• 한국가금학회지
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• 제28권3호
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• pp.231-237
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• 2001

육계를 13주간 사육하면서 5주령부터 시험사료를 급여한 후 세포표면항원의 발현에 미치는 영향을 측정하기 위하여, 아마종실과 항산화제를 첨가하지 않은 대조구($T_{1}$ ), 아마종실만을 첨가한 사료($T_{2}$ ), 아마종실과 u-toco-pherol을 첨가한 사료($T_{3}$ ), 아마종실에 u-tocopherol과 셀레늄을 첨가한 사료($T_{4}$ )를 육계에 급여한 바 면역반응에 미치는 영향은 다음과 같았다. 1차 면역에 관여하는 monocyte 군은 시험사료의 급여기간이 증가할수록 $T_{1}$ 에 비하여 $T_{2}$ , $T_{3}$ , $T_{4}$ 구에서 유의적으로 증가하는 경향을 보였는데 그중 $T_{2}$ 구와 $T_{3}$ 구에서 많이 증가되었다. B세포는 시험사료의 급여기간보다는 급여사료에 따라 증가하였는데,$T_{2} , $T_{3}, $T_{4}$ 구는 $T_{1}$ 구에 비하여 2배 이상 증가하였다. CD4 양성반응(T helper cell)과 CD8 양성 세포(T $cytotoxic^pressor cell)는 $T_{2}$ , $T_{3}$ ,$T_{4}$ 구는 $T_{1}$ 구보다 증가하였으나 사료에 따라 일정한 차이는 없었다. MHC classII는 시험사료의 종류나 급여 기간에 따라 차이는 없었다.었다.

• 한국콘텐츠학회논문지
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• 제19권5호
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• pp.542-552
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• 2019

본 연구는 뇌병변장애인의 고용특성 및 취업 영향요인을 확인하는데 목적이 있다. 연구대상은 317명이다. 분석자료는 한국장애인고용공단의 장애인 고용패널조사 자료를 활용하여 카이스퀘어, 회귀분석을 실시하였다. 변수는 장애건강 요인, 취업관련 요인, 가구관련 요인으로 구성된다. 첫째, 뇌병변장애인 취업집단은 미취업집단에 비해 중증장애, 건강상태가 좋은 경우, 일상생활 도움제공자가 없는 경우, 보조도구가 없는 경우, 고학력, 유자격증, 공공취업서비스 경험이 있는 경우, 주변인 취업알선 받은 경우, 직접 구직 문의 경험이 있는 경우, 유배우자, 비수급자, 가족 취업지지가 높은 경우가 유의미하게 나타났다. 둘째, 뇌병변장애인 취업에 영향을 미치는 요인은 일상생활 도움제공자, 학력, 주변인 취업알선 경험, 배우자, 기초생활보장수급으로 나타났다. 결과를 바탕으로 뇌병변장애인의 취업 활성화를 위하여 일상생활, 교육제도, 사회관계망의 강화와 기초생활보장수급제도의 수정에 대해 제시하였다.

• IMMUNE NETWORK
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• 제19권1호
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• pp.7.1-7.11
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• 2019

Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal glands, but its cause remains largely unknown. Clinical data indicating that SS occurs in a substantial proportion of patients with lupus points to common pathogenic mechanisms underlying the two diseases. To address this idea, we asked whether SS develops in the lupus-prone mouse strain sanroque (SAN). Owing to hyper-activation of follicular helper T (Tfh) cells, female SAN mice developed lupus-like symptoms at approximately 20 wk of age but there were no signs of SS at that time. However, symptoms typical of SS were evident at approximately 40 wk of age, as judged by reduced saliva flow rate, sialadenitis, and IgG deposits in the salivary glands. Increases in serum titers of SS-related autoantibodies and numbers of autoantibody-secreting cells in cervical lymph nodes (LNs) preceded the pathologic manifestations of SS and were accompanied by expansion of Tfh cells and their downstream effector cells. Thus, our results suggest that chronic dysregulation of Tfh cells in salivary gland-draining LNs is sufficient to drive the development of SS in lupus-prone mice.

• IMMUNE NETWORK
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• 제1권3호
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• pp.236-243
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• 2001

Background: An immunological approach for aging mechanism appears to be important. Lymphocyte subsets analysis in peripheral blood is widely performed to assess the immune status and to diagnose and monitor various diseases. Some lymphocyte subsets are known to change with age, but only few data about age-related reference ragnes for these subsets in healthy individuals have been reported. So we attempted to report reference ranges for these subsets in each age group and review changes of the results with age for the secondary studies about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement (VDJ) including recombination activating genes (RAG-1 and RAG-2). Methods: Lymphocyte subset analysis was performed on 302 subjects, 189 males and 113 females with age group of all decades of life. Two color direct immunofluorescene flow cytometry (FCM) was done using $Simultest^{TM}$ IMK-Lymphocyte kit (Becton Dickinson, USA), $FACScan^{TM}$ (Becton Dickinson, USA) and $FACSCalibur^{TM}$ (Becton Dickinson, USA). Lymphocyte subsets analysed were T ($CD3^+$) and B cells ($CD19^+$), helper/inducer T ($CD4^+$) and suppressor/cytotoxic T cells ($CD8^+$), helper/suppressor ($CD4^+/CD8^+$) ratio and natural killer (NK) cells ($CD3^-CD16^+/CD56^+$). The absolute numbers of each subset were calculated from total lymphocyte counts. Data collected was analysed using SAS 6.12. A P-value of < 0.05 was considered significant. Results: We reported the counts and percentages of lymphocyte and these subsets in each age group. There were no statistically significant differences between male and female subjects. The percentage of $CD4^+$ T cells, and the count of NK cells did not show the significant difference among the various age groups. The age-related changes observed in our study were as following: 1) a decrease in the percentages of T cells, B cells and $CD8^+$ T cells ; 2) a decrease in the counts of B cells and $CD8^+$ T cells ; 3) an increase in the percentage and count of NK cells ; and 4) an increase in the $CD4^+/CD8^+$ ratio. Conclusion: The characteristics of aging process appeared to be showing a marked decrease of lympocyte subsets T and B cells as well as T8 ($CD8^+$). The age-related increase of the percentage of cells bearing NK marker can be interpreted as a compensatory consequence to cope with the decrease of T cells related to the thymic involution. These changes with age appeared to be for the secondary study about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement.

• 문화기술의 융합
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• 제4권3호
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• pp.99-104
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• 2018

문화유산 산업은 한나라의 흥망성쇠에 결정적 영향을 미친다. 본 연구에서 문화유산 산업에 대한 선진국의 여러 가지 정책과 제도를 소개한다. 이를 통해 나라의 상황에 맞게 고쳐 나아가, 문화유산 산업 발전 관련 정책을 제시한다. 특히 '젊우미'라는 제도를 제안해, 청년취업과 문화유산 산업 증진의 두 가지 발전을 위한 정책을 위해 문화재 보존 인력양성, 문화재의 디지털 데이터베이스화 와 문화재 스토리 발굴을 제안한다.

• Molecular & Cellular Toxicology
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• 제3권1호
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• pp.46-52
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• 2007

In the course of novel TLR (Toll like receptor) 9 ligand, we found novel CpG ODN (Oligodeoxynucleotide) was active in augmenting antibody in mice. However, immune mechanism of new CpG ODNs is unclear. To clarify this, we examined immunoadjuvanticity by employing in vitro and in vivo immune profiles. In brief, in vitro treatment of novel CpG ODN upregulated the expression of TNF-$\alpha$, IL-6, and IL-12 mRNA in macrophages as well as that of IFN-$gamma$ mPNA in mouse splenocytes. In parallel, in vivo injection of novel CpG ODN directly activates macrophages and splenocytess, consequently upregulating MHC class II and CD86. Finally, we demonstrated anti-HBs antibody augmentation of novel CpG ODN. Collectively, this data indicates that novel CpG ODN is immunoadjuvant armed with Th1 typed immune machinery.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제4권6호
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• pp.1327-1342
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• 2010

With the wide deployment of biometric authentication systems, several issues pertaining security and privacy of the biometric template have gained great attention from the research community. To resolve these issues, a number of biometric template protection methods have been proposed. However, the design of a template protection method to satisfy four criteria, namely diversity, revocability and non-invertibility is still a challenging task, especially performance degradation when template protection method is employed. In this paper, we propose a novel method to generate a revocable minutiae-based fingerprint template. The proposed method consists of feature extraction from fingerprint minutiae pairs, quantization, histogram binning, binarization and eventually binary bit-string generation. The contributions of our method are two fold: alignment-free and good performance. Various experiments on FVC2004 DB1 demonstrated the effectiveness of the proposed methods.

• 대한수의학회지
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• 제32권1호
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• pp.25-34
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• 1992

The present study were carried out to investigate the effects of Vomitoxin(Deoxynivalenol, DON) induced dysregulation of IgA synthesis. The data presented here demonstrate that exposure to dietary DON increases serum IgA and concurrently decreases IgG and IgM. Peyer's path(PP) and splenocytes from mice fed dietary DON produced increased IgA in mitogen stimulated and macrophage(MØ) perform essential role for Ig synthesis and was affected by the presence of DON. The synthesis and secretion of IgM and IgG under the presence of DON do not require T cell helper activity, whereas those of IgA do require such activity. These results suggest that dietary DON alters the regulation of IgA production and may act as an immunostimulator.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2000년도 추계학술발표논문집 (하)
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• pp.1117-1120
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• 2000

인터넷 소프트웨어 개발자는 인터넷 보안 소프트웨어, 네트워크 실습 교육용 소프트웨어 등의 다양한 서비스 개발을 위해, 데이터 링크 계층의 프레임에 직접 접근하는 방법을 요구한다. 이러한 개발자를 위해, Windows 2000은 사용자 계층에서 인터넷 관련 네트워크 자원에 접근할 수 있는 Winsock, NPP, Internet Protocol Helper API를 지원한다. 하지만, 개발자가 이러한 API, 특히 Winsock API를 통해 직접 데이터 링크 계층의 프레임에 접근하는 데에는 한계가 있다. 따라서, 본 논문에서는 NDIS Library를 이용하여 일반 개발자가 손쉽게 데이터 링크 계층의 프레임에 접근할 수 있는 packet driver API를 설계하였다. API를 구성하는 각 클래스는 계층적 구조로 설계하였으며 Visual C++를 사용하여 구현하였다.

• 가정과삶의질연구
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• 제20권3호
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• pp.101-111
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• 2002

The purpose of this study was to obtain data on the child care support and job satisfaction of married women employed outside home. The data for this study were collected from a survey of 350 married women employed outside home who were residing in North Cholla Province. Major fimding are summarized in the following. First, many married women were pressured by the burdens child rearing(54.5%) and houshold chores(39.6%). Second, the daycare arrangements for children under age seven were diverse. Just under half of the children were cared for by the employed mother'parents(25.1%), or by the mother's parents-in law(21.1%). The rest were sent to daycare center(40.6%), cared for by a hired helper(7.6%), or sent to an industrial on- site daycare center(1.0%). Third, about half of the married employed mothers(47.5%) wished for an on-site daycare service at their workplace. Fourth, the variables that affected employed mothers job satisfaction were age, job, husband's job type, the income of the mother, the reason of the mother's employment, the degree of husband's houshold labor participation, and the type of social and employer's support for chid care.