• Journal of the korean academy of Pediatric Dentistry
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• v.43 no.1
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• pp.1-7
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• 2016

The developmental age of permanent teeth was evaluated in children and adolescents according to age and gender using the Nolla Method. A retrospective study was performed on panoramic radiographs of 1,200 subjects aged 4-15 years, including 50 children for each age/gender group. Three well-trained examiners estimated the developmental stage of upper and lower permanent teeth using the Nolla Method. The inter-examiner reliability was excellent (intra-class correlation coefficient value = 0.973). The mean developmental age was calculated. In boys, Nolla stage 6, indicated by crown completion, was seen in the central incisor, lateral incisor, canine, first premolar, second premolar, first molar, and second molar at 5.4, 6.4, 6.7, 7.5, 7.8, 4.6, and 8.1 years, respectively, in the maxilla and at 4.8, 5.1, 6.0, 6.5, 7.2, 4.5, and 8.0 years, respectively, in the mandible. In girls, Nolla stage 6 was seen at 5.3, 6.0, 6.3, 7.3, 7.7, 4.8, and 8.1 years, respectively, in the maxilla and at 4.8, 5.1, 5.9, 6.5, 7.2, 5.0, and 7.9 years, respectively, in the mandible. In this study, the developmental age of permanent teeth was evaluated in Korean children and adolescents who visited Yonsei University Dental Hospital. This study may be helpful in diagnosis and treatment planning in the clinic.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.475-481
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• 2020

This study investigated the mental health factors of juveniles according to socio-demographic characteristics and mental health related characteristics using the Korea Youth Risk Behavior Web-Based Survey 2019 Data. The study subjects were total 57,303 students (middle school: 29,384, high school: 27,919). The data was analyzed with descriptive statistics, frequency analysis, χ²-tests and regression analysis using SPSS ver. 18.0. The findings revealed that socio-demographic characteristics (gender, residential area, residential type, economic status, school achievement) and mental health related characteristics (subjective assessment, stress cognition, overcoming fatigue through sleeping, experiencing sadness and despair, suicidal ideation, suicidal planning, suicidal attempts, experience of hospital care for violence, experience of smoking, drinking, sexual relations and/or habitual drug use, internet use except for study) were factors that influenced factors related to the mental health of juveniles (p<0.05). The mental health of juveniles was closely related with health behaviors. This study could be used as a tool for the development and establishment of juveniles' health promotion and prevention strategies in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7061-7069
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• 2015

Background: During the past decades, the incidence and mortality rate of stomach cancer has demonstrated a great decrease in the world, but it is still one of the most common and fatal cancers especially among men worldwide, including Iran. The MYC proto-oncogene, which is located at 8q24.1, regulates 15% of genes and is activated in 20% of all human tumors. MYC amplification and overexpression of its protein product has been reported in 15-30% of gastric neoplasias. The aim of this investigation was to find the relative efficacy of CISH (chromogenic in situ hybridization) or IHC (immunohistochemistry) in diagnosis and prognosis of gastric cancer, as well as the relationship of amplification and expression of C-MYC gene with patient survival. Materials and Methods: In this cross-sectional study, 102 samples of gastric cancer were collected from patients who had undergone primary surgical resection at the Cancer Institute Hospital, Tehran University of Medical Sciences, from July 2009 to March 2014. All samples were randomly selected from those who were diagnosed with gastric adenocarcinomas. CISH and IHC methods were performed on all of them. Results: Patients were classified into two groups. The first consisted of stage I and II cases, and the second of stage III and IV. Survival tests for both groups was carried out with referrnce to CISH test reults. Group II (stage III & IV) with CISH+ featured lower survival than those with CISH- (p=0.233), but group I (stage I & II) patients demonstrated no significant variation with CISH+ or CISH- (p=0.630). Kaplan-Meier for both groups was carried out with IHC test findings and showed similar results. This data revealed that both diffuse and intestinal types of gastric cancer occurred significantly more in men than women. Our data also showed that CISH+ patients (43%) were more frequent in comparison with IHC+ patients (14.7%). Conclusions: For planning treatment of gastric cancer patients, by focusing on expanding tumors, which is the greatest concern of the surgeons and patients, CISH is a better and more feasible test than IHC, in regard to sensitivity and specificity. Therefore, CISH can be used as a feasible test for tumor growth and prognosis in stage III and IV lesions. This study also indicated that C-MYC amplification in gastric cancer is correlated with survival in advanced stages.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8063-8067
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• 2014

Background: Cervical cancer is a major public health problem in Bangladesh. Persistence of high risk human papillomavirus (HRHPV) influences the progression of the disease, with an important role in followup for cervical intraepithelial neoplasia (CIN). Objective: To establish application of high risk HPV DNA test in the follow-up of women after treatment of CIN. Materials and Methods: This cross-sectional and hospital based study was carried out among 145 CIN treated women during the previous six months to three years at the colposcopy clinic of Bangabandhu Sheikh Mujib Medical University, Dhaka, between January 2011 and June 2012. Pap smear and HPV samples were collected and colposcopy was performed to find out the persistence of the disease. Cervical samples obtained were tested for HPV DNA using the Hybrid Capture II (HC-II) test. A cervical biopsy was collected whenever necessary. The results were compared to assess the efficacy of different methods during follow up such as Pap smear, HPV test and colposcopy. Results: Mean age of the recruited women (n=145) was 33.6 (${\pm}7.6$), mean age of marriage was 16.8 (${\pm}2.9$) and mean age of 1st delivery was 18.8 (${\pm}3.5$) years. More than half had high grade CIN before treatment and 115 (79.3%) women were managed by LEEP and 20.7% were managed by cold coagulation. Among the 145 treated women, 139 were negative for HPV DNA and six of them (4.1%) were HPV positive. Sensitivity of Pap smear (40.0) and HPV DNA test (40.0) was poor, but specificity was quite satisfactory (>93.0) for all the tests. Conclusions: The high risk HPV DNA test can be an effective method of identifying residual disease. It can be added to colposcopy and this should be applied to all treated women attending for their first or second post-treatment follow-up visit at 6 months to one year, irrespective of the grade of treated CIN.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8455-8460
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• 2014

Background: The National Central Cancer Registry of China (NCCR) affiliated to the Bureau of Disease Control, National Health and Family Planning Commission of China is responsible for cancer surveillance in the entire country. Cancer registration data from each local registry located in each province are collected by NCCR annually to be analyzed and published to provide useful information for policy makers and cancer researchers. Materials and Methods: Until 1st June, 2013, 219 population-based cancer registries submitted data of 2010 to the National Central Cancer Registry of China covering about 207,229,403 population, and 145 cancer registries were selected after quality evaluation for this study. Colorectal cancer cases were selected from the database according to ICD-10 coded as "C18-C20". We calculated the crude incidence and mortality rates by sex, age groups and location (urban/rural). The China population in 2000 and Segi's population were used as standardized populations for the calculation of age-standardized rates. The 6th National Population Census data of China was used to combined with the cancer registries' data to estimate the colorectal cancer burden in China in 2010. Results: Colorectal cancer was the sixth most common cancer in China. It was estimated that there were 274,841 new cases diagnosed in 2010 (157,355 in males and 117,486 in females), with the crude incidence rate of 20.1/100,000, highest in males in urban areas. Age-standardized rates by China standard population of 2000 (ASRcn) and World standard population (Segi's population, ASRwld) for incidence were 16.1/100,000 and 15.9/100,000 respectively. There were 132,110 cases estimated to have died from colorectal cancer in China in 2010 (76,646 men and 55,464 women) with the crude mortality rate of 10.1/100,000. The ASRcn and ASRwld for mortality were 7.55/100,000 and 7.44/100,000 respectively, higher in males and urban areas than in females and rural areas. The incidence and mortality rates increased with age, reaching peaksin the 80-84 year old, and oldest age groups, respectively. Conclusions: Colorectal cancer is one of the most common incident cancers and cause of cancer death in China. Primary and secondary prevention, with attention to a health lifestyle, physical activity and screening should be enhanced in the general population.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.3
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• pp.1-9
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• 2016

Objectives: Cold Hypersensitivity of Hands and Feet (CHHF) has been diagnosed objectively by Digital Infrared Thermal Imaging (DITI) and has been known to be associated with autonomic nervous system (ANS), which can be assessed by Heart Rate Variability (HRV). This study evaluated the correlation between severity of CHHF and HRV variables.Methods: We studied 155 non-menopausal women with CHHF who visited Kyung Hee University Hospital at Gangdong from 01 October 2013 to 30 April 2016. We measured DITI and HRV of each patient. We used DITI to calculate the severity of CHHF with thermal difference between upper arm (L4, 俠白穴) and palm (P8, 勞宮穴) of both hands and anterior thigh (ST32, 伏兎穴) and dorsum of foot (LI3, 太衝穴) of both feet. The correlation between severity of CHHF and HRV variables were analyzed.Results: In time domain analysis, there was significantly positive correlation between the severity of CHHF and both SDNN and RMSSD. In frequency domain analysis, there was significantly positive correlation between the severity of CHHF and TP, HF and HF Norm while there was significantly negative correlation between the severity of CHHF and LF Norm as well as between the severity of cold hypersensitivity of both hands and LF/HF ratio.Conclusions: The more severe CHHF is, the more increased the function of parasympathetic nerve system (PNS) and relatively decreased the function of sympathetic nerve system (SNS) is. Also, it has known that cold hypersensitivity could be caused by deficiency syndrome and qi deficiency has the same ANS tendency as CHHF. Therefore, in practical fields, this result can be helpful in planning treatment and deciding prognosis in respect of deficiency syndrome.

• Radiation Oncology Journal
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• v.33 no.4
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• pp.320-327
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• 2015

Purpose: To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). Materials and Methods: We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 10-30 fractions. When the ${\alpha}/{\beta}$ value for the tumor was assumed to be 10 Gy for the biologically equivalent dose (BED), the total doses ranged from 39 to $119Gy_{10}$ (median, $55Gy_{10}$). Nineteen lesions were treated with concurrent chemotherapy (CCRT). Results: With a median follow-up time of 16 months, the median overall survival for 18 patients was 33 months. Eight lesions (26%) achieved complete response. The 1- and 3-year local progression free survival (LPFS) rates for 31 lesions were 45% and 34%, respectively. On univariate analysis, significant parameters influencing LPFS rates were chemotherapy response before HT, aim of HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, $PTV{\leq}113mL$ and $BED>48Gy_{10}$ were associated with a statistically significant improvement in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, each of whom had also received CCRT. Conclusion: The current study demonstrates the efficacy and tolerability of HT for mCRC. To define optimal RT dose according to tumor size of mCRC, further study should be needed.

• Journal of Korean Academy of Nursing
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• v.19 no.2
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• pp.160-172
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• 1989

This research was done to clarify the factors related to sexual satifaction in women who have had a hysterectomy, and to idenify which factors had statistically significant influence of sexual satisfaction of the subjacts. The objective of this study was to identify the variables related to sexual adaptation which might be changed by nursing intervention. This was a cross-sectional descriptive correlation study. There were 230 subjects in the study, and they were selected by a convenient sampling method. The tool. for this study was developed by the researcher through modification of the Dergatis Sexual Function Inventory(DSFI). A pilot study was done to determine the necessary modifications. Data collection was done between Sept. 1987 and Du. 1987 using a mailed questionnaire. The characteristics of the subjects were as follows : The mean age of the subjects was 42.3 years and 204(87.4%) of the subjects had nine or more years of education. The mean income of the subjects was 85.8870 won / month, and 179(77%) of them were housewives. The mean number of pregnancies and children were 4.9 and 2.5 respectively. Oophorectomies were included in the surgery for 66(28.7%) of the subjects. Only 12(5.2%) were planning to have more children. Only 88(38.3%) of the subjects had received information prior to the surgery regarding health problems related to the operation and less than half, 111 (48.3%), had received this kind of information before discharge. Lay persons were the source of information about the post-operation status for 196 (85.2%) of the subjects, but the content of the information did not significantly influence the sexual satisfaction score. Only 16(7.0%) of the subjects said they regretted having a hysterctomy while 102(44.3%) said they were pleased to have had a hysterectomy. Ninety (39.1 %) of the subjects reported that their husbands had “stress” and 164(71.3%) of the subjects reported “stress”. The results of this study are summarized as follows : 1. The mean score for sexual satisfaction of the subjects was 34.24 with a possible maximum score of 50.00. Eighty two(35.8%) were responded that they were satisfied with their sexual life but 61 (26.5%) were responded that they were dissatisfied with their sexual life 2. The following 15 factors extracted from the results of the data analysis were significantly related to sexual satisfaction(p＜.05) ; support of husband, body image, emotion, knowledge of sex, menopausal symptoms, sexual behavior, the feelings the subjects had about the hysterectomy, stress for both subject and husband, the number of children, health information given before operation, job, age, level of education and income. The five most important factors influencing sexual satisfaction were identified by using stepwise multiple regression analysis. The most important factor was support of husband, which explained 17.83% of the total variance. The remaining factors in order of significance were : Knowledge of sex, income, job, and emotional status. Those five factors explained 35.16% of the sexual satisfaction. In conclusion, for the care of women who are going to be discharged from hospital after having had a hysterctomy, nurses have to work with the husbands to help them to understand the importance of their support. Nurses also need to make sure that the subjects have an adequeate knowledge of sexual life after a hysterectomy. Also nursing interventions should focus on subjects who do not have a job, who are of low economic status, and the subjects who are under the unpleasant mood.

• Korean Journal of Head & Neck Oncology
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• v.22 no.1
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• pp.29-32
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• 2006

Background: The location of parotid gland tumors can influence the duration and the difficulty of the operation. If the information about tumor location was available preoperatively, it would allow accurate operative planning and counseling of patients in terms of the length of the operation and the potential morbidity. Methods: This study was based on a retrospective review of 100 patients with parotid gland tumors underwent parotidectomy from January 2000 to October 2005 at Yong-Dong Severance Hospital. Based on computed tomographic(CT) scan findings, 4 landmarks such as facial nerve(FN) line, Utrecht(U) line, Conn's are(CA), and retromandibular vein (RV) were drawn on the scans in same plane. The location of tumors were determined by the landmarks and confirmed by the operative findings. The accuracy of each landmarks was evaluated. To find out the accuracies according to tumor size, the tumors were divided into 2 groups; less than 2 cm and larger than 2 cm in diameter. Results: U line was the most accurate(94%), sensitive(89.3%) and specific(97.7%) in predicting tumor location of the parotid gland. However, in small tumors less than 2cm, FN line (p=0.022) and RV criteria (p=0.028) were more reliable in accuracy. Conclusion: CA, FN line, U line, and RV are all useful landmarks in preoperative prediction for the location of parotid gland tumors. However, U line was the most accurate, but we must consider that proper landmark should be used in prediction according to the size of tumor because the accuracy of landmark may change.

• Journal of Korean Public Health Nursing
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• v.11 no.2
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• pp.57-72
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• 1997

The objectives of this study are : 1) To understand self-care ability, living habits, utilization patterns of medical facililties for the elderly in Puk-Cheju county which has the highest percent age of senior citizens among Cheju rural community: 2) To identify factors which influence living quality and long life for the eldely 3) To develop health care service with a view to guaranteering living quality The eldely population of Puk-Cheju county was $10.8\%$ in 1995. It will be increasing and is projeted $23.0\%$ by 2030. The result indicated that utilizations rate by out-patient were 5.89 claims and utilizations rate by in-patient were 0.17 claims per person. The highest disease among respondents were disease of musculoskeletal system and connective tissue. A total of 310 elderlys were responded to analyze self-care ability and health behavior. The most important factors of long life were to have peaceful mind$(50.0\%)$. The common disease of acute and chronic disease was musculoskeletal system disease. $66.8\%$ of respondents went to hospital and local clinic when they got sick. The most needed health care service was home visiting service among public health center, representing $31.4\%$. The repondent's self-care ability and self-efficacy were relatively superiority. A total of 92 elderlys were conducted the intelligence test for the rate of dementia and their average age was 74.3. The result of Minimental State Scale indicated that 25% of respondents were suspected to be dementia. The followings are recommendations based on the survey result. 1) Concidering every conditions of self-care ability and health status for elderly. It is important to embody appopriate health care service. 2) Considering concrete method, it is necessary to establish health service, which match health status and self-care ability, and various planning for sepecial facilities for the elderly. 3) It is desiable to make actual programs for the elderly in each community level. 4) It must be develop the better use of volunteers and programs for prevention of dementia. Finally, Concerning the orgarnization of public health center, community health center need to be reorganized for health service for the elderly. It is important to develop and operate health promotion for the elderly, and it is necessary to form the foundation for the support of facilities equipments. This contribute to promote health status for the rural elderly.