaic (PV) module. This study described that degradation characteristics of PV module under damp heat (DH, $85^{\circ}C$ and 85% R.H.) condition test for 1,000 h. Solar cell ribbons were utilized to hot dipping plate with Pb-free solder alloys. Two types of Pb-free solder plated ribbons, Sn-3.0Ag-0.5Cu (SAC305) and Sn-48Bi-2Ag, and an electroless Sn-40Pb solder hot dipping plated ribbon as a reference sample were prepared to evaluate degradation characteristics. To detect the degradation of PV module with the eutectic and Pb-free solder plated ribbons, I-V curve, electro-luminescence (EL) and cross-sectional SEM analysis were carried out. DH test results show that the reason of maximum power (Pm) drop was mainly due to the decrease fill factor (FF). It was attributed to the crack or oxidation of interface between the cell and the ribbon. Among PV modules with the eutectic and Pb-free solder plated ribbon, the PV module with SAC305 ribbon relatively showed higher stability after DH test than the case of PV module with Sn-40Pb and Sn-48Bi-2Ag solder plated ribbons.

• 대한기계학회논문집B
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• 제20권6호
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• pp.1931-1940
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• 1996

The effect of periodic passing wake on the film-coolant flow issuing normally from a flat plate was investigated experimentally. The passing wake was generated by rotating thin circular bars. Depending on the rotational direction the test plate could be simulated as a pressure surface or a suction surface of a gas turbine blade. The phase-averaged velocity components were measured using an X-type hot-wire probe. The Reynolds number based on the free-stream velocity and injection hole diameter was 23, 500 and the velocity ratio which is the ratio of film coolant velocity to free-stream velocity was 0.5. The velocity-triangle induced by the wake was similar to that induced by the one generated at the blade trailing edge. The vertical velocity component induced by the passing wake, which approaches to the suction surface and moves away from the pressure surface, played a dominant role in the variation of the flow field. The variation in the phase-averaged velocity on the pressure surface was greater than on the suction surface, but the turbulence kinetic energy variation on the suction surface appeared larger than on the pressure surface.

• 한국분무공학회지
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• 제9권4호
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• pp.53-66
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• 2004

An experimental study was carried out in order to investigate the influence of flow conditions on a boundary layer in the near-wake of a flat plate. The flow conditions in the vicinity of the trailing edge that is influenced by upstream condition history are an essential factor that determines the physical characteristics of a near-wake. Tripping wires attached at various positions were selected to change flow conditions of a boundary layer. The flows such as laminar, transitional, and turbulent boundary layer at 0.98C from the leading edge are imposed in order to investigate the evolution of symmetric and asymmetric wake. An x-type hot-wire probe(55P61) is employed to measure at 8 stations in the near-wake. Test results show that the near-wake for the case of a turbulent boundary layer is relatively insensitive to instability after separating at the trailing edge, and Reynolds shear stress in the near-wake for the case of a turbulent boundary layer collapses due to turbulent kinetic energy.