• YAKHAK HOEJI
• /
• v.29 no.2
• /
• pp.62-69
• /
• 1985

The isomeric intermediates, $3{\alpha}$and $3{\beta}-amino-5{\alpha}-cholestane required for the synthesis of N-nitrosoureas, N-(2-chloroethyl)-N-nitrosocarbamoyl-$3{\alpha}-amino-5{\alpha}$-cholestane (9), N-methyl-N-nitrosocarbamoyl-3${\alpha}-amino-5{\alpha}-cholestane$ (10), N-(2-chloroethyl)-N-nitrosocarbamoyl-$3{\beta}-amino-5{\alpha}-cholestane$: (7), and N-methyl-N-nitrosocarbamoyl-$3{\beta}-amino-5{\alpha}-cholestane$ (8) were obtained through the $LiAlH_{4}$ reduction of $5{\alpha}$-cholestan-3-one oxime, followed by the chromatographic separation: the assignment of the stereochemistry of both isomers were based on the shape and chemical shift of $C_{3}$-proton resonances on their NMR spectra and on the elution mobility on the TLC. The urea intermediates, N-(2-chloroethyl) carbamoyl-3.alpha.-amino-5.alpha.-cholestane (13), N-methylcarbamoyl-$3{\alpha}-amino-5{\alpha}-cholestane$ (14), N-(2-chloroethyl) carbamoyl-$3{\beta}-amino-5{\alpha}-cholestane (11) and N-methyl-$3{\beta}-amino-5{\alpha}$-cholestane (12) were prepared by the treatment of each isomers ($3{\alpha}$-amino-and $3{\beta}-amino-5{\alpha}$-cholestane) with alkyl isocyanates in anhydrous $CHCl_{3}$, and the corresponding nitrosoureas, 7-10 were obtained by the nitrosation of the ureas, 11-14, with AcOH (or HCOOH)/$NaNO_{2}$ in ice-cold condition. The inhibitory activity of the nitrosoureas, 7-10, and their intermediates, 12-14 towards the growth of L1210 murine leukemia cells, were examined. Among them, the compounds 9 and 10 exhibited high activity having $ED_{50}$ to be 5.5g/ml and 6.1g/ml, respectively.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.23 no.7
• /
• pp.845-851
• /
• 2019

We design, implement, and evaluate a user-level ad hoc network routing protocol on the COTS (commercial off-the-shelf) mobile devices. In situations such as disaster recovery, emergency communication between mobile devices is necessary. For wide deployability and usability of such a system, we design and implement the networking protocols on the user level instead of modifying the kernel of mobile devices. In order to support reliable data transfer in high mobility scenarios, we selected to implement AODV (Ad Hoc On-Demand Distance Vector) as the routing protocol and TCP as the transport layer protocol. With our implementation of ad hoc networking stack on COTS smartphones, we conducted experiments in various networking environments. Our experimental results show that ad hoc networking is possible in up to 12 hops in a line topology and 5 concurrent devices in a star topology.

• Korean Journal of Materials Research
• /
• v.28 no.12
• /
• pp.702-708
• /
• 2018

This study deals with the effect of microstructure factors on the strain aging properties of API X70 pipeline steels with different microstructure fractions and grain sizes. The grain size and microstructure fraction of the API pipeline steels are analyzed by optical and scanning electron microscopy and electron backscatter diffraction analysis. Tensile tests before and after 1 % pre-strain and thermal aging treatment are conducted to simulate pipe forming and coating processes. All the steels are composed mostly of polygonal ferrite, acicular ferrite, granular bainite, and bainitic ferrite. After 1 % pre-strain and thermal aging treatment, the tensile test results reveal that yield strength, tensile strength and yield ratio increase, while uniform elongation decreases with an increasing thermal aging temperature. The increment of yield and tensile strengths are affected by the fraction of bainitic ferrite with high dislocation density because the mobility of dislocations is inhibited by interaction between interstitial atoms and dislocations in bainitic ferrite. On the other hand, the variation of yield ratio and uniform elongation is the smallest in the steel with the largest grain size because of the decrease in the grain boundary area for dislocation pile-ups and the presence of many dislocations inside large grains after 1 % pre-strain.

• Korean Journal of Applied Biomechanics
• /
• v.28 no.4
• /
• pp.227-236
• /
• 2018

Objective: The purpose of this study was to investigate the effects of a 12-week combined exercise program on gait parameters in elderly women with osteoarthritis. Method: The subjects of this study were 11 elderly women (age: $67.09{\pm}2.47$, height: $157.35{\pm}4.30cm$, weight: $62.49{\pm}6.36kg$) with knee osteoarthritis. The combined exercise program of this study was divided into aerobic exercise and lower extremity strengthening exercises. The exercises were performed for 60 minutes per session, three times a week, for a total of 12 weeks. The maximum joint moments of the hip, knee, and ankle joints with walking were obtained with 8-3D cameras (MX-T20, Vicon, USA) and 2-force plate (AMTI OR6-7-400, AMTI, USA). SPSS Windows version 23.0 was used for statistical analysis. A paired t-test was used for pre-post comparison. An alpha level of .05 was utilized in all tests. Results: The maximum extension moment was significantly higher in the hip joint after P1 on the X axis. The maximum joint moment of P3 in extension was statistically significantly lower after intervention. On the Z axis, the maximum joint moment was significantly lower after the exercise intervention at P3. There was a statistically significant increase in the extension moment of the left and right knee joints in the X axis after exercise intervention. In the right ankle joint, P1 (plantar flexion moment) showed a statistically significant high moment after exercise intervention. Conclusion: These results suggest that combined exercise, including lower limb and aerobic exercise, may have a positive effect on mobility and walking moments in patients with osteoarthritis of the knee.

• Journal of Gynecologic Oncology
• /
• v.29 no.6
• /
• pp.87.1-87.4
• /
• 2018

Objective: Upper paraaortic lymph node dissection (UPALD) to the infrarenal level is one of the most challenging robotic procedures. Because robotic system has the limitation in robotic arm mobility. This surgical video introduces a novel robotic approach, lower pelvic port placement (LP3), to perform optimally and simultaneously both UPALD and pelvic procedures in gynecologic cancer patients using da Vinci Xi system. Methods: The patient presented with high-grade endometrial cancer. She underwent robotic surgical staging operation. For the setup of the LP3, a line was drown between both anterior superior iliac spines. At 3 cm below this line, another line was drown and four robotic ports were placed on this line. Results: After paraaortic lymph node dissection (PALD) was completed, the boom of robotic system was rotated $180^{\circ}$ to retarget for the pelvic lateral displacement. Robotic ports were placed and docked again. The operation was completed robotically without any complication. Conclusion: The LP3 was feasible for performing simultaneously optimal PALD as well as procedures in pelvic cavity in gynecologic cancer patients. The advantage of LP3 technique is the robotic port placement that affords for multi-quadrant surgery, abdominal and pelvic dissection. The LP3 is facilitated by utilizing advanced technology of Xi system, including the patient clearance function, the rotating boom, and 'port hopping' that allows using every ports for a camera. The LP3 will enable surgeons to extend the surgical indication of robotic surgical system in the gynecologic oncologic field.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.20 no.4
• /
• pp.57-70
• /
• 2021

This study aims to investigate the security demand about the traffic policing by analyzing civil complaints. Latent Dirichlet Allocation(LDA) was applied to extract key topics for 2,062 civil complaints data related to traffic policing from e-People. And additional analysis was made of reports of violations, which accounted for a high proportion. In this process, the consistency and convergence of keywords and representative documents were considered together. As a result of the analysis, complaints related to traffic police could be classified into 41 topics, including traffic safety facilities, passing through intersections(signals), provisional impoundment of vehicle plate, and personal mobility. It is necessary to strengthen crackdowns on violations at intersections and violations of motorcycles and take preemptive measures for the installation and operation of unmanned traffic control equipments, crosswalks, and traffic lights. In addition, it is necessary to publicize the recently amended laws a implemented policies, e-fine, procedure after crackdown.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.34 no.4
• /
• pp.1-11
• /
• 2021

Objectives: Nephrotic syndrome is a kidney disorder, which is characterized by proteinuria, edema (swelling), and hyperlipidemia. Maydis Stigma (Corn silk) has been widely used in Asia as a traditional medicine and is known to have a diuretic effect and is used for the treatment of edema and indigestion. Methods: The aim of this study is to investigate the improvement effect of Maydis Stigma in treating nephrotic syndrome induced by puromycin aminonucleoside. Sprague-Dawley rats were intravenously injected with 75 mg/kg/day puromycin aminonucleoside, then treated with either Losartan or 200 mg/kg/day Maydis Stigma for seven days. Results: Maydis Stigma significantly decreased ascites and proteinuria level. Plasma levels of blood urea nitrogen (BUN) and plasma creatinine reduced significantly by Maydis Stigma. In addition, treatment with Maydis Stigma attenuated histological damage. Treatment with Maydis Stigma also restored podocin expression and reduced inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α) and high-mobility group box-1 (HMGB1). Conclusions: Maydis Stigma ameliorates kidney injury in nephrotic syndrome rat models. Maydis Stigma exerts a renoprotective effect owing to its anti-inflammatory effects and reductions of ascites and proteinuria. Thus, these results indicate that Maydis Stigma is likely to be a promising agent in the treatment of nephrotic syndrome.

• Journal of the Society of Naval Architects of Korea
• /
• v.58 no.5
• /
• pp.281-293
• /
• 2021

Oil and steel prices, which are major pricescosts in the shipbuilding industry, were predicted. Firstly, the error of the moving average line (N=3-5) was examined, and in all three error analyses, the moving average line (N=3) was small. Secondly, in the linear prediction of data through existing theory, oil prices rise slightly, and steel prices rise sharply, but in reality, linear prediction using existing data was not satisfactory. Thirdly, we identified the limitations of linear prediction methods and confirmed that oil and steel price prediction was somewhat similar to actual moving average line prediction methods. Due to the high volatility of major price flows, large errors were inevitable in the forecast section. Through the time series analysis method at the end of this paper, we were able to achieve not bad results in all analysis items relative to artificial intelligence (Prophet). Predictive data through predictive analysis using eight predictive models are expected to serve as a good research foundation for developing unique tools or establishing evaluation systems in the future. This study compares the basic settings of artificial intelligence programs with the results of core price prediction in the shipbuilding industry through time series prediction theory, and further studies the various hyper-parameters and event effects of Prophet in the future, leaving room for improvement of predictability.

• Journal of Convergence for Information Technology
• /
• v.11 no.3
• /
• pp.87-94
• /
• 2021

This study was conducted to identify the mental health and quality of life of cardiovascular disease patients by their activities restriction through the second analysis of the 7th KNHANES collected from 2016 to 2018. The subjects of this study were 521 adults with angina or myocardial infarction who had no missing variables among 24,269 subjects. The difference between mental health and quality of life according to the activity restriction was analyzed by Chi-square method and the effect of mental health and quality of life by activity restriction by Logistic regression method using the SAS 9.4 version. The results of the analysis showed that the stress level, the depression for the last two weeks and suicide thought level was high when there was activity restriction, which had a significant effect on mental health. Mobility, selfcare and usual activities were disrupted, and pain/inconvenience and anxiety/depression increased when there was activity restriction, which also showed a significant effect on quality of life. Therefore, it is suggested that the development and operation of effective physical activity promotion program to minimize activity restriction is necessary to improve mental health and quality of life of cardiovascular patients.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.20 no.1
• /
• pp.51-61
• /
• 2010

Koinonia system is designed to fully utilize the advantage of Binary CDMA so as to guarantee QoS in wireless networks. In this paper, we propose the new network structure based on this system and refer to it as BLAN(Binary CDMA LAN). Although BLAN is similar structure to IEEE 802.11 WLAN, it will ensure the fast handover and QoS. We also propose the AKA(Authentication and Key Agreement) protocol and Reauthentication protocol to be used for communication in BLAN. These protocols are securely and efficiently designed using the user identity module to support the more powerful authentication. Hence, BLAN, including the proposed protocols, will support the high mobility and security. In conclusion, we expect that BLAN can be applied to future infrastructure on special environment, and it can be helpful showing the new network model which alternate WLAN.