• 제목/요약/키워드: hematological changes

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마우스에서 Capillary hepatica 감염에 의한 혈액상의 변화 (Hematological changes in mice infected with Capillary hepatica)

  • 신은경;김종술;박양주;이유섭;한정희
    • 한국동물위생학회지
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    • 제20권3호
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    • pp.289-295
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    • 1997
  • This study was performed to induced in mice infected with Capillaria hepatica and treated cyclophosphamide. The typical changes of mice were observed hematologically. The results were as follows ; 1. The liver/body weight ratios of mice were Increased to thee peak at the 6th week and then gradually decreased. 2. Hematologically, eosinophils were increased to the peak at the 6th week and then gradually decreased.

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청영탕이 CHT로 유발된 백서의 뇌부종 및 신경장애 증상에 미치는 영향 (Effects of Cheongyoung-tang on CHT-Induced Brain Edema and Neurological Disturbance Symptom in Rats)

  • 정상수;이상관;성강경
    • 동의생리병리학회지
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    • 제16권5호
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    • pp.948-954
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    • 2002
  • This study was carried out to evaluate Effects of Cheongyoung-tang on CHT-Induced Brain Edema and Neurological Disturbance Symptom in Rats. we make a comparative study of the such parameters as neurological severity score(NSS) and changes in water content, lactate, glucose and hematological substance. 1. ΔNSS increased in CYT1 and CYT2 as compared with the control group, which showed no efficacy. 2. In water content of both hemispheres, CYT1 and CYT2 as compared with the control group have no difference. 3. Water content of the left hemisphere decreased in CYT1 and CYT2 as compared with the control group. 4. The lactate level in serum decreased in CYT1 and CYT2 as compared with the control group. 5. In hematological changes, RBC, PLT and MCHC increased in CYT1 and CYT2 as compared with the control group, but MCV decreased. According to these results, CYT has an effect on CHT-induced brain edema and neurological symptom.

쥐노래미(Hexagrammos otakii)의 생존율, 산소 소비율과 혈액 성상에 미치는 염분의 영향 (Effects of Salinity on Survival, Oxygen Consumption, and Hematological Response of Greenling Hexagrammos otakii)

  • 오승용;명정구;박진우
    • 한국수산과학회지
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    • 제48권5호
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    • pp.712-718
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    • 2015
  • The effects of salinity on survival, oxygen consumption, and hematological response of greenling Hexagrammos otakii, mean body weight 147.1±3.8 g, were investigated under salinity conditions of 33.4 (control), 33.1, 32.8, 32.2, 31.0, 28.7, 23.9, 14.5, and 3.8 psu, to evaluate physiological effects in relation to changes in salinity. The survival and hematological responses of fish were measured at each salinity after 96- and 24-h exposures. The oxygen consumption rate (OCR) of fish was measured in triplicate under conditions of stepwise salinity exposure (33.4→33.1→32.8→32.2→31.0→28.7→23.9→14.5→3.8 psu) with an interval of 24 h at each salinity, using a continuous flow-through respirometer. No fish mortality was observed in the range of 33.4 to 14.5 psu, but the survival rate was reduced to 53.3% at 3.8 psu after 96 h of exposure. The OCRs did not significantly differ in the range between 33.4 to 28.7 psu (P>0.05), but significantly increased at 23.9 and 14.5 psu, and then dramatically decreased at 3.8 psu compared to the control (P<0.05). Hematological variables, such as glucose, glutamic pyruvic transaminase (GPT), hematocrit, and Na+, were affected by reduced salinity. This result may be applicable for habitat and culture management of greenlings.

Effects of Salinity Changes on Hematological Responses in Juvenile Ship Sturgeon Acipenser nudiventris

  • Shahkar, Erfan;Kim, Dae-jung;Mohseni, Mahmoud;Yun, Hyeonho;Bai, Sungchul C.
    • Fisheries and Aquatic Sciences
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    • 제18권1호
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    • pp.45-50
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    • 2015
  • A 10-day trial was conducted to evaluate the salinity tolerance and hematological responses of juvenile ship sturgeon Acipenser nudiventris under different salinity levels. A total of 240 fish averaging $6.2{\pm}0.13g$ (mean${\pm}$SD) were randomly distributed into 12 tanks in groups of 20, and each tank was then randomly assigned to one of three replicates of four different salinities at 0, 4, 8 and 12‰. At the end of 10 days of experimental period, plasma protein value of fish exposed to 0‰ and 4‰ salinities was significantly higher than those of fish exposed to 8‰ and 12‰ salinities (P < 0.05). Significantly higher values for plasma cortisol and glucose were obtained in fish exposed to 12‰ salinity compared to the fish exposed to 0‰ and 4‰ salinities (P < 0.05). Plasma potassium and sodium values increased significantly by increment of salinity levels (P < 0.05). Therefore, these results indicated that in natural environments, juvenile ship sturgeon, A. nudiventris in migratory populations could be able to migrate and adjust successfully into brackish water with a salinity of up to 8‰ without any short-term hematological stress responses.

Toxicity Screening of Single Dose of Inorganic and Organic Arsenics on Hematological and Serum Biochemical Parameters in Male Cynomolgus Monkeys

  • Kim, Choong-Yong;Han, Kang-Hyun;Heo, Jeong-Doo;Han, Eui-Sik;Yum, Young-Na;Lee, Jin-Young;Park, Kyung-Su;Im, Ruth;Choi, Seong-Jin;Park, Jung-Duck
    • Toxicological Research
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    • 제24권3호
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    • pp.219-225
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    • 2008
  • A screening study of the acute toxicity of organic arsenics such as arsenobetaine and arsenocholine, a product of arsenic methylation metabolite, and inorganic arsenic was carried out to examine hematological and serum biochemical parameters in cynomolgus monkeys(Macaca fascicularis). We found soft and liquid feces, and vomiting in all treated groups with inorganic and organic arsenics. The monkeys in inorganic arsenic-treated group showed a significant increase in vomiting frequency compared with those in three organic arsenics-treated groups. These results suggest that inorganic arsenic might be more toxic than three other organic arsenics tested. The monkeys in inorganic arsenic-treated group showed a decrease in platelet and an increase in monocyte on day 4 and the monkeys in arsenocholine-treated group showed an increase in reticulocyte percentage on day 8. The monkeys in inorganic-treated group also showed decreases in AST and ALT values and the monkeys in arsenobetaine-treated group showed a decrease in AST value and an increase in T-CHO value. However, these hematological and biochemical changes were within the physiological ranges, showing that the single dose of inorganic and organic arsenics did not affect at least hematological and serum biochemical parameters. The present study of toxicity with single dose of arsenics provides valuable indicators for longer term study of toxicity of repeated doses of arsenics in primates.

청소년 대상의 현미-채식 급식 프로그램이 주관적 건강상태, BMI 및 혈액지표에 미치는 효과 (Effects of brown rice-vegetable school meal program on subjective health status, BMI and hematological parameters among high school students)

  • 문경자;김혜영
    • 한국산학기술학회논문지
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    • 제16권11호
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    • pp.7385-7393
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    • 2015
  • 본 연구는 청소년 대상으로 현미와 채식 급식을 제공하여 주관적 건강상태, BMI, 혈액학적 지표들의 변화를 알아보기 위한 단일군 실험설계 연구이다. 연구대상자는 현재 고등학교에 재학 중인 17명의 남학생과 18명의 여학생이었다. 12주간 학교 급식으로 대상자들에게 현미와 채식 식단을 점심과 저녁에 제공하였으며, 프로그램 적용 전후 설문조사와 혈액검사를 통해 자료를 수집하였고, 수집된 자료는 paired t-test로 차이검증 하였다. 12주후에 대상자들은 주관적 건강상태가 좋아졌으며, BMI는 감소하였고, 혈액 소견 중에 Hct, Hb, Hct, total protein과 albumin은 감소하였으며, 여학생 군에서는 Ca과 triglyceride level도 유의하게 감소하였다. 하지만 감소된 모든 수치는 정상범위 내였다. 이러한 결과는 청소년기 때 현미와 채식 식단은 건강한 식습관 형성을 통해 체중을 감소시키고, 성인기의 뇌심혈관계 질병들을 예방하는데 도움이 될 것이다.

비글개에 대한 Paecilomyces sinclairii의 급성 경구독성에 관한 연구 (Acute Oral Toxicity of Paecilomyces sinclairii in Beagle Dogs)

  • 안미영;강세찬;정나진;구현정;곽승준;유은정;정진아;고진경;류강선
    • Toxicological Research
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    • 제19권3호
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    • pp.241-245
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    • 2003
  • The acute toxicity of Paecilomyces sinclairii was tested in beagle dogs. We daily examined clinical signs, body weights, and hematological/biochemical examinations for 14 days after administration of Paecilomyces sinclairii with different dose levels (0, 0.4, 2 and 10 g/kg). There were no clinical signs and no significant changes in hematological and biochemical analysis. These results showed that Paecilomyces sinclairii did not induce any remarkable acute toxic response and the $LD_{50}$ was greater than 10 g/kg in beagle dogs.