• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.125-130
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• 2005

Background and purpose: We evaluated the reliability of two electrodermal measurement devices on meridian skin areas; Electro Acupuncture according to Dr. Voll (EAV) method and newly developed MIR-1. Methods: Eighteen volunteers were tested repeatedly on the same condition with each device. To explore the intra-rater, inter-rater, and test-retest reliabilities, one rater tested each subject twice in succession, then the other rater tested the subject in a row. Finally, retests on the subjects with each device were performed 1 week later. The reliability was determined by Pearson correlation and intraclass correlation statistics. Results: EAV method showed poor reliability, while MIR-1 showed good reliability. Conclusion: It is suggested that further research on the reliability and useful device in both fields of clinical practice and biomedical research.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.131-135
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• 2005

Background and purpose: The measurement of direct current (DC) potential on skin area of meridian has recently been adopted to explore the electrophysiological characteristics of meridian system, But there exists two problems to be explained; the entity of the DC potential to be measured and the characteristics of electrode gel interface of measurement system, It is not clear whether the DC potential reflect, at least hypothetically, the entity of meridian, and if there exist any unstable factor in the DC potential measurement system. Methods: In this study, we designed an electronic circuit model of skin and applied known DC potential sources $({\pm}10.75mV,\;0mV)$ to the electrode interface of the skin model. Results: The result showed that the measured DC potential changed according to the time, and the same phenomenon was observed when the electrode gel was replaced with an electric condenser. It is suggested that the measurement of DC potential on electrode gel interface is very difficult and produces unstable values due to the capacity effect of electrode gel. Conclusion: Further studies on the DC potential evaluation in the context of meridian study should consider and bypass this problem.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.15 no.1
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• pp.77-86
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• 2011

Objectives: With increased rate of chronic disease, concerns about preventive medicine has raised. Therefore questionnaire of subhealth status was developed and analysed in our previous study. A large number of chronic diseases is related to emotional issues. This study was to confirm a relationship between mood state and health status in terms of modern people's healthcare. Methods: Subhealth Questionnaire and Korean version of Profile of Mood States(k-POMS) were putted by 113 college students. And correlation and regression analysis was conducted. Results: Subhealth questionnaire and k-POMS proved a significant correlation. In particular, subhealth factor 3(mood) had a significant correlation with all factors of k-POMS. Subhealth factor 1(body), subhealth factor 2(life) and subhealth factor 6(society) had significant correlations with 5 factors of k-POMS. Subhealth factor 4(energy) and subhealth factor 5(heredity) did not show significant results. 'Fatigue' factor of k-POMS was proved to be the most important factor influencing the subhealth status and illness, indicating high correlations with all of subhealth status.

• Journal of Korean Medical classics
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• v.25 no.3
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• pp.149-158
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• 2012

Objectives : In modern meditation, psychologic therapy and happy life have been in the main status. The aim of this study is to search about the value of modern meditation systematically and to summarize the contents on the meditation in "Donguibogam(東醫寶鑑)". Methods : We investigated the meditation-related materials in "Donguibogam(東醫寶鑑)", and discussed them in comparison with the other contents found in "Huangdi's Internal Classic(黃帝內經)" and some scriptures on meditation and self-discipline. Results : The mind-body concept in Korean Medicine takes meditation and self-discipline into main consideration. Meditation and self-discipline mean the endless pursuing the nature of mind and body, thus leading to self-practice about the true meaning of life. "Donguibogam(東醫寶鑑)" includes the views on the meditation and self-discipline from the various angles based on Confucianism, Buddhism and Taoism. Conclusions : Meditation and self-discipline rooted in East Asian tradition are good ways to reach the true nature of mind-body system of universe and to help people seek happiness in their lives.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1327-1333
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• 2006

Many traditional herbal remedies exhibit several beneficial effects including anti-inflammation. Panax notoginseng Buck F.H. Chen. is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Korean and Chinese medicine. The pharrnacokinetic profiles of the main P. notoginseng are still not accurately investigated. The exact mechanism of the anti-inflammatory action of P. notoginseng, however, has not been determined. In the present study, we examined the effect of P. notoginseng on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW264.7 macrophages. The results indicated that P. notoginseng concentration-dependently inhibited LPS-induced NO production. Furthermore, P. notoginseng inhibited the expression of LPS-induced iNOS and COX-2 proteins without an appreciable cytotoxic effect on RAW264.7 cells. Berberine also inhibited LPS-induced iNOS protein as potently as P. notoginseng. This was consistent with the findings that P. notoginseng and also berberine inhibited prostaglandin E2 synthesis induced by LPS.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.307-310
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• 2021

In the recent years, studies using Computer-Aided Diagnostics(CAD) have been actively conducted, such as signal and image processing technology using breast ultrasound images, automatic image optimization technology, and automatic detection and classification of breast masses. As computer diagnostic technology is developed, it is expected that early detection of cancer will proceed accurately and quickly, reducing health insurance and test ice for patients, and eliminating anxiety about biopsy. In this paper, a quantitative analysis of tumors was conducted in ultrasound images using a gray level co-occurrence matrix(GLCM) to experiment with the possibility of use for computer assistance diagnosis.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.24 no.1
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• pp.1-13
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• 2020

Objectives Mibyeong is an ideological concept that means the state between the healthy and diseased conditions. The purpose of this study was to suggest a research direction to establish the diagnostic criteria for the Mibyeong by reviewing the research results for the Mibyeong. Methods Academic databases (OASIS for Korean database, Embase for English database, and CNKI for Chinese database) were used to search related literatures, and articles describing the concept or diagnostic criteria of the disease were selected. Results The concept of Mibyeong consisted of three different conditions: (1) subjective symptoms without a specific disease, (2) abnormal examination findings without a specific disease, and (3) a state in between health and disease. No matter which of the three conditions is applied, the spectrum of condition was very wide and diverse. Conclusions It is impossible to apply appropriate and monolithic diagnostic criteria to all types of Mibyeong. Therefore, we suggests that the Mibyeong be classified into several subtypes and the diagnostic criteria suitable for each type be established.

• Korean Journal of Ecology and Environment
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• v.41 no.4
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• pp.499-511
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• 2008

The major focus of this study is to evaluate a newly developed stream naturalness index system 'Habitat-riparian Indexing System (HIS).' There have been many studies that have assessed stream naturalness in order to provide information required for restoration. The results of these studies were enough for the purpose of the studies; however, the methodologies were limited especially with respect to rapid measurement and the representation of ecological habitats. Therefore, we derived crucial variables from a popularly utilized method and merged them with other criteria obtained from overseas approaches, resulting in the development of the HIS method. The stability of HIS was evaluated by comparing the results with the Stream Naturalness Index (SNI) of Cho (1997). We monitored 100 stream sites in the Nakdong River system using the two different methods for two sampling periods (spring and autumn), and the results were compared using statistical analyses. The determination coefficients between the index values from two methods were c.a. 0.6 for both seasons, and statistics revealed that HIS had a relatively higher stability, providing index values for stream environments. The results of this work suggest a possibility of the utility of HIS for other stream habitats.

• Journal of Periodontal and Implant Science
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• v.47 no.2
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• pp.66-76
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• 2017

Purpose: Oral wound healing requires gingival fibroblasts to respond to local growth factors. Epigenetic silencing through DNA methylation can potentially decrease the responsiveness of gingival fibroblasts to local growth factors. In this study, our aim was to determine whether the inhibition of DNA methylation sensitized gingival fibroblasts to transforming growth factor-${\beta}1$ (TGF-${\beta}1$). Methods: Gingival fibroblasts were exposed to 5-aza-2'-deoxycytidine (5-aza), a clinically approved demethylating agent, before stimulation with TGF-${\beta}1$. Gene expression changes were evaluated using quantitative polymerase chain reaction (PCR) analysis. DNA methylation was detected by methylation-sensitive restriction enzymes and PCR amplification. Results: We found that 5-aza enhanced TGF-${\beta}1$-induced interleukin-11 (IL11) expression in gingival fibroblasts 2.37-fold (P=0.008). 5-aza had no significant effects on the expression of proteoglycan 4 (PRG4) and NADPH oxidase 4 (NOX4). Consistent with this, 5-aza caused demethylation of the IL11 gene commonly next to a guanosine (CpG) island in gingival fibroblasts. The TGF-${\beta}$ type I receptor kinase inhibitor SB431542 impeded the changes in IL11 expression, indicating that the effects of 5-aza require TGF-${\beta}$ signaling. 5-aza moderately increased the expression of TGF-${\beta}$ type II receptor (1.40-fold; P=0.009), possibly enhancing the responsiveness of fibroblasts to TGF-${\beta}1$. As part of the feedback response, 5-aza increased the expression of the DNA methyltransferases 1 (DNMT1) (P=0.005) and DNMT3B (P=0.002), which are enzymes responsible for gene methylation. Conclusions: These in vitro data suggest that the inhibition of DNA methylation by 5-aza supports TGF-${\beta}$-induced IL11 expression in gingival fibroblasts.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.16 no.2
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• pp.23-32
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• 2012

Objectives : The purpose of this research is to develop the clinical pathway for optimizing the integrative medical service (oriental-western integrated medical service) and to analyze the clinical pattern of the integrative patients who received the oriental-western integrated medical service. Methods : This research developed the clinical pathway by interviewing with doctors, nursing and experts at K Medical Center. To analyze the clinical patterns, this research used 860 integrative patients and 6345 non-integrative patients at K Medical Center since 2007. Results and Conclusions : 1. We developed the clinical pathway for optimizing the integrative medical service. 2. Comparing the clinical pattern of the integrative patients with the non-integrative patients, the results indicated that the interval and frequency of the integrative patients is shorter than that of the non-integrative patients. 3. Comparing the medical treatment type, the integrated patients take much more medical care and more frequently participate in medical treatment. 4. In conclusion, it is different that the clinical pathway of the integrative medical service from the non-integrative medical service and the integrative medical treatment is more effective than the non-integrative medical treatment.