• Interdisciplinary Bio Central
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• 제5권4호
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• pp.8.1-8.3
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• 2013

Unlike the traditional view, it is not mysterious about how G. Mendel chose the seven characters of the pea, Pisum sativum, that he studied. He first chose the pea that met three conditions he set up and repeated experiments for two years. Apparently, he knew that those characters were controlled by countable elements. Then, he derived the prediction on the basis of his idea about the elements, and selected the seven characters that satisfied the prediction. He knew "no prediction no science". In population genetics the Hardy-Weinberg principle is well known and cited in many papers and books. However, Mendel already derived the same principle in his paper, because he was acquainted also with physics and mathematics. Actually, the principle was trivial when they derived, but not at all when Mendel did. It is also well known that Mendel's laws were forgotten and rediscovered at the term of the 19th century. That may not be true either. His laws were internationally well known before the rediscovery. In fact, the 1881-year version of the Encyclopedia Britannica contains his laws.

• Journal of the Korean Data and Information Science Society
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• 제23권2호
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• pp.411-417
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• 2012

In this paper, we consider the estimation of multinomial proportions. Multinomial distribution is the most important multivaritate distribution. Estimation of multinomial parameters for multinomial distribution is widely applicable to many practical research areas including genetics. We investigated the properties of several frequency substitution estimates and derived the maximum likelihood estimate of multinomial proportions of Hardy Weinberg proportions. Phenotype and genotype frequencies of allele are used to the estimation of multinomial proportions. These estimates are then analyzed via numerical data. Small sample Monte Carlo simulation is conducted to compare considered estimates of multinomial proportions.

• Asian-Australasian Journal of Animal Sciences
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• 제26권7호
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• pp.911-915
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• 2013

The aim of this study was to investigate allele frequencies at the CSN1S2 locus in two Chinese dairy goat breeds and the effects of its variation on dairy goat economic traits. Seven hundred and eight goats from Xinong Saanen (XS, n = 268) and Guanzhong (GZ, N = 440) breeds were selected. The milk samples of 268 XS goats were collected during the middle of lactation, body size parameters (708 goats) and daily milk yield (202 goats) were registered. The RFLP (restriction fragment length polymorphism) and SSCP (single strand conformation polymorphism) were used to detect the polymorphisms in CSN1S2. The Hardy-Weinberg (HW) equilibrium and the associations between body size, milk yield and composition and the genotypes were calculated. The results revealed that only A and F CSN1S2 alleles were found in the two Chinese dairy goat breeds. Allelic frequencies of A and F were 0.795, 0.205 and 0.739, 0.261 in Xinong Saanen and Guanzhong population respectively. Xinong Saanen breed was in Hardy-Weinberg equilibrium, while Guanzhong breed deviated from Hardy-Weinberg equilibrium (p<0.05). The association of polymorphism with economic traits indicated that the goats with FF genotype have higher milk fat and total solid concentration than those with AA and AF genotypes (p<0.05).

• Asian-Australasian Journal of Animal Sciences
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• 제21권6호
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• pp.776-783
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• 2008

In this study, we investigated the genetic diversity and phylogenetic relationship of six duck populations by employing the genetic polymorphisms of 20 microsatellites. The parameters used in this study included number of alleles, average effective numbers of alleles (E) and average rates of heterozygosity of each population. The results showed that all the microsatellite loci were highly polymorphic except that the locus AJ515896 in Muscovy duck was 0. The average PIC (0.762), average h (0.7843) and average E (5.261) of the six duck populations were all high, indicating that the gene polymorphisms and genetic diversity were high. The test of Hardy-Weinberg equilibrium showed that the six populations in this study were all in Hardy-Weinberg disequilibrium. The F-statistic analysis results showed the range of FST was from 0.0205 (AJ515895) to 0.2558 (AJ515896). The mean FST was 0.0936. Phylogenetic study revealed that Peking duck (Z1 and Z4), Shaoxing duck, Cherry Valley duck and Aobaixing duck were clustered in one group, while the Muscovy duck was clustered in one group alone. The phylogenetic relationships among different populations were in accordance with their breeding history and distribution. Our data suggested that the 20 microsatellite loci were effective markers for analysis of genetic relationships among duck populations.

• Asian-Australasian Journal of Animal Sciences
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• 제21권11호
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• pp.1535-1543
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• 2008

Microsatellites (MS) are useful for quantifying genetic variation within and between populations and for describing the evolutionary relationships of closely related populations. The main objectives of this work were to estimate genetic parameters, measure genetic distances and reconstruct phylogenetic relationships between Australian Angora/Angora_Aus/ and Cashmere/Cashmere_Aus/ populations and three Mongolian Cashmere goat (Bayandelger/BD/, Zavkhan Buural/ZB/, and Gobi Gurvan Saikhan/GGS/) populations based on variation at fourteen MS loci. The level and pattern of observed and expected heterozygosity and polymorphic information content of the fourteen loci studied across the populations were quite similar and high. Except for SRCRSP07, all studied microsatellites were in Hardy-Weinberg Equilibrium (p<0.001). Moderate genetic variation (7.5%) was found between the five goat populations with 92.5% of total genetic variation attributable to diversity existing between the individuals within each population. The greatest Nei's genetic distances were found between the Angora and four Cashmere populations (0.201-0.276) and the lowest distances were between the Mongolian Cashmere goat populations (0.026-0.031). Compared with other Cashmere goat populations, the GGS (crossbred with Russian Don Goats) population had the smallest pairwise genetic distance from the Australian Angora population (0.192). According to a three-factorial correspondence analysis (CA), the three different Mongolian Cashmere populations could hardly be distinguished from each other.

• 응용통계연구
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• 제15권1호
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• pp.85-105
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• 2002

본 연구에서는 유전자 검사자료에서 각 유전자좌내 및 유전자좌간의 대립형질들간의 관계를 파악하기 위한 탐색적 방법을 고려하였다. 이를 위해 유전자데이터를 재배열한 후 대응분석 및 다중대응분석의 알고리즘을 적용하여 이를 수량화, 그래프화하는 방법 및 대응행렬도를 적용한 방법을 제안하였다 이러 한 수량화 및 그래프 결과가 하디-와인버그 평형검정 및 연관균형검정 결과와 어떤 관계가 있는지 알아보고 실제 한국인 집단에 대한 STR 유전자좌 자료를 이용하여 결과를 비교하였다.

• 생물정신의학
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• 제7권2호
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• pp.152-158
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• 2000

정신분열병과 DRD4 다형성이 연관이 없다는 보고들이 있어왔다. 그러나 지금까지의 결과로부터 정신분열병과 DRD4가 연관이 없다고 결론 내리는 것은 성급한 것일 수도 있다. 정신분열병의 유전적 취약성은 여러 유전자좌(locus)들이 같이 상호작용(interaction) 또는 공작용(coaction)에 의한 것일 가능성이 크다. 저자들은 DRD4 유전자의 exon III 48-염기쌍 다형성 [D4E3]과 exon I 12-염기쌍 다형성[D4E1]의 조합과 정신분열병의 연관성에 관하여 연구하였다. 207명의 친척이 아닌 한국인 정신분열병 환자와 191명의 정상 대조군이 연구에 참여했다. DRD4 유전자형을 중합효소연쇄반응을 통하여 확인하였으며, 정신분열병 환자군과 정상 대조군의 유전자형과 대립유전자의 빈도간의 차이를 연구하였다. 두 군간에 다형성에 있어 통계적 유의한 차이는 보이지 않았으며, 모든 유전자형의 빈도는 Hardy-Weinberg equilibrium에서 예상되는 분포와 유의한 차이가 없었다. 정신분열병 환자군과 정상 대조군에서 DRD4 유전자의 다형성을 조합하여, D4E1과 D4E3 다형성의 조합의 분포에 있어 비교하였을 때, $A1A2^*2/4$의 분포에 있어 두 군간에 유의한 차이가 있었다(p<0.01). 이러한 소견은 D4E1과 D4E3 다형성의 조합중 하나인 $A1A2^*2/4$이 정신분열병의 취약성에 있어 방어적인 역할을 할 가능성을 시사하는 것이다.

• Journal of the Korean Data and Information Science Society
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• 제10권2호
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• pp.465-472
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• 1999

We considered a bootstrap method for constructing confidenc intervals for a one parameter model using multinomial sampling. The convergence rates or the proposed bootstrap method are calculated for model-based maximum likelihood estimators(MLE) using multinomial sampling. Monte Carlo simulation was used to compare the performance of bootstrap methods with normal approximations in terms of the average coverage probability criterion.

• Journal of the Korean Data and Information Science Society
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• 제18권3호
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• pp.599-608
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• 2007

This study was conducted to establish an individual identification system in Hanwoo cattle. Samples of 33 Hanwoo individuals from Korean elite sire families were used. Thirteen major microsatellite markers were selected from alleles amplified, their frequencies, H(Heterozygosity) and PIC(Polymorphism Information Content) with Hardy-Weinberg equilibrium. Next, in order to evaluate the power of the markers selected on the individual animal identification, MP(Match probability) and R(Relatedness coefficient) with the percentage of animal incorrectly identified were computed. Finally nine microsatellite markers were selected and discussed.

• 생명과학회지
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• 제17권7호통권87호
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• pp.882-888
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• 2007

전분 젤 전기영동을 사용하여 한국내 분포하는 동자개 여섯 집단에서 유전적 다양성과 집단구조를 평가하였다. 14개 대립유전자좌위에서 9좌위가 다형현상을 나타내었다(64.3%). 종수준과 집단수준에서 유전적 다양성은 각각 0.286과 0.277이였다. Wright의 고정지수에서 Hardy-Weinberg 평형에 비해 전반적인 이형접합체 결핍이 나타났다. 이 결핍은 집단내 유효한 개체수의 부족을 시사한다. 집단간 유전적 분화 정도는 0.064로 대부분의 유전적 변이(93.6%)가 집단내에 있음을 의미한다. 간접적으로 평가된 집단간 이주하는 개체수는 3.67로 나타났다. 제한된 유전자 유동과 유효집단의 감소는 유전적 부동을 유발하고, 주기적인 포획으로 인한 개체수의 감소는 유전자 상실로 이어지고 있다. 대부분의 집단이 겨울철 가뭄과 여름철 홍수로 심한 병목을 겪고 있었다.