• 대한두경부종양학회지
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• 제18권1호
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• pp.46-49
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• 2002

Background: Free flaps have become a very important role in the ablative head and neck surgery with functional preservation of defect sites. The forearm free flap has many advantage of lack of bulk, ease of dissection, vascularity, and malleability. Patients and Methods: A review of 51 radial forearm free flaps performed between may 1990 and feburary 2001 at the Korea University was undertaken to determine outcome. Patient age ranged 27 to 72 years (mean 56). There were 44 men and 7 women. The most prevalent neoplasm was squamous cell carcinoma. Results: The tans verse cervical artery and the external jugular vein were the most frequent receipient sites for microvascular anastomosis. Total flap loss occurred in 2 cases (4%) and other complications were seen in 42%. Fifteen patients received preoperative irradiation and the complication was higher than non-irradiation patients, but statistically not significant. Conclusion: The radial forearm free flap offers a variety of reconstructive options for head and neck. Its low flap loss and complication rates offer the best choice for reconstruction of defect of head and neck malignancy.

• 한국산학기술학회논문지
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• 제10권11호
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• pp.3260-3268
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• 2009

냉각재상실사고이후 원전의 원자로건물집수조 여과기에서 화학적 영향을 고려한 수두손실을 종합적으로 평가하기 위한 시험장치를 개발하였다. 시험장치에서 원자로건물집수조와 시험장치에서 물 부피에 대한 여과기 면적의 비가 일치하도록 시험조건을 설정하고 시험을 수행하였다. TSP pH 조절제 조건에서 칼슘실리케이트는 시험 초기에 수두손실을 급격히 상승시켰기 때문에 원자로건물에서 모든 칼슘실리케이트를 제거하여야 함을 확인하였다. 비상노심냉각계통 살수지속시간의 차이에 따른 시험결과는 장기살수조건이 단기살수조건에 비해 12배 정도 높은 수두손실을 보였다. 살수조건 시험결과를 화학적 영향이 없는 수두손실과 비교하면 단기살수와 장기살수의 각 조건에서 5.6배 및 60.8배 수두손실이 증가하는 결과를 보였다. 화학적 영향은 재순환수에 노출된 물질의 양에 따라 초기의 일정기간 동안 알루미늄 및 아연도금 판의 부식에 의해 급격히 증가하고 이들이 부동피막을 형성한 이후에는 NUKONTM 및 콘크리트 등에서 침출된 화학종의 침전에 기인하여 증가율이 감소하는 경향을 보였다. 실험결과는 TSP에 의한 알루미늄의 부동피막 형성이 살수시간이 길어지고 알루미늄의 양이 많을 경우 효과적이지 않다는 것을 보였다.

• 한국유체기계학회 논문집
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• 제10권4호
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• pp.21-28
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• 2007

The ratio of disk friction loss in a centrifugal pump is very large for the total pump loss in the range of very low specific speed. Therefore, impeller radius should be shortened to increase the pump efficiency because the disk friction loss is proportional to the fifth power of impeller radius. In order to compensate the decreased head by the shortened impeller radius, vane angle at impeller outlet should be increased. However, as the vane angle at impeller outlet becomes larger, performance instability occurs at low flow rate regions. In this study, J-Groove is adopted to suppress the performance instability and detailed examination is performed for the influence of the J-Groove on the pump performance. The results show that J-Groove gives good effect on the suppression of performance instability. Moreover, as J-Groove increases pump head considerably, the pump size can be smaller for head requirements.

• 방사성폐기물학회지
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• 제10권1호
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• pp.1-11
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• 2012

Rorabaugh(1953)에 의해 재정리된 단계양수시험 해석해 $s_w=BQ+CQ^p$는 단열암반대수층에서 비선형으로 증가하는 수위강하에 매우 적합하며, 현장에서 관측된 수위강하 값과 추정된 수위강하 사이의 제곱근 평균제곱오차(RMSE) 값이 매우 낮음을 보여주었다. 우물수두손실($CQ^p$)의 $C$ 값은 $3.689{\times}10^{-19}{\sim}5.825{\times}10^{-7}$, $P$ 값은 3.459~8.290의 범위로 산정되었으며, 지표로부터 하부심도로 내려 갈수록 양수율 증가에 따른 수위강하는 매우 크게 나타났다. 단열암반대수층에서의 우물수두손실은 다공질매질에서와 달리 단열특성(단열의 틈, 간격, 상호 연결성)에 의한 영향으로 나타나므로, 우물수두손실의 $C$ 와 $P$ 값은 단열암 반대수층의 난류구간과 고 저 투수성 단열암반의 특성을 해석하는데 매우 중요하다. 그 결과, 우물수두손실 항의 $C$ 와 $P$ 값에 대한 회귀분석 결과로부터 암반대수층의 난류구간과 수리특성의 관계가 파악되었으며, $C$ 와 $P$ 값의 관계가 단열암반대수층의 수리특성 해석에 있어 매우 유용함을 확인할 수 있었다.

• Journal of Oral Medicine and Pain
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• 제16권1호
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• pp.33-72
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• 1991

The purpose of this study was to investigate the stress distribution and the displacement in the temporomandibular joints following the teeth loss patterns. The three dimensional finite element method was used for a mathematical model. The finite element model was composed of 1,632 elements and 2,411 nodes in the mandible with articular disc and mandibular fossa of the temporal bone. The masseter, the temporal and the internal pterygoid muscle forces were applied at each insertion site, bisecting point of gonion and antegonion, tip of the coronoid process, and gonion at the ration of 2:2:1 respectively. The directions of muscles force were obtained from frontal and lateral cephalometric tracings using bony landmarks of the skull. The results were as follows : 1. In control model, the minimum principal stresses were concentrated on the region of anterosuperior part of the condyle head and articular disc, and maximum principal stresses on the anterior part of the condyle head and posterolateral part of the articular disc. 2. In case of unilateral teeth loss, the greater principal stress appeared at the teeth loss side and the principal stresses increased at the teeth loss side as the number of the posterior teeth loss went up. 3. In case of bilateral teeth loss, the principal stresses were greater than those of the control model and as the number of the posterior teeth loss increased, the grater principal stresses on the temporomandibular joints appeared at the both side. 4. When the posterior teeth existed bilateral, the principal stress patterns were similar to those of the control model. 5. The displacement ws directed mainly upward and backward in the upper part of the temporomandibular joints and upward and forward in the largest part of the condyle head. The displacement increased as the number of the posterior teeth loss went up.

• 대한두경부종양학회지
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• 제24권2호
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• pp.184-188
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• 2008

Objectives：Weight loss and malnutrition in patients undergoing radiotherapy for head and neck cancer are usual and preventable. The effect of nutritional support with oral high protein liquid was evaluated. Material and Methods：From Feb. to Dec. 2007, twenty patients received nutritional supplement with oral high protein liquid during radiotherapy for head and neck cancer and the nutritional status was evaluated. Weight loss was compared with control group of similar clinical characteristics. Results：Nutritional parameters such as weight, arm circumference, hemoglobin, hematocrit, total protein, albumin, transferring and the number of lymphocyte were relatively well maintained in patients with nutritional support with oral high protein liquid. In addition weight loss was minimal and significantly lower compared with control group. Conclusion：Nutritional support with oral high protein liquid was effective on maintaining nutritional status for the patients with head and neck cancer during radiotherapy.

• 대한기계학회논문집B
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• 제22권1호
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• pp.70-78
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• 1998

The present study has tested semi-empirical loss models for a reliable performance prediction of mixed-flow pumps with four different specific speeds. In order to improve the predictive capabilities, this paper recommends a new internal loss model and a modified parasitic loss model. The prediction method presented here is also compared with that based on two-dimensional cascade theory. Predicted performance curves by the proposed set of loss models agree fairly well with experimental data for a variety of mixed-flow pumps in the normal operating range, but further studies considering 'droop-like' head performance characteristic due to flow reversal in mixed-flow impellers at low flow range near shut-off head are needed.

• Journal of Audiology & Otology
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• 제25권1호
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• pp.27-35
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• 2021

Background and Objectives: This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. Subjects and Methods: Forty-nine diabetic with unilateral SSNHL were retrospectively included. All patients received systemic high dose steroid therapy within one month after onset and had more than one month of follow-up audiogram. The basic characteristics of the patients, initial and follow-up audiograms, laboratory data, and methods of steroid treatment were collected. Results: Compared to reference values in healthy subjects, 79%, 55%, and 45% of the patients had higher values of mean neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), respectively. Older patients had significantly less degree of hearing loss, but they also had significantly worse hearing thresholds in the unaffected ear. After steroid treatment, less than half patients (47%) showed hearing recovery. Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. Conclusions: Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary.

• 대한청각학회지
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• 제25권1호
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• pp.27-35
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• 2021

Background and Objectives: This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. Subjects and Methods: Forty-nine diabetic with unilateral SSNHL were retrospectively included. All patients received systemic high dose steroid therapy within one month after onset and had more than one month of follow-up audiogram. The basic characteristics of the patients, initial and follow-up audiograms, laboratory data, and methods of steroid treatment were collected. Results: Compared to reference values in healthy subjects, 79%, 55%, and 45% of the patients had higher values of mean neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), respectively. Older patients had significantly less degree of hearing loss, but they also had significantly worse hearing thresholds in the unaffected ear. After steroid treatment, less than half patients (47%) showed hearing recovery. Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. Conclusions: Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary.

• Journal of Audiology & Otology
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• 제23권2호
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• pp.69-75
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• 2019

Background and Objectives: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage manifested in sphingolipidosis. Recently, it was noted that experimental use of HPβCD could partially resolve the symptoms in both animals and human patients. Despite its desirable effect, HPβCD can induce hearing loss, which is the only major side effect noted to date. Understanding of the pathophysiology of hearing impairment after administration of HPβCD and further development of preventive methods are essential to reduce the ototoxic side effect. The mechanisms of HPβCD-induced ototoxicity remain unknown, but the resulting pathology bears some resemblance to other ototoxic agents, which involves oxidative stress pathways. To indirectly determine the involvement of oxidative stress in HPβCD-induced ototoxicity, we tested the efficacy of an antioxidant reagent, ebselen, on the extent of inner ear side effects caused by HPβCD. Materials and Methods: Ebselen was applied prior to administration of HPβCD in mice. Auditory brainstem response thresholds and otopathology were assessed one week later. Bilateral effects of the drug treatments also were examined. Results: HPβCD-alone resulted in bilateral, severe, and selective loss of outer hair cells from base to apex with an abrupt transition between lesions and intact areas. Ebselen co-treatment did not ameliorate HPβCD-induced hearing loss or alter the resulting histopathology. Conclusions: The results indirectly suggest that cochlear damage by HPβCD is unrelated to reactive oxygen species formation. However, further research into the mechanism(s) of HPβCD otopathology is necessary.