• Clinics in Shoulder and Elbow
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• 제26권2호
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• pp.140-147
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• 2023

Background: The management of acromioclavicular (AC) joint dislocation remains controversial. Recently, anatomic coracoclavicular (CC) fixation with a double clavicular tunnel and three flip-buttons has shown promising results. This study aimed to evaluate functional and radiological outcomes in patients with high-grade AC joint dislocation treated with anatomic CC fixation using double clavicular tunnels and three flip-buttons. Methods: A retrospective, unicentric study was performed. The study included patients with high-grade AC joint dislocation who underwent surgery with anatomic CC fixation using double clavicular tunnels and three flip-buttons. Demographic data were obtained from medical records. A functional evaluation using subjective shoulder value (SSV), visual analog scale (VAS), and disabilities of the arm, shoulder, and hand (DASH) questionnaires was performed, and an evaluation of preoperative and postoperative comparative Zanca view images was performed. Factors associated with functional outcomes and radiological AC reduction were analyzed. Results: A total of 83 patients completed follow-up and were included in the analysis. The mean SSV, VAS, and DASH scores were 92.8, 0.8, and 6.4, respectively. Patients who had complications experienced significantly worse functional outcomes (DASH: P=0.037). Suboptimal final AC reduction was observed in nine patients (11.1%), and significantly more frequently in patients older than 40 years (P=0.031) and in surgeries performed more than 7 days after injury (P=0.034). There were two reoperations (2.4%). Conclusions: Anatomic CC fixation with a double clavicular tunnel and three flip-buttons leads to good functional outcomes, low complication rates, and high rates of optimal AC reduction.

• Biomolecules & Therapeutics
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• 제18권2호
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• pp.152-158
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• 2010

Melanin concentrating hormone is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the G-protein coupled receptor family, especially plays an important role in the complex regulation of energy balance and body weight mediated by the melanin concentrating hormone receptor subtype 1 (MCH1). Compelling pharmacological evidence implicating MCH1 signaling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies as MCH1 antagonists may have potential therapeutic benefit in the treatment of obesity and metabolic syndrome. Although fluorescence-based calcium mobilization assay platform has been one of the most widely accepted tools for receptor research and drug discovery, fluorescence interference and shallow assay window limit their application in high throughput screening and have led to a growing interest in alternative, luminescence-based technologies. Herein, a luminescence-based functional assay system for the MCH1 receptor was developed and validated with the mitochondrial targeted aequorin. Aequorin based functional assay system for MCH1 presented excellent Z' factor (0.8983) and high signal-to-noise ratio (141.9). The nonpeptide MCH1 receptor antagonist, SNAP 7941 and GSK 803430, exhibited $IC_{50}$ values of 0.62 ${\pm}$ 0.11 and 12.29 ${\pm}$ 2.31 nM with excellent correlation coefficient. These results suggest that the aequorin based assay system for MCH1 is a strong alternative to the traditional GPCR related tools such as radioligand binding experiments and fluorescence functional determinations for the compound screening and receptor research.

• 한국의류학회지
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• 제42권5호
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• pp.799-808
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• 2018

This study develops triacetate-containing functional fabrics with a cool-touch and cool-absorbent. For this purpose we used composite yarns made using triacetate filament and PET High absorbance quick dry filament as well as the composite fabric woven. The fineness of the yarn and structure of fabric varied the cover factor varied. The blend ratio of triacetate was differently set. When the triacetate content was the same, the cool touch of the fabric having a large cover factor and small SMD increased. The surface became smooth and the contact area became large; in addition, both the Qmax value and the cool-touch became large. In the case of similar density, the cool-touch of the fabric having a large content of triacetate increased. The cool-absorbent of the fabric containing triacetate showed a similar level of the PET High absorbance quick dry filament fabric treated with and endothermic cooling agent. It was possible to develop a functional coolness fabric with a cool-touch and a cool-absorbent when the content of triacetate and cover factor were well combined.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 춘계학술대회 초록집
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• pp.94.2-94.2
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• 2011

In this work, multi-functional groups, i.e., nitrogen and oxygen, contained microporous carbons (MF-MCs) were prepared by the one step carbonization of the poly(vinylidene chloride-co-acrylonitrile-co-methyl methacryalte) (PVDC-AN-MMA) without activation. The electrochemical performance of MF-MCs was investigated as a function of carbonization temperature. It was found that MF-MCs had a high specific surface area over $800m^2/g$ without additional activation, resulting from the micropore's formation by the release of chlorine groups. In addition, although functional groups decreased, specific surface area was increased with increasing carbonization temperature, leading to the enhanced electrochemical performance. The pore size of the carbon distributed mainly in small micropore of 1.5 to 2 nm, which was idal for aqueous electrolyte. Indeed, the unique microstructure features, i.e. high specific surface area and optimized pore size provided high energy storage capability of MF-MCs. These results indicated that the microporous features of MF-MCs lead to feasible electron transfer during charge/discharge duration and the presence of nitrogen and oxygen groups on the MF-MCs electrode led to a pseudocapacitive reaction.

• 대한가정학회지
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• 제43권7호
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• pp.23-35
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• 2005

This study examined the consumer complaining behavior after purchasing functional health foods and investigated the variables which influence public and private consumer complaining behavior. The subjects of this study were 206 consumers who were dissatisfied after purchasing functional health foods. The survey was conducted during September. 15-October 6, 2003. Percentiles, frequencies, means, $X^2$ and logistic regression were utilized for data analysis with SPSS program. Major findings were as follows: 1 The groups reporting public complaining behavior were over college graduate, high income workers, professional and clerical workers(demographic variables). Purchasing related variable were high purchasing price, strategy of sales person and. ad, purchasing channel through door to door sales, telemarketing, multi level sales, and home shopping, purchasing purpose of weight control and cosmetic. 2. The groups reporting private complaining behavior were high school graduate, low income workers, housewives and the unemployed(demographic variables). Purchasing related variable were low purchasing price, the case of consumer need, purchasing in the shop, purchasing purpose of health restoration.

• Molecules and Cells
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• 제27권2호
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• pp.225-235
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• 2009

Antibody phage display provides a powerful and efficient tool for the discovery and development of monoclonal antibodies for therapeutic and other applications. Antibody clones from synthetic libraries with optimized design features have several distinct advantages that include high stability, high levels of expression, and ease of downstream optimization and engineering. In this study, a fully synthetic human scFv library with six diversified CDRs was constructed by polymerase chain reaction assembly of overlapping oligonucleotides. In order to maximize the functional diversity of the library, a ${\beta}$-lactamase selection strategy was employed in which the assembled scFv gene repertoire was fused to the 5'-end of the ${\beta}$-lactamase gene, and in-frame scFv clones were enriched by carbenicillin selection. A final library with an estimated total diversity of $7.6{\times}10^9$, greater than 70% functional diversity, and diversification of all six CDRs was obtained after insertion of fully randomized CDR-H3 sequences into this proofread repertoire. The performance of the library was validated using a number of target antigens, against which multiple unique scFv sequences with dissociation constants in the nanomolar range were isolated.

• Journal of Crop Science and Biotechnology
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• 제11권1호
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• pp.75-82
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• 2008

Functional stay-green is a beneficial trait that may increase grain yield through the sustained photosynthetic competence during monocarpic senescence in cereal crops. The temporal changes of photosynthesis and related characteristics throughout the grain filling period of a stay-green japonica rice "SNU-SG1" was compared in growth chamber conditions with three high-yielding cultivars(HYVs) and their $F_1$ hybrids with SNU-SG1. SNU-SG1 exhibited a typical characteristic of functional stay-green in terms of chlorophyll degradation and photosynthetic competence during grain filling. According to the photosynthesis-light response curve measured at 10 and 35 d after heading for the flag leaf, SNU-SG1 exhibited higher initial light conversion efficiency and thus higher gross photosynthetic rate at light saturation compared to HYVs. Light saturation point was not different among genotypes, ranging from 1000 to 1500 ${\mu}mol$ photon $m^{-2}s^{-1}$. Net photosynthetic rate at light saturation($P_{max}$) of the upper four leaves in SNU-SG1 was much higher and sustained longer throughout grain-filling than HYVs and $F_1$ hybrids. The sustained high photosynthetic competence of SNU-SG1 during grain filling was ascribed to the longer maintenance of high mesophyll conductance that resulted from not only high chlorophyll content and its delayed degradation but also the slow degeneration of photosystem II(PS II) as judged by chlorophyll fluorescence($F_v/F_m$) of flag leaves. $F_1$ hybrids showed slow degeneration of photosystem II similar to the male parent SNU-SG1 while chlorophyll degradation pattern close to female parents, thus exhibiting a little higher $P_{max}$ than female parents. These results suggest that SNU-SG1 has a typical functional stay-green trait that can be utilized for increasing rice yield potential through the improved dry matter production during grain filling.

• 한국자기공명학회논문지
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• 제24권4호
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• pp.104-116
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• 2020

Fipronil, the phenylpyrazole insecticide, is effective and used in various fields. Especially, fipronil was reliable because it was known to be specific on invertebrate animals than vertebrate animals including mammals. However, fipronil had potential risks that affect vertebrate animals as it blocks the gamma-aminobutyric acid (GABA) receptors that also exists in vertebrates as well as invertebrates. Therefore, it was necessary that harmful effects of fipronil on vertebrates are clarified. For this purpose, the zebrafish (Danio rerio) were used on behalf of vertebrate animals in present study. The zebrafish were exposed to 5 ㎍/L, 25 ㎍/L, and 50 ㎍/L of fipronil during 12, 24 and 72 hours. To closely observe toxic process, 12 hours and 24 hours of additional time point were set in the exposure test. Nuclear magnetic resonance (NMR)-based metabolomics is an approach to detect metabolic changes in organism resulted from external stimuli. In this study, NMR-based metabolomics showed the metabolic changes in zebrafish caused by fipronil exposure. Metabolic analysis revealed that fipronil interfered with energy metabolism and decreased the antioxidant ability in zebrafish. Antioxidant ability decline was remarkable at high exposure concentration. In addition, metabolic analysis results over time suggested that reactions for alleviating the excessive nerve excitation occurred in zebrafish after fipronil exposure. Through this study, it was elucidated that the adverse effects of fipronil on vertebrate animals are evident. The risk of fipronil on vertebrates can be no longer ignored. Moreover, this study has a meaning of practically necessary research for organism by examining the effects of fipronil at low concentrations existed in real environment.

• 한국육종학회지
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• 제41권4호
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• pp.547-551
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• 2009

"칠보"는 국립식량과학원 영덕출장소에서 2007년에 육성한 쌀 품위가 좋고 밥맛이 양호하며 바이러스병에 강한 중만생 벼 품종으로 주요 특성과 수량성을 요약하면 다음과 같다. 1. 출수기는 평야지의 보통기 재배에서 8월 15일로 "화성벼"보다 3일 늦은 중만생종이다. 2. 주당수수는 18개로 "화성벼"보다 3개 많으며 수당립수는 적은 편이고 등숙비율은 더 높으며 현미천립중은 비슷한 중립종이다. 3. 심복백이 거의 없고 "화성벼"보다 맑고 투명하며 도정률 및 완전미율이 높고 아밀로스 및 단백질함량은 비슷하며 밥맛은 "화성벼"보다 양호하다. 4. 불시출수와 수발아가 않되는 편이고, 위조현상에 강하고 성숙기 엽노화가 느린 편이며 내냉성은 "화성벼"보다 출수지연은 심하고 임실률은 중정도이다. 5. 잎도열병은 중도저항성이며, 줄무늬잎마름병에는 강하나 흰잎마름병, 오갈병 및 검은줄오갈병에는 약하고 벼멸구 등 충해에는 감수성이다. 6. 쌀수량은 5.57 MT/ha로 "화성벼"보다 8% 증수 되었으며, 이모작재배에서는 5.33 MT/ha, 만식재배에서는 4.60 MT/ha의 수량성을 보였다.

• 한국육종학회지
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• 제41권4호
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• pp.635-639
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• 2009

간식용 대립 땅콩의 선호도가 높음에 따라 대립 양질 다수성 신품종 육성을 위하여 다수성인 '새들'과 단경 다수성 '사도노카'를 인공교배하여 육성한 풍안의 주요 특성을 요약하면 다음과 같다. 1. 풍안은 버지니아 초형으로 개화기가 빠르고 지상부 생장습성은 단경 다분지성이다. 2. 풍안은 대광땅콩에 비해 성숙협수, 성숙협비율, 협실비율, 100립중등 양호한 등숙특성을 보이며 100립중이 88 g인 대립품종이다. 3. 도복에 매우 강한 특성을 나타내며 흑반병, 그물무늬병에 비교적 강하고 낙엽율도 낮아 생육후기까지 녹엽 유지에 유리하였다. 4. 풍안은 단백질이 29.5%, 기름함량이 48.1%이고 지방산은 올레산과 리놀산의 비율이 같은 특성을 가진다. 5. 풍안은 3년간 지역적응시험 결과 대광땅콩에 비하여 전국평균 4.67 ton로서 16% 증수되었다. 6. 풍안은 경장이 짧고 병해에도 강한 편이나 충분한 성숙을 위하여 강원도와 산간 고냉지를 제외한 지역에서 적응성이 높은 품종이다.