• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.12
• /
• pp.7681-7684
• /
• 2013

Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poor survival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We used immunohistochemistry to investigate HLA-G expression, tumor infiltrating CD8+ T lymphocytes, and Treg cells in 52 gastric cancer patients. Results: There were 29 cancer-related deaths during the follow-up period. Kaplan-Meier analysis indicated that patients with HLA-G-positive (n=16) primary tumors had a significantly poorer prognosis than patients with HLA-G-negative tumors (n=36, p=0.008). The median survival time was 14 months and 47 months, respectively. Patients with high numbers of Tregs and low numbers of CD8+T lymphocytes in the primary tumor had a poorer prognosis than those with low numbers of Tregs and high numbers of CD8+T lymphocytes (p=0.034, p=0.043). Multivariate Cox proportional hazard regression analysis showed that HLA-G expression (hazard ratio: 2.662; 95% confidence interval: 1.242-5.723; p=0.012) and stage (hazard ratio: 2.012;95% confidence interval: 1.112-3.715; p=0.041) were independent unfavorable factors for patient survival. Conclusions: We found a significant positive correlation between HLA-G expression and the number of tumor infiltrating Tregs (p=0.01) and a negative correlation with the number of CD8+T lymphocytes (p=0.041). HLA-G may protect gastric cancer cells from cytolysis by inducing Foxp3+Treg lymphocytes and suppressing CD8+T lymphocytes.

• Journal of Korean Neurosurgical Society
• /
• v.60 no.2
• /
• pp.239-249
• /
• 2017

Objective : The purpose of this study is to evaluate the associations between 30-day mortality and various radiological and clinical factors in patients with traumatic acute subdural hematoma (SDH). During the 11-year study period, young patients who underwent surgery for SDH were followed for 30 days. Patients who died due to other medical comorbidities or other organ problems were not included in the study population. Methods : From January 1, 2004 to December 31, 2014, 318 consecutive surgically-treated traumatic acute SDH patients were registered for the study. The Kaplan-Meier method was used to analyze 30-day survival rates. We also estimated the hazard ratios of various variables in order to identify the independent predictors of 30-day mortality. Results : We observed a negative correlation between 30-day mortality and Glasgow coma scale score (per 1-point score increase) (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.52-0.70; p<0.001). In addition, use of antithrombotics (HR, 2.34; 95% CI, 1.27-4.33; p=0.008), history of diabetes mellitus (HR, 2.28; 95% CI, 1.20-4.32; p=0.015), and accompanying traumatic subarachnoid hemorrhage (hazard ratio, 2.13; 95% CI, 1.27-3.58; p=0.005) were positively associated with 30-day mortality. Conclusion : We found significant associations between short-term mortality after surgery for traumatic acute SDH and lower Glasgow Coma Scale scores, use of antithrombotics, history of diabetes mellitus, and accompanying traumatic subarachnoid hemorrhage at admission. We expect these findings to be helpful for selecting patients for surgical treatment of traumatic acute SDH, and for making accurate prognoses.

• Journal of Preventive Medicine and Public Health
• /
• v.37 no.3
• /
• pp.274-281
• /
• 2004

Objectives : This study was performed to investigate the injury rates and risk factors for preschool children in Daegu city and Kyungpook province. Method : A questionnaire survey about medically attended injuries during the preschool period was performed in nine primary schools located in Daegu city, Pohang city and Goryung County. The overall injury rate was estimated using person-year. The causes and patterns of the injuries, and their risk factors were examined. Result : A total of 469 medically attended injuries were reported in 330 of the 959 study subjects during the preschool period. The overall annual injury rate was 7.5 per 100 children. The injury rate increased sharply during the period from infant (2.4) to 1 year of age (7.5), and the peak injury rate (9.2) was reported for 5 year olds. The most common causes of injuries were falling (36.0%), followed by being struck by an object (23.7%), and traffic accidents (14.1%). Among the traffic accidents, 72.8% occurred while playing on the road, riding a bicycle or roller-skating. A proportional hazard model showed that males (hazard ratio=1.49, p<0.001 compared with female) and the mother's higher education level (hazard ratio of college or higher= 1.51, p=0.013; high school=1.32, p=0.085 compared with those of middle school or lower) were significant risk factors of childhood injury. Conclusion : The results of this study suggested that efforts for children's safety should be made, especially from the toddler stage, and in male children. To develop a more specific childhood injury prevention program, a surveillance system for injuries should be established. Further study of the relationship between mother's occupation and injury rates is also needed.

• Journal of Veterinary Clinics
• /
• v.35 no.6
• /
• pp.251-257
• /
• 2018

We determined the relationships between calving season and the incidence of postpartum disorders, milk yield, and reproductive performance in dairy cows. Data regarding cow parity, postpartum disorders, milk yield, and reproduction were collected from 1,478 lactations. The incidence of retained placenta was higher in spring- and summer-calving cows than in autumn- and winter-calving cows (P < 0.05). The incidence of septicemic metritis was highest in spring- and summer-calving cows, and was higher in autumn-calving cows than in winter-calving cows (P < 0.05). The incidence of metabolic disorders was higher in summer-calving cows than in autumn- and winter-calving cows (P < 0.01). The mean milk yield 1 and 2 months after calving was higher in spring-calving cows than in summer-calving cows (P < 0.05). The percentage of cows that had resumed cycling, defined by detection of a corpus luteum using ultrasonography 4 weeks after calving, was highest in autumn-calving cows, and was higher in summer- and winter-calving cows than in spring-calving cows (P < 0.05). The hazard of first insemination by 150 days after calving was higher in summer- and autumn-calving cows (hazard ratio [HR] = 1.19; P < 0.05) than in spring-calving cows. The hazard of pregnancy by 210 days after calving was also higher in summer-calving (HR = 1.24; P < 0.05) and autumn-calving (HR = 1.59; P < 0.0001) cows than in spring-calving cows. The probability of conception at the first insemination was higher (P < 0.0001) in autumn-calving (odds ratio [OR] = 1.96) and winter-calving (OR = 2.04) cows than in spring-calving cows. In conclusion, spring calving is associated with the worst, and autumn calving with the best, postpartum health and reproductive performance, whereas milk yield is higher in spring-calving cows than in summer-calving cows. Therefore, an effective strategy to support postpartum health and fertility should be instituted for spring-calving dairy cows kept in the Korean climate.

• Journal of Korean Neurosurgical Society
• /
• v.65 no.4
• /
• pp.507-513
• /
• 2022

Objective : The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson's disease (PD). Methods : Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD. Results : After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837-4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795-4.511). According to a subgroup analysis, in males and females aged <65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control. Conclusion : Individuals with PD have a greater chance of AMI, according to this cross-national study.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.13 no.8
• /
• pp.667-673
• /
• 2001

As an alternative cooling method to reduce environmental hazard, vortex tubes have been studied for energy separation into cold and hot streams. Hence, the experiments were carried out systematically to find the best ratio of vortex chamber diameter to tube diameter. Also, the work was don to investigate how inlet pressure and geometric ratios of vortex tube affected temperature differences at tow needs as ell as cooling capacity and cooling efficiency. The result showed that the maximum temperature differences at the both ends and the maximum cooling efficiency were obtained when the ratio of vortex chamber diameter was about 1.45, while the inlet pressure ws not higher than 0.7 MPa.

• Earthquakes and Structures
• /
• v.11 no.2
• /
• pp.245-264
• /
• 2016

A suitable ground motion intensity measure (IM) plays a crucial role in the seismic performance assessment of a structure. In this paper, we introduce a scalar IM for use in evaluating the seismic response of single-layer reticulated domes. This IM is defined as the weighted geometric mean of the spectral acceleration ordinates at the periods of the dominant vibration modes of the structure considered, and the modal strain energy ratio of each dominant vibration mode is the corresponding weight. Its applicability and superiority to 11 other existing IMs are firstly investigated in terms of correlation with the nonlinear seismic response, efficiency and sufficiency using the results of incremental dynamic analyses which are performed for a typical single-layer reticulated dome. The hazard computability of this newly proposed IM is also briefly discussed and illustrated. A conclusion is drawn that this dominant vibration mode-based scalar IM has the characteristics of strong correlation, high efficiency, good sufficiency as well as hazard computability, and thereby is appropriate for use in the prediction of seismic response of single-layer reticulated domes.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.2 no.4 s.7
• /
• pp.77-85
• /
• 2002

Korean government compensates 100% for natural disaster relief fund to public facilities, and provides 70 percents to crops through unit price calculation. This study estimated disaster damage according to the standard production cost of crops. Disaster damage was estimated according to the unit price of crops. Those crops are lettuce, pumpkin, red pepper, spinach, tomato and cucumber. As a result, the ratio of natural disaster relief fund to damage was revealed as $3.3%{\sim}13.8%$ with present method, 5.7%{$\sim}34.1%$ with suggested method. Suggested method is the first one considered damage ratio of crops, producer price and raising period.

• PNF and Movement
• /
• v.17 no.2
• /
• pp.253-261
• /
• 2019

Purpose: The purpose of this study was to identify the causal relationship between workplace stress and working posture and the development of work-related neck pain in office workers. Methods: The study participants included 62 office workers who had not experienced neck pain in the previous 12 months. A battery of measures to evaluate potential workplace risk factors in an office setting were conducted at baseline, and the 12-month incidence of work-related neck pain was reported via monthly questionnaires. Survival analysis was used to evaluate the longitudinal relationship between the workplace risk factors and the development of work-related neck pain. Results: The incidence of work-related neck pain was 1.91 (95% CI: 1.06-3.45) per 100 person months. The incidence of neck pain was predicted to be less likely to happen when workers had a more upright thorax posture during computer work (hazard ratio, 0.94; 95% CI: 0.89-0.99). However, stress may deteriorate the preventative effects of other risk factors on neck pain and showed a positive relationship with episodes of neck pain (hazard ratio, 1.37; 95% CI: 1.03-1.84). Conclusion: Understanding the psychophysiological effects of neck pain may explain the development of neck pain in office workers. Our interest in prevention plans and treatments should therefore involve a multifactorial pathology of neck pain in the workplace.

• The Korean Journal of Nuclear Medicine
• /
• v.34 no.1
• /
• pp.39-54
• /
• 2000

Purpose: Dipyridamole stress myocardial perfusion SPECT could predict prognosis, however, long-term follow-up showed change of hazard ratio in patients with suspected coronary artery disease. We investigated how long normal SPECT could predict the benign prognosis on the long-term follow-up. Materials and Methods: We followed up 1169 patients and divided these patients into groups in whom coronary angiography were performed and were not. Total cardiac event rate and hard event rate were predicted using clinical, angiographic and SPECT findings. Predictive values of normal and abnormal SPECT were examined using survival analysis with Mantel-Haenszel method, multivariate Cox proportional hazard model analysis and newly developed statistical method to test time-invariance of hazard rate and changing point of this rate. Results: Reversible perfusion decrease on myocardial perfusion SPECT predicted higher total cardiac event rate independently and further to angiographic findings. However, myocardial SPECT showed independent but not incremental prognostic values for hard event rate. Hazard ratio of normal perfusion SPECT was changed significantly (p<0.001) and the changing point of hazard rate was 4.4 years of follows up. However, the ratio of abnormal SPECT was not. Conclusion: Dipyridamole stress myocardial perfusion SPECT provided independent prognostic information in patients with known and suspected coronary artery disease. Normal perfusion SPECT predicted least event rate for 4.4 years.