• Journal of People, Plants, and Environment
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• v.24 no.6
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• pp.663-672
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• 2021

Background and objective: As the 'Healing Agriculture Research and Development and Promotion Act' came into effect on March 25, 2021, social interest in agro-healing has been increasing exponentially. This study was conducted to analyze the priorities of agro-healing classification system and to provide basic data to inform policy directions and related research for the development and activation of agro-healing. Methods: The survey data collected from 18 experts were analyzed using the analytic hierarchy process (AHP) method in determine the relative weights of the main and sub-criteria for the classification system. There were three main criteria identified: agro-healing input industry, agro-healing service industry, and agro-healing-related/derived industry. There were also 11 sub-criteria. Results: The top three sub-criteria with the highest complex weights include "community service," "social rehabilitation" and "treatment and rehabilitation," all of which correspond to the main criterion "agro-healing service industry". In addition, the complex weights of the sub-criteria corresponding to the main criterion "agro-healing related/derived industry" are as follows: "other agro-healing support service," which ranked 4th, and "training and education institutions for agro-healing experts," which ranked 5th when prioritizing the criteria. Conclusion: The results of this study suggest that the main criterion to be considered first in establishing a classification system is "agro-healing service industry". Therefore, it is necessary to continue research on detailed service classifications and systems with verified validity to ensure expertise in human resources, and organization related to social purpose services in agro-healing.

• CELLMED
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• v.2 no.3
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• pp.23.1-23.7
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• 2012

The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load. This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots' beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

• Korean Journal of Veterinary Research
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• v.39 no.5
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• pp.974-985
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• 1999

Osteoporosis is defined as a decrease in bone mass that leads to an increased risk of fracture. The therapeutic effect of $1{\alpha}$,25 dihydroxycholecalciferol, the hormonal form of vitamin $D_3$ that mediates calcium translation in intestine and bone, on the healing process of fracture has still been controversial. These studies were designed to understand the healing process of normal fibular fracture, the osteoporotic changes after ovariectomy, and the therapeutic effects of $1{\alpha}$,25 dihydroxycholecalciferol on the osteoporotic fracture in rats. The simple transverse fractures of rat fibulae were produced with a rotating diamond saw. The changes of the biochemical and mechanical indices of rats were investigated. The mechanical study based on bending test revealed the healing of the fibular fracture in the 5th week after simple transverse fracture. The osteoporosis impaired more the healing of osteoporotic fibular fracture than normal non-osteoporotic fibular fracture. The healing process of osteoporotic fracture was facilitated by the treatment with $1{\alpha}$,25 dihydroxycholecalciferol, however, was delayed more than the healing process of normal fracture. The bone strength based on the bending test also confirmed this tendency. The bone strengths in the 5th week after fracture of normal bone, osteoporotic bone, and $1{\alpha}$,25 dihydroxycholecalciferol-treated osteoporotic bone were 75%, 41%, and 67%, respectively, in comparison with those of intact bone. In conclusion, $1{\alpha}$,25 dihydroxycholecalciferol was effective in promoting the osteoporotic fracture healing.

• The Journal of the Korean dental association
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• v.16 no.1 s.104
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• pp.43-50
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• 1978

The purpose of this study is to determine the effects of Cyclophosphamide on the healing process of fractures of the mice. Tweny-one young adult male mice were used. All of them were experimentally fractured in the left mandibular body areas, and Cyclophosphamide 0.1mg. per 30gr. body wt. was administrated intramuscularly to the experimental group. the mice of both control and experimental groups were sacrificed 1,3,5,7,10,14, and 21st day after operations and microscopic slides were made. The author has observed the histopathological findings. The results were as follows; 1. There were no specific difference between the experimental and control group in the early stage (1~5th day after operation) of the healing process of the mandibular fracture. 2. In the healing process of fractures 7-10th day after operation, the fibrous tissure formation and osteoblastic activity were poor in the experimental groop compared with the control group. 3. In the healing process of fractures 14-21th day after operation, the connective tissue and new bone formation were very poor in the experimental group compared with the control group. 4. On the whole, cyclophosphamide affected the experimentally fractured wound to delay healing in the jaw bone of the mice.

• Journal of the Korean Recycled Construction Resources Institute
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• v.9 no.3
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• pp.367-374
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• 2021

In this study, the applicability of mechanochemical process for the manufacture of self-healing admixtures and the effect of mechanochemical process on the self-healing performance were evaluated. The self-healing admixtures were adopted as a highly reactive materials(expansive agent, swelling material and crystal growth agent) for mechanochemical processes. The self-healing admixtures for the mechanochemical process application were evaluated by X-Ray Diffraction and Fourier Transform Infrared Spectroscopy analysis, water permeability performance was used to evaluate self-healing performance of mortar. As a result of the evaluation, the self-healing performance of the WM(With-Mortar)3 sample to which mechanochemical process increased by 4.1% compared to the WM1 sample that was not treated, and the average healing index was 94.3%.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.309-314
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• 2004

This study focused on the introduction of damage repair for polymeric composite carbody. called selfing tech-healinique. using microcapsules loaded with the healing agent The manufacturing process for microcapsules with the healing agent was introduced and tile characteristics of microcapsules manufactured by varying with various manufacturing process variables were evaluated. The DCPD was used for the healing agent and microcapsules were made of urea-formaldehyde resin. The magnitude and the size distribution of microcapsules were measured by a particle size analyzer using laser diffraction technique. Thermal stability was investigated by using a TGA under continuous and isothermal heating conditions for the healing agent. microcapsules without the healing agent. microcapsules with the healing agent.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.12 no.2
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• pp.21-33
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• 1990

This study was performed to evaluate the effects of preoperative and postoperative radiation on the healing of surgical wound and the relationship between surgery-radiation interaval histopathologically. Experimental animals were 64 rats of Sprague-Dawely strain weighing about 180grams. In postoperative radiation group, a single dose of 1000 rads irradiation was delivered on 1,2,3, weeks after incision and 24 animals were sacrificed on the 1st, 3rd, 7th, and 14th day after radiation. In preoperative radiation group incision was performed on 1,2,3,4 weeks after a single dose of 1000 rads and 32 animals were sacrificed on the 1st, 3rd, 7th, and 14th after incision. Tissue specimens were prepared as usual methods and stained with hematoxyline-eosin for ordinary light microscopy. Histopathologic study revealed the following favorable results : 1. In 2 and 3 weeks radiation group after incision, the healing process was unaffected by radiation. 2. In 1 week radiation group after incision, the healing process was slightly retarded, as compared with 2,3 weeks radiation group after incision. 3. In 1,2 and 3 weeks incision group after radiation, the healing process appeared about 7 days later than that of control group. 4. In 4 weeks incision after radiation, the healing process was unaffected by radiation.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.5 no.2
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• pp.23-33
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• 2007

Summary of background data: At the wound from life of the human being very regarding at and a healing process the wound in the portion which is important meantime the many research is accomplished and healing process at the wound the research is small very from the physical therapy territory. Purpose: This study was performed to examine the effects of cold therapy and pulsed ultrasound treatment in the process of acute wound healing. To this end, we measured changes in the length of the wounds, and observed tissues through an optical microscope in order to evaluate the healing process of the acute wounds. Methods: We divided twenty Sprague-Dawley rats into four experimental groups of five rats each and treated them for three days after wound creation. Then we extracted tissues from the wounds on day 6th after wound creation and then took them out for hematoxylin-eosin(HE) staining. We measured changes in the length of the wounds every other day. Result: We were able to detect significant statistical differences in the cold therapy and pulsed ultrasound-treated wounds compared with control wounds. We observed tissues through an optical microscope and found the tissues in cold therapy and pulsed ultrasound-treated wounds healed well. Conclusions: Overall results indicated that the use of cold therapy and pulsed ultrasound treatment were effective in the process of acute wound healing.

• Journal of the Korean Geographical Society
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• v.51 no.1
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• pp.109-125
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• 2016

Human life has been inextricably linked with healing. Recently, as the demands of healing are higher, it is more necessary to study spaces, places and mobilities related to healing in geographical studies. This paper draws on a case study of urban peoples walks along Seoul City Wall to explore what healing factors affect the people walking along historical landscapes in urban center and understand geographical implications of the healing process. Based on the concept and analytical lens of 'therapeutic mobilities' introduced by Gatrell, this research analyzes texts written on 181 blogs. The results show the main factors that affect their healing are 'weather climate', 'walk stroll', and 'nightscape'. Futhermore, the blogs' narratives focusing on these main factors imply healing place-making, time as limiting factor, and the social body within nightscape in the healing process.

• Journal of Microbiology and Biotechnology
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• v.17 no.10
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• pp.1661-1669
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• 2007

Gamma-aminobutyric acid (GABA) is a non-protein amino acid. It is well known for its role as an inhibitory neurotransmitter of developing and operating nervous systems in brains. In this study, a novel function of GABA in the healing process of cutaneous wounds was presented regarding anti-inflammation and fibroblast cell proliferation. The cell proliferation activity of GABA was verified through an MTT assay using murine fibroblast NIH3T3 cells. It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-$1{\beta}$, and TNF-${\alpha}$ in LPS-stimulated RAW 264.7 cells. To evaluate in vivo activity of GABA in wound healing, excisional open wounds were made on the dorsal sides of Sprague-Dawley rats under anesthesia, and the healing of the wounds was apparently assessed. The molecular aspects of the healing process were also investigated by hematoxylineosin staining of the healed skin, displaying the degrees of re-epithelialization and linear alignment of the granulation tissue, and immunostaining and RT-PCR analyses of fibroblast growth factor and platelet-derived growth factor, implying extracellular matrix synthesis and remodeling of the skin. The GABA treatment was effective to accelerate the healing process by suppressing inflammation and stimulating re-epithelialization, compared with the epidermal growth factor treatment. The healing effect of GABA was remarkable at the early stage of wound healing, which resulted in significant reduction of the whole healing period.