• 무역학회지
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• 제44권2호
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• pp.21-35
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• 2019

This study analyzes factors that affect the corporate value of Korean companies operating in Latin American countries. Primary factors are associated with characteristics of the host country, the parent company, and subsidiaries. Empirical results show that asset specificity is the main factor influencing firm value. This region is geographically far from Korea and culturally different. Therefore, the source of competitive advantage such as asset specificity should be large enough to offset liability of foreignness for successful entry into the region. This paper also found that joint ventures are more advantageous than direct investments. Joint ventures in Latin American can minimize risk, complement technology and information, and reduce trade barriers.

• 디지털융복합연구
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• 제18권12호
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• pp.231-242
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• 2020

코로나 19와 치열한 시장 경쟁으로 공유 경제 플랫폼 업체들은 고객과의 장기적 관계를 형성하는 것이 점차 중요해지고 있다. 이런 맥락에서 본 연구에서는 Airbnb 고객들의 재구매 의사 결정 메커니즘을 살펴보고자 하였다. Airbnb 고객들의 재구매 의도 형성의 선행 요인으로 고객 만족과 브랜드 이미지를 고려하였다. 또한, 가격 공정성, 진정한 경험, 즐거움, Airbnb 신뢰, 호스트 신뢰가 고객들의 재구매 의사 결정에 미치는 영향도 함께 살펴보았다. 본 연구는 Airbnb 이용 고객 154명을 대상으로 연구 가설을 검증하였다. 연구 분석 결과 고객 만족과 브랜드 이미지는 재구매 의도에 유의한 영향을 미쳤으며, 재구매 의도 분산의 62.0%를 설명하였다. 고객 만족에는 즐거움, 진정한 경험, Airbnb 신뢰는 유의한 영향을 미쳤지만, 가격 공정성과 호스트 신뢰는 유의한 영향을 미치지 않았다. 브랜드 이미지는 가격 공정성, 진정한 경험, 즐거움, Airbnb 신뢰에 영향을 미쳤지만, 호스트 신뢰에는 유의한 영향을 미치지 않았다. 본 연구결과를 통해 공유 경제 플랫폼 환경에서 고객들의 재구매 의사 결정에 대한 이해를 증진하여 학문 및 실무적 시사점을 제공해 줄 수 있을 것으로 기대된다.

• 경영정보학연구
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• 제25권1호
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• pp.213-231
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• 2023

라이브 스트리밍의 급속한 발전과 더불어 온라인 호스트가 중요한 정보원으로서 라이브 스트리밍 커머스 성과에 영향을 미치는 데 중요한 역할을 한다. 하지만 제품 유형이 호스트의 특징과 라이브 스트리밍 커머스 성과 사이의 관계에 대한 연구는 많이 이루어지지 않고 있다. 본 연구는 정교화 가능성 모델(Elaboration Likelihood Model)과 정보원 이론(Information Source Theory)을 기반으로 라이브 스트리밍 커머스의 매출에 영향을 미치는 요인과 이들 간의 관계에 대한 제품 유형의 조절 역할을 실증적으로 연구하는 것을 목적으로 한다. 2021년 10월 10일부터 2022년 2월 10일까지 수집된 11,422건의 라이브 스트리밍 커머스 데이터를 분석한 결과, 다중채널 네트워크(Multi-Channel Network)와 팔로워수는 라이브 스트리밍 커머스의 판매량에 긍정적인 영향을 미치는 반면, 평판 점수는 매출에 부정적인 영향을 미치는 것으로 나타났다. 또한 저관여 제품의 비율이 이 관계들에 미치는 조절 효과도 확인되었다. 이번 연구 결과는 라이브 스트리밍 커머스 성과에 대한 문헌을 풍부하게 하고, 시사점뿐만 아니라 연구의 한계점과 향후 연구 방향에 대해서도 논의하였다.

• 디지털융복합연구
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• 제15권6호
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• pp.1-8
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• 2017

본 연구는 한국이 투자대상국인 OECD국가를 대상으로 외국인직접투자에 영향을 주는 요인을 파악하기 위하여 현지국과 투자국의 문화 거리와 부패인식지수의 차이를 활용하여 외국인직접투자에 영향을 주는 요인을 규명하였다. 연구결과 문화적 차원과 부패인식지수에 따라 외국인직접투자에 차이가 나타나는 것을 살펴볼 수 있었다. 문화적 성향에 따라 외국인직접투자가 증대될 수도 감소될 수도 있으며, 부패인식지수가 높을수록 투자가 활발하게 이루어졌다. 외국인직접투자에 영향을 주는 요인에 있어서 현지국과 투자국사이의 권력거리가 작을수록, 개인주의 대 집단주의 거리가 클수록 투자건수와 규모가 증대되는 것으로 나타났으며, 투자국의 부패인식지수가 높을 때 외국인직접투자가 증대되는 것으로 나타났다. 본 연구결과를 통하여 문화와 부패인식정도가 무역거래에 영향을 줄 수 있음을 확인함으로써 무역거래시 교역당사자간의 문화적 성향과 문화적 거리를 고려하여야 하며, 공공부패 등을 비롯한 사회적 변수를 적절하게 관리함으로써 무역 및 경제성장에 영향을 줄 수 있다는 시사점을 제시하였다.

• Clinical and Experimental Pediatrics
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• 제50권6호
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• pp.519-523
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• 2007

Aplastic anemia is a rare disease, which is characterized by pancytopenia and hypocellular bone marrow without infiltration of abnormal cells or fibrosis. The incidence in Asia is higher than in the West and new cases are diagnosed at a rate of 5.1 per million pediatric populations per year in Korea. The pathophysiology is understood roughly by defective hematopoiesis, impaired bone marrow micro-environment and immune mechanism. Treatments are performed on basis of pathogenesis and selected depending on the severity. Immunosuppressive therapy with antilymphocyte or antithymocyte globulin and cyclosporine is effective in the majority of patients but has some problems including relapse or clonal evolution. Recently, there have been clinical trials of immunosuppression with hematopoietic growth factors or other drugs. Allogeneic hematopoietic stem cell transplantation (HSCT) is curative in children with severe aplastic anemia. The overall survival in HSCT from HLA-identical sibling is higher than alternative donor, including HLA matched unrelated donor or cord blood. We have to consider quality of life after HSCT because of high survival rate. However, chronic graft versus host disease and graft failure are important factors that affect the quality of life and overall survival. We need further investigation to make new regimens aimed at overcoming these risk factors and perform clinical trials.

• 한국식품영양과학회지
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• 제14권3호
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• pp.305-313
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• 1985

There is a trend that the total number of cancer cases is steadily increasing as the population grows. It has been estimated that 85% of the cancer rate in the U.S. is attributed to environmental factors. Among the environmental factors, diet and nutrition appear to be related to the largest number of human cancers. Diet and nutrition might be related to cancer by several mechanisms. Food may contain a direct carcinogen or precursors that become carcinogens by spontanous reactions, or by host metabolism, or through the actions of microbial flora. Chemicals that cause cancers generally have reactive electrophilic centers which can combine with electron-rich atoms in nucleic acids and cause cancers by changing the genetic activity of the cells. A variety of factors in foods might be involved in the etiology of carcinogenesis. Chemicals in food that cause cancers include carcinogens of plants and animal origin and also those in drinking water. Other then these, fungal metabolites alcohol, asbestos, heavy metals, pesticides, and food additives might be included as food carcinogenesis. The method of cooking foods also might contribute to carcinogenesis. Some chemicals in foods act as promoters in carcinogenesis. Prevention of cancers by dietary practises have received much interest. Consumption of certain vegetables or cellulose can reduce carcinogenic activity of several compounds. A variety of antioxidants or micronutrients may be effective anticarciongens. Glutathione in the soluble fraction of the cells, is a major defense against oxidative and alkylating carcinogens. Recently anticarcinogenic activity of chlorophyll was demonstrated. Daily consumption of milk appears to effectively reduce stomach cancer.

• Molecules and Cells
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• 제24권1호
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• pp.1-8
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• 2007

Natural killer (NK) cells play a crucial role in innate immune system and tumor surveillance. NK cells are derived from $CD34^+$hematopoietic stem cells and undergo differentiation via precursor NK cells in bone marrow (BM) through sequential acquisition of functional surface receptors. During differentiation of NK cells, many factors are involved including cytokines, membrane factors and transcription factors as well as microenvironment of BM. NK cells express their own repertoire of receptors including activating and inhibitory receptors that bind to major histocompatibility complex (MHC) class I or class I-related molecules. The balance between activating and inhibitory receptors determines the function of NK cells to kill targets. Binding of NK cell inhibitory receptors to their MHC class I-ligand renders the target cells to be protected from NK cell-mediated cytotoxicity. Thus, NK cells are able to discriminate self from non-self through MHC class I-binding inhibitory receptor. Using intrinsic properties of NK cells, NK cells are emerging to apply as therapeutic agents against many types of cancers. Recently, NK cell alloactivity has also been exploited in killer cell immunoglobulin-like receptor mismatched haploidentical stem cell transplantation to reduce the rate of relapse and graft versus host disease. In this review, we discuss the basic mechanisms of NK cell differentiation, diversity of NK cell receptors, and clinical applications of NK cells for anti-cancer immunotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3677-3683
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• 2015

Abnormally expressed microRNAs (miRNAs) and genes have been found to play key roles in esophageal squamous cell carcinoma (ESCC), but little is known about the underlying mechanisms. The aim of this paper was to assess inter-relationships and the regulatory mechanisms of ESCC through a network-based approach. We built three regulatory networks: an abnormally expressed network, a related network and a global network. Unlike previous examples, containing information only on genes or miRNAs, the prime focus was on relationships. It is worth noting that abnormally expressed network emerged as a fault map of ESCC. Theoretically, ESCC might be treated and prevented by correcting the included errors. In addition, the predicted transcription factors (TFs) obtained by the P-match method also warrant further study. Our results may further guide gene therapy researchers in the study of ESCC.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권4호
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• pp.253-262
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• 2000

Aspergillus is considered to be an attractive host for heterologous protein production because of its safety and ability to secrete large amounts of proteins. In order to obtain high productivity, thus far promoters of amylases have been most widely used in A. oryzae. Recent progress in cloning and expression analysis, including EST sequencing, revealed that glycolytic genes represent some of those most strongly expressed in A. oryzae. Therefore, promoters of glycolytic genes could be important alternatives to promoters of amylases because lower amounts of proteases are produced in the presence of glucose. Several A. oryzae transcription factors responsible for the induction and/or maximum expression of many industrially important genes encoding amylases and proteases have been cloned and characterized. In addition to the transcriptional regulatory factors, the gene encoding the largest subunit of RNa polymerase II, constituting the basic transcription machinery, has also been cloned from A. oryzae. This recently acquired understanding of the details of transcriptional regulatory mechanisms and factors will facilitate engineering flexible controls for the expression of proteins important for the fermentation industries.

• 지식경영연구
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• 제20권1호
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• pp.231-249
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• 2019

Technology transfer from a multinational company to a local subsidiary is essential for successful local market operations. This study aims to analyze the impact of market, cultural and institutional environmental factors on international technology transfer and innovation performance based on the S-C-P paradigm. We collected data from one hundred ninety-five subsidiaries of Korean parent firms located in seventeen countries and used structural equation modeling to test hypotheses. The analysis findings are as follow; First, both market and cultural environment directly affect international technology transfer. However, institutional environment such as protection of intellectual property does not affect international technology transfer. Due to the less risk of technology disclosure involved in technology transfer within the MNE organization can be not relationship between protection of intellectual property in the host country and the foreign subsidiary's transfer of technology. The risk of infringement of intellectual property is relatively low in intra-firm transfer of technology. Second, the technology introduced from the parent company has a positive effect on the innovation performance of local subsidiaries. This implies that multinational companies that have entered unfamiliar overseas markets should be able to effectively transfer the inherent advantages of the parent company to their overseas subsidiaries, and that their ability to adapt to the local environment is important.