• 종양간호연구
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• 제6권1호
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• pp.37-46
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• 2006

Purpose: The purpose of this study was to identify the influencing factors on anxiety of patients who had received hemopoietic stem cell transplantation(HSCT). Method: A total of 81 patients who had undergone a HSCT at a university hospital were recruited from July of 2001 to June of 2002. They were asked to complete questionnaires about anxiety, self-esteem, family support, doctor's support and nurse's support. Result: The mean score of anxiety, self-esteem, family support, doctor's support and nurse's support was 41.9, 3.0, 4.6, 7.6 and 7.3, respectively. A significant negative correlation was found between anxiety and self-esteem. Self-esteem was positively correlated with family support, doctor's support and nurse's support. The major variable that influenced anxiety was the self-esteem, explaining 25.4% of the anxiety. Conclusion: On the basis of these results, it is necessary for HSCT patients to develop a nursing intervention for the enhancement of self esteem. Also, family support, doctor's support and nurse's support should be considered as a main support system in the nursing strategy for improving the quality of life of patients undergone HSCT.

• 대한한의학회지
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• 제41권4호
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• pp.12-26
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• 2020

Objectives: The aim of this study is to investigate the mechanisms involved in the anti-inflammatory and anti-tumor effects of Rhus verniciflua Stokes (RVS) on PMA-differentiated human monocytic leukemia THP-1 cells. Methods: Cells were treated with various concentrations of RVS decoction (0-300㎍/ml) for 24, 48, and 72h. Cell viability was evaluated by MTS/PMS assay. The expressions of MMP-2, MMP-9, TIMP-1, TIMP-2, iNOS and COX-2 mRNA and proteins were measured using RT-PCR and western blotting, respectively. Results: RVS suppressed expression of MMP-2 and MMP-9 mRNA. It also down-regulated iNOS and COX-2 mRNA and protein expression. RVS inhibited NF-𝜅B p65 activity and the phosphorylation of Akt and MAPK (ERK and p38 MAPK). Instead, the phosphorylation of JNK is increased at a very low concentration but decreased at higher concentrations. Conclusion: RVS is regarded to inhibit the expression of MMP and TIMP as well as iNOS and COX-2 gene expression via directly inhibiting the activation of NF-𝜅B and phosphorylation of MAPK pathway in THP-1 cells. This suggests RVS have potential to be used as a therapeutic agent for acute myeloid leukemia (AML).

• 대한한방종양학회지
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• 제3권1호
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• pp.129-147
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• 1997

현재 서양의학에서 활용되고 있는 항암 요법으로는 외과처치(外科處置), 화학요법(化學療法), 방사선요법(放射線療法) 및 면역요법(免疫療法) 등(等)이 있으며, 그 중에서도 항암제(抗癌劑)에 의한 화학요법과 방사선요법이 가장 많이 응용되고 있다. 그런데 이들은 암세포(癌細胞)뿐만 아니라 정상세포(正常細胞)까지도 살상(殺傷)함으로써 종양세포(腫瘍細胞)를 억제하는 동시에 골수조혈기(骨髓造血器), 소화계통(消化系統) 및 면역기능(免疫機能)을 포함하는 인체의 정상적인 기능을 손상시키는 문제점으로 그 사용에 제한을 받고 있다. 따라서, 본 연구는 삼용부정탕(蔘茸扶正湯)의 항암요법으로 손상된 조직의 회복 및 조혈촉진 효과를 규명하기 위해 생쥐를 대상으로 하여 실험하였다. 그 결과, 생쥐 비장세포에 대한 증식효과(增殖效果), 조혈촉진인자(造血促進因子)의 분필능(分泌能), 방사선에 대한 임파구의 방어효과(防禦效果), 방사선에 대한 조혈세포 방어효과(防禦效果), 방사선(9Gy)을 조사받은 생쥐의 생존율(生存率) 등에서 유의성 있는 결과를 얻어내어 아래와 같이 보고하는 바이다.

• 대한한방종양학회지
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• 제2권1호
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• pp.91-100
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• 1996

Radiotherapy is an irreplaceable method of cancer treatment but, it has various side effects, especially damage to the hemopoietic system. A lot of radioprotectors have been found but they also have toxic effects. Many kinds of crude drugs(Oriental Chinese medicine)with low toxicity have been reported to promote the recovery from radiation damage. Recently, the trial to combine radiotherapy with herbal treatment of cancer patients shows a desirable result, an enhancement in recovery of the blood system.. This study was performed to determine whether prescriptions to support the healthy energy and strengthen the body resistence, Buzhongyiqi-tang and Siliu-tang, promote the recovery of splenocytes of N:GP(s) mice from radiation damage. We investigated the proliferative effect of Buzhongyiqi-tang, Siliu-tang and EIB(ethanol insoluble fraction of Buzhongyiqi-tang) on N:GP(S)mice splenocytes before or after ${\gamma}$-irradiation. We also investigated the morphology of splenocytes cultured with these herbs. Buzhongyiqi-tang and Siliu-tang promoted the proliferation of splenocytes in a concentration of 0.1 mg/ml compared with normal control(p<0.001). After 1-5Gy of ${\gamma}$-irradiation they also showed the effect of recovery of hemopoietic cells, especially in Buzhongyiqi-tang(4Gy:p<0.005; 5Gy:p<0.05). In addition, EIB(ethanol insoluble fraction of Buzhongyiqi-tang) showed the highest proliferative effect of all agents suggesting that more effective fractions could be found from crude herbs or prescriptions. These results suggest that it is possible to make use of Buzhongyiqi-tang, Siliu-tang or EIB as radio-protective agents.

• 대한물리치료과학회지
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• 제5권4호
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• pp.729-750
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• 1998

The purpose of this Review is to help activities of daily living by normalizing bodily functions through the use of negative pressure. Cupping therapy has been holding the important role as a form of treatment in ancient medicine of Oriental and Occidental country, and still being used widely due to it's effectiveness. Principle of Cupping therapy is to neutralize somatic dysfunctions by elimination of nonphysiological somatic fluid of hematoma through application of negative pressure on region of dermatomal meridian. The effectiveness of Cupping therapy as follows; 1) Effects on acid base balance of bodily fluid. 2) Through the reabsorption of subcutaneous hematoma, it affects on formation of immune system and produce the blood serum cleaning reaction. 3) By application of negative pressure on subcutaneous, induce renal system to produce steroid hormone. 4) By stimulating hemopoietic system, it maxmize the blood production level. Recently, Alternative medicine has been a focus due to it's nature of effectiveness and safety without adverse complication. Therefore, every family possess and use the cupping modality for preventive measure and/or treatment purpose in order to eliminate accumulated byproducts of body and clean the blood system.

• Imaging Science in Dentistry
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• 제45권1호
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• pp.55-60
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• 2015

Multiple myeloma is a clonal neoplastic proliferation of terminally differentiated B-lymphocytes involving the skeletal system in a multifocal fashion. Its oral manifestations are less common in the maxilla than in the mandible due to the lower amount of hemopoietic bone marrow in the maxilla. We report the case of a 50-year-old man who presented with a mass in the left maxillary alveolar region with tooth mobility. The mass had become enlarged after the teeth were extracted 15 days previously. Radiographs demonstrated multiple punched-out radiolucent lesions in the skull and pelvic region. Computed tomography images showed a soft tissue density mass in the left maxilla, eroding the floor and walls of the maxillary sinus. Although several analytical techniques were used to characterize the lesion, it was finally confirmed as multiple myeloma through immunohistochemistry.

• 한국동물학회지
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• 제18권3호
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• pp.127-130
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• 1975

1) 자라의 비장을 싸고있는 皮膜은 筋內細胞가 없으며 哺乳類의 그것과 마찬가지로 망상섬유와 탄력섬유 및 교원섬유를 함유하고 있다. 2) 자라의 비장의 脾株는 개구리 비장보다 발달되고 짧은 脾株가 잘 발달되어 있다. 3) 자라 비장의 血管系는 哺乳類와 거의 비슷하나 특히 中心動脈이 잘 발달되고 脾洞의 발달은 포유류의 脾洞構造나 數量面에서 下等性을 보인다. 4) 자라 비장의 造血細胞의 출현빈도가 포유류와 양서류등 다른 脊椎動物보다 훨씬 많이 出現된다.

• International Journal of Industrial Entomology and Biomaterials
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• 제18권2호
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• pp.113-120
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• 2009

Embryonic lethal abnormal visual (elav) is a lethal gene in Drosophila inducing the abnormal development and function of nervous system. We cloned a Bm-elav gene by bioinformatics and biological experiment, based on sequence of ELAV protein and dbEST of Bombyx mori. The full-length of Bm-elav cDNA is 1498 bp, contains a 906 bp open read frame (ORF) encoding a precursor of 301 amino acid residues with a calculated molecular weight of 34 kDa and pI of 8.99. Bm-ELAV protein precursor contains three RNA recognition motifs (RRM) in $24{\sim}91$, $110{\sim}177$ and $222{\sim}295$ bit amino acid residues respectively, and belongs to RNA-binding protein family. Bm-ELAV shared varying positives, ranging from 56% to 60% (Identities from 41% to 45%), with RRM from other species of Xenopus tropicalis, Apis mellifera, Tribolium castaneum, Branchiostoma belcheri and Drosophila. Gene localization indicated that Bm-elav is a single-copy gene, gene mapping within 12-chromosome from 7916.68 knt to 7918.16 knt region of nscaf2993. Spatiotemporal expressions pattern analysis revealed that Bm-elav expressed higher in most tested tissues and developmental stages in whole generation, such as silk gland, fat body, midgut, hemopoietic organ and ovary, but almost no expression in terminated diapause eggs. This suggested that the expression of Bm-elav in early developmental embryonic stages might induce abnormal development like in Drosophila. Cloning of the Bm-elav gene enables us to test its potential role in controlling pests by transferring the gene into field lepidopteran insects in the future.

• 대한한방내과학회지
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• 제41권2호
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• pp.267-274
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• 2020

Objectives: This study is aimed to describe the effects of using a traditional Korean herbal medicine, Jaeumkunbi-tang, on acute dizziness and gait disturbance that arose during treatment for trigeminal neuralgia. Methods: We closely observed one female patient who had been hospitalized complaining of trigeminal neuralgia and acute onset of dizziness. The patient was treated using Korean medical treatments, such as Oyaksungi-san, Jaeumkunbi-tang, acupuncture, and moxibustion. We evaluated the patient's condition using the visual analog scale (VAS) at the Department of Hepato-Hemopoietic System, Kyung Hee University Korean Medicine Hospital in June 2019 for 12 days. Results: The patient's dizziness was decreased after treating with Jaeumkunbi-tang for five days as measured by the VAS score. Conclusions: Jaeumkunbi-tang appears to be effective for controlling dizziness.

• 대한한방내과학회지
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• 제39권2호
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• pp.176-183
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• 2018

Objectives: To observe the treatment progress of two patients diagnosed with alcoholic liver cirrhosis. Methods: We closely observed two patients with alcoholic liver cirrhosis who had visited the Department of Hepato-hemopoietic System, Kyung Hee University Korean Medicine Hospital in 2017. They were treated with Chungganhaeju-tang and auricular acupuncture, and we evaluated the changes in their general conditions and laboratory tests. Results: In the first case, the patient underwent continuous drinking despite the treatment, and the laboratory tests showed exacerbation. During the treatment, the patient stopped drinking for one week, and both clinical symptoms and laboratory tests were slightly improved. However, overall, there were no substantial improvements. In the second case, clinical symptoms and laboratory tests were markedly improved as the patient took herbal medicine and was treated with auricular acupuncture combined with abstinence from drinking. Conclusion: Two patients with alcoholic liver cirrhosis were observed with the treatment of Chungganhaeju-tang and auricular acupuncture. A patient with continuous drinking showed no improvements while a patient with abstinence from drinking showed substantial improvements in both clinical symptoms and laboratory tests.