• 대한방사선방어학회:학술대회논문집
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• 대한방사선방어학회 2011년도 추계 학술발표회 및 심포지엄
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• pp.212-213
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• 2011

The biological effects of low dose ionizing radiation (LDIR) remain insufficiently understood. We examined for the scientific evidence to show the biological effects of LDIR using radiation-sensitive immune cells. We found that Ikaros protein was responsed to low dose-dependent effects of gamma radiation in IM-9 B lymphocytes. Ikaros encodes zinc finger transcription factors that is important regulators of a hematopoietic stem cells (HSCs) progression to the B lymphoid lineage development, differentiation and proliferation. In this study, we observed that cell proliferation was enhanced from 10% to 20% by LDIR (0.05 Gy) in IM-9 B lymphocytes. The Ikaros protein was phosphorylated in its serine/threonine (S/T) region and decreased its DNA binding activity in the cells exposed to LDIR. We found that Ikaros phosphorylation was up-regulated by CK2/AKT pathway and the residues of ser-304 and ser-306 in Ikaros was phosphorylated by LDIR. We also observed that Ikaros protein was localized from the nucleus to the cytoplasm after LDIR and bound with Autotaxin (ENPP2, ATX) protein, stimulating proliferation, migration and survival of immune cells. In addition, we found that the lysoPLD activity of ATX was dependent on Ikaros-ATX binding activity. These results indicate that the Ikaros is an important regulator of immune activation. Therefore, we suggest that low dose ionizing radiation can be considered as a beneficial effects, stimulating the activation of immune cells.

• Toxicological Research
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• 제23권3호
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• pp.189-196
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• 2007

Cytochrome P450 (P450) enzymes are the major catalysts involved in the biotransformation of various drugs, pollutants, carcinogens, and many endogenous compounds. Most of chemical carcinogens are not active by themselves but they require metabolic activation. P450 isozymes playa pivotal role in the metabolic activation. The activation of arylamines and heterocyclic arylamines (HAAs) involves critical N-hydroxylation, usually by P450. CYP1A2 plays an important role in these reactions. Broad exposure to many of these compounds might cause carcinogenicity in animals and humans. On the other hand, P450s can be also involved in the bioactivation of other chemicals including alcohols, aflatoxin B1, acetaminophen, and trichloroethylene, both in humans and in experimental animals. Understanding the P450 metabolic activation of many chemicals is necessary to develop rational strategies for prevention of their toxicities in human health. An important part is the issues of extrapolation between species in predicting risks and variation of P450 enzyme activities in humans.

• The Journal of Korean Physical Therapy
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• 제33권1호
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• pp.1-6
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• 2021

Purpose: This study examined the effects of heel insoles on the static balance and leg muscle activity and posture control strategy during external perturbation. Methods: Thirty healthy young men participated in the study. The subjects underwent two experimental conditions: 1) no heel insole condition (0cm) and 2) wearing heel insole condition (5cm). The static balance was measured using an I-Balance device, which measured the change in the center of gravity (COG). The onset time of muscle activation and muscle activation of the erector spinae (ES), hamstring (HAM), gastrocnemius (GCM) were measured using surface EMG electrodes to determine the change in posture control strategy during external perturbation. Results: The speed and distance of COG were significantly higher in the wearing heel insoles condition than the no heel insole condition (p<0.05). In addition, significant differences in the onset time of the GCM, HAM, and ES muscle activation were observed when there was no heel insole condition during external perturbation (p<0.017). On the other hand, no significant differences in the onset time of muscle activation were observed between GCM and HAM when wearing the heel insole condition during external perturbation (p<0.017). Moreover, muscle activation of the GCM was significantly higher in the wearing heel insoles condition than the no heel insole condition during external perturbation (p<0.05). Conclusion: These findings suggest that heel insoles may have disadvantages, and increased efforts are needed to maintain balance and change the posture control strategy during external perturbation.

• 보건의료산업학회지
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• 제10권2호
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• pp.145-154
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• 2016

Objectives : Because people have increasingly more interest in their quality of life, the anti-aging industry has grown worldwide. The purpose of this study is to suggest strategies for galvanizing the anti-aging industry in Korea. Methods : To accomplish this aim, we explored the definition, classification, problem and activating strategies of the anti-aging industry through a systematic review. Results : From the results, the following suggestions are given: planning a national strategy to galvanize the anti-aging industry, establishing an anti-aging research institute, developing a business model, developing an anti-aging cluster, statistics development and an information system related to anti-aging, training personnel, and legislation. Conclusions : The anti-aging industry has the potential to reduce health expenses through early intervention of diseases due to aging and through activation of the national economy by win-win growth of the industry related to aging. Therefore, understanding the anti-aging industry as well as political support is critical.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.225.1-225.1
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• 2001

• 원예과학기술지
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• 제32권5호
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• pp.710-720
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• 2014

Movements of the upper and lower limb muscles during five common gardening tasks were analyzed by using electromyography (EMG). Twenty adults aged in their twenties (mean age, $24.8{\pm}2.4$ years) were recruited. On two separate occasions, subjects visited a garden plot to perform digging, raking, troweling, weeding, and hoeing; all tasks were performed three times with 20 s intervals for each trial. To measure muscle activation during the five gardening tasks, surface EMG was used. Bipolar surface EMG electrodes were attached to eight upper limb muscles (bilateral anterior deltoid, biceps brachialis, brachioradialis, and flexor carpi ulnaris) or eight lower limb muscles (bilateral vastus lateralis, vastus medialis, biceps femoris, and gastrocnemius) on both sides of the body, for a total of 16 muscles. During the five tasks, photographs were taken of movement phases using a digital video camera. The right flexor carpi ulnaris and brachioradialis showed higher activation than the other upper and lower limb muscles measured during the tasks. All 16 upper and lower limb muscles were actively used only during digging. According to movement analysis of each activity, digging was classified into four movement phases, whereas raking, troweling, weeding, and hoeing each were divided into three movement phases. In each activity, there were high-impact phases in terms of muscle activation; the flexor carpi ulnaris and brachioradialis were identified as major muscles in each impact phase. This analysis may be used to generate biomechanical profiles of gardening tasks for practitioners when designing efficient gardening interventions for physical health or rehabilitation.

• Physical Therapy Rehabilitation Science
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• 제6권3호
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• pp.152-157
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• 2017

Objective: The aim of this study was to determine the intra-rater and inter-rater reliability of the dual rehabilitative ultrasound imaging (D-RUSI) when simultaneously measuring muscle thickness changes at rest and during co-contraction of the biceps brachii (BB) and triceps brachii (TB). Design: Cross-sectional study. Methods: This study included 36 healthy participants (23 men, 13 women). The participants sat on a chair in a comfortable position with a cushion placed under their elbow to maintain a 90-degree elbow flexion angle. The muscle thickness of the biceps brachii and triceps brachii was measured twice using the D-RUSI by two examiners during resting and co-contraction states. One week later, the same procedure was performed once again. Results: The intra-class correlation coefficients (ICCs) for intra-rater reliability ranged from 0.887 to 0.989 and the confidence interval was within an acceptable range of 0.778 to 0.994. The standard error of measurement (SEM) values ranged from 0.303 to 0.866 and the minimal detectable change (MDC) values ranged from 0.84 to 2.40. The ICCs for inter-rater reliability ranged from 0.758 to 0.925. The SEM values ranged from 0.702 to 1.486 and the MDC values ranged from 1.95 to 4.12. Conclusions: The use of the D-RUSI of the BB muscle had a very good intra-rater reliability and very good inter-rater reliability at the resting state, and a, good inter-rater reliability at the co-activation state. ICC values showed very good intra-reliability and inter-reliability for the TB muscle. the D-RUSI is a useful tool for simultaneously measuring the thickness of two muscles when the BB is an agonist and the TB is an antagonist during co-activation of the upper arm.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.105-105
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• 2002

A wide range of chemicals derived from plant and human-made xenobiotics are reported to have hormonal activity. The present studies were performed to examine the estrogenic effect of Kwao Keur, Pueraria mirifica (PM), that has been used a rejuvenating folk medicine from Thailand, using recombinant yeast, MCF-7 cell proliferation and HepG2 cell transient transfection assay.(omitted)

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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• pp.105-105
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• 2002

• 보건교육건강증진학회지
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• 제15권2호
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• pp.67-79
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• 1998

Health education is essential service of health promotion program, and health promotion is external extension of health education. However, the implementation of health education in community is not well because of lack of budget and health education specialist, deficient cognition for health promotion. Hence, introduction for the credential on health educator is to assist community and school health through the training of the specialist This study was carried out to establish the credential health educator for activation of health promotion program in Korea. In detail, this study aimed at 1) to confirm the law for health education, 2) to understand the credential on health education specialist in U. S. and the certification on other parts in Korea, 3) to establish the proper credential on health educator in Korea. Finding the results were as follows: The law on health education was Regulation on Health Promotion which has defined the health educator and responsibility of health education. In case of U. S., the credential on health education specialist has implemented since 1992, and the sort of credential on health education specialist were community health educator, public health educator, school health educator, and health promotion specialist. Therefore, major opinion to introduce the proper credential on health education in Korea were suggested: the first, establishment of educational processing on the training of specialized health educator, the second, introduction of examination on the evaluation for ability as health educator. the last. planning for application of health educator in community.