• Development and Reproduction
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• v.27 no.1
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• pp.25-37
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• 2023

Acetaminophen [Paracetamol, N-acetyl-para-aminophenol (APAP)] is a common over-the-counter analgesic agent as nonsteroidal anti-inflammatory drugs (NSAIDs). The high doses or the long-term treatment of acetaminophen via usual gavage feeding resulted in damage of testicles that presented recoverable impairment, as well as liver and kidney. The influence of acetaminophen was examined in male golden hamsters treated with acetaminophen-containing diet feeding. They were divided into 5 groups and subjected to this experiment for 4 weeks: animals housed in long photoperiod (LP) as LP control, animals housed in short photoperiod (SP) for 4 weeks as SP control (SP4), and groups of animals treated with low, middle, and high concentrations of acetaminophen (Low, Middle, High groups). Also animals housed in SP for 8 weeks were included (SP8) to contrast testicular activities, if necessary. As results, spermatozoa filled the seminiferous tubules of the testicles of animals in LP control and SP4 groups. The aspects were seen in the animals taken diets of low and middle doses of acetaminophen. The animals who fed high dose of acetaminophen showed large or small testicles. The large testicles displayed all germ cells at the steps of spermatogenesis. The small testicles presented no sperm as the animals housed in SP for 8 weeks. Thus these results indicate that acetaminophen invokes the antigonadal effects and accelerates the regressing process of the testicles in the animals compared to the animals exposed to SP.

• Journal of the Korean Society of Radiology
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• v.17 no.3
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• pp.385-392
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• 2023

Caroli's disease is a fibrocystic liver disease. Autosomal recessive disorder is characterized by congenital multiple dilatation of the bile duct. Computerized tomography, magnetic resonance imaging, cholangiography and ultrasound are among the methods for diagnosing caroli disease. Computerized tomography is essential for detecting and distinguishing fibroplastic liver disease and is useful for determining intrahepatic bile duct dilatation. However, awareness of the possible side effects of using contrast mediums is necessary. A typical method of magnetic resonance cholangiography is used for magnetic resonance imaging. A non-invasive examination can reduce the pain of the patient, and the anatomical structure of the bile pancreatic duct and the presence or absence of lesions can be easily and quickly observed. Biliary contrast is an effective diagnostic method that can directly visualize various cystic dilatations throughout the enlarged bile duct. However, since this procedure is also an invasive procedure, it is recommended not for diagnosis but for treatment purposes. Ultrasonography can confirm similar findings to computerized tomography. The hepatic artery root is difficult to prove with conventional grayscale ultrasound. However, it is of clinical value in that it can not only describe dilated bile ducts with vascular roots in the tube but also easily identify color Doppler signals in the tube. With the development of video diagnostics, early diagnosis has become possible through computerized tomography, magnetic resonance imaging, cholangiography, and ultrasound. In order to further contribute to the development of video diagnostics so that long-term prognosis can be improved after treatment through early diagnosis, we examined what aspects of each test's caroli disease appear.

• Korean Journal of Computational Design and Engineering
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• v.18 no.4
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• pp.250-257
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• 2013

This paper introduces a failure analysis procedure that underpins real-time fault prognosis. In the previous study, we developed a systematic eventization procedure which makes it possible to reduce the original data size into a manageable one in the form of event logs and eventually to extract failure patterns efficiently from the reduced data. Failure patterns are then extracted in the form of event sequences by sequence-mining algorithms, (e.g. FP-Tree algorithm). Extracted patterns are stored in a failure pattern library, and eventually, we use the stored failure pattern information to predict potential failures. The two practical case studies (marine diesel engine and SIRIUS-II car engine) provide empirical support for the performance of the proposed failure analysis procedure. This procedure can be easily extended for wide application fields of failure analysis such as vehicle and machine diagnostics. Furthermore, it can be applied to human health monitoring & prognosis, so that human body signals could be efficiently analyzed.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2001.01a
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• pp.508-510
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• 2001

Adopting the method of user weighting fuzzy mathematics, the author accomplished the subject title “Study on Expert System of Chicken\`s Common Diseases Diagnostics”, which could properly diagnose 30 kinds of chicken\`s common diseases and the accordance rate reached 80% verified through 244 disease cases. On the basis of the accomplishment, the multimedia technology was adopted further more to establish a system, which integrated with the input, display, query, and processing of sound, picture and text etc., combined with the previous chicken disease diagnostic expert system, make the output information of computer more rich and comprehensive, and the accordance rate of disease diagnosis could be improved. The system consists of database, knowledge base, graphics and picture base. This system is easy to operate and interface of which is vivid and intuitive. It could output diagnostic result and prescribe rapidly, so that, such a system is not only adapted to large, medium chicken farm but also to grass-roots veterinary station for developing health care and disease diagnosing. It is sure that the system could have side prospect of application.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.1
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• pp.149-156
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• 2008

In the situation providing the aged society, the contents of the symptoms of senility centering around the aged-pulse condition were arranged. The results were as follows. In the questions about the aged symptoms, the results of indicating the gradual physical-age following the aged symptoms with the real age(from 40 to 100, 7 grade) and the gradual physical-age following the ageing grade of male and female (the 3 grade of the female / the 4 grade of the male) could have the differentiations. And the distinction of the aged pulse condition was observed two pulse condition ; the one is the minute pulse condition(Mi, Sei ;微細) as lowering function and the other is the Hyun, Ghin(弦, 緊) pulse condition as the blood's tention and contration.

• Proceedings of the Korean Information Science Society Conference
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• 2007.06d
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• pp.204-207
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• 2007

최근 대두되고 있는 무선 센서네트워크는 실생활의 많은 부분에 있어 그 응용 분야를 넓혀 가고 있다. 본 연구는 WSN의 응용 중 Human Health Care에 주안을 두어 WSN을 이용한 원격 진료 시스템에 대해 설계 및 구현을 하였다. 원격 진료 시스템을 위해 각 센서 노드들은 인체의 Body 정보를 수집할 수 있는 센서들을 가지고 신체의 각 부위에 부착된다. 또한 각 센서 노드들은 고유의 Human Body Code를 가지고 있으며 이 고유의 Code에 의해 인체의 어느 부위에서 측정된 Data인지를 Sink 노드로 전송하게 된다. Sink 노드는 수집된 정보를 원격에 위치한 의료진들에게 전송하며 원격의 의료진들은 Sink 노드에서 전송된 정보를 바탕으로 진료 정보를 환자 및 User에게 Feedback하게 된다. Human Body Code는 인체를 세분화하고 각 세분화한 신체 부위에 계층적으로 고유의 Code를 부여한다. 본 연구에서는 실제 Human Body Code를 직접 제작한 센서 Node에 주입하여 Human Body Network을 구성하여 인체에서 센싱되는 Data를 원격에 위치한 PC에서 진료 가능한 원격 진료 시스템을 구현하였다.

• International Journal of Aeronautical and Space Sciences
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• v.10 no.2
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• pp.34-42
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• 2009

Gas turbine performance diagnostics is a method for detecting, isolating and quantifying faults in gas turbine gas path components. On-line precise fault diagnosis can promote greatly reliability and availability of gas turbine in real time operation. This work proposes a GUI-type on-line diagnostic program using SIMULINK and Fuzzy-Neuro algorithms for a helicopter turboshaft engine. During development of the diagnostic program, a look-up table type base performance module are used for reducing computer calculating time and a signal generation module for simulating real time performance data. This program is composed of the on-line condition monitoring program to monitor on-line measuring performance condition, the fuzzy inference system to isolate the faults from measuring data and the neural network to quantify the isolated faults. Evaluation of the proposed on-line diagnostic program is performed through application to the helicopter engine health monitoring.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.17-24
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• 2011

Cho Heon Yeong's 'Tongsokanuihagwollon' is an introductory and essential book on Traditional Korean Medicine(TKM), and now we can nearly take it as classic. It contains almost whole contents of TKM : physiology, pathology, herbology, meridian & acupoint, internal medicine, diagnostics, formula science, etc. He wanted to help people get TKM services easily on their own through this book. In the first chapter following the introduction, he inserted Yin-Yang theory, and his lecture on Yin-Yang theory continues for 88 pages, taking 17% of the whole book. Yin-Yang theory chapter is composed of 14 parts which tells about concept, definition and meaning of Yin-Yang, change of Yin-Yang according to time, season, constitution, body region, meridian, herb, etc. Last part refers to disharmony & dysfunction of Yin-Yang in body, so he showed both theoretical and clinical view of Yin-Yang theory. He wrote some quotations from the book 'Complete Works of Jingyue(景岳全書)', 'Huangdi's Internal Classic(黃帝內徑)', 'Introduction to Medicine(醫學入門)', etc. He tried to explain easily about Yin-Yang theory with modern but rough language of science. He seemed to already know clearly that without modern science TKM cannot progress and will soon be overwhelmed by western medicine, and acted his own way to spread spirit of TKM in the period of rapid change & conflict between two civilizations.

• Biomedical Science Letters
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• v.26 no.3
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• pp.127-135
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• 2020

Coronavirus is generally known to cause minor respiratory diseases in animals and humans. However, some coronavirus genus is reported to cause animal-to-human interspecies infection. Since the end of 2019, a new type of coronavirus (COVID-19) infection is spreading rapidly throughout the world, leading to the declaration of the pandemic by the World Health Organization (WHO). Despite various clinical studies to counter COVID-19 infection, the total confirmed cases and death rates are still accumulating. To break down this new threat, we should pay attention to newly revealed information based on scientific facts. In this review, we introduced the clinical characteristics, diagnostic methods, and treatment of patients infected with COVID-19. Moreover, we highlighted the correlation between COVID-19 severity and patients with underlying diseases. Potential risks associated with COVID-19 can be differed depending on the condition of patients and can cause pulmonary complications. Therefore, lung capacity exams are expected to help predict the progression of the disease along with previously established detection methods such as molecular diagnostics and immunoassay. Although physiological research hasn't yet been emphasized to evaluate COVID-19 infection, this review is expected to be valuable to give new inspiration to deal with COVID-19 which might strike again in the future.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.3
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• pp.194-199
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• 2017

This study aimed to identify the effects of lifestyle on Mibyeong, and provide basic data for health promotion activities for management of Mibyeong. A total of 405 data were analyzed for Daejeon University employees from July, 2015 to Jan, 2016. In this study, we collected the data about sex, age, BMI, dietary habit, physical activity, smoking, drinking, and Mibyeong index. There was a difference between Mibyeong groups according to irregular eating, eating of night snack, and smoking for men, while overeating, irregular eating, and physical activity for women. Logistics regression analysis, adjusting for sex and age, was used to estimate related factors of Mibyeong. Compared to the healthy group, Mibyeong 2 group tended to overeat 4 times a week with odds ratio of 3.52, eat irregularly with odds ratio of 2.67, lack of physical activity with odds ratio of 3.30, and to smoke with odds ratio of 3.07. This study suggests that lifestyle, particularly dietary habit, physical activities, and smoking, might be significantly associated with Mibyeong. Good lifestyle could help prevent Mibyeong.