• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10985-10989
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• 2015

Background: The capability for DNA double-strand breaks (DSBs) repair is crucial for inherent radiosensitivity of tumor and normal cells. We have investigated the clinicopathologic significance of DNA repair gene expression in nasopharyngeal (NP) carcinoma. Materials and Methods: A total of 65 NP cancer patients who received radiotherapy were included. The immunopositivity to Ku 70, DNA-PKcs, MRN, RAD50, XRCC4, and LIG4 were examined in all tumor tissues. Results: The patients comprised 42 males and 23 females, with a median age of 56 years (range, 18-84). The expression levels of RAD50 (0,+1,+2,+3) were 27.7%, 32.3%, 21.5%, and 18.5%. LIG4 (${\pm}$) were 43.1% and 56.9% respectively. The 5-year OS rate of patients with LIG4 (${\pm}$) were 90% and 67.9%, respectively (p=0.035). The 5-year TTP rate of patients with LIG4 (${\pm}$) were 75.9%, 55.5%, respectively (P=0.039). Conclusions: Our results suggest the possibility of predicting the radiosensitivity of NP cancer by performing immunohistochemical analysis of LIG4.

• Radiation Oncology Journal
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• 제4권1호
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• pp.45-50
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• 1986

1984년 RTOG에서 두경부 편평세포암의 방사선치료시, 원발병소의 완전관해 가능성을 예측할 수 있는 Multivariate Modelling System을 제시하였다. 저자들은 1971년 1월부터 1983년 12월까지 조직병리학적으로 확진된 비인강암으로 연계대학교 의과대학 연세암센타, 치료방사선과에 내원하여 근치적 방사선 치료를 받은 81예를 대상으로, 그들이 제시한 system에 의해 계산된 PPC(Probability of Primary Clearance : 원발병소 완전관해 가능성)와 생존율과의 관계를 후향적으로 분석 고찰하였다. 전례를 대상으로 한 5년 생존율은 $36\%$, 중앙생존기간은 39개월이었다. 편의상, PPC에 따라 3군으로 구분하였고, 각군에 따른 생존율은 Group 1 (PPC가 $81\%$이상인 27예)은 $66\%$(중앙생존기간: 72개월 이상), Group 2(PPC가 $71\~80\%$의 20예)는 $27\%$(31개월) 및 Group 3(PPC가 $70\%$ 이하의 29예)의 $4\%$(12개월)순이었다. 그러고 각 Group간의 PPC와 생존율은 통계학적으로 유의한 차이를 보였다.

• International Journal of Oral Biology
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• 제49권1호
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• pp.18-25
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• 2024

Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

• 대한방사선치료학회지
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• 제26권1호
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• pp.99-105
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• 2014

목 적 : 본 연구에서는 두경부 암 환자의 방사선 치료 시 Neck node lower region까지 Target이 위치한 환자의 경우 기존의 상품화 된 두 가지 고정용구와 자체개발한 Shoulder Retractor의 유용성을 비교 평가하고자 한다. 대상 및 방법 : 본원에서 치료한 두경부암 환자 6명을 대상으로 사용한 고정용구의 종류에 따라 각각 2명씩 분류하여 좌, 우 Shoulder 위치변화와 Set up의 정확성을 OBI를 이용한 2D/2D 영상정합 위치보정 후 좌표 분석을 통해 비교하여 유용성을 확인해 보았다. 결 과 : 고정용구 종류에 따른 영상정합 위치보정 값(OBI A-P상 좌, 우 Shoulder 위치변화값)에 대한 평균값과 표준편차는 A그룹에서는 RT.Shoulder $1.07mm{\pm}3.99mm$, LT.Shoulder $-4.35mm{\pm}2.09mm$이고, B그룹에서는 RT.Shoulder $-0.37{\pm}5.91mm$, LT.Shoulder $1.26{\pm}5.28mm$, C그룹에서는 RT.Shoulder $-0.63{\pm}2.44mm$, LT.Shoulder $0.25mm{\pm}1.61mm$으로 나타났다. SET UP의 영상유도좌표 분석에서는 평균 및 표준편차 값이 A그룹에서 Vrt $-2.06{\pm}2.68mm$, Lat $-1.11{\pm}8.15mm$, Lng $0.34{\pm}3.78mm$, Rot $0.51{\pm}0.77^{\circ}$이고, B그룹에서 Vrt은 $-1.18{\pm}1.82mm$, Lat $-0.94{\pm}2.13mm$, Lng $-0.67{\pm}1.98mm$, Rot $0.91{\pm}1.04^{\circ}$이고, C그룹에서 Vrt은 $0.12{\pm}2.18mm$, Lat에서 $-0.79{\pm}1.62mm$, Lng에서 $-0.79{\pm}2.64mm$, Rot $0{\pm}0.49^{\circ}$으로 나타났다. 결 론 : 자체개발한 고정용구는 좌,우 Shoulder의 위치변화에 대한 재현성을 유지시킴에 있어 유용함을 알수있었고, 환자 변위요소(환자가 잡은 줄을 놓치는 현상과 발 끝의 위치와 모양에 따라 잡은줄이 한쪽으로 치우치는 현상)와 환자의 체중 변화로 인한 환자 자세의 고정문제를 줄임으로써 Set up의 오차를 줄이고 환자의 재현성을 유지시키는데 도움이 될 것으로 사료된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권1호
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• pp.18-23
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• 2000

방사선 조사로 인한 치아우식증 및 점막염 등에 대한 병인 이해 및 예방과 치료에 대한 기초 자료를 구하고자, 1997년에서 1998년 사이에 서울대학교병원 구강악안면외과에 내원한 구강암 환자 중 방사선 치료 예정인 자 7명에서 방사선 조사전부터 조사 중 및 조사후 6개월까지 타액의 total aerobe, candida, Staphylococci, lactobacilli, S.mutans, S. salivarius(mitis, sanguis)의 방사선 조사에 따른 타액의 세균 조성 변화를 알아보았다. 본 연구에서 얻은 방사선 치료를 받은 환자에서의 타액내 세균의 동정과 조성 변화에 대한 본자료를 토대로 하여 다음과 같은 유의한 결론을 얻을 수 있었다. (1) 두경부 악성 종양으로 방사선 치료를 받는 환자에서 구강청결용으로 사용할 약제의 항균 범위를 정하는데 기준 참고자료로 사용할 수 있을 것으로 사료된다. (2) 방사선 조사 후 타액의 면역화학적 조성 성분의 변화에 따른 기회감염의 증가와 특정 세균에 의한 감염과의 연관 관계를 이해하는데 도움을 받을 수 있다. (3) 방사선 조사에 따른 면역저하 환자에서 예방적인 항생제 투여시 유의한 참고 자료가 될 수 있을 것으로 사료되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3741-3745
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• 2012

Background: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the most common form of liver cancer. However, while it is associated frequently with hepatitis C virus (HCV) there is only an elementary understanding of its molecular pathogenesis. Methods: To gain insight into the molecular mechanisms of HCV-induced hepatocarcinogenesis, we performed microarray analysis on 75 surgical liver samples from 48 HCV-infected patients. Results: There were 395 differentially expressed geness between cirrhotic samples and HCC samples. Of these, 125 genes were up-regulated and 270 genes were down-regulated. We performed pathway enrichment analysis and screened as described previously. Conclusions: The differentially expressed genes might be involved in hepatocarcinogenesis through upregulating the pathways of ECM-receptor interaction, focal adhesion, cell adhesion molecules and other cancer-related pathways, and downregulating the pathways of "complement and coagulation cascades". We hope our results could aid in seeking of therapeutic targets for HCV-induced hepatocellular carcinoma.

• 대한두개안면성형외과학회지
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• 제14권2호
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• pp.129-132
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• 2013

Cutaneous squamous cell carcinoma is the second-most common skin cancer and represents 20% of all skin cancers. Cutaneous squamous cell carcinoma often spreads to the parotid gland through lymph nodes, but, direct invasion of an adjacent organ may also occur. We present the case of 78-year-old man with ulcerated mass on the right infra-auricular area. The histopathologic finding was squamous cell carcinoma. There was no evidence of distant metastasis, but the mass was found to invade the superficial lobe of the right parotid gland. The mass was widely excised and superficial parotidectomy was performed while preserving the facial nerve. The defect was covered by primary closure. Postoperative radiotherapy was performed. At 20 months after surgery, our patient had no facial palsy, local recurrence, or metastasis. Cutaneous squamous cell carcinoma involving the parotid gland is an aggressive, rapidly advancing lesion, which if not recognized and treated early will result in high morbidity and mortality. Squamous cell carcinoma of the parotid gland has shown that patients who receive adjuvant radiotherapy have a lower recurrence rate and a higher survival rate than patients treated with surgery alone. The role of elective neck dissection remains controversial.

• Archives of Plastic Surgery
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• 제35권6호
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• pp.698-702
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• 2008

Purpose: Basal cell carcinoma is one of the most common cancers in the western population and the annual incidence rate is still on an increasing course. In Asian countries such as Korea, the incidence of basal cell carcinoma is reported to be remarkably low but is estimated to be in a steep increase nowadays. This study was to analyze the recent clinical trends of basal cell carcinoma in Korea by reviewing a single institution's experience. Methods: Throughout an 11-year period, the surgical excision of 143 cases of basal cell carcinoma was performed in our department. General data of these cases such as the primary site of cancer, age and sex of the patient, operative methods, recurrence rate were reviewed retrospectively. Results: Among the 143 patients included in this study, 82 patients were men and 61 patients were women. The ages ranged from 27 to 89 years with a mean age of 64.0 years. The head and neck region was the most frequently involved primary site for the cancer as 95.1% of the total cases occurred in this area. Especially the nose and perinasal area were the most frequent region, which was followed by the periorbital area, cheek, and perioral area. During this study period, 9 cases showed recurrence of the cancer as the overall recurrence rate was 6.3%. Conclusion: Gradual increase in the incidence of basal cell carcinoma was demonstrated in this study. Basal cell carcinoma showed high incidence in the old-age population as 68.5% of the total patients were more than 60 years of age. High recurrence rate was noted in the nasal region especially after local flap reconstruction. A more cautious approach is to be required when handing such high risk lesions. Multiple factors such as extended life span, increased outdoor leisure activity and exposure to sunlight, higher accessibility to medical services and increased understanding of the public about skin cancer are assumed to be the main reasons for this increase of basal cell carcinoma.

• 대한후두음성언어의학회지
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• 제24권1호
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• pp.41-46
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• 2013

Background & Objectives : The Speech Handicap Index (SHI) is used to assess speech problem of head and neck cancer patients. The aim of this preliminary study was to evaluate the reliability and validity the Korean version SHI. Materials and Methods : Sixteen patients with oral cavity cancer and 26 normal control were participated in the study. Test-retest reliability of the Korean version of SHI was completed by 20 out of 42 subjects after 2weeks. Mann-Whitney U test was used to compare the Korean version of SHI scores between normal population and patients group. The relationship between the Korean version of SHI and diadochokinesis (DDK) was investigated using Spearman correlation coefficients. Results : The Korean version of SHI provided a high internal consistency (${\alpha}$=0.99) and test-retest reliability (Spearman rho 0.98). The mean SHI scores [total (T), speech (S), and psychosocial (P)] in normal population were 0.8 (T), 0.2 (S) and 0.4 (P), whereas those in patients group were 58.1 (T), 27.9 (S) and 27.0 (P) respectively. There were significant differences in total SHI score as well as in all of the sub-SHI scores between two groups. Moreover, significant correlation between the Korean version of SHI parameters (T, S, P) and sequential motion rate (SMR) were yielded in patients group. Conclusion : The Korean version of SHIwas reliable and valid. It can be useful as a supplementary clinical tool for diagnosing and measuring treatment efficacy of speech problems related to oral cavity cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5089-5094
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• 2015

FADS1 (fatty acid desaturase 1) plays a crucial role in fatty acid metabolism, and it was recently reported to be involved in tumorigenesis. However, the role of FADS1 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. In the current study, we investigated the expression and clinical pathologic and prognostic significance of FADS1 in ESCC. Immunohistochemical analyses revealed that 58.2% (146/251) of the ESCC tissues had low levels of FADS1 expression, whereas 41.8% (105/251) exhibited high levels of FADS1 expression. In positive cases, FADS1 expression was detected in the cytoplasm of cells. Correlation analyses demonstrated that FADS1 expression was significantly correlated with tumor location (p=0.025) but not with age, gender, histological grade, tumor status, nodal status or TNM staging. Furthermore, patients with tumors expressing high levels of FADS1had a longer disease-free survival time (p<0.001) and overall survival time (p <0.001). Univariate and multivariate analyses revealed that, along with nodal status, FADS1 expression was an independent and significant predictive factor (p<0.001). In conclusion, our study suggested that FADS1 might be a valuable biomarker and potential therapeutic target for ESCC.