• 한국간호교육학회지
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• 제30권3호
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• pp.222-231
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• 2024

Purpose: This study is to explore the antecedent factors of daycare teacher behaviors concerning the eye health of preschool children by applying an extended parallel process model. Methods: Focus group interviews were conducted with ten daycare center teachers on September 4 and 14, 2023. A data analysis was performed according to the content analysis method by clustering the data into the four categories: the two threat factors of severity and susceptibility and the two efficacy factors of self-efficacy and response-efficacy. Results: Daycare center teachers' perception of the severity of eye health problems in preschool children was high in relation to eye trauma, but it was recognized that viewing the electronic devices were of a less severe because symptoms were not noticed in a short period of time. They also showed low susceptibility because they were not sufficiently interested in the eye health hazard behaviors of preschool children. The self-efficacy of daycare center teachers was low because this was a lack of knowledge about symptoms of eye problems. However, they recognized that eye health activities performed in the preschool age could prevent negative eye health outcomes, thus showing a high response efficacy. Conclusion: In the future, it is necessary to increase the sensitivity and engagement of daycare center teachers concerning with the eye health of preschool children and to increase their self-efficacy. It will also be necessary to develop various interventions to improve eye health for preschool children that can be implemented by daycare center teachers.

• 지질공학
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• 제18권3호
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• pp.303-309
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• 2008

중요 석조문화재가 위치하고 있는 강원도 양양군 소재 진전사지 주변지역에 대한 사면재해 가능성을 예측하였다. 연구지역에 대한 현장조사, 실내시험, 지질 및 지형자료 분석을 통해 산사태에 유의한 영향요소를 평가하고 그 자료들을 예측모델에 적용하여 산사태예측도를 작성하였다. 그리고 산사태예측도에 의해 발생확률을 등급별로 분류함으로써 산사태로 인한 석조문화재의 피해가능성을 검토하였다. 산사태예측도에 의하면, 발생확률 70% 이상으로 산사태가 발생될 가능성이 높은 지역은 대상면적의 10.1%인 $3,489m^2$정도로 비교적 넓은 면적비율을 나타내었다. 피해영향권에 속한 높은 고도의 산사면에서 산사태가 발생할 경우 국보 제122호인 진전사지삼층석탑과 보물 제439호인 진전사지부도에 사태물질로 인한 피해가능성이 예상된다.

• 한국지형학회지
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• 제15권2호
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• pp.25-35
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• 2008

2006년 7월의 태풍 에위니아와 빌리스에 의한 집중호우로 인해 급경사의 사면이 많고 기복이 큰 강원도 지역에서 토사재해가 크게 발생하였다. 특히 한계령을 관통하는 국도 44호선 도로는 단층선곡을 따라 건설되어 토사재해의 가능성이 가장 높은 편에 속하는 지역이다. 오색천 주변에서 발생한 토석류는 호우에 의해 공극수압이 상승하고 사면부의 무게가 증가하면서 발생한 능선부와 산정부의 산사태에 의해 촉발되었다. 또한 기존의 붕적물 또는 계안퇴적물에 가해진 하천의 압력에 의해서도 특히 공격사면 쪽에서 많은 토석류가 발생하였다. 하천의 상류부에서는 도로주변의 급경사의 절개지와 사면부의 얇은 풍화층에서 산사태가 발생한 반면, 중류부에서는 계류부의 토석류가 도로변의 배수구조물 용량을 초과하여 월류가 발생하여 도로와 교량이 파괴되었고, 하류부에서는 하천범람에 의한 계류부 양안의 침식과 토석류에 의한 피해가 가장 크게 나타났다. 하류부 퇴적층의 경우 토석류가 일회성이 아니라 과거 수차례 더 발생했었다는 사실을 보여주고 있다. 따라서 기후변화와 관련하여 호우의 빈도와 강도가 높아질 것으로 예측되는 만큼 추후 토사재해와 관련된 정보시스템의 구축과 관리시스템에 대한 연구가 절실히 요구된다.

• Korean Journal of Radiology
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• 제22권8호
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• pp.1369-1378
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• 2021

Objective: Few attempts have been made to investigate the prognostic value of dynamic contrast-enhanced (DCE) MRI or dynamic susceptibility contrast (DSC) MRI of non-enhancing, T2-high-signal-intensity (T2-HSI) lesions of glioblastoma multiforme (GBM) in newly diagnosed patients. This study aimed to investigate the prognostic values of DCE MRI and DSC MRI parameters from non-enhancing, T2-HSI lesions of GBM. Materials and Methods: A total of 76 patients with GBM who underwent preoperative DCE MRI and DSC MRI and standard treatment were retrospectively included. Six months after surgery, the patients were categorized into early progression (n = 15) and non-early progression (n = 61) groups. We extracted and analyzed the permeability and perfusion parameters of both modalities for the non-enhancing, T2-HSI lesions of the tumors. The optimal percentiles of the respective parameters obtained from cumulative histograms were determined using receiver operating characteristic (ROC) curve and univariable Cox regression analyses. The results were compared using multivariable Cox proportional hazards regression analysis of progression-free survival. Results: The 95th percentile value (PV) of Ktrans, mean Ktrans, and median Ve were significant predictors of early progression as identified by the ROC curve analysis (area under the ROC curve [AUC] = 0.704, p = 0.005; AUC = 0.684, p = 0.021; and AUC = 0.670, p = 0.0325, respectively). Univariable Cox regression analysis of the above three parametric values showed that the 95th PV of Ktrans and the mean Ktrans were significant predictors of early progression (hazard ratio [HR] = 1.06, p = 0.009; HR = 1.25, p = 0.017, respectively). Multivariable Cox regression analysis, which also incorporated clinical parameters, revealed that the 95th PV of Ktrans was the sole significant independent predictor of early progression (HR = 1.062, p < 0.009). Conclusion: The 95th PV of Ktrans from the non-enhancing, T2-HSI lesions of GBM is a potential prognostic marker for disease progression.

• 한국지리정보학회지
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• 제15권2호
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• pp.57-70
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• 2012

본 연구에서는 지리정보시스템(GIS)을 기반으로 확률강우량과 인공신경망을 적용하여 2006년 태풍 에위니아에 의하여 발생한 강원도 인제 덕적리 지역의 산사태 취약성도 및 미래 위험도를 작성 및 검증하고자 한다. 산사태 취약성 및 위험도와 관련된 요인으로는 지질, 지형도(경사, 경사방향, 곡률도), 토양도(토양 지형, 토질, 토양 배수, 토양 모재 및 유효토심), 임상도(영급, 경급, 소밀도 및 수종) 등을 GIS 기반의 공간 데이터베이스로 구축하였다. 전체 산사태 발생 위치는 694개소이며 이중 50%는 인공신경망의 산사태 발생 지역으로 적용하였으며, 나머지 50%는 취약성도 및 위험도 검증에 활용하였다. 산사태 발생 강우량 임계치는 1일 202mm 및 3일 누적 449mm로 적용하였다. 확률강우량은 1973년부터 2006년까지의 실측 강우량을 정리하여 2106년까지 목표연도별(1년, 3년, 10년, 50년 및 100년) 산사태 취약성도를 작성하였다. 연구결과 연구지역은 강우량의 증가에 의하여 미래 산사태 가능성이 지속적으로 증가하였다. 향후 본 연구는 강우량의 변화에 의한 산사태 위험성 분석에 한 축을 차지 할 수 있다는 점에서 중요성이 있다고 하겠다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.299-304
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• 2014

Cholangiocarcinoma (CCA), a malignancy of biliary duct with a very poor prognosis, is the leading cause of cancer death in countries of the Mekong subregion. Liver fluke infection is the main etiological factor, but genetic variation has been recognized as also important in conferring susceptibility to CCA risk. Nuclear factor (erythroid derived 2)-like 2 (NRF2) is a key transcription factor in detoxification and antioxidant defense. Emerging evidence has demonstrated that genetic polymorphisms in the NRF2 gene may be associated with cancer development. The objectives of this study were to investigate the association of NRF2 genetic polymorphism with CCA risk and to evaluate the influence of the NRF2 genotype on survival time of affected patients. Single nucleotide polymorphisms (SNPs) of the NRF2 gene, including rs6726395: A/G, rs2886161: C/T, rs1806649: C/T, and rs10183914: C/T, were analyzed using TaqMan$^{(R)}$ SNP genotyping assays. Among 158 healthy northeastern Thai subjects, the allele frequencies were 41, 62, 94, and 92%, respectively. The correlation of NRF2 SNPs and CCA risk was analyzed in the 158 healthy subjects and 198 CCA patients, using unconditional logistic regression. The results showed that whereas the NRF2 SNPs were not associated with CCA risk (p>0.05), Kaplan-Meier analysis of 88 intrahepatic CCA patients showed median survival time with rs6726395 genotypes of GG and AA/AG to be $344{\pm}138$ (95%CI: 73-615) days and $172{\pm}37$ (95%CI: 100-244) days, respectively, (p<0.006). On multivariate Cox proportional hazard analysis, the GG genotype of rs6726395 was found to be associated with longer survival with a hazard ratio of 0.54 (95%CI: 0.31-0.94). In addition, non-papillary adenocarcinoma was associated with poor survival with a hazard ratio of 2.09 (95%CI: 1.16-3.75). The results suggest that the NRF2 rs6726395 polymorphism can be a potential prognostic biomarker for CCA patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10209-10215
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• 2015

To assess the contribution of tumor necrosis factor $(TNF){\beta}$ +252 polymorphisms to risk and prognosis of hepatocellular carcinoma (HCC), we enrolled 150 pairs of sex- and age-matched patients with HCC, patients with cirrhosis alone, and unrelated healthy controls. $TNF{\beta}$ +252 genotypes were determined by polymerase chain reaction with restriction fragment length polymorphism. Multivariate analysis indicated that $TNF{\beta}$ G/G genotype [odds ratio (OR), 3.64; 95%CI, 1.49-8.91], hepatitis B surface antigen (OR, 16.38; 95%CI, 8.30-32.33), and antibodies to hepatitis C virus (HCV) (OR, 39.11; 95%CI, 14.83-103.14) were independent risk factors for HCC. There was an additive interaction between $TNF{\beta}$ G/G genotype and chronic hepatitis B virus (HBV)/HCV infection (synergy index=1.15). Multivariate analysis indicated that factors associated with $TNF{\beta}$ G/G genotype included cirrhosis with Child-Pugh C (OR, 4.06; 95%CI, 1.34-12.29), thrombocytopenia (OR, 6.55; 95%CI, 1.46-29.43), and higher serum ${\alpha}$-fetoprotein concentration (OR, 2.53; 95%CI, 1.14-5.62). Patients with $TNF{\beta}$ G/G genotype had poor cumulative survival (p=0.005). Cox proportional hazard model indicated that $TNF{\beta}$ G/G genotype was a biomarker for poor HCC survival (hazard ratio, 1.70; 95%CI, 1.07-2.69). In conclusion, there are independent and additive effects between $TNF{\beta}$ G/G genotype and chronic HBV/HCV infection on risk for HCC. It is a biomarker for poor HCC survival. Carriage of this genotype correlates with disease severity and advanced hepatic fibrosis, which may contribute to a higher risk and poor survival of HCC. Chronic HBV/HCV infected subjects with this genotype should receive more intensive surveillance for early detection of HCC.

• 한국지반공학회논문집
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• 제31권6호
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• pp.59-69
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• 2015

최근 들어 집중호우로 인한 산사태 및 토석류 피해가 종종 발생하고 있다. 이에 따라 산사태 재해 예측에 관한 연구 중 산사태 민감도 분석과 토석류 위험도 분석 관련 연구는 활발하게 진행되어 왔지만, 사면 지역에 적용하기 적합한 전이 분석 관련 연구는 부족한 실정이다. 본 연구에서는 판별분석과 로지스틱 회귀 분석과 같은 통계적 방법을 이용하여 실제 토석류가 발생했던 지역에서 추출한 지형학적 인자, 지질학적 인자 등을 토대로 토석류 전이규준을 제시하였다. 10개의 지형학적 및 지질학적 인자가 독립변수로 사용되었으며 실제 466개소(비전이: 228개소, 전이: 238개소)의 토석류 비전이 및 전이 데이터가 수집되었다. 우선, Fisher의 판별 분석이 수행되었으며, 수행 결과 실제경우와 91.6%의 분류 정확도를 보였다. 하지만 전이와 비전이 두 그룹간의 공분산 동질성이 만족되지 않았으며 또한 독립변수들이 정규분포를 보이지도 않았다. 두 번째로 이항 로지스틱 회귀분석이 수행되었으며, 분석 결과 92.3%의 분류 정확도를 나타냈으며 모든 통계적 조건들도 유의하게 나타났다. 따라서 이항 로지스틱 회귀 분석을 이용한 전이 규준은 토석류 재해 발생 여부를 예측하는데 효과적으로 사용될 수 있을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1939-1944
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• 2015

MicroRNA-27a (miR-27a) is deemed to be an oncogene that plays an important role in development of various cancers, and single nucleotide polymorphism (SNP) of miR-27a can influence the maturation or aberrant expression of hsa-miR27a, resulting in increased risk of cancer and poor prognosis for non-small cell lung cancer (NSCLC). This study aimed to assess the effects of rs895819 within miR-27a on susceptibility and prognosis of NSCLC patients in 560 clinical confirmed cases and 568 healthy check-up individuals. Adjusted odds/hazard ratios (ORs/HRs) and 95% confidential intervals (CIs) were calculated to evaluate the association between rs895819 and the risk and prognosis of NSCLC. The results showed that allele A and genotype GG of rs895819 were significantly associated with an increased risk of NSCLC (38.9% vs 30.8%, adjusted OR=1.26, 95%CI=1.23-1.29 for allele G vs A; 18.1% vs 11.7%, adjusted OR=1.67, 95%CI=1.59-1.75 for genotype GG vs AA). Moreover, positive associations were also observed in dominant and recessive models (53.7% vs 49.9%, adjusted OR=1.17, 95%CI=1.13-1.20 for GG/AG vs AA; 18.1% vs 11.7%, adjusted=1.65, 95%CI=1.58-1.73). However, no significant association was found between rs895819 and the prognosis of NSCLC in genotype, dominant and recessive models. These results suggested that miR-27a might be involved in NSCLC carcinogenesis, but not in progression of NSCLC. The allele G, genotype GG and allele G carrier (GG/AG vs AA) of rs895819 might be genetic susceptible factors for NSCLC. Further multi-central, large sample size and well-designed prospective studies as well as functional studies are warranted to verify our findings.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.345-350
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• 2005

Acute toxicities of five pharmaceutical products were evaluated with aquatic microbes, invertebrates, and fish. The test pharmaceuticals, i.e., cimetidine, carbamazepine, diltiazem, acetaminophene, and metformin have been often detected in aquatic environment, but theire cological hazard on receptors of various trophic levels has seldom been evaluated. In the present study, we conducted acute toxicity assays with a marine bacterium, Vibrio fischeri, an invertebrate, Daphnia magna, and a fish, Japanese medake (Oryzias latipes). In general, D. magna, showed the most sensitive response to the test chemicals. Diltiazem exhibited the lowest EC50 value after 96 hr of exposure at 7.6 mg/L, followed by cimetidine >acetaminophen > metformin = carbamazepine in an order of decreasing susceptibility. With the fish, diltiazem and carbamazepine showed the 96 hr EC50 values at 14.1${\sim}$35.4 mg/L while acetaminophen, cimetidine, and metformin did not cause 50% mortality at 100 mg/L. Similar pattern was noted with the Microtox Assay, with which the median effective concentrations for acetaminophen, cimetidine, and metformin were found at the range between 301.8 and 755.4 mg/L. Carbamazepine and diltiazem exposure to the microbes resulted in EC50 values around 50 mg/L. Predicted no effect concentrations (PECs) of these pharmaceuticals derived from the EC5O values obtained from this study, and predicted environmental concentrations (PECs) obtained from available literatures were utilized to estimate ecological risks of the test compounds. No test pharmaceuticals resulted in risk quotients (PEC/PNEC) greater than 1, which suggests no serious potential ecological concerns. It should be noted however that further studies including the refinement of PEC derivation, identification and toxicity assessment of the metabolites and/or their interactions with other stressors may be warranted to better understand the environmental consequences of the residual pharmaceutical discharge to the waterway.