• International journal of thyroidology
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• 제11권2호
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• pp.176-181
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• 2018

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis has been reported in Graves' disease patients treated with antithyroid drugs (ATDs), especially propylthiouracil. ATD-induced ANCA-associated vasculitis usually involved the kidneys followed by the respiratory organs and skin. The treatment of ANCA-associated vasculitis induced by ATDs is to stop ATD therapy immediately, which often leads to an overall good prognosis. We report a case of ANCA-associated vasculitis in the peripheral nerves of the lower extremities in a 66-year-old woman who was treated with methimazole (MMI) for Graves' disease. To our knowledge, this is the third case of peripheral nervous system (PNS) involvement of ATD-induced vasculitis and the first case of PNS vasculitis associated with MMI.

• 대순사상논총
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• 제33집
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• pp.287-317
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• 2019

예술을 한마디로 정의하거나 그 범위를 특정하기란 어렵지만, 일반적으로 예술이란 어떤 특정한 대상이나 환경, 경험과 기억을 작품 활동을 통해 창조적으로 표현한 미적 산물의 총칭이라 할 수 있다. 이 글에서는 작품의 대상을 풍경, 풍경 중에서도 외면과 혐오의 대상으로 여겨지는 무연고 묘지로 하였으며, 무연고 묘지가 된 역사적 배경과 사실을 매체를 통해, 또 그 묘지를 돌보는 사람들의 전언을 통해 확실히 인지한 후 작품을 형상화하였다. 본 작품은 무연고 묘지와 무연고 묘지를 돌보며 삶을 살아가는 사람들이 만들어낸 '풍경'을 작품 속에 담아냈다. 작품은 사회적 산물로서 사회로부터 동기부여를 받기 때문에, 작가는 시대적 사회상을 객관적이고 냉철하게 판단하여 밝은 것 이면에 있는 어두운 것이나 어두운 것 이면에 있는 밝은 것을 찾아내 작품으로 승화시킴으로써, 더 나은 세계를 추구해야 한다. 이러한 취지에서 본 논자의 작품 2013년 <조화(弔花, 造花, 調和)>, 2015년 <풍경의 가장자리>, 2017년~2018년 <풍경이 된 몸>과 <기억하는 풍경>은 묘원에 있는 조화(弔花), 오랫동안 찾지 않은 무덤, 버려진 무연고 무덤이 있는 풍경을 소재로 하였다. 예술가들은 자신이 의도한 생각을 작품에 반영하여 관객과 소통을 원한다. 더 나아가 창작의 성격과 목적이 명확하다면 관람객들의 작품에 대한 이해도를 극대화할 수 있다. 본 논자는 지금까지 창작한 작품 중 대순사상과 관련지어 해석할 수 있는 것들을 소개함으로써 작품의 의미를 더하려고 했다. 따라서 이 글은 작품의 대순사상적 해석에 대한 하나의 시도라고 해도 좋을 것이다. 대순사상과의 연관성을 살펴보기 위해서는 작품 해설이 우선해야 할 것이다. 작품 <풍경이 된 몸>의 소재로 전남 나주, 대구, 경기도 안성에 있는 무연고 묘지, 작품 <기억하는 풍경>의 소재로 경기도 안산에 있는 선감학원과 제주도 4·3 사건의 무연고 묘지를 다루었다. 특히 <기억하는 풍경> 작품 중의 하나로 제주 4·3 사건을 배경으로 한 작품에는 <백비_기억하는 풍경>이라는 부제를 달았다. 그리고 작품의 대순사상적 해석을 위해 작품 <풍경이 된 몸> 중 나주 무연고 묘지에 대한 것은 음양합덕(陰陽合德)에, 안성 무연고 묘지에 관한 것은 성·경·신(誠敬信)에, 대구 사형수 무연고 묘지와 <기억하는 풍경> 작품인 안산 선감학원의 무연고 묘지와 제주도 4·3 사건 백비(白碑)에 관한 것은 해원상생(解冤相生)에 적용시켜 대순사상적 관점에서 해석해 보았다.

• 대한핵의학회지
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• 제21권2호
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• pp.133-141
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• 1987

To evaluate the values of the thyroid autoantibody measured by radioimmunoassay (RIA) and compare it with hemagglutination method (HA) in the normal and the thyroid disease, data were obtained from total 618 persons; 236 healthy persons, 217 patients with Graves' disease (including 113 patients with undertreated Graves' disease), 100 Hashimoto's disease, 31 thyroid nodule, and 34 simple goiter. RSR kit made in England was used and could be detected to at least 3 U/ml. The positive rates of normal group were antimicrosomal antibody (AMA) 31.8%, antithyroglobulin antibody (ATA) 44.5% by RIA and there was no considerable change in sex and age distribution. In Graves' disease, the positive rates of AMA and ATA were 90.4, 76.9% by RIA, 85, 39% by HA. In Hashimoto's disease, 94,91 % by RIA, and 87,48% by HA, respectively. The autoantibody titer by RIA in thyroid autoimmune disease as well as in normal group was more senisitive than that by HA, especially in ATA. There were linear relationships between the titer of RIA and that of HA in AMA of Graves' disease and AMA and ATA of Hashimoto's disease. There was no relationship among thyroid autoantibody, free $T_4$ index, TBII, and TSH. The titers of AMA and ATA were found to decrease in patients with Graves' disease during the course of antithyroid drug therapy. Of the 236 normal subjects, thirty-seven (15.7%) had concentrations of above 7.5 U/ml in AMA, forty. four (18.6%) above 9 U/ml in ATA. These values were considered as the upper limit for the normal range. In Graves' disease, 82.7, 53.8% were above 7.5, 9 U/ml, respectively; In Hashimoto's disease, 82, 79% were positive. We conclude that RIA was more sensitve than HA in measuring the thyoird autoantibody, but we will study further more for determining the normal range and its interpretation.

• 한국실내디자인학회논문집
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• 제36호
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• pp.30-36
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• 2003

The purpose of this study is to analyze the contextual cognition of space in architecture focusing on Aldo Rossi and Michael Graves, the representative architects of spatial cognition in contextual architecture. This study on the contextual cognition of architectural space can be connected with linguistics and aesthetics's approaches. The conclusions of the study as per the above mentioned aims and intentions are as follows : The concept of spatial analysis in Aldo Rossi's contextual cognition in architecture is described the Analogical Space of Speculative Aesthetics by Diachronie Restoration That of Michael Graves' contextual cognition Is defined Semiotics Space of Empirical Aesthetics by Synchronie Repeatition.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1970년도 제9차 학술대회
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• pp.84.3-85
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• 1970

• Journal of applied mathematics & informatics
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• 제6권1호
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• pp.321-327
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• 1999

Graves and Nomizu investigated an indefinite version of the Cartan's result. Specifically they obtained the conditions for all non-degenerate planes to have the same sectional curvature in the in-definite Riemannian manifold. In this paper we are to study the cosym-plective version of the results of Graves and Nomizu and characterize an indefinite cosymplectic spce form.

• Tuberculosis and Respiratory Diseases
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• 제62권5호
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• pp.417-420
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• 2007

저자들은 사르코이드증 환자에서 그레이브스병이 동반된 1예를 경험하였으며 이는 아직 국내에서 보고된 바 없기에 문헌고찰과 함께 보고하는 바이다.

• 대한핵의학회지
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• 제18권1호
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• pp.19-24
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• 1984

Clinical measurement of thyroid autoantibodies in sera of some thyroid disorders have been widely applied since about twenty years ago. We investigated the incidence and titers of both anti microsomal and antithyroglobulin antibodies in forty eight cases with controls and one hundred and thirty three patients with some form of thyroid disorders. The results were as follows; 1) In controls, antimicrosomal antibodies were positive in 2% but anti thyroglobulin antibodies were all negative. 2) In a series of one hundred and thirty three patients with thyroid disease, anti microsomal antibodies were positive in 44% but antithyroglobulin antibodies were positive in only 15%. 3) The rate disclosing the positive results of antimicrosomal antibodies were 71 % in Hashmoto's disease, 60% in Graves' disease, and 38% in primary hypothroidism, respectively. On the other hand, the positive results of antithyroglobulin antibodies showed 21 % in Graves' disease, 19% in primary hypothyroidism, and 18% in Hashmoto's disease, respectively. Though there were relatively high rate of both antimicrosomal and anti thyroglobulin antibodies in patients with nodular goiter, they were only seven cases in our series. 4) The rate with the extremely high titers of antimicrosomal and antithyroglobulin antibodies$(>1:160^2)$ was 83% and 67% in Hashmoto's disease, 50% and 67% in primary hypothyroidism, and 41% and 18% in Graves' disease. Accordingly, the thyroid autoantibodies were commonly found higher positive rate in patients with Hashmoto's disease, primary hypothyroidism, and Graves' disease. Among these disorders, the extremely high positive rate of the thyroid autoantibodies was found in patients with Hashmoto's disease.

• 대한핵의학회지
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• 제22권1호
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• pp.21-26
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• 1988

Serum TBII measured by radioreceptor assay using $^{125}I-bovine$ TSH and porcine thyroid well membrane was checked before, 6 months and 12 months after initiation of thionamide regimens in 63 Graves' disease patients and was related with their remission state. 1) A significant difference (p < 0.01) in pre-treatment TBII was noted between the remitted [N = 45, TBII $40.9{\pm}18.2%$ $(mean{\pm}S.D)$] and the unremitted (N = 18, TBII $64.1{\pm}15.3%$) groups. 2) After 6 months of therapy, TBII were significantly decreased in both groups (to $20.2{\pm}10.3%$ and to $45.2{\pm}16.3%$, p<0.05 for each group) 3) At 12th month, TBII activities were not significantly decreased compared to the 6th month levels in both groups. 4) 3 of the 58 patients who were initially TBII positive (over 15%) converted negative. All the 3 belonged to the remitted group. 5) No significant differences were seen in initial and posttreatment TBII levels between propylthiouracil treated (N = 36) and methimazole treated (N = 27) cases. with above mentioned results, we observed that the TBII decreased significantly with 6 months of thionamide therapy and concluded that the pretreatment measurement of serum TBII may be clinically useful in predicting the response to thionamide regimen in the treatment of Graves' disease.

• Journal of Yeungnam Medical Science
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• 제31권2호
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• pp.148-151
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• 2014

Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, < $0.08{\mu}IU/L$ thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.