• 동의생리병리학회지
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• 제25권1호
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• pp.100-108
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• 2011

The object of this study was two. One was if Polygonati Rhizoma preparata had a benzo(a)pyrene, the other was to evaluate the single dose toxicity of 9 repetitive steaming and fermenting processed Polygonati Rhizoma, dried root parts of Polygonati Rhozoma preparata extract, in male and female mice. We measured a content of benzo(a)pyrene in Polygonati Rhozoma preparata using a method with HPLC/FLD. And for single dose toxicity, aqueous extracts of Polygonati Rhozoma preparata (EPP; Yield = 35.4 %) was administered to female and male ICR mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. As results, we could not find any mortality, clinical signs, and changes in the body and organ weight except for slight soft feces sporadically detected in EPP treated male mice at 1 day after administration. In addition, no EPP-treatment related abnormal gross findings and changes in histopathology of principle organs were detected except for some sporadic accidental findings. The results obtained in this study suggest that benzo(a)pyrene was not existed in Polygonati Rhozoma preparata and the 50% lethal dose and approximate lethal dose of EPP aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines. However, it also observed that the possibilities of digestive disorders, like soft feces when administered over 500 mg/kg of EPP aqueous extracts in the present study.

• Toxicological Research
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• 제23권4호
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• pp.373-382
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• 2007

This study was conducted to obtain acute information of the oral dose toxicity of PGB-1, a novel polyglucosamine polymer produced from a new strain Enterobacter sp. BL-2 in male and female mice. In order to calculated 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250, 125 and 0 (vehicle control) ml/kg (body wt.). The mortality and changes on body weight, clinical signs, gross observation and organ weight and histopathology of principle organs were monitored 14 days after dosing with PGB-1. We could not find any mortalities, clinical signs, body weight changes and gross findings. In addition, significant changes in the organ weight and histopathology of principal organs were not observed except for some sporadic findings. The results obtained in this study suggest that PGB-1 may not be toxic in mice and may be therefore safe for clinical use. The $LD_{50}$ and approximate LD in mice after single oral dose of PGB-1 were considered over 2000 mg/kg in both female and male mice.

• Toxicological Research
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• 제22권4호
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• pp.431-438
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• 2006

The object of this study was to obtain acute toxicity information (single oral dose toxicity) of lyophilized water extract of Puerariae Radix (PR) in both male and female mice. In order to investigate the 50% lethal dose $(LD_{50})$, approximate lethal dosage (ALD), test substances were once orally administered to female and male ICR mice at dose levels of 2000 and 0 (control) mg/kg (body wt.) according to the recommendation of KFDA Guidelines [2005-60, 2005]. The mortality and body weight changes, clinical signs and gross observation were monitored during 14 days after dosing. Organ weight and histopathology of 12 principal organs were measured. As the results, we could not find any mortality, clinical signs, body weight changes and gross findings except for PR extracts unrelated sporadic findings. In addition, no abnormal changes related PR extracts treatment on the organ weight and histopathology of principal organs were detected except for some sporadic findings including hyperplasia of lymphoid follicles in the popliteal lymph nodes and spleen as pharmacological effects of PR extracts. The results obtained in this study suggest that the PR extracts does not cause any toxicological signs except for pharmacological effects of enhancement of Immune system. The $LD_{50}$ and ALD of PR extracts in both female and male mice were considered as over 2000 mg/kg because no mortalities were detected up to 2000mg/kg that was the highest dose recommended by KFDA and Organization for Economic Co-Operation and Development.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2021년도 춘계학술대회
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• pp.59-59
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• 2021

Stachys sieboldii Miq. (SSM) and Acorus gramineus Soland. (AGS) have been used as traditional medicines for thousands of years in parts of Asia, including Korea, China, and Japan. Recent researches on SSM and AGS have documented a wide spectrum of therapeutic properties, including anti-inflammatory, anti-oxidative, neurodegenerative disease effects. However, the toxicity and safety of SSM and AGS, and their mixture (medicinal herber mixture, MHMIX) were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of SSM, AGS and MHMIX. SSM, AGS and MHMIX were orally administered at a dose of 5,000 mg/kg in ICR mice. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing, upon necropsy. We also measured parameters of organ weight, clinical chemistry, and hematology. No dead and no clinical signs were found during the experiment period after administration of a single oral dose of SSM, AGS and MHMIX. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. Therefore, LD50 value of SSM, AGS and MHMIX may be over 5,000 mg/kg and it may have no side toxic effect to ICR mice. The results on the single-dose toxicity of SSM, AGS and MHMIX indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.

• 한국구조물진단유지관리공학회 논문집
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• 제4권4호
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• pp.211-218
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• 2000

Many bridges are severely damaged by the overloaded heavy vehicle and the trend will become more serious because the traffic volume is continuously increasing. Currently, the vehicles with gross weights over 40 tonf or axle weight over 10 tonf are not allowed on the public road. However, this regulation is not based on a systematic study on the bridge capacity and assumed to be much too conservative depending on the vehicle types and bridge types. In this study, the permit weights of heavy vehicles of diverse axle spacings and axle load distribution are calculated considering the structural characteristics of bridge superstructures. In order to consider the various load effects of heavy weight vehicle crossings, three conditions are considered in the calculation of permit vehicle load. From the results, the permit vehicle weights of the simple girder bridges are calculated.

• 한국도로학회논문집
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• 제12권3호
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• pp.17-26
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• 2010

도로와 교량을 관리하고 유지보수 하는 일은 전 세계의 도로 관리자들에게는 중요한 문제이며, 차량 주행의 안전성을 확보하고 도로유지 비용의 증가를 막기 위하여 세계의 여러 나라에서 다양한 시책이 이루어지고 있다. 아시아에서도 이러한 유사한 노력을 해왔으며 최근에는 차량 중량에 대한 시책이 한국과 일본 등에서도 본격화 되고 있다. 본 연구에서는 이러한 여건에 기여하기 위해서 불균등 간격으로 막대 모양 센서(Piezo Quartz 방식)를 설치하여 높은 정확성으로 동적 축중량 계측을 가능하게 하는 기술을 개발하였으며, 실제 도로에서 축중량과 총중량 등의 계측 정확도를 평가하였다. 축중량과 총중량 등의 계측 정확도는 센서의 배치 수에 따라서 차이가 있다. 본 연구에서는 자동단속을 실현하기 위하여 총중량 계측 정확도의 오차범위를 ${\pm}5%$ 이하의 목표로 개발을 하여 8-point 계측 시스템에 의해 그 목표를 달성했다. 그러나, 이 시스템이 널리 이용되기 위해서는 용이하게 보급되어 질 수 있도록 적합한 시스템 규모로 사이즈를 소형화하는 것이 무엇보다 시급하다. 따라서, 계측의 정확성과 시스템 규모(계측점 수)와의 관계를 평가하였고, 최적의 계측점 수로써 3-point 측정을 제안하여 그 성능을 실제의 도로상에서 평가를 하였다. 또한, 본 연구에서는 대형 차량의 성능 향상에 따른 고속화에 대하여 평가 및 검토를 하였다.

• 동의생리병리학회지
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• 제22권6호
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• pp.1562-1565
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• 2008

HCMCO5 is a herbal extract which comprises of eight different herbs. We studied whether this prescription has an acute toxicity in rats. SPF Sprague-Dawley male and female rats were administered orally with HMC05 extract of 2,000 mg/kg for 14days. We examined mortality, clinical signs, body weights and gross findings during the tests. The result showed no dead animals. We also could not find a significant body weight changes during the experimental period. In addition, no differences were found between control and HMC05 treated groups in clinical signs and other findings. These results indicate that HMC05 extract did not show any toxic effects, and oral ADL value was over 2,000 mg/kg in SD rats.

• Toxicological Research
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• 제17권1호
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• pp.11-15
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• 2001

This study was carried out to evaluate the irritant potential of A mouthwash in hamster cheek pouch. The test substances were applied twice daily to right pouches of hamsters for 14 consecutive days. Animals were administered with A mouthwash, Listerine, saline and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, mortality, body weight changes and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between saline and A mouthwash treated group in gross and histopathological findings. Therefore, these results suggest that there was no irritant potential of A mouthwash in hamster cheek pouch.

• 응용통계연구
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• 제20권1호
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• pp.11-22
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• 2007

통계청에서는 서비스업 총 조사를 매 5년을 주기로 실시하는데, 가장 최근의 서비스 산업 총 조사는 2001년에 실시되었다. 본 연구에서는 2001년에 조사된 사업체별 통계를 기업의 규모에 따른 기업체별 통계로 전환하여, 서비스 산업에서 중소기업이 차지하는 비중을 추정하는 새로운 방법을 제안하고자 한다. 이를 통해 중소기업의 전반적인 현황을 파악하는데 많은 도움이 되리라 기대한다.

• 산업경영시스템학회지
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• 제3권3호
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• pp.59-66
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• 1980

The purpose of this paper to study on measuring method in technical progress. Technology is combination method of raw material and capital, land, labour. The first step to technical Progress is COBB-DOUGLAS production function, so technical progresses are important role in economic growth and development. General production function from Y=f(K, L, T) and COBB-DOUGLAS production function Y=${AK^I}{L^b}$ is first condition. Technical progress is saving of production factor In capital saving, labour saving, neutral saving. Marred Hicks Robinson has Insist on technical progress by each view of production factor, but, what is most excellent measuring method of technical progress\ulcorner I : productivity index method. II : Gross Production function method. Productivity method used in every products level in weight values, gross method function method used in production factor attributed to products. Above two measuring method has delicate problem in each input factor, substitution relation and production factor simultaneously linked each others This basic problem based on technical progress is not solubable in this time.