• Journal of Korean Neurosurgical Society
• /
• 제37권3호
• /
• pp.232-234
• /
• 2005

We report a rare case of a patient with meningeal solitary fibrous tumor. A 60-year-old woman presented with right leg monoparesis. Brain magnetic resonance imaging demonstrates a well enhancing huge mass, located in left parietal lobe. Cerebral angiography demonstrating increased vascularity in area of the tumor, which had feeder vessels extending from the internal carotid artery and external carotid artery. A presumptive diagnosis of meningioma or hemangiopericytoma was considered. At surgery, the consistency was firm and had destroyed the dura and skull. A gross total resection was performed. Immunohistochemically, tumor was strongly, and widely, positive for CD34 and vimentin. There was no staining for epithelial membrane antigen(EMA), S-100 protein, cytokeratin, and glial fibrillary acidic protein (GFAP). Differential diagnosis of intracranial solitary fibrous tumor includes fibroblastic meningioma, meningeal hemangiopericytoma, neurofibroma, and schwannoma.

• 대한세포병리학회:학술대회논문집
• /
• 대한세포병리학회 1992년도 제5차 추계학술대회 초록집
• /
• pp.8.2-9
• /
• 1992

• Journal of Yeungnam Medical Science
• /
• 제28권1호
• /
• pp.77-83
• /
• 2011

Non-islet cell tumor-induced hypoglycemia (NICTH) is associated with mesenchymal tumor types, including hemangiopericytoma, fibrosarcoma, mesothelioma, and neurofibroma, as well as carcinoma of the liver, adrenal glands, and kidneys. Non- islet cell tumors induce hypoglycemia by overproducing an abnormal form of insulin-like growth factor II (IGF m. Complete removal of the tumor or reduction of the tumor mass is a successful therapeutic strategy in cases of NICTH. However, if the tumor re-grows, curative resection is nearly impossible, and hypoglycemia occurs repeatedly. Glucocorticoids are effective in terms of long-term relief from hypoglycemia through promotion of gluconeogenesis in the liver, tumor suppression, production of 'big'-IGF-II, and correction of the attendant biochemical abnormalities involving the growth hormone (GH)-IGF axis. We found that administration of corticosteroid therapy to a patient suffering from NICTH resulted in improvement of hypoglycemia associated symptoms.

• 대한핵의학회:학술대회논문집
• /
• 대한핵의학회 1992년도 제31차 춘계학술대회
• /
• pp.186.2-187
• /
• 1992

• 대한두경부종양학회지
• /
• 제14권1호
• /
• pp.99-102
• /
• 1998

혈관외피세포종(Malignant hemangiopericytoma)은 난원형의 혈관외피세포(pericyte)들로 구성된 매우 드문 혈관종의 일종으로 대개 사지 및 후복막에 발생되며, 안면부와 경부에도 약 25%가량의 발생율이 보고되어 있다. 성별 발생빈도의 차이는 없고 $20{\sim}50$대에서 호발하며, 종양은 대부분 서서히 성장하고 경계가 명확한 무통성의 고형 종괴로 나타난다. 악성과 양성의 구별은 조직학적 소견과 주변 조직으로의 침습, 원격전이 여부 등을 고려하여 판단하지만, 양성으로 진단된 경우에도 수년 내에 재발 및 원격전이가 나타나는 경우가 다수 보고되므로 악성과 양성의 감별이 매우 어렵고. 양성인 경우에도 악성 잠재성이 존재하는 것으로 알려졌다. 치료는 수술적 완전절제가 유일한 방법이나 절제가 불완전한 경우는 수술 후 외부 방사선 조사를 한다. 항암제 투여는 효과면에서 논란이 있지만, 원격전이나 수술과 방사선 치료가 실패한 경우 시행할 수 있다. 저자들은 최근 안면부에 발생한 악성 혈관외피세포종 환자 1예를 치험하였기에 보고하는 바이다.

• Archives of Plastic Surgery
• /
• 제38권3호
• /
• pp.319-322
• /
• 2011

Purpose: Glomus tumor is a benign neoplasm of the normal glomus body, occurring as painful subcutaneous nodules, frequently located in the subungual area. There are few cases of facial glomus tumor reported and we report a case of glomus tumor developing on the columella of nose. Methods: A 68-year-old female presented with a mass of the columella grown for 2 years. The nodule was 0.6 cm in diameter, red-colored without any symptoms such as pain, tenderness and cold hypersensitivity. The pathologic result after punch biopsy was hemangiopericytoma. Excision with local anesthesia was executed. Results: The postoperative recovery of the patient was uneventful, Histopathological examination indicated a glomus tumor. Immunostaining revealed positivity for vimentin, actin, and negativity for desmin, CD-34. After 8 months follow up, there is neither complication nor evidence of local recurrence on clinical examination. Conclusion: To accomplish an accurate diagnosis of glomus tumor, the histopathological examination is essential together with immunochemical studies. The differential diagnosis include hemangioma, lipoma, epidermal inclusion cyst, dermoid cyst and arteriovenous malformation in this region. We report a case of glomus tumor on the face with uncommon clinical features.

• Radiation Oncology Journal
• /
• 제24권2호
• /
• pp.149-155
• /
• 2006

수막에 발생하는 혈관주위세포종은 경질막에 기초한 드문 종양으로서 국소재발과 함께 신경축이나 신경외 장소로 원격전이를 일으킬 수도 있다. 저자들은 수막에 발생한 혈관주위세포종 환자 2예에서 수술 전 방사선치료와 수술 후 방사선치료를 각각 경험하였기에 방사선치료의 역할에 관한 문헌고찰과 함께 보고하고자한다. 첫 번째 증례는 41세 남자로 3개월 동안 두통과 우측 반부전마비가 있었다. 1차 수술과 2차 수술 시 종양은 거의 제거할 수 없었고 수막 혈관주위세포종으로 진단되었다. 수술 전 방사선치료를 좌측 전두두정부의 큰 잔여종양에 일 회에 1.8 Gy씩 31회에 걸쳐 총 55.8 Gy를 조사하였다. 방사선치료 후 CT검사상 종양은 현저하게 크기가 줄었고 방사선치료 후 6개월에 시행한 3차 수술 시 잔여 종양의 크기는 $2{\times}2cm$로 완전히 제거되었다. 추적 CT검사상 국소재발의 소견은 없었고, 1차 수술 후 4년 10개월 동안 원격 전이 없이 생존하고 있다. 두 번째 증례는 45세 여자로 갑작스러운 두통과 시력 장애로 수막종이 의심되어 종양제거수술을 받았는데 조직 검사상 우측 전두엽에 발생한 혈관주위세포종으로 진단되었으며 시상동을 침습한 소견을 보였으나 완전히 제거되었다. 국소재발을 줄이기 위해 수술 후 방사선치료가 의뢰되었고 방사선치료는 우측전두엽 부위에 일 회에 1.8 Gy씩 30회에 걸쳐 총 54 Gy를 조사하였다. 수술 후 5년 동안 국소 재발이나 원격전이 없이 정상적인 활동을 유지하면서 생존하고 있다.

• Journal of Korean Neurosurgical Society
• /
• 제58권3호
• /
• pp.211-216
• /
• 2015

Objectives : Although surgical resection is used to treat meningeal hemangiopericytoma (MHPC), there is a high risk of subsequent recurrence. This study investigated factors associated with treatment outcomes and recurrence in patients who had undergone surgical resection of intracranial MHPC. Methods : Fifteen patients underwent surgical treatments performed by one senior neurosurgeon between 1997 and 2013. Clinical data, radiologic images, surgical outcomes, recurrence, and other relevant characteristics were reviewed and analyzed. Results : Fifteen patients were included in the analysis, 12 (80%) of whom had tumors in the supratentorial region, and 3 (20%) of whom had tumors in the infratentorial region. Complete resection was achieved in all 15 patients, and 3 (20%) patients were administered radiosurgery and conventional radiotherapy after surgery as adjuvant radiotherapy. Three patients developed recurrence, 2 of whom had not received adjuvant radiotherapy. In 1 of the patients who had not received adjuvant radiotherapy, recurrence developed at the original tumor site, 81 months after surgery. The other 2 recurrences occurred at other sites, 78 and 41 months after surgery. The 5- and 10-year overall survival rates were 88.3%, while the 5- and 10-year recurrence-free survival rates were 83% and 52%, respectively. Additionally the mean Ki-67 index differed significantly between patients who did and did not develop recurrence (43% vs. 14%; p=0.001). Conclusion : Because of the high risk of MHPC recurrence, MHPC tumors should be completely resected, whenever feasible. However, even when complete resection is achieved, adjuvant radiotherapy might be necessary to prevent recurrence.

• Journal of Korean Neurosurgical Society
• /
• 제54권4호
• /
• pp.309-316
• /
• 2013

Objective : Intracranial hemangiopericytomas (HPCs) are rare tumors with aggressive behavior, including local recurrence and distant metastasis. We conducted this retrospective study to evaluate the efficacy of grossly total resection and adjuvant radiotherapy (RT) for these tumors. Methods : A total of 13 patients treated for intracranial HPC from January 1995 through May 2013 were included in this retrospective study. We analyzed the clinical presentations, radiologic appearances, treatment results, and follow-up outcomes, as well as reviewed other studies. Results : The ages of the patients at the time of diagnosis ranged from 26 to 73 years (mean : 48 years). The majority of the patients were male (92.3%), and the majority of the tumors were located in the parasagittal and falx. The ratio of intracranial HPCs to meningiomas was 13 : 598 in same period, or 2.2%. Seven patients (53.8%) had anaplastic HPCs. Nine patients (69.2%) underwent gross total tumor resection in the first operation without mortality. Eleven patients (84.6%) underwent postoperative adjuvant RT. Follow-up period ranged from 13 to 185 months (mean : 54.3 months). The local recurrence rate was 46.2% (6/13), and there were no distant metastases. The 10-year survival rate after initial surgery was 83.9%. The initial mean Karnofsky performance scale (KPS) was 70.8 and the final mean KPS was 64.6. Conclusion : Gross total tumor resection upon initial surgery is very important. We believe that adjuvant RT is helpful even with maximal tumor resection. Molecular biologic analyses and chemotherapy studies are required to achieve better outcomes in recurrent intracranial HPCs.

• Journal of Chest Surgery
• /
• 제38권2호
• /
• pp.175-179
• /
• 2005

흉강입구를 침범한 종양을 근골보존 경흉골병 접근술을 이용하여 수술한 증례를 보고하고자 한다. 우측 상지의 근력 약화를 주소로 69세의 남자 환자가 내원하였다. 단순 흉부 방사선 사진에서 우측 폐 상엽에 기관지 확장증, 만성 결핵과 진균덩이가 관찰되었다. 전산화단층촬영에서 종양이 제 6, 7번 경추와 제 1번 흉추의 척추강내 경막외에 위치하며 우측 흉곽 첨부에까지 연장되어 있었다 신경외과에서 먼저 후궁절제술을 시행하여 척추강 안의 종양을 절제한 후, 흉부외과에서 근골보존 경흉골병 접근술을 통하여 흉강입구를 침범한 종양을 제거하였다. 종양은 혈관외피세포종으로 진단되었으며, 환자는 수술 후 합병증 없이 회복되었다.