• 제목/요약/키워드: glomerulonephritis

검색결과 173건 처리시간 0.029초

지황음자(地黃飮子)의 기원(起源), 방해(方解) 및 활용(活用)에 대한 고찰(考察) (Study on The Origin, Explanation and Application of Jihwangeumja(地黃飮子))

  • 홍승헌;김윤경;권동렬
    • 대한한의학방제학회지
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    • 제11권1호
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    • pp.37-44
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    • 2003
  • The source of prescription of Jihwangeumja to treat the mental confusion due to phlegm caused by kidney 'deficiency and Yin and Yang deficiency is found in 'Hwangjesomunseonmyeongronbang $\ll$黃帝素問宣明論方$\gg$'. The source of prescription of Jihwangeum is found in 'Seongjechongnok $\ll$聖濟總錄$\gg$'. Therefore, it seems reasonable to change the prescription to 'Jihwangeum' from 'Jihwangeumja' and to change the source of prescription to 'Seongjechongnok $\ll$聖濟總錄$\gg$' from 'Hwangjesomunseonmyeongronbang $\ll$黃帝素問宣明論方$\gg$'. In addition, 'Jihwangeum' is influenced by 'Naebosan' in 'Cheongeumbang $\ll$千金方$\gg$'. Jihwangeumja gave the substantial influence on the treatment of 'Endogenous wind due to hyperactivity' of Yeopcheonsa. Jihwangeumja supplements the true Yuan, smooths the circulation of the flow inside a body and coordinates the interaction between heart and kidney so that it ultimately eliminates sputum and activates circulation inside a body. If the guideline of diagnosis is accurate, many kinds of diseases can be effectively treated through the principle of treating different disease with the same therapy. In addition, it will be also effectively used for headache after cerebral hemorrhage, trigeminal neuralgia(sore tongue), diabetes insipidus, nervous breakdown, hyperthyroidism, chronic glomerulonephritis, infertility and anemia.

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Protective effect of Shenqi-wan and its fractions on N-methyl-D-aspartate-induced excitotoxicity in rat hippocampus

  • Lee, Joung-Hun;Kim, Youn-Sub;Kim, Young-Sick;Kim, Sung-Eun;Sung, Yun-Hee;Kim, Bo-Kyun;Lee, Jin-Woo;Ham, Dae-Hyun;Lee, Hye-Jung;Kim, Chang-Ju
    • Advances in Traditional Medicine
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    • 제7권5호
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    • pp.534-539
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    • 2008
  • Shenqi-wan, Oriental herbal medicine formulation, has traditionally been used for the treatment of delayed mental and physical development in children, complications of diabetes, and glomerulonephritis. In the present study, we investigated the protective effect of the aqueous extract of Shenqi-wan and its fractions against N-methyl-D-aspartate (NMDA)-induced exitotoxicity in rat hippocampal CA1 neurons. Fractions were elucidated at 0 - 10 min, 11 - 20 min, and 21 - 30 min by using gravity column chromatography method. In the present results, treatment with NMDA on cultured hippocampal slices induced neuronal death in the hippocampal CA1 region. Pretreatment with the Shenqi-wan did not exerted protective effect, however its fractions suppressed NMDA-induced neuronal damage. The fraction elucidated at 11 - 20 min showed the most potent protective effect. These results revealed that effective substances of the Shenqi-wan against NMDA-induced excitotoxicity may exist mainly in the fraction elucidated at 11 - 20 min.

급성 신부전을 동반한 성인 Henoch-Sch$\ddot{o}$nlein 자반증 1예 (A Case of Adult onset Henoch-Sch$\ddot{o}$nlein Purpura with Acute Renal Failure)

  • 김석민;장경애;정선영;박찬서;박종원;도준영;김용진;윤경우
    • Journal of Yeungnam Medical Science
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    • 제25권1호
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    • pp.58-63
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    • 2008
  • Henoch-Sch$\ddot{o}$nlein purpura (HSP) is a leukocytoclastic vasculitis of small vessels with deposition of IgA, commonly resulting in skin, joint, gastrointestinal, and kidney involvement. HSP is an uncommon disorder in adults and accounts for 0.6% to 2% of adult nephropathy. We report a case of HSP with acute renal failure successfully treated with corticosteroid. In this case, the patient presented with vasculitic purpuric rash on lower extremity, arthralgia in the wrist, abdominal pain, hematochezia, oliguria and azotemia. Abdominal CT showed wall thickening of the small and large bowels. Skin biopsy revealed leukocytoclastic vasculitis. Percutaneous renal biopsy showed no crescent formation, but mesangial IgA and $C_3$ deposits were observed by immunofluorescence. The patient was treated with corticosteroid (1mg/kg per day) and hemodialysis. After treatment, renal function improved and purpuric lesion, arthralgia and abdominal pain disappeared. Thus, when adults present with purpuric rash and rapidly progressive glomerulonephritis (RPGN), HSP should be a diagnostic consideration.

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Henoch-Sch$\ddot{o}$nlein 자반병 신염으로 의심했던 현미경적 다발혈관염 1례 (A Case of Microscopic Polyangiitis Initially Suspected with Henoch-Sch$\ddot{o}$nlein Purpura Nephritis)

  • 임종근;문경철;구자욱
    • Childhood Kidney Diseases
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    • 제16권2호
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    • pp.132-137
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    • 2012
  • Henoch-Sch$\ddot{o}$nlein 자반병 신염과 유사한 증상을 가지는 10세 여자에게 발생한 급격한 신기능 저하를 동반하지 않은 현미경적 다발혈관염 1례를 경험하였기에 보고하는 바이다. 이 혈관염의 경우. 진단 시점 또는 치료 시작할 때의 신장기능 저하가 심할수록 병의 예후가 나쁘므로[20], 사구체 여과율이 떨어지기 전에 빠른 진단과 치료가 필요하다. Henoch-Sch$\ddot{o}$nlein 자반병이 의심될 경우 단백뇨와 혈뇨가 지속되면, 다른 혈관염과의 감별을 위해 ANCA, 신장 조직검사가 도움을 줄 것으로 생각된다.

Coagglutination에 의한 $\beta$-용혈성 연쇄구균의 혈청군 동정 (Serological grouping of $\beta$-hemolytic streptococci by a coagglutination technique)

  • 정윤섭;윤양숙;김윤정;이삼열;김성광;이병수;김주덕
    • 대한미생물학회지
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    • 제14권1호
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    • pp.11-15
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    • 1979
  • Identification of group A $\beta$-phemolytic streptococci is very important to provide an appropriate preventive measure of possible rheumatic fever and acute glomerulonephritis. For such purpose bacitracin susceptibility of streptococci because of its simplity has been most widely used despite of its occasional faulty results. Recently, a coagglutination technique was advocated using streptococcal group specific antibodies adsorbed to protein A-containing staphylococci. This study was conducted to evaluate the coagglutination technique using reagents prepared by ourselves. The specificity, reproducibility and stability were ascertained and the following results were obtained. 1. The identification by coagglutination technique using our own reagent gave the same results compared with the Lancefield precipitation technique. The result also agreed with the Phadebact grouping. 2. There were no variation in group A and B identification due to lot difference. However, there were a few discrepant results in group C and G identification which was conducted in different days with different lots of our reagent. 3. The stability of our reagents was less satisfactory compared to the commercial product. An effort to improve the stability was considered necessary. 4. For coagglutination, it was found convenient to use supernatant of Todd-Hewitt broth incubated for 24 hours. Both parafin-ringed slide glass and RPR card gave comparable results and the former could be used when the latter is not available.

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양측 전경골 동맥과 비골 동맥 폐쇄를 동반한 베게너 육아종증 1예 (A Case of Wegener's granulomatosis with obstruction of both anterior tibial and peroneal arteries)

  • 이상학;양동규;조현명;송건훈;박재민;유정선;장준;김성규;이원영;신동환
    • Tuberculosis and Respiratory Diseases
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    • 제43권5호
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    • pp.779-785
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    • 1996
  • 저자 등은 두통과 비루를 주소로 내원한 46세 남자에서 비강, 폐, 신장을 침범하고, 양측 전경골 동맥과 비골 동맥 폐쇄를 동반한 베게너 육아종증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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현미경적 다발성 혈관염 2예 (Two Cases of Microscopic Polyangiitis)

  • 송경은;임승관;조숙경;정연무;최준혁;신승수;오윤정;박광주;황성철;임현이
    • Tuberculosis and Respiratory Diseases
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    • 제55권6호
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    • pp.623-630
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    • 2003
  • 저자들은 급성신부전과 미만성 폐포출혈이 있으면서 중추신경병증이 동반된 현미경적 다발성 혈관염 환자 l예와 특발성 괴사 사구체신염 진단 후 스테로이드 감량 도중 폐침윤이 동반된 전신적인 현미경적 다발성 혈관염의 형태로 재발한 환자 l예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Correlation between glomerular filtration rate and urinary N acetyl-beta-D glucosaminidase in children with persistent proteinuria in chronic glomerular disease

  • Hong, Jeong-Deok;Lim, In-Seok
    • Clinical and Experimental Pediatrics
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    • 제55권4호
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    • pp.136-142
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    • 2012
  • Purpose: Urinary excretion of N acetyl-beta-D glucosaminidase (NAG) and ${\beta}_2$-microglobulin (${\beta}_2$-M) was increased in the presence of proximal tubular damage. Based on these urinary materials, we investigated the ability of expecting renal function in chronic glomerular diseases. In this study, we evaluated the relationship between glomerular filtration rate (GFR) urinary NAG, and urinary ${\beta}_2$-M. Methods: We evaluated 52 children with chronic kidney disease at the Chung-Ang University Hospital between January 2003 and August 2009. We investigated the 24-hour urinalysis and hematologic values in all 52 patients. Serum creatinine, creatinine clearance (Ccr), serum cystatin C, urinary ${\beta}_2$-M and urinary NAG were measured. Results: Out of 52 patients, there were 13 children with minimal change in disease, 3 children with focal segmental glomerulosclerosis, 17 children with immunoglobulin A nephropathy, 15 children with Henoch-Sch$\ddot{o}$nlein purpua nephritis, 3 children with poststreptococcal glomerulonephritis, and 1 child with thin glomerular basement membrane disease. In these patients, there were significant correlation between the Ccr and urinary NAG (r=-0.817; $P$ <0.01), and between the GFR (as determined by Schwartz method) and urinary NAG (r=-0.821; $P$ <0.01). In addition, there was a significant correlation between the GFR (as determined by Bokencamp method) and urinary NAG (r=-0.858; $P$ <0.01). Conclusion: In our study, there was a significant correlation between the GFR and urinary NAG, but there was no correlation between the GFR and urinary ${\beta}_2$-M, suggesting that the GFR can be predicted by urinary NAG in patients with chronic glomerular disease.

아스페르길루스와 연관된 기관지중심성 육아종증 1예 (A Case of Bronchocentric Granulomatosis Associated with Aspergillus)

  • 김양기;전기원;김철;김기업;기신영;어수택;김용훈;박춘식
    • Tuberculosis and Respiratory Diseases
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    • 제45권6호
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    • pp.1290-1297
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    • 1998
  • 본 증례는 평소 건강히 지내던 38세 여자에서 아토피나 천식과의 연관성이 없이 호흡기계 증상 및 폐침윤을 동반한 예로, 비특이적인 증상 및 방사선학적 소견으로 일반적인 폐침윤에 대한 치료에 반응하지 않고 병변이 좌폐상엽의 설상엽에 국한되어 있어 수술을 통해 확진 하였기에 문헌고찰과 함께 보고하는 바이다.

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만성 속발성 신질환 모델동물에서 콜라젠 변화의 지표 (Markers of Collagen Change in Chronic Secondary Renal Disease Model in Rat)

  • 남정석;김기영;이영순
    • Toxicological Research
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    • 제12권2호
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    • pp.213-221
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    • 1996
  • In order to develop a suitable secondary renal disease model and diagnostic markers of renal disease in the rat, the change of PIIIP (aminoterminal procollagen III peptide) in serum and hydroxyproline levels in the renal tissue that reflect the synthesis of extracellular matrix (ECM) during development of experimental renal diseases were observed. Two types of experimental primary diseases, diabetes mellitus administrated by streptozotocin (STZ, 75 mg/kg, i.p.) and liver cirrhosis produced by bile duct ligation/scission (BDL/s) operation, were induced. The hydroxyproline level increased according to the high PIIIP and NCl(carboxyterminal procollagen IV peptide) in Western blot analysis as early as 1 week in the STZ treated-rat kidney. Increased renal ECM was observed at 15 weeks in STZ and BDL/s model under the microscopic examination. High PAS positive reaction was found in capillary basement membrane in STZ treated-rats and mesangium in BDL/s operated rats at this time, showing the histological characteristics of diabetic nephropathy and cirrhotic glomerulonephritis in human, respectively. Such secondary renal failure were supported by additional tests including urinalysis and renal function test. The serum PIIIP detected by ELISA was a useful parameter to estimate synthesis rate of renal ECM during development of renal disease without extrarenal fibrosis i.e. liver cirrhosis in rats. This study is proposed that STZ treatment or BDL/s operation may be a suitable experimental animal model for the induction and development of chronic secondary renal diseases. Morover, it was found that hydroxyproline level in renal tissues was a good parameter of the change of renal ECM at the early stage of the diseases without apparent histological changes. Especially, serum PIIIP could be a choice as a diagnostic or prognostic marker during the development of renal diseases in rats.

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