• 대한한방내과학회지
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• 제40권6호
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• pp.1219-1224
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• 2019

Objective: To investigate the possibility of hepatotoxicity by supplemental foods or folk herbs such as Salvia Plebeia R. Br. Methods: A hospitalized male patient with alcoholic liver disease and electrolyte imbalance had recovered, and then followed by rapid hepatic serum enzymes after taking S. Plebeia. This study monitored the clinical outcome and biochemical parameters. Result: A 58-year male had drunk frequently, which led to alcoholic steatohepatitis and hospitalization. Two weeks after his discharge from hospital, he felt nausea, dizziness, and mild difficulties in speech and walking, resulting in re-hospitalization at the Korean Medical Hospital. The symptoms disappeared on correction of the electrolyte imbalance suspected to have been caused by severe sweating while working in the outdoors, and the patient was discharged. During treatment and monitoring of his health as an outpatient, the serum hepatic enzyme rapidly elevated approximately 10-fold in hepatic enzymes; the enzyme levels fluctuated according to whether or not he was taking the boiled water of S. Plebeia. The RUCAM score was 12, which met the criteria for toxic hepatitis by S. Plebeia. His general condition and abnormal hepatic enzymes recovered with cessation of S. Plebeia and administration of Chungganplus syrup (CGX). Conclusion: This study reports the hepatotoxic risk of Salvia Plebeia, which is commonly used as a folk remedy in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3131-3135
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• 2015

Objective: To investigate whether the expression of serum soluble neural cell adhesion molecule (sNCAM) is associated with hepatic encephalopathy (HE) in hepatocelular carcinoma (HCC) patients. Materials and Methods: The Oncomine Cancer Microarray database was used to determine the clinical relevance of NCAM expression in different kinds of human cancers. Sera from 75 HCC cases enrolled in this study were assessed for expression of sNCAM by enzyme linked immunosorbent assay (ELISA). Results: Dependent on the Oncomine Cancer Microarray database analysis, NCAM was down regulated in 10 different kinds of cancer, like bladder cancer, brain and central nervous system cancer, while up-regulated in lung cancer, uterine corpus leiomyoma and sarcoma, compared to normal groups. Puzzlingly, NCAM expression demonstrated no significant difference between normal and HCC groups. However, we found by quantitative ELISA that the level of sNCAM in sera from HCC patients with HE ($347.4{\pm}151.9ng/ml$) was significantly more up-regulated than that in HCC patients without HE ($260.3{\pm}104.2ng/ml$), the p-value being 0.008. sNCAM may be an important risk factor of HE in HCC patients, the correlation coefficients was 0.278 (P<0.05) on rank correlation analysis. Conclusions: This study highlights that up-regulated level of serum sNCAM is associated with HE in HCC patients and suggests that the high expression can be used as an indicator.

• 생명과학회지
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• 제19권6호
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• pp.804-808
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• 2009

본 연구에서는 12주 유산소 트레이닝 전에 비해 트레이닝 후, 간 기능을 나타내는 효소들이 모두 감소함을 나타냈으나 모두 통계적으로 유의한 차이는 나타내지 못했으며 이는 트레이닝이 간 기능에 영향을 미치지 못한 선행연구[5,15]들에서와 같은 결과를 나타냈다. 하지만 부분적으로 전체 대상자 13명 중 3명(23%)의 간 효소들 즉, 임상적 비정상을 나타낸 알부민(albumin), 토탈빌리루빈(total bilirubine), AST가 트레이닝 후, 정상적인 임상수치로 돌아와 규칙적인 12주 유산소 트레이닝이 제 2형 당뇨(T2DM) 환자의 간 효소에 통계적으로 유의한 차이는 나타내지 못했지만 임상적 판단 수치에 영향을 미친 것은 사실이다. 하지만 모든 비정상적인 간 기능 효소가 정상으로 회기한 것도 아니며 통계적으로 유의한 차이도 나지못했기 때문에 제 2형 당뇨환자(T2DM)의 간 기능 효소를 증진시키는 데 있어 운동 트레이닝의 효과는 성급히 판단하기 어려우며 운동 강도와 기간 등 좀 더 세분화고 다양한 연구가 필요하다고 생각된다.

• 대한임상검사과학회지
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• 제49권3호
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• pp.263-270
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• 2017

노루궁뎅이버섯의 자실체가 고지방과 콜레스테롤을 급여한 Sprague Dawley계 암컷 흰쥐의 지질대사와 생리활성에 미치는 영향을 조사하고자 생후 5주령의 흰쥐에 표준 식이를 급여한 정상군(NC군), 표준 식이에 15%의 돈지와 1%의 콜레스테롤을 첨가한 식이를 급여한 고지방 콜레스테롤군(HFC군), 고지방 콜레스테롤 식이에 노루궁뎅이버섯 자실체 분말을 5% 첨가한 군(HFC+HE군) 등 총 3개의 군으로 나누어 6주간 실험을 진행하였다. 실험동물의 체중증가와 식이효율은 HFC군에 비해 HFC+HE군이 유의하게 감소하여 NC군과 유사한 수준을 나타냈다. 식이섭취량은 NC군과 HFC군에 비해 HFC+HE군이 유의하게 낮았다. HFC+HE군의 혈청 총콜레스테롤, LDL-콜레스테롤의 농도는 NC군과 HFC군에 비해 유의하게 낮았고 동맥경화지수(AI)도 NC군과 HFC군에 비해 유의성 있게 낮았다. 그러나 혈청의 중성지방 농도는 NC군에 비해 유의성은 없었으나 HFC군에 비해 유의하게 낮았다. HFC+HE의 혈청 알부민, 크레아티닌, 요산 및 총단백질의 농도는 NC군의 수준을 나타냈다. 혈청의 AST, ALT 및 ALP 활성은 NC군과 유사하였으나 HFC군에 비해 유의하게 낮았다. 실험 5~6주에 배출된 변을 채취하여 총지질과 총콜레스테롤의 양을 분석한 결과 NC군과 HFC군에 비해 변의 총지질과 총콜레스테롤 함량이 유의하게 높아 변으로 배출된 총지질과 총콜레스테롤의 양이 많게 증가한 것으로 나타났다. 따라서 고지방 콜레스테롤식이에 5%의 노루궁뎅이버섯 자실체 분말을 첨가한 식이를 급여한 흰쥐의 체중은 정상군의 수준을 유지하였고, 혈청의 총콜레스테롤, LDL-콜레스테롤 및 중성지질의 농도도 정상군과 유사하게 낮았으며, 동맥경화지수도 낮아 노루궁뎅이버섯이 흰쥐의 지질대사를 정상으로 유지시키는 효과를 나타내는 것으로 사료되었다.

• Clinical and Experimental Pediatrics
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• 제51권7호
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• pp.760-765
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• 2008

폐흡충증은 갑각류나 생가재 내의 Paragonimus의 유충의 섭취로 발생하는 기생충 감염이다. 폐 폐흡충증이 가장 흔한 임상 양상이지만 몇몇 이소 폐흡충증이 보고되고 있다. 그 가운데 피하조직의 폐흡충증은 매우 드물다. 6개월 전 게장을 먹은 과거력이 있는 2세 5개월 남아가 우측 복벽의 종류를 주소로 내원하였다. 흉부 X선과 CT 상 폐실질에 이상 없이 우측 흉수만 발견되었고 간비대를 보이고 있었다. 말초혈액 검사상 호산구 증다증을 동반한 백혈구 증가증 및 혈청 면역글로불린 E의 상승을 보였다. 이후 ELISA 상 폐흡충 항체에 양성반응을 보여 P. westermani에 의한 흉수를 동반한 피하조직의 폐흡충증으로 진단할 수 있었다. 환아는 praziquantel 복용으로 치료를 하였으나 피하조직의 폐흡충증 종류가 더 악화되어 이를 수술적으로 제거하였고 조직검사상 기생충의 감염으로 의심되는 염증반응을 관찰할 수 있었다. 이에 본 저자들은 소아에서 감염된 피하조직의 폐흡충증의 드문 증례를 보고하는 바이다.

• 한국식품위생안전성학회지
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• 제13권2호
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• pp.171-187
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• 1998

Garlic occupies a special position among the many foods of vegetable origin because it is the sole food for Koreans during the their lives. And vitamin A has been ingested by forms of food or additives. Cadmium has been described as one of the most dangerous trace elements in the food and environment of man and livestocks. Since the de novo synthesis of stress proteins can be detected early after exposure to some agents, analysis of cadmium-induced changes in gene expression , ie. alterations in patterns of protein synthesis, may be useful to develop as biomarkers of exposure and damage for food hygiene. He acute and chronic combine effects of cadmium (Cd, CdCl2 20mg/kg), garlic oil(Dds: diallyl disulfide 50mg/kg, 3 times a week) and vitamin A(Ra: retinol acetate 50,000 IU/kg, 3 times a week) on Wistar male rats were evaluated concerning cadmium contents, tissues enzyme activity, HSP expression histopathological and electron microscopical examinations. The results of the study are as follows ; 1. Less cadmium was absorbed through the digestive tracts, but the ratio of contents in tissue were not changed by the simultaneous adminstration of diallyl disufide or retinol acetate. 2. ALT(alanine aminotransferase) , AST(aspartate aminotransferase), glucose, BUN (blood urea nitrogen), creatinine, the key indices of the clinical changes in hepatic and renal function were significantly hanged by the cadmium treatment after 1 week in liver, after 4 weeks in kidney. 3. Histopathological changes in cadmium treated rats were appeared at 8 weeks age treatment in kidneys. Homogenous eosinophilic material was accumulated in cortical and collecting tubular lumens at 16 weeks. Degenerated or necrotized tubular cells were observed in cortex and medulla. Degenerated seminiferous tubules and homogeneous eosinophilic material was seen in interstitial tissue of rat treated with cadmium for 16 weeks. Calcium deposits were seen in degenerated seminiferous tubules and the tubules showed severe calcification of rat treated with cadmium for 16 weeks. Electron microscope changes in kidney were observed in rats treated with CdCl2 20 mg/kg. Proximal convoluted tubule cells showed selling of cytoplasm and narrow lumen. Capillary endothelial cells showed cytoplasmic vacuoles and swelling. Degenerated epithelial cells were accumulated in tubular lumen of kidney. 4. Enhanced synthesis of 70 KDa relateve molecular mass proteins were detected in 2 hours after cadmium, exposure, with maximum activity occurring at 8~48 hours. Induction of HSP 70 was evident at proximal tubules and glomeruli in kidney. Testicular cells produced enough HSP to be detected normally. From the above results, it could be concluded that HSP70 induction by the cadmium treatment was a rapid reaction to indicated the exposure of xenobiotics, and retinol acetate reduced the cadmium induced nephrotoxicity.