• 한국축산식품학회지
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• 제22권1호
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• pp.55-58
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• 2002

본 연구는 생리활성 casein phosphopeptide의 경제적인 생산방법과 CPP의 칼슘 가용화 능력을 검정하기 위하여 수행되었다. 먼저 정제된 CPP-III는 N 13.1%, P 2.3∼2.4%, N/P비 5.4∼5.6 정도로 CPP 순도가 매우 높은 것으로 나타났다. 경제적인 면을 고려하여 CPP-III보다는 순도가 떨어지는 CPP-I, CPP-II의 제조방법을 확립하였다. 한편 CPP의 칼슘가용화 능력을 생리적 pH 조건하에서 검정한 결과 CPP와 polygutamic acid는 Ca 침전 형성 저지효과가 현저하였으나, DPP는 효과가 없었다.

• Journal of Dairy Science and Biotechnology
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• 제36권3호
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• pp.164-170
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• 2018

본 연구에서는 CPP와 CSO를 사용하여 약 187~282 nm 크기의 균일한 구형의 나노 복합체를 성공적으로 제조하였다. 나노 복합체는 제조 공정 요인인 CPP 농도와 pH 조절을 통해 입자 크기, 다분산 지수, 그리고 표면 전하와 같은 나노 복합체의 물리화학적 특성을 조절할 수 있음을 확인하였다. 또한 CPP/CSO 나노 복합체의 분말화 공정을 통해 분말화 된 나노 복합체의 식품 적용성을 증진시킬 수 있음을 알 수 있었으며, food-grade 물질인 CPP와 CSO를 사용하여 제조한 나노 복합체는 향후 잠재적인 칼슘 전달체로써 식품 산업에 이용될 수 있을 것으로 기대된다.

• Journal of Dairy Science and Biotechnology
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• 제39권1호
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• pp.27-35
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• 2021

본 연구에서는 CPP와 CSO를 사용하여 제조한 나노 복합체의 유식품 적용성 및 포집된 생리활성물질인 비타민 D의 in vitro release를 평가하였다. 그 결과, CPP/CSO 나노 복합체는 model milk 및 model yogurt 적용 후 12일간의 저장기간 동안 높은 물리적 안정성을 지녀 식품 적용성이 뛰어남을 규명하였다. 또한 제조 공정 요인인 CPP 농도와 pH 조절을 통해 비타민 D를 90% 이상 포집할 수 있었으며, in vitro release 평가를 통해 비타민 D를 위에서 보호하고, 장에서 release 하는 나노 복합체의 특성을 규명하였다. 결론적으로 본 연구에서 제조된 CPP/CSO 나노 복합체는 뛰어난 유식품 적용성을 지닐 뿐만 아니라, 칼슘흡수 증진을 위한 비타민 D를 효과적으로 포집할 수 있으며, 포집된 비타민 D를 소장까지 안전하게 전달할 수 있는 효과적인 나노 전달체로 활용될 수 있을 것으로 기대된다.

• 전자통신동향분석
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• 제15권6호통권66호
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• pp.85-93
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• 2000

본 고에서는 이동전화요금부과방식으로서 발신자부담방식(CPP)과 수신자부담방식(RPP)의 개념과 장.단점, CPP와 RPP 도입국가의 운영현황을 조사 분석하였다. 아울러 RPP를 CPP로 전환할 경우 발생되는 문제점과 영향에 대해서도 조사하는 한편 그 시사점을 분석 제시하였다.

• 한국치위생학회지
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• 제8권1호
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• pp.13-22
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• 2008

This study compared tooth's remineralization using enamel surface artificially demineralized with 0.1M lactate and HCL solution using Vicker's Hardness Number(VHN) to compare CPP-ACP and remineralization of nano-sized Carbonate Apatite's initial caries. Using pH circulation models divided into 0% nano-CA, 5% nano-CA, 10% nano-CA, 10% CPP-ACP and D.W. they were treated for 5 minutes, three times a day for 14 days to get the following results. 1. There were no significant differences among the initial surface hardness of samples demineralized surface of front tooth in 5 groups. and all 5 groups' surface hardness reduced significantly after demineralization of enamel. 2. When inquiring into hardness changes through pH circulation model, the highest hardness change was in 5% nano-CA group. Also. 10% nano-CA and 10% CPP-ACP groups increased significantly. but there was no significant difference statistically. In generalizing the above experiment results, nano-sized Carbonate Apatite showed remineralization, and compared to 10% CPP-ACP group, 5% nano-CA had remineralization to artificial caries. thus implies that when we develop method to contact with tooth of nano-CA in the future, it is expected to gain synergy effect on function of saliva, a natural remineralization material.

• 말소리와 음성과학
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• 제4권4호
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• pp.71-77
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• 2012

Sasang constitution experts utilize voice characteristics as an auxiliary measure for deciding a person's constitutional group. This study aims at establishing a relationship between speech features and the constitutional groups by subjective listening evaluation of voice characteristics. A speech database of 841 speakers whose constitutional groups have been already diagnosed by Sasang constitution experts was constructed. Speech features related to speech source and vocal tract filter were extracted from five vowels and one sentence. Statistically significant speech features for classifying the groups were analyzed using SPSS. The features contributed to constitution classification were speaking rate, Energy, A1, A2, A3, H1, H2, H4, CPP for males in their 20s, F0_mean, CPP, SPI, HNR, Shimmer, Energy, A1, A2, A3, H1, H2, H4 for females in their 20s, Energy, A1, A2, A3, H1, H2, H4, CPP for male in the 60s, and Jitter, HNR, CPP, SPI for females in their 60s. Experimental results show that speech technology is useful in classifying constitutional groups.

• 한국미생물·생명공학회지
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• 제21권5호
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• pp.468-472
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• 1993

For the production of Casein Phosphopeptide(CPP) inhibiting the insolubility of calcium, 10% sodium caseinate was treated with 1.5% of protease from Streptococcus sp.. Optimal conditions and productivity for the CPP production, and properties of the CPP were compared with tryptic hydrolysates of sodium caseinate. Optimum conditions of pH, temperature and reaction time were 8.0, 50C, 4 hrs, respectively. Under these conditions the productivity of CPP was 23% and Molecular weight of CPP was ranged from 3, 000 to 17, 000. The results also showed that the insolubility of calcium was completely inhibited by using 1.5 times of CPP for the amount of calcium.

• KSBB Journal
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• 제23권1호
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• pp.59-64
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• 2008

Streptococcus faecalis var. liquefaciens를 calcium alginate gel에 고정화 후 CPP생산 가능성을 실험하였다. 균체를 회수하여 담체에 고정화하는 방법보다는 배양액 전체를 고정화하는 방법이 보다 높은 생산성으로 CPP를 생산하였다. Streptococcus faecalis var. liquefaciens 전세포 고정화 방법에 의한 sodium casenate로부터의 CPP 생산의 최적조건은 bioreactor부피대비 bead사용량이 30%, 반응온도는 $50^{\circ}C$, 반응 pH는 7.0, 기질의 농도는 10% 이었다. 또한, 고정화 균체를 이용한 연속적인 생산은 회분식 반응에서 설정된 최적 조건하에서 20% 수준의 CPP를 최소한 1개월 이상 연속적으로 생산할 수 있었다.

• 말소리와 음성과학
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• 제6권2호
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• pp.47-54
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• 2014

The purpose of this study was to analyze spectral versus cepstral measurements in esophageal speakers. The comparison between the measurements in thirteen male esophageal speakers was compared with the control group of thirteen normal speakers using the sustained vowel /a/. The main results can be summarized as below: (a) the CPP and L/H ratio of the esophageal group were significantly lower than those of the control group (b) the CPP was significantly correlated with the spectral parameters such as jitter, shimmer, NHR and VTI, and (c) the ROC analysis showed that the threshold of 10.25dB for the CPP achieved a good classification for esophageal speakers, with 100% perfect sensitivity and specificity. Thus, it was known that cepstral-based acoustic measures such as CPP, may be more reliable predictors than other spectral-based acoustic measures such as jitter and shimmer. And it was found that cepstral-based acoustic measures were effective in distinguishing esophageal voice quality from normal voice quality. This research will contribute to establishing a baseline related to speech characteristics in voice rehabilitation with laryngectomees.

• 대한수의학회지
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• 제40권3호
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• pp.431-437
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• 2000

The aim of this study was to evaluate the involvement of CPP32 (caspase-3), one of the death-related enzymes, in the course of experimental autoimmune encephalomyelitis (EAE). EAE was induced in Lewis rats immunized with an emulsion of rat spinal cord homogenate with complete Freunds adjuvant supplemented with Mycobacterium tuberculosis (H37Ra, 5mg/ml). The expression of CPP32 in the spinal cords of rats with EAE was studied. In normal rat spinal cords, CPP32 is constitutively, but weakly, expressed in neurons and some neuroglial cells. In the EAE spinal cords, many inflammatory cells were positive for CPP 32, and the majority of CPP32(+) cells were identified as ED1(+) macrophages. During this stage of EAE, the number of CPP32(+) cells in brain cells, including neurons and astrocytes, increased, and these cells also had increased CPP32 immunoreactivity. CPP32 immunor eactivity was not always matched with apoptosis of inflammatory cells in EAE lesions. We speculate that CPP32, which is constitutlvely expressed in brain cells, increases in response to neuroimmunological stimulation in both brain neuronal cells and inflammatory cells. The functional role of CPP32 in neuroimmunological disorders is discussed.