• 한국연초학회지
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• 제11권1호
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• pp.27-39
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• 1989

This study was conducted to determine the time and methods of predicting tobacco yield. by analysis of climatic factors in the period of tobacco season during 8 years from 1979 to 1986 at the Daegu district, south eastern part of Korean peninsular. The results obtained are summarised as follows: 1. Climatic factors of each month which have influence on tobacco yield were the amount of rainfall in May and sunshine hours in July. Among climatic factors at tobacco growth stages, the precipitation yield. But these meteorological factors had different effect on variety. 2. Between tobacco yields and climatic factors by even values of each month, tobacco yield was estimated by equations, flue cured tobacco :Y=190.6-5.230X1+ 0.474$\times$2 + 0.142X3(Xl : Minimum temperature of April, X2: Precipitation during May, X3:Sunshine duration on July), air cured tobacco : Y= 195.3-0.447Xl + 0.363$\times$2 + 0.l12$\times$3(Xl :Maximum temperature of May, X2:Precipitation during May. X3: Sunshine duration on July). While between tobacco yield and climatic factors at different growth stage, predicting equation of yield could be derived, flue cured tobacco : Y=205.8+0.510Xl +0.289$\times$2 + 0.305$\times$3 (Xl :Average temperature during the early growth stage, X2 :Precipitation during the early and maximum growth stage, X3 : Sunshine hours during the leaf and tips maturing stage), air cured tobacco Y=194.T-0.498Xl 10.615$\times$2+0.121$\times$3(Xl ;Maximum temperature during the transplanting time, X2 : Precipitation during the maximum growth stage, X3 : Sunshine hours during the leaf and tips maturing stage).

• 한국산림과학회지
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• 제83권3호
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• pp.380-390
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• 1994

우리나라의 해안지역(海岸地域)에서 주로 생육(生育)하고 있는 해송임분(海松林分)을 대상으로 하여 그의 수고생장(樹高生長)과 생장(生長)에 영향(影響)을 미칠 것으로 예상(豫想)되는 16개의 지형인자(地形因子)와 13개의 토양인자(土壤因子) 그리고 9개의 기상인자(氣象因子)와의 관계(關係)를 분석(分析)하였다. 해송(海松)의 수고생장(樹高生長)에 영향(影響)을 미치는 인자(因子)는 지형인자(地形因子)의 국소지형, 토양견밀도, 토양B층깊이, 유효토심, 토양습도, 모암, 토성 등과 토양인자(土壤因子)의 유효인산, 전질소함량, 염기포화도, 치환성 $Ca^{{+}+}$ 등 그리고 기상인자(氣象因子)의 상대습도와 총강수량으로 나타나 이들 인자(因子)가 수고생장(樹高生長)에 기여(寄與)하고 있음을 알 수 있었다. 따라서 임목(林木)의 생장(生長)에는 지형(地形), 토양(土壤), 기상인자(氣象因子)등이 상호 복합적으로 관여(關與)하고 있으므로, 이들 관여인자(關與因子) 상호간의 관계를 구명(究明)하여 임지(林地)의 임목생산력(林木生産力)을 추정(推定)하고, 적지적수(適地適樹)를 판정(判定)하며, 비배관리(肥培管理) 지침(指針)을 설정(設定)하므로써 해송임분(海松林分)의 합리적(合理的) 경영관리(經營管理)에 기여(寄與)할 것으로 기대(期待)된다.

• 동국한의학연구소논문집
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• 제9권
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• pp.1-23
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• 2000

Osteoporosis is a common disorder characterized by reduced bone mineral density, deterioration of the microarchitecture of bone tissue and increased risk of fracture. The aim of treatment of osteoporosis is to maintain and, ideally, to restore bone strength safely. In recent years the role of polypeptide growth factors in bone metabolism has begun to appear. It has been proposed that alterations in the expression or production of growth factor can modulate the proliferation and activity of bone forming cells. Thus, the role of structurally diverse peptides for the management and diagnosis of osteoporosis has attracted the attention of many investigators. This paper reviews numerous findings concerning the use of polypeptides, hormones, and growth factors, for the management of osteoporosis. Many of the compounds mentioned here are experimental prototypes of new therapeutic classes. Though it is unlikely that some of the compounds may ever be used clinically, development of safe and efficacious agents in each class will define the future course of therapy for osteoporosis.

• 경영과학
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• 제34권1호
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• pp.15-25
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• 2017

We evaluated industry growth and employment effects of every possible pairs of 22 manufacturing sectors and 16 regions (i.e, 352 region-sectors). We used annual data of manufacturing sectors from 2008 to 2014 for the evaluation. The evaluation comprises of two steps; We first find several region-sectors that outperform others with respect to the effects of industry growth and employment, which are measured by location quotient analysis, shift share method, employment to GDP ratio and employment elasticity. In addition, cross-efficiency analysis follows to classify region-sector pairs into two sub-categories : efficient region-sectors that deserve to hold the current level of investments and inefficient region-sectors where we should consider efficiency improvements. To examine the efficiency, R&D investment, employment size, and capital investment were used as input factors and production volume, added value, changes in employment size, changes in annual salary per capita were used as output factors. For region-sector pairs that have outstanding growth and employment effects but are inefficient, we employed a CCR DEA model and analyzed how much to adjust the values of input and output factors to improve the efficiency scores. The analysis results showed that inefficiency is mainly due to several factors such as R&D investment, changes in employment size and changes in annual salary per capita.

• Applied Microscopy
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• 제43권1호
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• pp.27-33
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• 2013

Inflammatory cells express the inflammatory cytokines and growth factors induced by lipopolysaccharide (LPS). Odontoblasts are located at the pulp-dentin interface and extend their cell processes far into the dentin where they are the first cells to encounter microorganisms or their products. Therefore, this study examined the expression of some growth factors related to the signal pathway, such as growth factor receptor binding protein 2 (Grb2)-Ras in odontoblast-like dental pulp cells, after a treatment with LPS. After 60 minutes, the mRNA and protein expression levels of Grb2 and Ras were higher in the LPS-treated cells than in the control cells. The level of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNA expression was increased significantly to a level similar to that of Grb2 and Ras at 60 minutes. The platelet-derived growth factor-AA (PDGF-AA) mRNA level was expressed strongly in the odontoblast like dental pulp cells without an association with LPS stimulation. Scanning electron microscopy revealed many extensions of the cytoplasmic processes and the number of processes increased gradually at 30, 60 and 90 minutes after LPS stimulation. From these results VEGF and bFGF expression might be induced through the Grb2-Ras signal transduction pathway in LPS treated odontoblasts.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2003년도 춘계학술대회 논문집
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• pp.398-404
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• 2003

Most previous researches for the hybrid composite materials such as FRMLs(Al/AFRP, Al/GFRP) have evaluated the fatigue delamination behavior using the traditional fracture mechanism. However, most previous researches have not generally been firmed yet. Because delamination growth behavior in hybrid composite should be consider delamination growth rate, $dA_D$/da using the delamination shape factors, fs instead of traditional fracture mechanic parameters. The major purpose of this study was to evaluate the relationship between delamination shape factor, fs and delamination growth rate, $dA_D$ . And a propose parameter on the delamination aspect ratio, b/a. The details of the study are as follow : 1) Relationship between crack length, a and delamination width,b. 2) Relationship between delamination aspect ration, b/a and delamination area rate,($(A_D)_{N}(A_D)_{ALL}$. 3) Variation of delamination growth rate, $dA_D/da$ was attendant on delamination shape factors, $fs_1$, $fs_2$, $fs_3$. The test results indicated the delamination growth rate depends on delamination shape factors.

• 지식경영연구
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• 제20권2호
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• pp.197-216
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• 2019

The Korean government has been focusing on supporting technology startups to solve social and economic problems such as low growth, declining economic growth rate, rising youth unemployment rate and lack of new growth engine. Although the failure rate of young technology startups is very high, relevant researches are still scant. On the basis of previous researches, this study has identified four growth factors of technology startups: characteristics of entrepreneurs, technical superiority and originality of business items, focused marketing strategy, and follow-up government support projects. Five young technology startup cases were selected and analyzed in the cosmetics industry which were supported by the Six-month Challenge Platform project of Chungbuk Creation Economic Innovation Center. The main findings of the case study were as follows: First, product development through inhouse R&D rather than external contracted R&D was beneficial to acquiring follow-up government support projects and external investment. Second, choosing a small niche market and concentrating marketing efforts on the target market had a positive effect on firm performance. And, third, relevance of entrepreneurs' college major and technological originality of business items were confirmed to influence firm performance positively in the early stage. The results are expected to help young technology startups survive successfully and establish a foothold for growth in their early stage.

• 유통과학연구
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• 제21권1호
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• pp.23-31
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• 2023

Purpose: this study is aimed at assessing the contribution of education and innovation to the economic growth of Kazakhstan, the correlation between them is checked based on two levels on a national scale and a regional scale. Based on the literature review, it was revealed that in the vastness of the scientific community, there are many views concerning the influence of educational and innovative factors on economic growth. Research design, data and methodology: the research methodology is divided into two levels, at the first level, a correlation analysis is carried out between key factors and the economic growth of the country (GDP), at the second level, the same factors are analyzed, but the impact on the economic growth of the region (GRP) is estimated. Statistical data on educational and innovation potential is taken from the Bureau of National Statistics for the period 2003-2021. Results: in this study, it was revealed that the economic development of regions could be influenced by such indicators that cannot affect the entire state in aggregate and vice versa. In addition, the correlation analysis results showed that investments in innovations affect economic growth at the country and the regional level. Conclusions: based on the results of the assessment of educational and innovative potential, policy recommendations and further research in this area were proposed.

• 한국산림과학회지
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• 제107권1호
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• pp.35-42
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• 2018

본 연구는 낙엽송 수확 벌채지 내 식재된 낙엽송 조림목의 초기 근원경과 수고 생장에 영향을 주는 지황 및 토양 인자를 구명하기 위해 수행되었다. 낙엽송 조림목의 생장에 영향을 줄 것으로 판단되는 낙엽송 조림지 내 지황 및 토양 인자 15개를 이용하여 생장 영향 인자를 도출하였다. 도출된 인자들로 최적 조합에 의해 6년생 낙엽송 조림목의 근원경과 수고 생장추정식을 개발하였다. 근원경 생장에 영향을 주는 인자들은 유효 인산(+), 유효 토심(+), 유기물(-), 모래 비율(-), pH(-), 고도(-) 등의 순으로 6개가 도출되었고, 근원경 생장추정식의 결정 계수($R^2$)는 0.51이었다. 수고 생장에 영향을 주는 인자들은 유효 토심(+), 고도(-), 경사(-), 유효 인산(+) 등의 순으로 4개가 도출되었고, 수고 생장추정식의 $R^2$는 0.46이었다. 낙엽송 조림목의 근원경과 수고 생장은 공통적으로 유효 토심, 유효 인산, 고도 인자들에 의해 영향을 받는 것으로 조사되었다. 따라서 도출된 영향 인자들은 낙엽송 조림목의 우수한 초기 생장을 위해 재조림 대상지 선정 시 고려해야 할 중요한 인자들로 작용할 것이다.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.89-96
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• 2023

Uric acid produced by guanine deaminase (GDA) is involved in photoaging and hyperpigmentation. Reactive oxygen species (ROS) generated by uric acid plays a role in photoaging. However, the mechanism by which uric acid stimulates melanogenesis in GDA-overexpressing keratinocytes is unclear. Keratinocyte-derived paracrine factors have been identified as important mechanisms of ultraviolet-induced melanogenesis. Therefore, the role of paracrine melanogenic growth factors in GDA-induced hypermelanosis mediated by uric acid was examined. The relationships between ROS and these growth factors were examined. Primary cultured normal keratinocytes overexpressed with wild type or mutant GDA and those treated with xanthine or uric acid in the presence or absence of allopurinol, H₂O₂, or N-acetylcysteine (NAC) were used in this study. Intracellular and extracellular bFGF and SCF levels were increased in keratinocytes by wild type, but not by loss-of-function mutants of GDA overexpression. Culture supernatants from GDA-overexpressing keratinocytes stimulated melanogenesis, which was restored by anti-bFGF and anti-SCF antibodies. Allopurinol treatment reduced the expression levels of bFGF and SCF in both GDA-overexpressing and normal keratinocytes exposed to exogenous xanthine; the exogenous uric acid increased their expression levels. H₂O₂-stimulated tyrosinase expression and melanogenesis were restored by NAC pretreatment. However, H₂O₂ or NAC did not upregulate or downregulate bFGF or SCF, respectively. Overall, uric acid could be involved in melanogenesis induced by GDA overexpression in keratinocytes via bFGF and SCF upregulation not via ROS generation.