• 한방비만학회지
• /
• 제16권1호
• /
• pp.27-35
• /
• 2016

Objectives: This study investigated the effects of water extract of Coix lacrymajobi var. mayuen on obesity and its associated factors in high fat diet (HFD) induced obese mice. Methods: Male C5BL/6 mice were randomly assigned to 4 groups, normal group (chow diet), a HFD, HFD with water extract of Coix lacrymajobi var. mayuen 100 mg/kg (W-Coix), and HFD with phentermine 5 mg/kg (Phen) as positive control. Body weight, food intake, fasting blood glucose were checked every week and then organs, blood serums were collected after 16 weeks of treatment. Results: Body weight and adipocyte size were significantly lesser in W-Coix than in HFD group; however energy efficiency in W-Coix were not different with HFD. The oral glucose tolerance test, serum glucose and insulin were significantly decreased in W-Coix, also lipid accumulations in liver tissue and lipid levels (total cholesterol, high density lipoprotein-cholesterol) were improved with W-Coix treatment. However skeletal muscle loss with HFD was not changed in W-Coix compared with HFD group. Conclusions: The W-Coix treatment decreased body weight, adipocyte size and it is associated with improved glucose and lipid metabolism. Further studies are needed to know the mechanism of antiobesity in W-Coix.

• Preventive Nutrition and Food Science
• /
• 제18권2호
• /
• pp.98-103
• /
• 2013

In this study, we evaluated the hypolipidemic and antioxidative effects of biotransformed soybean powder (BTS; Phellinus baumii-fermented soybean) on lipid metabolism in rats. Sprague-Dawley (SD) male rats were divided into basal diet group (BA), high fat diet group (HF), high fat diet containing 10% BTS group (10 BTS), and high fat diet containing 20% BTS group (20 BTS). Changes in the content of various isoflavones, including daidzein and genistein, within the soybean after fermentation to BTS were investigated. The levels of daidzein and genistein were $149.28{\mu}g/g$ and $364.31{\mu}g/g$, respectively. After six weeks experimental period, Food efficiency ratio in the 10 and 20 BTS group was significantly lower than the HF group (P<0.05). Total serum levels of cholesterol, triglycerides, low-density lipoprotein cholesterol, and atherogenic index ratio in the 10 or 20 BTS group were significantly lower than the HF group. The levels of alanine aminotransferase, aspartate aminotransferase and thiobarbituric acid reactive substance were significantly lower in the groups that received 10% and 20% BTS than the HF. The activities of SOD and CAT were significantly higher in the 10 and 20 BTS group than the HF group. The activity of XO in the 10 and 20 BTS group was significantly lower than in the HF group by 20% and 23%, respectively. In conclusion, these data suggest that BTS is an effective agent in improving lipid metabolism and antioxidant enzyme system.

• 한국응용과학기술학회지
• /
• 제34권2호
• /
• pp.254-259
• /
• 2017

본 연구에서는 스트렙토조토신(Streptozotocin,STZ)으로 유발된 당뇨쥐에게 맥문동(Liriope platyphylla,Lp)에탄올 추출물(수율:30.7%)을 1,000mg/kg용량으로 7일간 경구 투여 후 혈청속의 혈당함량과 당대사와 관련된 몇 몇 효소와 지질대사와 관련된 물질을 측정한 결과 혈당과 triglyceride(TG), total cholesterol의 농도는 STZ대조군과 비교하여 맥문동 투여군에서 유의적인 감소를 나타내었고, glucose-6-pase(g-6-pase)활성은 STZ 대조군과 비교하여 유의적인 감소를, glucokinase(gk)활성은 증가를 나타내었다. 또한 hepatic glycogen 함량은 STZ대조군과 비교하여 유의적인 증가를 나타내었다. 따라서 본 실험 결과 맥문동 에탄올 추출물을 스트렙토조토신으로 유발된 당뇨쥐에 있어서 항 당뇨 성분을 함유하고 있음을 알 수 있었다.

• Journal of Nutrition and Health
• /
• 제31권5호
• /
• pp.921-926
• /
• 1998

The purpose of this study was to investigate the potential hypolipidemic effect of adlay extract in streptozotocin-induced diabetic rats. Fifty six rats were fed either a control diet or adlay extract diets of : Methanol 1%(Ml%) ; Methanol 2%(M2%) ; Methanol 4%(M4%) ; Chloroform-Methanol 1%(CMl%) ; Chloroform-Methanol 2%(CM2%) ; Chloroform-Methanol 4%(CM4%) for 3 weeks. The amount of extracts added was 1%, 2% or 4% by diet weight respectively. The levels of glucose, total cholesterol(TC), high-density-lipoprotein cholesterol (HDL-C), free-fatty acid(FFA) and triglyceride(TG) in plasma, liver and skeletal muscle were compared. Among diabetic rats, there were no significant differences in the plasma level of glucose and TC regardless of a different extraction procedure or different amount of extracts added. While the plasma 7G level tended to increase with times passed in diabetic control group, was not increased with times passed in CM groups and was significantly lower in CM groups at 3rd week. Compared to the diabetic control group, the levels of FFA tended to be lower in all M groups and were not different in all CM groups. The levels of HDL-cholesterol were not different in all M groups and were significantly lower in all CM groups than diabetic control group. Compared to diabetic control group, liver triglyceride level was lower in M4% group and no significant difference was seen in Ml%, M2% and all CM groups. Muscle triglyceride level tended to be lower in Ml%, M2% and CM2% group and significantly was lower in M4% and CM4% group. Thus, it can be suggested that a CM extract of adllay could have a potential hypotriglyceridemic effect on diabetic subjects. (Korean J Nutrition 31(5) : 921∼926, 1998)

• Asian-Australasian Journal of Animal Sciences
• /
• 제19권3호
• /
• pp.418-424
• /
• 2006

This experiment was conducted to explore the efficacy of lacquer (Rhus verniciflua) supplementation on growth performance, nutrient digestibility, carcass traits and serum biochemical values in commercial broilers. Eight hundred and forty Hubbard broiler chicks (1d old) were randomly distributed and allotted to four dietary treatments for five weeks. Each treatment had 5 replicates with 42 birds each. The dietary treatments were (1) control (2) 1% lacquer, (3) 2% lacquer and 4) 4% lacquer supplied as meal in the diet. Supplementation with lacquer improved weight gain (p = 0.0960) showing a linear trend during the starter phase (0-3 wk), but weight gain, feed intake and feed conversion ratio remained unaffected at the finisher phase (4-5 wk) and overall (0-5 wk). The nutrient digestibility studies conducted after 18 and 35 days of experimental feeding showed a linear (p<0.05) increase in digestibility of CP and ether extract at both measurement timess. The carcass studies were conducted on two birds per replicate (10 per treatment) at the end of both 3 and 5 wk. The dressing percentage, liver weight, heart weight, abdominal fat and the breast meat expressed as a percentage of live weight, did not differ significantly due to treatments at both phases. The serum cholesterol and high-density lipoprotein (HDL) showed a linear decrease (p = 0.0683 and p = 0.0322, respectively) as the level of supplementation increased at 3 wk; at 5 wk serum cholesterol, HDL and triglyceride levels decreased significantly showing a positive linear effect of lacquer on fat metabolism. The meat color values such as lightness, redness and yellowness did not reveal any significant trend. Overall, it could be concluded that lacquer supplementation at higher levels did not affect growth performance, but had a positive impact on fat metabolism by influencing fat digestibility and reducing serum cholesterol and triglyceride.

• 한국산학기술학회논문지
• /
• 제16권10호
• /
• pp.7034-7042
• /
• 2015

본 연구는 2013년도 국민건강영양조사 원시자료를 분석한 이차분석 연구로서, 대사증후군 대상자의 삶의 질 정도 및 영향요인을 확인하기 위해 시도되었다. 층화집락복합표본추출을 이용하여 선정된 8,018명 중 만 19세 이상이며 대사증후군 구성요소와 삶의 질에 대한 결측치가 없는 4,890명을 대상으로 자료를 분석하였다. 연구결과, 대사증후군 유병률은 22.1%이고, 5가지 구성요소 중 유병률이 가장 높은 것은 고밀도지단백 콜레스테롤 저하이었다. 삶의 질(EQ-5D Index)은 대사증후군이 있는 집단이 정상군보다 유의하게 낮고, 대사증후군의 구성요소 중에는 복부둘레가 과다한 집단이 정상군보다 0.018점 낮았다. 연구결과를 바탕으로, 대사증후군 대상자의 삶의 질에 대한 관심과 함께 삶의 질 향상을 위한 중재 프로그램이 개발 및 제공되어야 할 것이다.

• Journal of Korean Biological Nursing Science
• /
• 제21권1호
• /
• pp.85-97
• /
• 2019

Purpose: This study was performed to analyze the levels of blood pressure and to identify good or poor blood pressure control (BPC) groups among hypertension patients. The study was based on the Korea National Health and Nutrition Examination Survey (KNHANES VI and VII) conducted from 2013 to 2016. Methods: The sociodemographic and clinical data of 4,151 Korean hypertension patients aged 20-79 years and who were taking antihypertensive medications was extracted from the KNHANES VI and VII database. Descriptive statistics for complex samples and a decision-tree analysis were performed using the SPSS WIN 24.0 program. Results: The mean age was $62.46{\pm}0.21years$. The mean systolic blood pressure (SBP) was $128.07{\pm}0.28mmHg$, and the diastolic blood pressure (DBP) was $76.99{\pm}0.21mmHg$. 71.9% of participants showed normal blood pressure (SBP < 140mmHg and DBP < 90mmHg). From the decisiontrees analysis, the characteristics of participants related to good BPC group were presented with 9 different pathways same as those from the poor BPC group. Good or poor BPC groups were classified according to the patients' characteristics such as age, living status, occupation, education, hypertension diagnosis period, numbers of comorbidity, perceived health status, total cholesterol, high density lipoprotein-cholesterol, alcohol drinking per month, and depressive mood. Total cholesterol level (< 201mg/dL or ${\geq}201mg/dL$ cutoff point) was the most significant predictor of the participants' BPC group. Conclusion: This decision-tree model with the 18 different pathways can form a basis for the screening of hypertension patients with good or poor BPC in either clinical or community settings.

• 대한영양사협회학술지
• /
• 제29권1호
• /
• pp.31-48
• /
• 2023

This study evaluated the nutrient adequacy ratio (NAR) and depression based on the sleep duration of adult women using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016 and 2018. A total of 4,507 subjects were divided into two groups: sleep hours<7 (lack of sleep, LS) and 7≤sleep hours (normal sleep, NS). For a more detailed analysis, the subjects were further divided into normal sleep with no depression (NSND) and lack of sleep with depression (LSWD) groups. When compared with NS group, the nutrient intake of the LS group was observed to be higher in carbohydrates (P<0.05) and thiamine (P<0.01), but had a significantly lower mean nutrient adequacy ratio (P<0.05). Also, the LS group showed a higher frequency of early menopause (P<0.001) and depression (P<0.05) than the NS group. In the analysis of anthropometry and blood parameters of the subjects based on their sleep duration, the LS group showed a lower body mass index (BMI, P<0.05), lower blood creatinine (P<0.01), glycated hemoglobin (P<0.05), and high-density lipoprotein (HDL) cholesterol (P<0.01) levels adjusted by age and menopause than the NS group. When compared to the NSND group, the LSWD group had a lower intake of cholesterol (P<0.05), vitamin A (P<0.05), vitamin C (P<0.05), and folic acid (P<0.05). There was no variation in the menopausal status, NAR, and mean nutrient adequacy ratio between the NSND and LSWD groups. However, there were differences in total blood cholesterol (P<0.05) and depression based on sleep duration. Apart from nutritional status, differences in BMI and blood parameters were observed based on sleep duration.

• Asian-Australasian Journal of Animal Sciences
• /
• 제21권6호
• /
• pp.853-860
• /
• 2008

This experiment was conducted to study the effects of chromium (Cr), dietary crude protein (CP) level and potential interactions between these two factors on growth rate and carcass response, insulin activity and lipid metabolism in lambs. Forty-eight, 9-week-old weaned lambs (Dorper$\times$Small-tail Han sheep, mean initial body weight = $22.96kg{\pm}2.60kg$) were used in a $2{\times}3$ factorial arrangement of supplemental Cr (0 ppb, Cr0; 400 ppb, Cr1; or 800 ppb, Cr2 from chromium yeast) and CP levels (157 g/d to 171 g/d for each animal, LP; or 189 g/d to 209 g/d for each animal, HP). Growth data and blood samples were collected at the beginning and end of the feed trial, after which the lambs were killed. Both Cr additive groups and the HP group increased final weight and average daily gain, especially the Cr1 and HP group (p<0.01). HP increased pelvic fat weight (p<0.05), fat thickness of the 10th rib (p<0.05), longissimus muscle area (p<0.01) and rate of deposition of intramuscular fat (p<0.01). Supplemental Cr decreased the rate of deposition of intramuscular fat (p<0.05). Fasting insulin level and the ratio of insulin to glucose were lower with Cr1 than other groups, but with no significant difference. Glucose concentration was not affected by any treatment. Nonesterified fatty acids increased in the Cr1 (p<0.05) and HP (p<0.05) conditions and there was a significant $Cr{\times}CP$ interaction (p<0.05). Cr1 decreased triglycerides (p<0.05) and total cholesterol (p = 0.151) and HP increased high-density lipoprotein cholesterol (p<0.05). Cr1 decreased lipoprotein lipase activity in subcutaneous adipose tissue (aLPL, p<0.05) and the ratio of aLPL to lipoprotein lipase activity in skeletal muscle (mLPL, p = 0.079). mLPL and hepatic lipase (hHL) were not affected by any treatment. In the present study, Cr had limited effects on growth rate and carcass response, whereas Cr and CP had some notable effects on plasma metabolites and enzyme activities. Cr has a potential effect on energy modulation between lipid and muscle tissue. In addition, few $Cr{\times}CP$ interactions were observed.

• 한국식품과학회지
• /
• 제48권1호
• /
• pp.77-85
• /
• 2016

본 연구는 가자 추출물(TCE), 차전초 추출물(PAE), 생강나무잎 추출물(LOE) 그리고 매생이 추출물(CFE)을 첨가하여 식빵을 제조하고, 매일 30 g의 식빵 식이를 6주령 SD 랫드에게 제공한 뒤 혈당과 지질과 관련된 지표들의 변화를 관찰하였다. 추출물이 첨가된 식빵을 섭취한 모든 그룹에서 체중, 음수량, 간과 신장의 무게, AST, ALP, ALT의 변화는 나타나지 않았다. 식이 섭취 후 혈당의 변화를 확인하기 위해 매주 1회 절식 후 공복혈당을 측정하였을 때 1주차 측정 결과에서 Con 그룹의 혈당 수치가 $134.63{\pm}27.12mg/dL$로 BT 그룹, BP 그룹, BL 그룹 그리고 BC 그룹과 비교하여 유의적인 차이를 보이며 혈당이 상승하였고, 4주차 측정 결과에서는 Con 그룹($123.63{\pm}9.62mg/dL$), BT(그룹 $119.13{\pm}9.60mg/dL$), BP 그룹($117.37{\pm}12.77mg/dL$), BL 그룹($116.50{\pm}14.43mg/dL$)과 비교해 BC 그룹에서 $108.13{\pm}4.64$의 혈당치로 유의적인 차이를 보이며 혈당이 감소하는 것을 보아 CFE가 첨가된 식빵은 혈당강하에 도움을 줄 수 있을 것으로 판단하였다(p<0.05). 이어진 경구당부하검사 120분대 혈당치에서 BT 그룹($124.63{\pm}17.15mg/dL$), BL 그룹($121.50{\pm}13.28mg/dL$)은 Con 그룹($138.50{\pm}6.09mg/dL$)의 혈당치와 비교하여 유의적인 차이를 보이며 감소하는 것을 보여주었으며(p<0.05), AUC에서 유의적인 차이는 나타내지 않았지만 BT 그룹, BP 그룹, 그리고 BL 그룹의 area value가 적어졌다. AUC와 경구당부하검사 결과를 종합해 볼 때 TCE, PAE 그리고 LOE가 첨가된 식빵은 기존식빵에 비해 내당능에 도움을 줄 수 있을 것으로 기대된다. 또한, 혈당과 관련된 중요 지표 중 하나인 당화혈색소 측정 결과에서 Con 그룹(4.06%)과 비교해 유의적인 차이를 보이며 BL 그룹(1.53%)와 BC 그룹(2.28%)은 당화혈색소 함량이 감소하는 것을 보였다(p<0.05). 지질 측정 지표인 TC, TG, LDL-cholesterol, HDL-cholesterol 측정결과에서 BL 그룹은 TC, LDL-cholesterol을 유의적으로 낮췄으 며 BC 그룹은 TC, LDL-cholesterol을 유의적으로 낮추고 HDL-cholesterol의 함량을 유의적으로 증가시켰다. LOE와 CFE가 첨가된 식빵 식이는 제공은 지질대사의 불균형을 조절할 수 있을 것으로 사료되며 나아가 동맥경화 예방에도 도움이 될 것으로 생각된다. 지질과 관련된 유전인자인 PPAR-${\alpha}$과 PPAR-${\gamma}$에 대한 mRNA 발현을 측정한 결과 BL 그룹, BC그룹에서 Con 그룹과 유의적인 차이를 나타내며 PPAR-${\alpha}$ mRNA 발현이 증가하였고, PPAR-${\gamma}$ mRNA 발현의 경우, BP 그룹, BL 그룹, BC 그룹에서 가장 적은 발현을 나타내었다. 실험 결과를 통해 추출물 중 여러 측정 항목에서 LOE와 CFE가 첨가된 식빵식이에서 가장 좋은 활성을 보였으므로 LOE와 CFE는 공복혈당 강하와 내당능에 효과가 있으며 HDL의 합성을 촉진하여 혈중 TC의 함량을 낮춘 것으로 생각된다. 또한 PPAR-${\alpha}$의 전사를 활발하게 하고 PPAR-${\gamma}$와 관련된 유전인자의 활성을 낮춰 지질대사의 균형을 유지시키는 것으로 사료된다.