• Journal of Ginseng Research
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• 제31권1호
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• pp.23-33
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• 2007

Ginsenosides are one of the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in korea. The anti-ischemic effects of the mixture of ginsenoside $Rg_3$, and CK on ischemia-induced isolated rat heart were investigated through analyses of changes in hemodynamics ; blood pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into four groups: normal control, the mixture of ginsenoside $Rg_3$ and CK, an ischemia-induced group without any treatment, and an ischemia-induced group treated with the mixture of ginsenoside $Rg_3$ and CK. There were no significant differences in perfusion pressure, aortic flow, coronary flow and cardiac output between them before ischemia was induced. The supply of oxygen and buffer was stopped for five minutes to induce ischemia in isolated rat hearts, and the mixture of ginsenoside $Rg_3$ and CK was administered during ischemia induction. Treatments of the mixture of ginsenoside $Rg_3$ and CK significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions. In addition, hemodynamics (except heart rate) of the group treated with the mixture of ginsenoside $Rg_3$ and CK significantly recovered 60 minutes after reperfusion compared to the control group (mixture+ischemia vs ischemia - average perfusion pressure: 74.4${\pm}$2.97% vs. 85.1${\pm}$3.01%, average aortic flow volume: 49.11${\pm}$2.72% vs. 59.97${\pm}$2.93%, average coronary flow volume: 58.50${\pm}$2.81% vs. 72.72${\pm}$2.99%, and average cardiac output: 52.47${\pm}$2.78% vs. 63.11${\pm}$2.76%, p<0.01, respectively). These results suggest that treatment of the mixture of ginsenoside $Rg_3$ and CK has distinct anti-ischemic effects in ex vivo model of ischemia-induced rat heart.

• Korean Journal of Radiology
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• 제21권6호
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• pp.717-725
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• 2020

Objective: To assess left ventricular remodeling patterns using cardiac computed tomography (CT) in children with congenital heart disease and correlate these patterns with their clinical course. Materials and Methods: Left ventricular volume and myocardial mass were quantified in 17 children with congenital heart disease who underwent initial and follow-up end-systolic cardiac CT studies with a mean follow-up duration of 8.4 ± 9.7 months. Based on changes in the indexed left ventricular myocardial mass (LVMi) and left ventricular mass-volume ratio (LVMVR), left ventricular remodeling between the two serial cardiac CT examinations was categorized into one of four patterns: pattern 1, increased LVMi and increased LVMVR; pattern 2, decreased LVMi and decreased LVMVR; pattern 3, increased LVMi and decreased LVMVR; and pattern 4, decreased LVMi and increased LVMVR. Left ventricular remodeling patterns were correlated with unfavorable clinical courses. Results: Baseline LVMi and LVMVR were 65.1 ± 37.9 g/m² and 4.0 ± 3.2 g/mL, respectively. LVMi increased in 10 patients and decreased in seven patients. LVMVR increased in seven patients and decreased in 10 patients. Pattern 1 was observed in seven patients, pattern 2 in seven, and pattern 3 in three patients. Unfavorable events were observed in 29% (2/7) of patients with pattern 1 and 67% (2/3) of patients with pattern 3, but no such events occurred in pattern 2 during the follow-up period (4.4 ± 2.7 years). Conclusion: Left ventricular remodeling patterns can be characterized using cardiac CT in children with congenital heart disease and may be used to predict their clinical course.

• 대한의생명과학회지
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• 제8권1호
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• pp.21-27
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• 2002

To investigate an effect of bum on the cardiac function, we studied some biochemical assay, ultrastructural changes and stereological analysis in heart tissue. Sprague-Dawley rats were induced a 15% total body surface area scald burn. 5 and 24 hours later, the heart was excised. Burned rats showed the decrease of heart weight per body weight (%) compared with control. The activity of serum aspartate aminotransferase was significantly increased at 5 (p＜0.001) and 24 hours (p＜0.01) after burn compared with control. And the activity of serum LDH was decreased at 5 hours after burn but increased at 24 hours compared with control. Ultrastructurally, enlargement of interstitium and destruction of sarcolemma were observed at 5 and 24 hours after burn. Especially at 5 hours postburn, hypercontraction band was noted and at 24 hours, wavy fiber and muscle fraying were noted. In stereological changes, volume density of mitochondria and myofibril was significantly decreased at postburn 5 and 24 hours. But volume density of sarcoplasmic reticulum was significantly increased at postburn 5 hours. Our data suggest that dermal scald bum causes myocardial dysfunction.

• Journal of Chest Surgery
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• 제14권3호
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• pp.187-194
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• 1981

Cardiac surgery is generally followed by a period of routine ventilator support. When the patient seems hemodynamically stable and relatively alert following surgery, respiratory adequacy is tested by the weaning trial. In this study, physiological and clinical prediction of postoperative respiratory adequacy, including values of pulmonary function tests, were examined in an attempt to identity those few variables which predicted the outcome of the ventilator weaning trial following surgery. Our series comprised 27 patients who underwent elective open intracardiac operations at the Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, from October 1979 to July, 1980. The pulmonary function tests performed on all patients included the following; forced vital capacity [FVC], forced expiratory volume [FEV1.0], forced expiratory flow [FEF 25--75~], residual volume [RV], and functional residual capacity [FRC], measured with a helium dilution technique. Of our 27 patients, 8 were successfully weaned within 20 hours of operation. All patients with cyanotic heart diseases or acquired heart diseases were unsuccessfully weaned. The bypass time in the successful weaning group was shorter in the mean value [82.8 minutes]than in the unsuccessful weaning group [120.5 minutes]. There was a relatively significant difference in the mean values for the two groups in arterial pressure, bleeding amounts and FiO2 among the postoperative monitoring variables, and in forced vital capacity [FVC]. The postoperative clinical assessments appeared vague but corresponded reasonably well to appraisal of success in weaning, especially in variables of cough and self-respiration efforts.

• 전자공학회논문지
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• 제54권5호
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• pp.138-142
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• 2017

광전용적맥파(PPG)는 조직의 미세혈관에서 혈류의 변화를 감지할 수 있는 간단하고 저가의 광학기법이다. PPG는 피부 표면에서 비침습 방식의 측정에 사용된다. 본 논문에서는 PPG 센서를 이용한 심박 모니터링 시스템을 구현하였다. 제안한 시스템은 PPG 센서를 이용하여 데이터를 수집하고, 2차 미분 방식으로 심박수를 검출한다. 제안한 시스템의 유용성을 확인하기 위하여 상용 의료기기와 RR-구간의 측정을 수행하였다.

• 대한의용생체공학회:의공학회지
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• 제18권1호
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• pp.65-70
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• 1997

A human version of Korean total artificial heart(TAM) was designed basso on the magnetic resonance imaging(MRI) data To obtain accurate measurement or human thoracic structure including the valvular sited we analyzed the dimensions of the natural heart of healthy persons and cardiomyopathy(CM) patients. The MRI findings were analyzed to measure the volume of the thoracic cavity that would be occupied by the TAM. The design upgrade of the mechanical performed was also performed with the computer aided design(CAD) system to develop a new version of Korean TAH.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.119-122
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• 1997

In this paper, we represented the variation of heart cavity area in the space domain by 3-d rendering. We arranged the 2-d sequence of ultrasonic image acquired in the time domain as volumetric data, and extracted heart cavity region from 3-d data. For the segmentation of 3-d volume data, we extracted the cavity region using the method of expanding the cavity region that is same statistical property. By shading which is using light and object normal vector, we visualized the volume data on image plane.

• 대한물리치료과학회지
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• 제23권1호
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• pp.1-8
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• 2016

Purpose : The purpose of this study was to investigate the response of pulmonary function and heart rate recovery of smoker and nonsmoker in males aged 20s after graded maximal exercise. Method : The subjects were composed of smoker group (n=12) and nonsmoker group (n=12) in males aged 20s. Each groups completed an graded maximal exercise with Bruce protocol and were assessed on the pulmonary function(forced vital capacity : FVC, forced expiratory volume-one second : FEV1, FEV1/FVC) and heart rate. Result : The results were as follows: First, heart rate in the measurement point was a statistically significant difference for smoker and non-smoker group after maximal exercise, but FVC, FEV1, FEV1/FVC was no difference. Second, FEV1/FVC between smoker and nonsmoker group was a statistically significant difference after maximal exercise, but FVC, FEV1, heart rate was no difference. Conclusion : The results of this study is that smoking is negative effects on FEV1/FVC of pulmonary function in males aged 20s after maximal exercise.

• Journal of Electrical Engineering and Technology
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• 제8권2호
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• pp.376-384
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• 2013

With the continuous aging of the populations in developed countries, the medical requirements of the aged are expected to increase. In this paper, a ring-type pulse oximeter finger sensor and a 24-hour ambulatory heart rate monitoring system for the aged are presented. We also demonstrate the feasibility of extracting accurate heart rate variability measurements from photoelectric plethysmography signals gathered using a ring-type pulse oximeter sensor attached to the finger. We designed the heart rate sensor using a CPU with built-in ZigBee stack for simplicity and low power consumption. We also analyzed the various distorted signals caused by motion artifacts using a FFT, and designed an algorithm using a least squares estimator to calibrate the signals for better accuracy.

• 한국의류학회지
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• 제24권8호
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• pp.1266-1275
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• 2000

This study was to research the actual condition of a dropworts working environment and to develope the clothing to reduce the work road. The actual conditions of working environment, working position and clothing were surveyed. Experiments were performed in the chamber and in the field. In the chamber, rectal temperature, 11 points skin temperatures(forehead, chest, abdomen, upperarm, forearm, dorsum manus, palm, thigh, calf, dorsum pedis and pelma), heart rates, microclimates inside clothing on the chest and subjective sensations were measured for comparing between 2 different types o garments. In the field, rectal temperature, abodomen skin temperature, 3 points microclimates inside clothing(chest, back and thigh), heart rates, the volume of EMG and subjective sensations were measured. The results were as follows; 1. There were no significant differences in rectal temperature between a old type protective clothing and a new type both in the chamber and the field. 2. Subjects wearing a old type clothing responded \"a little cold\", \"a little uncomfortable\" and subjects wearing a new type protective clothing responded \"normal\", \"comfortable\" both in the chamber and the field. 3. In the field test results, abodemen skin temperature in a old type clothing was higher and microtemperatures inside clothing of chest, back and thigh in a new type protective clothing were higher. 4. The volume of EMG was lower in the new type protective clothing than in the old one.protective clothing than in the old one.