• 대한한방내과학회지
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• 제19권2호
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• pp.7-16
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• 1998

Background and Purpose The increasing evidence for neurally mediated cardiac damage and sudden death has focused attention on the central autonomic control of cardiac function. Power spectral analysis of heart rate variability(HRV) can detect autonomic consequences of stroke. We performed power spectral analysis of heart rate variability from 24-hour holter recording to identify cerebral hemispheric lateralization and gender effect in cardiac autonomic control. Methods Data were obtained from 24-hour holter recordings in 30 consecutive patients with hemispheric brain infarction in the subacute phase. We analysed the time domain and frequency domain measures of HRV and ST segment by hemispheric lateralization and Gender. Results ST segment was depressed in women compared with man. There was no statistically significant differences between right and left hemisphere stroke patients in any standard index of HRV and ST segment changes. Conclusions These data are partial consistent with evidence from the recent literature that two cerebral hemispheres and gender have a differential influence on the nature and severity of cardiac dysfunction. We think the prospective and definite study was necessary.

• 수면정신생리
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• 제3권1호
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• pp.56-67
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• 1996

Objectives : This study was designed to find clinical factors that could be differentiated by the lateralization of lesion and also find clinical factors to predict the lateralization of lesion. Methods : The subjects were 65 cooperative inpatients and outpatients with non-traumatic subcortical cerebrovascular disease without neurologic and psychiatric history from January 1995 to September 1995 ; 48 patients in Kyung Hee University, Oriental Medicine Hospital, 35 patients in Anam Hospital, Korea University were examined as subjects, but authors excluded 20 patients whose data were incomplete or who had uncertain lesions on brain CT or MRI. The 65 patients were divided into three groups-group with left hemispheric lesion, group with right hemispheric lesion, group with both hemispheric lesion-according to the finding of brain imaging study. Their cognitive functions were evaluated by the Benton Neuropsychological Assessment(BNA), their subjective neurobehavioral symptoms by Symptom Check List-90-R(SCL-90-R), their objective neurobehavioral symptoms by Neurobehavioral Rating Scale, and their daily living functions by Geriatric Evaluation by Relative's Rating Instrument(GERRl) and Instrumental Activities of Daily Living Scale(IADLs). Results : The results were as follows : 1) The results of cognitive function test indicated that the group with right hemispheric lesion showed low functions in Tactile Form Perception(left), the group with left hemispheric lesion showed low functions in Finger localization(right), the group with right hemispheric lesion showed low functions in Finger Localization(left). 2) Though, there were little significant differences in subjective neurobehavioral symptoms, the group with right hemispheric lesion showed higher scores in all symptoms except hostility. 3) Though, there were little significant differences in objective neurobehavioral symptoms, the group with both hemispheric lesion showed higher scores in cognition, guilty/disinhibition, the group with left hemispheric lesion showed higher scores in lability of mood, the group with right hemispheric lesion showed highest scores in psychotism, neurotism, agitation-hostility and decreased motivation/emotional withdrawal. 4) There were little significant differences among three groups in Daily Living Functions, but the group with right hemispheric lesion showed the lowest functions in Instrumental Activities of Daily Living. 5) As a result of discriminant analysis on each factor's contribution to the prediction of lesion, Finger Localization(left), Phoneme Discrimination and Tactile Form Perception(right) showed that they had the potentiality to predict lesion. Conclusion : The results suggest that there are little significant differences among the groups of three non-traumatic subcortical cerebrovascular disease in cognitive functions, but the group with right hemispheric lesion showed more serious and various changes in subjective and objective neurobehavioral symptoms, and showed low functions in Instrumental Activities of Daily Living. This results suggest the possibility that the decline of the daily living function in the group with right hemispheric lesion were due to various symptoms, not due to cognitive dysfunction. The confirmation of the possibility should be worked out through the follow-up study of some groups containing cortical lesion. Apart from these findings, Finger Localization, Tactile Form Perception(right) and Phoneme Discrimination suggest that they can be used as clinically valuable cognitive parameters that predict the lateralization of lesion in non-traumatic cerebrovascular disease.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.163-170
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• 2006

Backgrounds: MEG can measure the task-specific neurophysiologic activity with good spatial and time resolution. Language lateralization using noninvasive method has been a subject of interest in resective brain surgery. We purposed to develop a paradigm for language lateralization using MEG and validate its feasibility. Methods: Magnetic fields were obtained in 12 neurosurgical candidates and one volunteer for language tasks, with a 306 channel whole head MEG. Language tasks were word listening, reading and picture naming. We tested two word listening paradigms: semantic decision of meaning of abstract nouns, and recognition of repeated words. The subjects were instructed to silently name or read, and respond with pushing button or not. We decided language dominance according to the number of acceptable equivalent current dipoles (ECD) modeled by sequential single dipole, and the mean magnetic field strength by root mean square value, in each hemisphere. We collected clinical data including Wada test. Results: Magnetic fields evoked by word listening were generally distributed in bilateral temporoparietal areas with variable hemispheric dominance. Language tasks using visual stimuli frequently evoked magnetic field in posterior midline area, which made laterality decision difficult. Response during task resulted in more artifacts and different results depending on responding hand. Laterality decision with mean magnetic field strength was more concordant with Wada than the method with ECD number of each hemisphere. Conclusions: Word listening task without hand response is the most feasible paradigm for language lateralization using MEG. Mean magnetic field strength in each hemisphere is a proper index for hemispheric dominance.

• 대한청각학회지
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• 제24권1호
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• pp.48-52
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• 2020

Lateralization for central auditory processing (CAP) with dichotic digits recognition (DDR) test is believed expression of hemispheric dominance. Multiple sclerosis (MS) is considered an inflammatory and autoimmune alteration of central nervous system (CNS). Hearing alterations in MS and their role in CAP has not been well studied. A patient with MS and new kind of alteration in lateralization of CAP with DDR test is presented. A 53 year of age female with MS of 16 years of evolution, nine of them remained asymptomatic. She has a persistent advantage of the right ear for DDR test; but other monaural tests showed predominance of the left afferent pathway. Brainstem auditory evoked potentials (BAEPs) and long latency auditory evoked potentials (LLAEPs) showed adequate right response with deficits in organization of left response in BAEP, and N2 wave. In the contrary direction of previous publication, we disclosed advantage for DDR test, BAEP, and LLAEP in the right ear. We observed no left ear suppression; with predominance of correct left percentages in monaural psychoacoustics tests. We must keep on searching to find pathophysiological meaning of predominant of right or left auditory laterality as a CAP disorder in patients with MS.

• Journal of Audiology & Otology
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• 제24권1호
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• pp.48-52
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• 2020

Lateralization for central auditory processing (CAP) with dichotic digits recognition (DDR) test is believed expression of hemispheric dominance. Multiple sclerosis (MS) is considered an inflammatory and autoimmune alteration of central nervous system (CNS). Hearing alterations in MS and their role in CAP has not been well studied. A patient with MS and new kind of alteration in lateralization of CAP with DDR test is presented. A 53 year of age female with MS of 16 years of evolution, nine of them remained asymptomatic. She has a persistent advantage of the right ear for DDR test; but other monaural tests showed predominance of the left afferent pathway. Brainstem auditory evoked potentials (BAEPs) and long latency auditory evoked potentials (LLAEPs) showed adequate right response with deficits in organization of left response in BAEP, and N2 wave. In the contrary direction of previous publication, we disclosed advantage for DDR test, BAEP, and LLAEP in the right ear. We observed no left ear suppression; with predominance of correct left percentages in monaural psychoacoustics tests. We must keep on searching to find pathophysiological meaning of predominant of right or left auditory laterality as a CAP disorder in patients with MS.

• Journal of Korean Neurosurgical Society
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• 제45권6호
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• pp.329-335
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• 2009

Objective : Determining language lateralization is important for the presurgical evaluation of patients with medically intractable epilepsy. The Wada test has been the gold standard for lateralization of language dominance before epilepsy surgery. However, it is an invasive test with risk, and have some limitations. Methods : We compared the volumetric analysis with Wada test, and studied the clinical potential of volumetric analysis to assess language laterality in large surgical candidates with temporal lobe epilepsy (TLE). To examine the efficacy of volumetric analysis to determine language lateralization during presurgical evaluation, we compared the volumetric analysis of the bilateral planum temporale with the results of Wada test in 59 patients with chronic intractable TLE (rTLE, n=32; lTLE, n=27) who underwent epilepsy surgery. We measured the gray matter volumes of planum temporale (PT) of each patients using the VoxelPlus2 program (Mevisys, Daejeon, Korea). Results : Overall congruence of the volumetric analysis with the Wada test was 97.75% in rTLE patients and 81.5% in lTLE patients. There were more significant leftward asymmetry of the PT in rTLE patients than lTLE patients. In lTLE patients, relatively high proportion (37%) of the patients showed bilateral or right hemispheric language dominance. Conclusion : These results provide evidence that the volumetric analysis of the PT could be used as an alternatives in language lateralization. Also, the results of the Wada test suggested that there was considerable plasticity of language representation in the brains of patients with intractable TLE and it was associated with an earlier age of brain injury.

• Investigative Magnetic Resonance Imaging
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• 제5권1호
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• pp.24-32
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• 2001

Purpose : We investigated the reproducibility of language lateralization by 4 different word generation paradigms or the rest contents in each paradigm using functional magnetic resonance imaging in normal volunteers Materials and Methods Nine normal volunteers with left-handedness (mean age: 25 yrs) were examined on a 1.57 MR unit using a single-shot gradient echo epibold sequence. Four different word generation paradigms of noun, verb, adjective and adverb were used in each normal volunteer for investigating language system. In each paradigm, two different rest contents consisted of only seeing the " +" symbol or reading the meaningless letters. Each task consisted of 96 phases including 3 activations and 6 rests of 2 different contents. Two activation maps in one task were obtained under two different rest contents using the correlation method. We evaluated the detection rates of Broca and Wernicke areas and the differences of language lateralization among four different word generation paradigms, or between the rest contents. Results : The detection rates of Broca and Wernicke areas were over 67 % in 4 different language paradigms and there was no significant difference of them among language paradigms, or between two different rest contents. Language dominances, in all 4 different language paradigms, were shown to be consistent in 66 %, but were contrary with language paradigms in some subjects. The rest contents made no significant effect on dominant language dominance determination, but the success rates of the dominant language dominances determined from 4 language paradigms were higher in reading the meaningless letter (100%, n=9) than in only seeing "+" on screen at the rest task (78%, n=7).

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 1989년도 한글날기념 학술대회 발표논문집
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• pp.278-281
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• 1989

한글 자모 인식과정의 특성을 알아보기 위하여 Stroop 및 반구 비대칭성 효과를 검증하였다. 피보험자들에게 두가지 색으로된 10개의 한글자모를 좌시야와 우시야에 제시하고, 그중 어떤 것이 가운데에 제시된 검사지극의 색 또는 자모형태와 같은 목표자극인가를 신속하게 판단하도록 하였다. 반구 비대칭성 및 Stroop 효과를 선택 반응시간을 측정하여 비교하였다. 자모 처리와 색깔 처리에서는 반구간 차이가 나타나지 않았다. 자모 처리에서 반구간 차이가 나타나지 않은 것은 한글 자모의 시각적 특성과 실험 절차의 특수성애 결부되어 해석되었다. Stroop 효과는 좌반구 보다는 우반구에서 의미있게 큰 것으로 나타났다. 따라서 대뇌 반구간의 비대칭성이 확인되었고 대뇌의 좌반구는 분석적 처리에, 우반구는 전체적인 처리에 전문화 되어 있다는 것을 확인하였다.

• Investigative Magnetic Resonance Imaging
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• 제4권1호
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• pp.52-57
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• 2000

목적: 기능적 자기공명영상을 이용하여 정신분열증 환자에서 운동자극에 의한 뇌 피질의 반응양상을 정상인과 비교하여 알아보고자 하였다. 대상 및 방법: 9 명의 오른손잡이 정신분열증 환자와 정신과학적으로 이상이 없는 6 명의 건강한 오른손잡이 자원자를 대조군으로 하였다. EPI 기법을 이용하여 한 절편 당 120 개의 연속영상 중 3 번의 휴식기와 활성화 시기를 반복하여 전체 4개의 절편에서 총 480개의 영상들을 얻었으며 오른손 운동을 운동자극으로 사용하였다. 영상 후 처리는 교차상관(cross correlation)을 이용하였고 운동자극 시에 우세 대뇌반구를 결정하기 위해 편측화 지수(lateralization index)를 측정하여 환자와 정상인 사이에서 비교하였다. 결과: 정상군에서는 오른손 운동자극시 좌측 감각운동중추에서 우측에 비해 월등히 많은 활성화를 나타내어 높은 펀측화 지수를 보인 반면 정신분열증 환자군의 경우는 좌측 감각운동중추의 활성화는 상대적으로 감소하고 동측인 우측의 활성화가 증가하여 정상군에 비해 낮은 편측화 지수를 나타냈다. 한 명의 환자에서는 우측 감각운동중추가 좌측에 비해 높은 활성화를 보이는 경우도 있었다(역편측화 reversed lateralization) 결론: 정상인에서 관찰되는 좌-우 감각운동피질의 기능적 비대칭성이 정신분열증환자에서는 다른 양상으로 관찰되었다. 이는 이 질환에서 뇌 피질내 운동회로의 기능적 이상이 있음을 반영하는 소견이며, 앞으로 기능적 자기공명영상이 이 질환의 진단과 연구에 많은 도움을 줄 것으로 생각한다.

• 인지과학
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• 제29권1호
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• pp.39-59
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• 2018

작업기억 부담이 부적 얼굴정서 처리에 미치는 영향을 밝히기 위해, N-back 과제 수행 도중 제시된 부적 얼굴표정에 의해 유발된 ERP성분들을 조사하였다. 한 개씩 순차적으로 제시되는 시각적 사물그림들에 대한 기억을 유지하고 갱신하도록 요구하면서(N-back 과제) 이 사물그림들이 제시되는 사이에 공포표정 또는 중립표정의 얼굴자극을 하나씩 제시하였는데, 작업기억 부담을 0-back 조건(저부담)과 2-back 조건(고부담)으로 조작하였다. N-back과제 수행반응을 분석한 결과, 고부담조건에 비해 저부담조건에서 더 빠르고 정확한 반응이 관찰되었다. 얼굴자극에 의해 유발된 ERP 평균진폭을 분석한 결과, 후두영역에서 측정한 P1 진폭에서는 정서가효과는 유의미하지 않았고 작업기억 부담효과만 유의미하였다(고부담 > 저부담). 후측 후두-측두 영역에서 측정한 N170 진폭에서 얼굴 정서가효과는 전반적으로는 유의미하였지만(부정 > 중립) 세부적으로는 작업기억부담과 반구에 따라 다르게 나타났는데, 정서가효과가 좌반구에서는 저부담조건의 경우에만, 우반구에서는 두 부담조건 모두에서 관찰되었다. 결국, 얼굴표정의 부적 정서가가 N170에 미치는 영향이 좌반구에서는 작업기억 부담에 의해 조절되었지만 우반구에서는 그렇지 않았다. 이러한 결과는, 부적 얼굴 표정의 초기 정서처리가 작업기억의 유지 및 조작 부담이 큰 경우 좌반구에서는 약화되거나 일어나지 않을 수 있는 반면, 우반구에서는 작업기억 부담의 크기에 관계없이 일어남을 보여주는 것으로써, 부적 얼굴정서 처리의 우반구 편재를 시사한다.