• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.4
• /
• pp.1081-1091
• /
• 2012

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematologic neoplasms characterized by morphologic dysplasia, aberrant hematopoiesis and peripheral blood refractory cytopenias. MDS is recognized to be associated with an increased risk of symptomatic anemia, infectious complications and bleeding diathesis, as well as a risk of progression to acute myeloid leukemia, particularly in patients with a high IPSS score. The advent of use of hematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) and recombinant erythropoietin (EPO) has improved symptoms in MDS patients in addition to some data that suggest there might be an improvement in survival. G-CSF is an effective therapeutic option in MDS patients, and it should be considered for the management of refractory symptomatic cytopenias. G-CSF and EPO in combination can improve outcomes in appropriate MDS patients such as those with lower-risk MDS and refractory anemia with ring sideroblasts (RARS). This article reviews use of growth factors for lower-risk MDS patients, and examines the data for G-CSF, EPO and thrombopietic growth factors (TPO) that are available or being developed as therapeutic modalities for this challenging disease.

• Animal Bioscience
• /
• v.37 no.5
• /
• pp.839-851
• /
• 2024

Objective: The main goal of our current study was to improve the growth curve of meat animals by decreasing the birth weight while achieving a finishing weight that is the same as that before selection but at younger age. Methods: Random regression model was developed to derive various selection indices to achieve desired gains in body weight at target time points throughout the fattening process. We considered absolute and proportional gains at specific ages (in weeks) and for various stages (i.e., early, middle, late) during the fattening process. Results: The point gain index was particularly easy to use because breeders can assign a specific age (in weeks) as a time point and model either the actual weight gain desired or a scaled percentage gain in body weight. Conclusion: The point gain index we developed can achieve the desired weight gain at any given postnatal week of the growing process and is an easy-to-use and practical option for improving the growth curve.

• Journal of the Korean Society of Safety
• /
• v.33 no.4
• /
• pp.78-83
• /
• 2018

Previous researches on the analysis of algae concentration were restricted to applying single-valued decay coefficient during simulation period, and the accuracy as well as the applicability were severely challenged. In this study, an equivalent tracking method of decay coefficient was proposed by introducing the time-series decay coefficients and restart option. Dye module in EFDC model was employed to route the temporal variation of Chl-a concentration. It was shown that the simulation results can be significantly improved up to 46% when the equivalent tracking method was activated.

• Molecules and Cells
• /
• v.44 no.5
• /
• pp.356-362
• /
• 2021

An increasing number of studies have revealed an interaction between gut microbiota and tumors. The enrichment of specific bacteria strains in the intestines has been found to modulate tumor growth and influence the mechanisms of tumor treatment. Various bacteria are involved in modulating the effects of chemotherapeutic drugs currently used to treat patients with cancer, and they affect not only gastrointestinal tract tumors but also distant organ tumors. In addition, changes in the gut microbiota are known to be involved in the antitumor immune response as well as the modulation of the intestinal immune system. As a result, the gut microbiota plays an important role in modulating the efficacy of immune checkpoint inhibitors. Therefore, gut microbiota could be considered as an adjuvant treatment option with other cancer treatment or as another marker for predicting treatment response. In this review, we examine how gut microbiota affects cancer treatments.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.9
• /
• pp.1527-1535
• /
• 2018

Bacterial strain BAS23 was isolated from rice field soil and identified as Bacillus amyloliquefaciens. Based on dual culture method results, the bacterium BAS23 exhibited potent in vitro inhibitory activity on mycelial growth against a broad range of dirty panicle fungal pathogens of rice (Curvularia lunata, Fusarium semitectum and Helminthosporium oryzae). Cell-free culture of BAS23 displayed a significant effect on germ tube elongation and mycelial growth. The highest dry weight reduction (%) values of C. lunata, H. oryzae and F. semitectum were 92.7%, 75.7%, and 68.9%, respectively. Analysis of electrospray ionization-mass spectrometry (ESI-MS) and $^1H$ nuclear magnetic resonance (NMR) spectroscopy revealed that the lipopeptides were iturin A with a C14 side chain (C14 iturinic acid), and a C15 side chain (C15 iturinic acid), which were produced by BAS23 when it was cultured in nutrient broth (NB) for 72 h at $30^{\circ}C$. BAS23, the efficient antagonistic bacterium, also possessed in vitro multiple traits for plant growth promotion and improved rice seedling growth. The results indicated that BAS23 represents a useful option either for biocontrol or as a plant growth-promoting agent.

• The Journal of Industrial Distribution & Business
• /
• v.8 no.1
• /
• pp.15-22
• /
• 2017

Purpose - Retail companies are turning from one type of retailer to multiple business categories through various reasons, such as taking advantage of existed types of retailers' channel distribution, information and know-how, and entering into new types of retailers. However, there is few research conducted about multiple type of retailers. Research design, data, and methodology - In this research, the references, data and new stores on E-mart will be collected. The dissertation, annual report, statistical data, land-book of E-mart will be also collected to confirm whether E-mart has made any acquisition towards another company. Results - There is a tendency to new stores expansion, store enlargement and prolonging the opening preparation of new stores, based on the core of new stores expansion of E-mart as a general supermarket type of retailers. Based on general supermarket type of retailers, E-mart begins to diversify its retail company's type of retailers. Conclusions - As a general supermarket which is the most important type of retailers, E-mart is expanding into SSM type of retailers to seek new power of growth while slowdown growth is shown in general supermarket type of retailers. The expansion into SSM type of retailers would be a wise option as a retail company, E-mart is able to keep growing in the future.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.43 no.2
• /
• pp.65-71
• /
• 2020

Worldwide plant market keeps maintaining steady growth rate and along with this trend, domestic plant market and its contractors also maintain such growing tendency. However, in spite of its external growth, win-win growth of domestic material industry that occupies the biggest share in plant industry cost portion is extremely marginal in reality. Domestic plant material suppliers are required to increase awareness of domestic material brand by securing quality and reliability of international standard through improvement of design quality superior to that of overseas material suppliers. Improvement of design quality of plant material becomes an essential element, not an option, for survival of domestic plant industry and its suppliers. Under this background, in this study, priority and importance by each evaluation index was analyzed by materializing plant design stage through survey of experts and defining evaluation index by each design stage and based on this analysis result, evaluation index of stage-gate based decision-making process that may improve design quality of plant material was suggested. It is considered that by utilizing evaluation index of stage-gate based decision-making process being suggested in this study, effective and efficient decision-making of project decision-makers would be enabled and it would be contributory to improve design quality of plant material.

• Korean Journal of Organic Agriculture
• /
• v.18 no.2
• /
• pp.135-154
• /
• 2010

The green craze has hit all the world lately. The green revolution which means immense changes for sustainable development under the new environment-economy system is foretelling that we should have new angle to the environment and economy. This paper is about the development of the model and indicators for construction of ECO(Energy Circulating Organic)-Village which is the green growth option of local community. This model is composed of three concepts - SPDC (about procedural methodology of Model), Virtuous Circle (about functional relationships of three requisites), Network (about spatial relationships between communities) - and evaluation indicators. Environment, tourism, industry (Energy & Organic Agriculture) are set as the three requisites for green growth of local community. Nations of the world plunge into the green war which is silent, general, sweeping changes. We can not win this war with the existing thinking system and policy. We need revolutionary changes reconsidering of environmental value and sustainable development strategy of the region. Each of us should go through the changes and this work would be the one among those efforts.

• Journal of Korean Society of Forest Science
• /
• v.89 no.2
• /
• pp.232-240
• /
• 2000

Correlation between Songyi(Tricholoma matsutake, pine mushroom, matsutake) production and the annual pine tree growth in Korea was analyzed with 18 years data of the mushroom production in Sangju area and the annual ring-growth of pine trees at Mt Sogni in the area. The two parameters were not significantly related to each other(r=0.408). A possible reason of this low relationship is that September and October climate affected annual Songyi production through mushroom primordial formation, continued growth of the primordia, while May and June climate did the annual tree-ring growth. Songyi production at Mt. Wolak in Chungcheongbukdo peaked while the minimum daily air temperature ranged about $7^{\circ}C$ to $13^{\circ}C$ during the first week of October in 1999. These show that Songyi production variation is not a simple trend depending on the energy the pine trees have accumulated. Rather, controlling soil moisture and air temperature during Songyi fruiting season can be a significant management option for improving the mushroom production.

• Biomolecules & Therapeutics
• /
• v.19 no.2
• /
• pp.231-236
• /
• 2011

The aim of this study was to investigate the effect of charge carrier lipid on the skin penetration, retention, and hair growth of topically applied finasteride-containing liposomes. Finasteride-containing liposomes were prepared by traditional thin film hydration method using Phospholipon$^{(R)}$ 85 G and cholesterol with or without charge carrier lipid (1,2 dimyristoyl-sn-glycero-3-phosphate or 1,2-dioleoyl-trimethylammonium-propane for anionic and cationic charge, respectively). Freshly prepared finasteride-containing liposome suspension was applied on the hairless mouse skin, and skin penetration and retention were measured using Keshary-Chien diffusion cell. Non-liposomal formulation (ethanol 10% solution containing 0.5 mg/ml of FNS) was also used as a control. The amount of finasteride in the diffusion cell and mouse skin was measured by HPLC. The hair growth was evaluated using depilated male C57BL/6N mice. Mean particle size of all finasteride-containing liposomes was less than a micron, and polydispersity index revealed size homogeneity. Skin penetration and retention studies showed that significantly less amount of finasteride was penetrated when applied as anionic liposome while more amount of the drug was retained. Specifically, in liposome prepared with 10% anionic charge carrier lipid, penetration was 12.99 ${\mu}g/cm^2$ while retention was 79.23 ${\mu}g/cm^2$ after 24 h of application. In hair growth study, finasteride-containing anionic liposomes showed moderate efficacy, but the efficacy was not found when applied as cationic liposomes. In conclusion, topical application of finasteride using anionic liposome formulation appears to be useful option for the treatment of androgenetic alopecia to avoid systemic side effects of the drug.