• 동의생리병리학회지
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• 제18권5호
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• pp.1242-1253
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• 2004

Leukemia is a blood disease that occurs in the abnormal process of leukocyte maturation. Its main medical treatment is chemical therapy and bone medical transplant. But its treatments give rise to ill effects and sequela. At present, the cause of leukemia is not fully understood. But oriental concept of curing leukemia is the holistic thinking that emphasizes the unity, wholeness, and the relationship between the human organs, including western medical concept of blood cause. So it is estimated that holistic medical treatment in oriental medicine could present new medical way of curing leukemia. I read over the diary on struggles against leukemia, survey on the leukemia patients, and, medical charts in the oriental clinics that treated in the holistic way, and I interviewed the leukemia patients. With these materials, I classified the early main attacking symptoms according to the chief complaints of one hundred leukemia patients. With these results collected, I present new alternative treatment by oriental medical diagnosis. The chief early complaints that leukemia patients give are fatigue, enervation, cold, contusion, fever, high fever, sweating at sleep, myalgia, arthralgia, and dizziness, in order of main symptoms. Fatigue occurs mainly by spleen and stomach weakness and marrow shortage. So it is estimated that It is important to treat the spleen that is responsible for supplementing the marrow. Because the leukemia patients have anemia and hemorrhage, to treat the spleen is important for hematopoiesis and controlling blood. In case of cold, it penetrates into the body when the body is weak. So its treatment is to increase body's health. But the cause of fever is difficult to classify into outer cause and inner cause. But in case of children under 14 years old, fever is the main sypmptom. I think this is because children have the body with pure vital energy. Hemorrhage is thought to be the result of yin-lack and heat-miasma of spleen and stomach channels. Contusion occurs from the qi-weakness and the not-controlling-blood. Sweating at sleep is from the yin-weakness. It is found with all weak symptoms. Dizziness is from the yin-blood impairment. Weight-loss is from the marrow shortage. Myalgia and arthralgia is mainly from inner weakness, not outer maisma. Most leukemia patients have the idea that holistic treatment of leukemia could be of assistance and give help to the low immunity. So it is expected that holistic medical treatment could contribute to knowing the cause and treatment of leukemia, and give people reliability on oriental medical treatment, through the profound diagnosis of leukemia.

• 미생물학회지
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• 제49권3호
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• pp.245-252
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• 2013

녹농균과 아시네토박터 바우마니는 병원에서 중요한 기회감염 균주이며 대부분의 항생제에 내성이다. 다제내성 녹농균(MDRPA)과 아시네토박터 바우마니(MDRAB)는 심각한 원내 감염을 일으키고 메티실린 내성 황색포도상구균(MRSA) 보다 치료가 어렵다. 비피도박테리아는 많은 유익한 프로바이틱스 중 하나로 그들의 항균활성에 대한 많은 연구가 이루어져 왔다. 본 연구에서는 한국인으로부터 분리한 비피도박테리움 속 균주들의 MDRPA와 MDRAB에 대한 항균활성을 조사하였다. 시프로플록사신, 토브라마이신, 겐타마이신, 메로페넴과 세프타지딤에 내성을 보이는 MDRPA와 MDRAB에 대한 비피도박테리움 속 균주들의 항균활성은 흡광도를 이용한 액체배지희석법에 의해 측정되었다. 모든 비피도박테리아 분리균주(비피도박테리움 어돌레센티스 9균주, 비피도박테리움 롱검 3균주와 비피도박테리움 슈도카테눌라툼 2균주) 중 비피도박테리움 슈도카테눌라툼 SPM1309의 배양 상등액은 MDRPA와 MDRAB에 대한 강한 증식 억제 효과를 보여주었다. 배양 시간 동안 혼합액의 탁도는 변화되지 않았으며, 이 억제 효과는 정균 작용이었다. 게다가 항균활성은 분자량 10 kDa 미만의 분획물에서 나타났으며, $70^{\circ}C$에서 10분간 열처리 한 후에서 항균활성이 유지되었기 때문에 활성물질은 열에 안정하였다. 본 연구결과는 MDRPA와 MDRAB 감염증의 대체치료법을 위한 비피도박테리움 슈토카테눌라툼 SPM1309의 잠재적인 가능성을 보여준다.

• 대한한방소아과학회지
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• 제12권1호
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• pp.111-131
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• 1998

1. In oriental medicine, the case of sinusitis can be explained, not only external invasion such as PUNG HAN(wind-cold), PUNG YUL(wind-hot), SHUP YUL(damp-heat), but also functional disorder of internal organ such as spleen(脾), lung(肺), kidney(腎) The western medicine classified the cause of sinusitis as two factors. That is bacterial infection factor-Haemophilus influenza, streptococcus pyogeues, streptococcus pneumonia- and viral infection factor-Rhinovirus, parainfluenza, Echo28, Coxsacki21, Sinusitis is complicated to allergic rhinitis, chronic otitis media purulent, chronic tonsilitis, sinubronchitis. On the condition of nasal septum deformity, turbinates deformity, nasal septum deviation, sinusitis can be developed. the predisposing factors of sinusitis is swimming, air pollution, malnutrition, shortage of immunity.2. According to survey, sinusitis occurred that children from 4 to 12 years old and from 5 to 7 years old occupied 70% 3. From the past history data, they experienced chronic tonsillar hypertropy(20%), otitis media, atopic dermatitis, allergic rhinitis, bronchial asthma, pneumonia, bronchiolitis, chronic sore throat, urticaria, milk allergy in sequence. 4. the symptoms of sinusitis is nasal obstruction, postnasal dripping, purulunt(yellow)or white discharge, cough, nose bleeding in sequence. nasal obstruction take the portion of 95%, postnasal dripping 65%, night time or early morning cough 60%. 5. The suffering period of sinusitis is 6 month minimum, 4 years maximum, most cases are included in a year. The suffering period of children was shorter than adult. 6. Diagnosis depend on inspection of nasal cavity, postnasal dripping, X-ray finding. 75% of patient(15case) showed both maxillary sinusitis, 25%(5cases) showed left or right maxillary sinusitis. 7. Treatment of oriental medicine, consist of Herb-medicine, acupuncture and exposing of Lazer beam. Kamihyunggyeyungyotang(加味荊芥蓮翹湯) is administered mainly as the medical therapy, Kamigwaghyangjeungkisan(加味藿香正氣散) Kimizwakwieum(加味左歸飮), Kamihyangsosan(加味香蘇散) is administered for a additional symptoms which occurred by influenza recurrence. Kamijeonxibackchulsan(加味錢氏白朮散) is administered to treat gastro-intestine trouble patients who have sinusitis. 8. The period of treatment is varied with patient conditions and X-ray finding. The minimal period is 35days, maximal period is 202days. So it took about 86days in average and about 50% of patient(10cases) is recovered in one or two month.

• Journal of Hospice and Palliative Care
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• 제17권4호
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• pp.270-277
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• 2014

목적: 본 연구는 중등도 이상의 통증을 호소하는 암환자의 통증간호기록을 분석하여 통증의 특성과 통증완화를 위한 중재 및 중재의 효과를 조사하는 후향적 연구이다. 방법: 대상자는 2011년 2월 1일부터 2월 28일까지 서울시에 소재한 C 대학교 병원의 암병동에 입원 환자 중 재원일수가 3일 이상 30일 이하이며, 18세 이상의 성인으로 NRS로 측정한 통증의 강도가 4점 이상인 363명이었다. 결과: 입원 후 4점 이상의 통증을 호소한 건수는 1,394건이었다. 통증의 부위는 복부가 가장 많았고, 통증의 악화요인은 움직였을 때가, 완화요인은 진통제를 투여받았을 때가 가장 많았다. 통증의 유형은 돌발성 통증이 가장 많았다. 통증을 조절하기 위해 사용한 비약물적 중재 중 온요법이 가장 많았다. 약물을 투여하기 전 통증의 강도는 평균 6.68점이었으며 약물투여 후 1시간에 평균 2.81점으로 감소되었다. 정규처방으로 진통제를 투여한 경우는 52.2%였으며, 마약성 진통제 중 Morphine sulfate가, 비마약적 진통제 중 Gabapentin이 가장 많이 사용되었다. 퇴원 시 통증의 강도는 3점 이하가 82.5%였다. 결론: NRS 4점 이상의 통증을 호소하는 암환자는 입원 초기부터 적극적으로 통증을 조절하는 것이 중요하다. 마약성 진통제로 통증을 조절하는 암환자와 가족은 물론 간호사를 대상으로 약제의 효과와 부작용에 대하여 교육하고, 또한 퇴원 후 가정에서 환자와 가족이 통증을 평가하고 기록하여 추후 치료에 반영할 수 있도록 교육하는 것이 필요하다.

• 대한한의학방제학회지
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• 제11권1호
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• pp.57-90
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• 2003

The result of Bibliographic studies on the pathological mechanism of the sudden coma, we got the conclusion like this. 1. The sudden coma is an acute syndrome that refers to be a sudden fainting, an unconsciousness, an aphasia or a cold clammy limb, and immediately awakes or dies, and awakes in a short time, and if we awake, it doesn't leave over and above a sequela. 2. The clinical presentation of the sudden coma can be summarized as follows : The 1st is a disease raising the sudden death due to unconsciousness accompanied by wry mouth & sudden syncope with coma. The 2nd is simply the state of cold limbs. The 3rd is the meaning of the physique and symptomes of the six meridians. The last is the ancient method of expression in contrast of the beriberi. 3. The pathological mechanism of the sudden coma consists of the toxoid from outside, Qi and Xie, fatigue, damp phegm, the damage from seven emotions and the damage from five mental elements, especially the mental disorder due to the angry energy, causes the problems when the fleming-up of liver fire and the depressed of liver qi raise the physiological disorder. 4. Therapeutic methods of sudden coma are soothing the liver and remove stasis, soothing depression and circulating of the qi, calming the liver and suppressing yang. When that is early stage, at first, we must checking upward adverse flow of the qi after promoting the circulation of qi and awakening, and then, we must regulate excessive deficiency of yin yang by therapy that is based on differentiated in symptoms according to heat & cold, deficiency & excess, and use invigorating herb medicine for supporting vigour.

• 대한한의학회지
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• 제18권2호
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• pp.223-244
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• 1997

Clinical observation was done on 290 cases of patients who were diagnosed as CVA with brain CT, TCD, MRI scan and clinical observation. They were hospitalized in the oriental medical hospital of Kyung-Won University from 1st January to 31st December in 1996. 1. The cases were classified into the following kinds : cerebral infarction, cerebral hemorrhage, and transient ischemic attack. The most case of them was the cerebr진 infarction. 2. There is no significant difference in the frequency of strokes in male and female. And the frequency of strokes was highest in the aged over 50. 3. In cerebral infarction the most frequent lesion was the territory of middle cerebral artery, and in cerebral hemorrhage the most frequent lesion was the basal ganglia. 4. The most ordinary preceding disease was hypertension, and the next was diabetes. 5. The rate of recurrence was high in cerebral infarction. 6. The frequency of strokes seems to have no relation to the season. 7. The cerebral infarction occurred usually in resting and sleeping, and the cerebral hemorrhage in acting. 8. The course of entering hospital, most patients visited this hospital as soon as CVA occurred. And the half of patient visited this hospital within 2 days after CVA attack. 9. In the cases of patients who were unconscious at the admission, the prognosis was worse than that of the alert patients. 10. The common symptoms were motor disability and verbal disturbance. 11. The average duration of hospitalization was 27.4 days, and in case of cerebral hemorrhage the duration was prolonged. 12. The average time to start physical therapy was 13.3rd day after stroke in cerebral infarction and it was 19.9th day after stroke in cerebral hemorrhage. 13. The common complications were urinary tract infection, pneumonia, myocardial infarction and so on. 15. At the time of entering hospital, in most cases the blood pressure was high, but blood pressure was well controlled at the time of discharge. 16. Generally reported, hypercholesterolemia and hypertriglyceridemia are usually found in cerebral infarction. But in this study, they were found more frequently in cerebral hemorrhage than in infarction. 17, In the most cases, western and oriental medical treatments were given simultaneously. 18. In acute or subacute stage, the methods of smoothening the flow of KI(順氣), dispelling phlegm(祛痰), clearing away heat(淸熱) or purgation(瀉下) were frequently used. And in recovering stage, the methods of replenishing KI(補氣), tonifying the blood(補血) or tranquilization(安神) were frequently used.

• 대한한방종양학회지
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• 제9권1호
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• pp.75-87
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• 2003

Recently, the occurrence and death rates of cancer have increased rapidly. Metastasis and recurrence is the most important factor of death from cancer. So inhibition of recurrence and metastasis can increase the cure rate of cancer disease. At the basic chinese traditional medicine(TCM), there are a lot of theory related to neoplasm treatment. The metastasis and recurrence of neoplasm was the basis of yudu(餘毒) on remained neoplasm cell and stagnation of blood, thermotoxo, phlegm, asthenia of healthy enerngy and stagnation of vital energy. The principles therapy of neoplasm on metastasis and recurrence was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils. But the major clinical features of neoplasm was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distingction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. This paper's results indicate that identification and effective use of THM can inhibite netastasis and recurrence and then it will help increasing survival rate. Also as BioTechnology(BT) has developed rapidly nowadays, as genes related to cancer have revealed. So it will give rise to the development of searching the mechanism of herb medicines which have inhibition effects of metastasis and recurrence.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10613-10619
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• 2015

Background: Both alcohol and aqueous extracts of Sauromatum giganteum(Engl.) Cusimano and Hett, the dried root tuber of which is named Baifuzi in Chinese, have been used for folklore treatment of cancer in Northeast of China. However, little is known about which is most suitable to the cancer therapy. Materials and Methods: Serum pharmacology and MTT assays were adopted to detect the effects of ethanol and aqueous extracts of Sauromatum giganteum(Engl.) Cusimano and Hett, prepared by heat reflux methods, on proliferation of different cancer cells. Results: Cancer cells treated with medium supplemented with 10%, 20%, 40% serum(v/v) containing ethanol extract had a decline in viability, with inhibition rates of 7.69%, 21.8%, 41.9% in MCF-7 cells, 42.8%, 48.1%, 51.8% in SGC-7901 cells, 44.1%, 49.2%, 53.7% in SMMC-7721 cells, 6.8%, 15.2%, 39.8% in HepG2 cells, 7.57%, 16.3%, 36.2% in HeLa cells, 6.24%, 12.5%, 27.4% in A549 cells, and 7.20%, 17.5%, 31.3% in MDA-MB-231 cells, respectively. Viability in the aqueous extract groups was no different with that of controls. Conclusions: An ethanol extract of Sauromatum giganteum(Engl.) Cusimano and Hett inhibited the proliferation of SMMC-7721, SGC-7901 and MCF-7 cells, which supports the use of alcoholic but not aqueous extracts for control of sensive cancers, which might include hepatocarcinoma, gastric cancer and breast cancer.

• Journal of Acupuncture Research
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• 제20권1호
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• pp.85-96
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• 2003

Objectives : We were studied the retaining needle to offer basic materials for the study of it. methods: To study the retaining needle, we were reviewed the ancient, the present text and the thesis. Results: 1. There are many ways form general acupuncture technique to needle-embedding therapy by the spending time of the retaining needle. 2. The method retaining needle is divided into Active method of the retaining needle(動留針法) and Passive methoid of the retaining needle(靜留針法) by the existence of Qi-promoting. 3. In case of Deficiency Syndrome, protracted discase, dolorific disorder, convulsive disorder, and Cold Syndrome, the spending time of the retaining needle takes longer, in case of Heat Syndrome and exterior Syndrome, the spending time of the retaining needle takes shorter. 4. In case of acute disease and attack of chronic disease, we can use Active methoid of the retaining needle(動留鍼法) with retaining needle for a long time, in case of chronic disease, we can use Passive methoid of the retaining needle(靜留針法). 5. In case of Young people, a man in the prime of life, and a people who can stand the stimulation of needle, we can make the spending time of the retaining needle be longer and use Active methoid of the retaining needle(動留針法), but in case of a baby and a weak people, we had better shorten the spending time of the retaining needle or not do it. 6. The spending time of the retaining needle must be shorter in spring and summer, must be longer in fall and winter. 7. The spending time of the retaining needle is various by acupuncture point. 8. When the spending time of the retaining needle is too longer, we can injure Vital-qi of a patient, otherwise in opposite situation, Pathogenic is stagnated so pathogenic stage is repeated.

• Parasites, Hosts and Diseases
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• 제51권3호
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• pp.269-277
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• 2013

Amoebic keratitis (AK) caused by Acanthamoeba is one of the most serious corneal infections. AK is frequently misdiagnosed initially as viral, bacterial, or fungal keratitis, thus ensuring treatment delays. Accordingly, the early detection of Acanthamoeba would contribute significantly to disease management and selection of an appropriate anti-amoebic therapy. Recently, the loop-mediated isothermal amplification (LAMP) method has been applied to the clinical diagnosis of a range of infectious diseases. Here, we describe a rapid and efficient LAMP-based method targeting Acanthamoeba 18S rDNA gene for the detection of Acanthamoeba using clinical ocular specimens in the diagnosis of AK. Acanthamoeba LAMP assays detected 11 different strains including all AK-associated species. The copy number detection limit for a positive signal was 10 DNA copies of 18S rDNA per reaction. No cross-reactivity with the DNA of fungi or other protozoa was observed. The sensitivity of LAMP assay was higher than those of Nelson primer PCR and JDP primer PCR. In the present study, LAMP assay based on directly heat-treated samples was found to be as efficient at detecting Acanthamoeba as DNA extracted using a commercial kit, whereas PCR was only effective when commercial kit-extracted DNA was used. This study showed that the devised Acanthamoeba LAMP assay could be used to diagnose AK in a simple, sensitive, and specific manner.