• Title/Summary/Keyword: grade B2

Search Result 847, Processing Time 0.027 seconds

Clinical Significance of SH2B1 Adaptor Protein Expression in Non-small Cell Lung Cancer

  • Zhang, Hang;Duan, Chao-Jun;Chen, Wei;Wang, Shao-Qiang;Zhang, Sheng-Kang;Dong, Shuo;Cheng, Yuan-Da;Zhang, Chun-Fang
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.13 no.5
    • /
    • pp.2355-2362
    • /
    • 2012
  • The SH2B1 adaptor protein is recruited to multiple ligand-activated receptor tyrosine kinases that play important role in the physiologic and pathologic features of many cancers. The purpose of this study was to assess SH2B1 expression and to explore its contribution to the non-small cell lung cancer (NSCLC). Methods: SH2B1 expression in 114 primary NSCLC tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' outcome. Additionally, 15 paired NSCLC background tissues, 5 NSCLC cell lines and a normal HBE cell line were evaluated for SH2B1 expression by RT-PCR and immunoblotting, immunofluorescence being applied for the cell lines. Results: SH2B1 was found to be overexpressed in NSCLC tissues and NSCLC cell lines. More importantly, high SH2B1 expression was significantly associated with tumor grade, tumor size, clinical stage, lymph node metastasis, and recurrence respectively. Survival analysis demonstrated that patients with high SH2B1 expression had both poorer disease-free survival and overall survival than other patients. Multivariate Cox regression analysis revealed that SH2B1 overexpression was an independent prognostic factor for patients with NSCLC. Conclusions: Our findings suggest that the SH2B1 protein may contribute to the malignant progression of NSCLC and could offer a novel prognostic indicator for patients with NSCLC.

Gold-Silver Mineralization of the Au-Ag Deposits at Yeongdong District, Chung-cheongbuk-Do (충청북도(忠淸北道) 영동지역(永同地域) 금은광상(金銀鑛床)의 금은광화작용(金銀鑛化作用)에 관한 연구(硏究))

  • Choi, Seon Gyu;Chi, Se Jung;Park, Sung Won
    • Economic and Environmental Geology
    • /
    • v.21 no.4
    • /
    • pp.367-380
    • /
    • 1988
  • Most of the gold (-silver) vein deposits at Yeongdong District are mainly distributed in the precambrian metamorphic rocks. Based on the Ag/Au total production and ore grade ratios, the chemical composition of electrum and the associated sulfides, the gold(-silver) deposits at Yeongdong District may be classified into 4 classes: pyrrhotite - type gold deposits( I), pyrite - type gold deposits (IT A; massive vein), pyrite - type gold deposits (II B; nonmassive vein) and argentite - type gold - silver deposits(III). The chemical study on electrum(including native gold) revealed that Au content (2.8 to 92.4 atomic%) of electrums varies very widely for different classes of deposits. The Au content of electrum associated with pyrrhotite (Class I), ranging from 47.1 to 92.4 atomic% Au, is clearly higher than that associated with pyrite (Classes IIA, IIB and III). In contrast, classes I, II, and III deposits do not show clear differences in Au content of electrum. In general, pyrrhotite - type gold deposits(I) are characterized by features such as simply massive vein morphology, low values in the Ag/Au total production and ore grade ratios, the absence or rarity of silver - bearing minerals except electrum, and distinctively simple mineralogy. Although the geological and mineralogical features and vein morphology of pyrite - type gold deposits(IIA)are very similar to those of pyrrhotite - type gold deposits (I), Class II A deposits reveal significant differences in the associated iron sulfide (i. e. pyrite) with electrum and Au content of electrum. The Ag/Au total production and ore grade ratios from Class II A deposits are relatively slightly higher than those from Class I deposits. Pyrite - type gold deposits(II B) and argentite - type gold - silver deposits (III) have many common features; complex vein morphology, medium to high values in the Ag/Au total production and ore grade ratios and the associated iron sulfide (i. e. pyrite). In contrast to Class II B deposits, Class III deposits have significantly high Ag/Au total production and ore grade ratios. It indicates distinct difference in the abundance of silver minerals (i. e. native silver and argentite). The fluid inclusion analyses and mineralogical data of electrum tarnish method indicate that the gold mineralization of Classes I and II A deposits was deposited at temperatures between $230^{\circ}$ and $370^{\circ}C$, whereas the gold (-silver) mineralization of Classes ITB and ill formed from the temperature range of $150^{\circ}-290^{\circ}C$. Therefore, Classes I and IT A deposits have been formed at higher temperature condition and/or deeper positions than Classes IIB and III.

  • PDF

Study on the Carcass Yield Grade of Hanwoo (한우도체 육량등급 설정 연구)

  • Lee, Jong-Mun;Yoo, Y.M.;Park, B.Y.;Chae, H.S.;Kim, D.H.;Kim, Y.K.;Choi, Y.I.
    • Journal of Animal Science and Technology
    • /
    • v.47 no.2
    • /
    • pp.261-270
    • /
    • 2005
  • Total number of 237 Hanwoos were purchased from the nationwide fanns based on the different market weights and sex. After slaughtering, they were evaluated to estimate the productivity of carcass components by the sex and market weight, and to predict the beef carcass yield grade equation. The main results in this study were summarized as follows; With respect to carcass characteristics, the yield percentages were different(P < 0.01) among sex groups, but were not different among market weight groups. Sex or market weights showed significant effects on the carcass yield grade(YG) factors(BFT, RA, carcass weight(CW). The YG equation from this study could be expressed as a multiple regression y = 64.74 - 0.0198 ${\times}$ CW(kg) - 5.226 $\time$ BFT(cm)+0.1339 $\time$ RA($cm^2$ $R^2$ = 0.52 Among the YG factors, the BFT was the highest contributor to the YG equation. Compared the previous equation reported in 1992 with the equation from this study, the bias values between predicted value and the actual cutability were 9.17 and 2.39, respectively. In conclusion, the equation estimated from this study was more accurate in predicting the cutability than that from the previous equation reported in 1992.

Floristic Study of Gyodongdo Island in Ganghwa-gun, Korea

  • Kim, Jung-Hyun;Kim, Sun-Yu;Lee, Byoung Yoon;Yoon, Chang-Young
    • Korean Journal of Environment and Ecology
    • /
    • v.29 no.2
    • /
    • pp.105-131
    • /
    • 2015
  • This study was carried out to investigate the flora of Gyodongdo island (Ganghwa-gun). The vascular plants from 11 field surveys were revealed to belong to a total of 629 taxa; 118 families, 364 genera, 561 species, 5 subspecies, 53 varieties, 7 forms and 3 hybrids. 184 taxa were the first records from this region. The plants in Gyodongdo island are composed of the deciduous broad-leaved and conifer-mixed forests which are the common ones in the middle part of the Korean Peninsula. Five taxa of Korean endemic plants such as Clematis brachyura Maxim., Viola seoulensis Nakai, Populus ${\times}$ tomentiglandulosa T. B. Lee, Forsythia koreana (Rehder) Nakai and Hemerocallis hakuunensis Nakai were collected. Endangered wild plants designated by the law called 'Protection Law for Endangered wild fauna and flora' were one taxon. The red list plants according to IUCN valuation basis were examined for 13 taxa; endangered (EN) species of Prunus yedoensis Matsum., Vulnerable (VU) species of both Utricularia pilosa (Makino) Makino and Iris ruthenica var. nana Maxim., Near Threatened (NT) species of Senecio argunensis Turcz., Least Concern (LC) species of Platycladus orientalis (L.) Franco, Potentilla discolor Bunge, Limnophila sessiliflora (Vahl) Blume, Acorus calamus L., Phacelurus latifolius (Steud.) Ohwi, Pseudoraphis ukishiba Ohwi, Belamcanda chinensis (L.) DC., and Not Evaluate (NE) species of both Astragalus sikokianus Nakai and Potamogeton oxyphyllus Miq. The floristic regional indicator plants found in this area were a total of 47 taxa comprising three taxa of grade V, four taxa of grade IV, nine taxa of grade III, 10 taxa of grade II, and 21 taxa of grade I. The naturalized plants were identified as 62 taxa and the percentage of naturalized index (NI) was 9.9 % and the percentage of urbanization index (UI) was 19.3 %, respectively. Furthermore, hemicryptophytes (28 %), therophytes (26 %), hydrophytes (13 %) and geophyte (12 %) showed high proportional ratio in life form spectrum.

Stream Health Assessments on Tributaries of Lake Paldang Using Index of Biological Integrity for Fish Community and Physical Habitat Parameters (어류 모델 메트릭과 물리적 서식지 변수를 이용한 팔당호 유입하천 하류부의 하천건강성 평가)

  • Choi, Myung-Jae;Park, Hae-Kyung;Lee, Jang-Ho;Yun, Seok-Hwan
    • Korean Journal of Ecology and Environment
    • /
    • v.42 no.3
    • /
    • pp.280-289
    • /
    • 2009
  • The fish communities and physical habitat conditions of fifteen tributaries of Lake Paldang in spring and autumn, 2008 were surveyed to evaluate the ecological health of the streams. The total 2,746 individuals were collected belonging to 11 families 31 genera 40 species. Two new species (Cottus koreanus, Gnathopogon strigaus) that have never been reported as yet in Lake Paldang watershed were found for the first time. The most dominant species in the tributaries was Acheilognathus yamatsutae (19.9%) which is Korean endemic species. Ecological health evaluation of fifteen tributaries using index of biological integrity (IBI) model for fish community and qualitative habitat evaluation index (QHEI) was performed. According th the IBI analysis, four streams (Siwoo-Stream, Jojong-Stream, Moonho-Stream and Mugab-Stream) were evaluated as "good" condition (B grade), Woosan-Stream were "poor" condition (D grade) and others were "fair" condition (C grade). Qualitative habitat evaluation index values of the four streams were the grade "II" indicating "good" condition and those of eleven streams were the grade "III", indicating 'fair' condition. On the whole, dataset of IBI and QHEI showed that ecological health of Jojong-Stream has been well maintained compared to other tributaries of Lake Paldang.

Interactive Effects of UV-B and Pesticides on Photosynthesis and Nitrogen Fixation of Anabaena doliolum

  • Chandrai, Lar;Vandana, Pandey
    • Journal of Microbiology and Biotechnology
    • /
    • v.12 no.3
    • /
    • pp.423-430
    • /
    • 2002
  • The effects of UV-B and commercial grade pesticides (butachlor and carbofuran), individually and in combination, were studied on a variety of physiological processes of rice field cyanobacterium Anabaena doliolum. Butachlor was found to be $2-12\%$ more toxic than carbofuran and $4-24\%$ than UV-B on the growth, photosynthesis, lipid peroxidation, membrane permeability, and nitrogenase activity of the test cyanobacterium. Of the three photosynthesis inhibitors, the butachlor-induced inhibition of whole chain was approximately 3 and $21\%$ higher than carbofuran and UV-B, respectively. Although the interaction of the stress factors caused a significant inhibition (P<0.01), it was still less than the additive effect on the parameters investigated, except for PSI.

A Study on the Job Attitude of Cook at Deluxe Hotel in Pusan (I) - An analysis on the general characteristics of the cook - (부산지역 특급호텔에 종사하는 조리사들의 직무에 대한 의식과 실태조사 연구 (I) -조리사들의 근무처, 근무부서 및 자격증 등 일반적인 현황 분석 -)

  • Shin, Ae-Sook;Lee, Jin-Yong
    • Journal of the Korean Society of Food Culture
    • /
    • v.11 no.2
    • /
    • pp.169-178
    • /
    • 1996
  • The purpose of this study was to get an information on hotel cook. So the food and beverage (F and B) enterprise is one of the most promising industry on post-industry society, and the cook is real agent to lead the F and B enterprise, we need to have a data, information and knowledge on cook to improve a culinary art training program and working environment. This study was surveyed by 216 cook to work for deluxe hotels at Pusan. The results were summarized as follows: 1. The almost cook worked with restaurant for $8{\sim}9$ hours/day, and a half of cook earned a million won in a month. A higher grade cook worked longer hours and earned more money than a lower grade one. 2. The most popular workplace of the cook was Western restaurant, the male cook working at a Western restaurant were more than female, the more female cook and novices worked at a Korean restaurant. 3. The most popular qualification that the cook take were a western culinary art one, and next were Korean one and Japanese one. The 77.8% cook worked at the place that fitted in with their culinary art qulification. 4. A half of cook insisted that they were a expert of western culinary art, and the next was the Korean, Japanese one in order. 5. The cook were unsatisfied with pay, work environment, human relation and promotion, and if they change their workplace, a lot of cook wished to manage their own restaurant. 6. The 63.4% of cook changed their workplace more than a time. The male cook got a more chance to change workplace than female one. The higher grade cook got a more chance to charge workplace. Almost cook got a no chance to study a culinary art at overseas. The most favorite place that the cook want to visit for studying was Europe, and next were Japan, America, Southeast Asia in order.

  • PDF

Production of Calves by Transfer of Vitro Produced Hanwoo Embryos (한우 체외수정란이식에 의한 산자 생산)

  • 조헌조;김주현;송상현
    • Journal of Embryo Transfer
    • /
    • v.15 no.3
    • /
    • pp.255-261
    • /
    • 2000
  • The objective of this study was to improve the efficiency of bovine embryo transfer by transferring of Hanwoo embryos into Hanwoo or Holstein recipients. The cryopreserved or fresh in vitro produced(IVP) embryos were transferred into uterine horn contralaterally or ipsilaterally to the corpus luteum. The recipients were inseminated by artificially on the next day of estrus. The pregnancy was diagnosed by rectal palpation at 60∼90 days after transfer of the embryos. The pregnancy rate by transfer of one or two embryos was 78%(7/9) and 74%(31/42), respectively. The pregnancy rates according to the grade of corpus lutea of recipients was 75% (20/27) and 82.0%(18/22) at the grade of A and B, respectively. Ten(67.0%) of 15 Holstein recipients transferred with IVP Hanwoo embryos and 5(42.0%) of 12 Holstein recipients transferred with frozen IVP Hanwoo embryos were pregnant. The single and twin calving ratio in Hanwoos was 77.0%(10/13) and 23.0%(3.13) in the recipients transferred with IVP embryos and 64.0%(7/10) and 27.0%(3/10) in the recipients transferred with frozen IVP embryos, respectively. Twenty-four pregnant cows following transfer of IVP embryos, 21(88.0%) calved the normal calves, and 2(8.3%) aborted. When the frozen IVP embryos were transferred, 16 pregnant cows calved 14(88.0%) normal calves and 2(13.0%) aborted. In conclusion, when one or two IVP bovine embryos were transferred into recipients, the A and B grade of corpus luteum resulted in high pregnancy rates. For the production of twin calves, transfer of the IVP or frozen IVP embryos could be suitable.

  • PDF

A Study on the Fire Resistance and Sound Insulation Performance of Apartment House Interior Finish Wall Lightweight Drywall (공동주택 세대내 경량벽체 내화 및 차음 성능기준 설정)

  • An, Jae-Hong;Yeo, In-Hwan;Kim, Kyoung-Woo
    • Journal of the Korea Institute of Building Construction
    • /
    • v.14 no.2
    • /
    • pp.143-149
    • /
    • 2014
  • Recently, the structure system for apartment buildings in Korea has been changing from wall to post-beam structure. This study examines the fire resistance and sound insulation of light-weight dried wall, a component of post-beam structure. For the fire resistance and sound insulation in Korea, the Compartment wall of apartment house in the case of building regulation has regulations specify the detailed requirement of fire compartment walls in apartment, but do not specify that of interior walls. This study proposes the fire resisting rate of the interior wall into three grades in which the highest grade requires fire resistance of 30 minutes and also proposes the requirement of sound insulation performance into three grades in which the lowest grade requires 35dB.

Breeding for Inprovement of Fatty Acid Composition in Rapeseed, Brassica napus L. Ⅶ. Studies on Classification of Spring Nature Grade of Double Zero Rapeseed Varieties (유채 지방산조성 개량육종에 관한 연구 제15보 양질유ㆍ양박 유채 육성계통들의 춘파성 정도 분류)

  • Lee, J.I.;Kwon, B.S.;Kim, S.K.;Bang, J.K.
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.28 no.2
    • /
    • pp.233-239
    • /
    • 1983
  • In order to obtain basic date for the cultivation and the breeding of double zero varieties of rapeseed, spring nature grade were investigated. Spring nature grade could be classified to 8 classes by the method of material maturity. The double zero varieties, Ⅶ group of spring adaptability has been developed from the cross "Oro" and "Midas" classified as summer type. A significant negative correlation was found between the spring adaptability and seed yield. On the other hand, a highly significant negative correlation was found between maturation and spring adaptability, cold resistnce and spring adaptability, plant from and spring adaptability. Ⅵ and Ⅶ group close to summer type showed spring growing adaptability, and 0, I and II group were appeared as winter type, autumn growing adaptability with cold tolerance.with cold tolerance.

  • PDF