• Journal of The Korea Institute of Healthcare Architecture
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• v.27 no.4
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• pp.29-39
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• 2021

Purpose: As the need for a hospital specializing in infectious diseases has increased, construction is being promoted. Hospitals specializing in infectious diseases receive some state subsidies, but in the case of private hospitals, hospital operation efficiency should be considered to prevent cost loss. Therefore, we aim to derive a building plan for a general ward in a hospital specializing in infectious diseases that can be used not only in normal times but also in times of crisis. Methods: In this study, relevant literature review and field interviews were conducted with medical staff working in facilities designated as infectious disease hospitals. Results: The general ward building plan of the hospital specializing in infectious diseases was classified into three categories and presented. 'Spatial composition' for nursing unit and ward zoning, 'Spatial plan' for ward space conversion in normal times and crises, 'Bedroom plan' for effective dimensions and area of the ward. Implications: It can be used as a guideline when designing an infection-facility ward. And it can be a basis for inducing improvements to prevent infection in the ward of existing medical facilities.

• Proceedings of the Korean Society of Radiological Science
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• 2004.09a
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• pp.80.2-80.2
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• 2004

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.751-760
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• 2018

BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is still an important issue that needs to be resolved. Many studies have aimed to improve efficiency, but developing accurate methods to determine efficacy is also critical. Studies using pluripotency to estimate efficacy are rare. Telomerase is highly associated with pluripotency. METHODS: We have described a quantitative method to measure telomerase activity, telomeric repeat elongation assay based on quartz crystal microbalance (QCM). To investigate whether this method could be used to determine the efficiency of in vitro osteogenic differentiation based on pluripotency, we measured the pluripotency pattern of cultures through stemness gene expression, proliferation ability and telomerase activity, measured by QCM. RESULTS: We showed that the pluripotency pattern determined by QCM was similar to the patterns of proliferation ability and gene expression, which showed a slight upregulation at the late stages, within the context of the general downregulation tendency during differentiation. Additionally, a comprehensive gene expression pattern covering nearly every stage of differentiation was identified. CONCLUSION: Therefore, this assay may be powerful tools for determining the efficiency of differentiation systems based on pluripotency. In this study, we not only introduce a new method for determining efficiency based on pluripotency, but also provide more information about the characteristics of osteogenic differentiation which help facilitate future development of more efficient protocols.

• BMB Reports
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• v.51 no.2
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• pp.85-91
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• 2018

Pluripotent stem cell (PSC) variations can cause significant differences in the efficiency of cardiac differentiation. This process is unpredictable, as there is not an adequate indicator at the undifferentiated stage of the PSCs. We compared global gene expression profiles of two PSCs showing significant differences in cardiac differentiation potential. We identified 12 up-regulated genes related to heart development, and we found that 4 genes interacted with multiple genes. Among these genes, Gata6 is the only gene that was significantly induced at the early stage of differentiation of PSCs to cardiomyocytes. Gata6 knock-down in PSCs decreased the efficiency of cardiomyocyte production. In addition, we analyzed 6 mESC lines and 3 iPSC lines and confirmed that a positive correlation exists between Gata6 levels and efficiency of differentiation into cardiomyocytes. In conclusion, Gata6 could be utilized as a biomarker to select the best PSC lines to produce PSC-derived cardiomyocytes for therapeutic purposes.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.647-650
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• 2014

Objective: To explore the efficiency of single application of lobaplatin in tran-scatheter arterial chemoembolization (TACE) for patients with a primary hepatic carcinoma who were unable or unwilling to undergo surgery. Methods: 173 patients with primary hepatic carcinoma diagnosed by imaging or pathology were randomly divided into experimental and control groups and respectively treated with lobaplatin and pirarubicin hydrochloride as chemotherapeutic drugs for TACE. The amount of iodipin was regulated according to the tumor number and size, and then gelatin sponge or polyvinyl alcohol particles were applied for embolisms. The efficiency of treatment in the two groups was compared with reference to survival time and therapeutic response. Results: The experimental group (single lobaplatin as chemotherapy drug) was superior to control group (single pirarubicin hydrochloride as chemotherapy drug) in the aspects of survival time and therapeutic response, with statistical significance. Conclusions: Single lobaplatin can be as a chemotherapy drug in TACE and has better efficiency in the aspects of mean survival time and therapeutic response, deserving to be popularized in the clinic.

• Korea Journal of Hospital Management
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• v.26 no.2
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• pp.68-78
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• 2021

Background:The purpose of this study was to identify factors influencing on hospital choice of the general hospital among customers with loyalty in Mongolia. Methods:This study was divided into 5 types of hospital choice factor such as physical, human, efficiency, accessibility, and hospital image. Data were assessed using 229 patients who visit at a general hospital in Mongolia. The collected data from June 20 to July 20 in 2020 were conducted the self-administered questionnaires and analyzed frequency, t-test, ANOVA, and logistic regression by using SPSS 25.0. Results:The level of education was significant in the mean difference of customer types by demographic characteristics. Expecially, factors affecting hospital choice of loyalty customers were human and hospital image. Conclusion:This study suggests that it is necessary to understand present and potential consumer's needs, wants, and demands. Also, it is important to concern about aspect of marketing strategy of the general hospital in Mongolia.

• The Korean Journal of Nuclear Medicine Technology
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• v.22 no.2
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• pp.105-111
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• 2018

Purpose Quality control of instrument takes up a large part in the Radioimmunoassays. The gamma-ray instrument, which is one of the important instruments in the laboratory, observes the condition and performance of instrument and performs quality control of the instrument by measuring the Normalization, Calibration, Background and etc. However, there are some automation instruments which can't measure the counting efficiency of gamma-ray meters, resulting in insufficient management in terms of performance evaluation of gamma-ray meters. Therefore, the purpose of this paper is to manage the quality control continuously and regularly by suggesting how to measure the counting efficiency of gamma-ray instruments. Materials and Methods In case of a comparative measurement method to a gamma-ray instrument dedicated to nuclear medical examination, the CPM and counting efficiency can be obtained after the measurement of normalization by inserting the I-125 $200{\mu}L$(CPM 50,000~500,000) into the test tube. With this CPM and counting efficiency values, it's possible to calculate the measurement of the DPM value and count the CPM from the automation instrument from the same source, and enter the DPM to calculate the counting efficiency using a comparative measurement method. Another method is to calculate the counting efficiency by estimating the half life using the radiation source information of the tracer in B test reagents of company A. Results According to the calculation formula using the DPM obtained by counting the normalization of gamma-ray meters, the detection efficiency was 75.16% for Detector 1, 76.88% for Detector 2, 77.13% for Detector 3, 75.36% for Detector 4 and 73.2% for Detector 5 respectively. Using another calculation formula estimated from the shelf life, the data of the detection efficiency from Detector 1 to Detector 5 were 74.9%, 75.1%, 76.5%, 74.9% and 73.2% respectively. Conclusion Although the accuracy of counting efficiencies of both methods are insufficient, this is considered to be useful for ongoing management of quality control if counting efficiency is managed after setting the acceptable ranges. For example, if the measurement efficiency is set to 70% or higher, the allowed %difference between measurements is within 3% and the %difference with the detector wall is set within 5%.

• The Journal of Society for e-Business Studies
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• v.19 no.3
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• pp.91-105
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• 2014

This study purposed to benchmark the number of patients who visited an oriental medicine hospital from its surrounding regions using data envelopment analysis (DEA) model, and to analyze the relationships between regional characteristics and efficiency scores from DEA. Study data was collected from one oriental medicine hospital operated in a metropolitan city in Korea. Patient locations were identified at the smallest administrative district, Dong, and number of patients was calculated at the Dong level based on the address of patients in hospital information system. Socio-demographic variables of each Dong were identified from the Statistics of Korea web-sites. DEA was used to benchmark the number of patients between Dongs and to compute the efficiency scores. Tobit regression analysis model was applied to analyze the relationship between efficiency scores and regional variables. 6 Dongs were identified as efficient after DEA. In Tobit analysis, number of medical aid recipients and number of total population in each Dong was significant in explaining the differences of efficiency scores. The study model introduced the application of DEA model in benchmarking the patients between regions. It can be applied to identify the number of patients in each region which a hospital needs to improve their performances.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.1
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• pp.75-84
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• 2016

This study is to analyze the efficiency of oriental hospitals using DEA. The input variables are the numbers of doctors, nurses, medical technicians, and beds. The output variables are the numbers of annual inpatients and outpatients. The statistical analysis tools used are EnPas and IBM SPSS Statistics 19. The result in efficiency analysis by establishment type showed that the national and public hospitals had the most efficiency. In the case of location, the efficiency of the oriental hospitals in Seoul was the highest but those in the Metropolitan areas had a relatively low efficiency. If the number of the beds was generally less than 50 beds, the hospitals were highly efficient, but the hospitals in the medium category of 51-100 beds were low in efficiency. The Logistic regression analysis conducted to analyze the variables that have affected the efficiency of oriental hospitals resulted that the efficiency increased by 1.045 everytime the number of nurses increased by 1.

• Clinical and Experimental Pediatrics
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• v.50 no.10
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• pp.1011-1017
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• 2007

Purpose : We tried to assess the optimal conditions to improve low transduction efficiency and their effect on target cells. Methods : Cultured NIH 3T3 cells were incubated with retroviral vectors bearing an enhanced green fluorescent protein (eGFP) gene. We varied the ratio of viral vectors to target cells (1:1-1:8) and the number of transfections (${\times}1$, ${\times}2$), and compared transduction efficiencies. Also, the effects of polybrene on transduction efficiency and viability of target cells were assessed. Transduction of the eGFP gene was evaluated by observing NIH 3T3 cells under a fluorescence microscope and efficiencies were measured by the percentage of eGFP positive cells using FACscan. Results : As the ratio of retroviral vectors to target cells increased, transduction efficiency was greatly improved, from 7% (1:1) to 38% (1:4). However, transduction efficiency did not increase any more when the ratio increased from 1:4 to 1:8. Cells transfected twice showed higher transduction efficiencies than cells transfected once, at a ratio of 1:8. The eGFP gene transduced to NIH 3T3 cells sustained its expression during repeated passages. However, after the third passage (day 9), the percentage of eGFP positive cells began to decline. The degree of this decline in eGFP expression was lower in cells transfected twice than in cells transfected once (P<0.05). The addition of polybrene did not have any toxic effect on NIH 3T3 cells and greatly increased transduction efficiency (P=0.007). In addition to vector component, transduction efficiency was very sensitive to culture confluence. Cells cultured and transfected in 24-well plate showed higher transduction efficiency, although cells cultured in 6- well plate proliferated more (P=0.024). Conclusion : Our data could be used as a basis for retrovirus-based gene therapy. Further study will follow using human cells as target cells.