• Title/Summary/Keyword: global status

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Quality of Life by Stage of Cervical Cancer among Malaysian Patients

  • Azmawati, Mohammed Nawi;Najibah, Endut;Ahmad Zailani Hatta, Mohd Dali;Norfazilah, Ahmad
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5283-5286
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    • 2014
  • Stage of cervical cancer may adversely affect the quality of life (QOL) among patients. The objective of this study was to predict the QOL among cervical cancer patients by the stage of their cancer. A cross-sectional study from September 2012 until January 2013 was conducted among cervical cancer patients who completed treatment. All patients completed a interviewer-guided questionnaire comprising four sections: (A) socio-demographic data, (B) medical history, (C) QOL measured by general health status questionnaire (QLQ-30) and (D) cervical cancer specific module CX-24 (EORTC) was used to measured patient's functional, symptom scale and their global health status. Results showed that global health status, emotional functioning and pain score were higher in stage III cervical cancer patients while role functioning was higher in stage I cervical cancer patients. Patients with stage IV cancer have a lower mean score in global health status (adjusted b-22.0, 95 CI% -35.6, -8.49) and emotional functioning (adjusted b -22.5, 95CI% -38.1, -6.69) while stage III had lower mean score in role functioning (adjusted b -14.3, 95CI% -25.4, -3.21) but higher mean score in pain (adjusted b 22.1, 95 CI% 8.56, 35.7). In conclusion, stage III and IV cervical cancers mainly affect the QOL of cervical cancer patients. Focus should be given to these subgroups to help in improving the QOL.

Current Status and Sustainable Development Strategies of Traditional Korean Medicine Official Development Assistance (ODA) in Global Health (국제보건에서 한의약 공적개발원조의 현재와 지속가능한 발전전략)

  • Yeeun Hwang;Seunghyeon Lee;Hyungwoo Kim;Hyoju Nam;Seungun Lee;Yousang Baik;Han Chae
    • The Journal of Korean Medicine
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    • v.45 no.1
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    • pp.257-270
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    • 2024
  • Objectives: Korea has a unique history of being both a recipient and a donor of Official Development Assistance (ODA), and the international community expects Korea to contribute to the development of developing countries by utilizing this experience. Traditional Korean medicine (TKM) seeks to contribute to global health, however the concept of ODA has been unclear and there has been no clear strategy and sustainable initiatives. Methods: This study examines the concept of ODA and its application in global health, including business objectives, scale, evaluation principles, and development strategies. Additionally, we reviewed the current status of Traditional Korean medicine globalization projects and conducted a SWOT analysis of the internal and external environment of the TKM sector. Based on these findings, we redefined the concept of ODA for TKM and proposed suggestions for its development. Results: The current study identified key ideas for TKM ODA. It should prioritize the improvement of primary healthcare in recipient countries, aligning with the international evaluation criteria of the SDGs. Secondly, TKM's 70 years of experience can be leveraged to enhance both the competence and economic benefits of recipient countries' medical systems. Based on these concepts, a TKM ODA development model was proposed, comprising two core visions, three development strategies and goals, and six core values. Conclusion: This study systematically examined the TKM in global health and suggested sustainable development strategies for TKM ODA. Through its expansion, TKM could contribute to the advancement of global traditional medicine and its overall engagement in healthcare.

Roles of the Community Facilities for Foreigners as a Platform for Urban Globalization - Focused on the Seoul Global Centers - (도시 국제화를 위한 플랫폼으로서 외국인 커뮤니티 시설의 역할에 관한 연구 - 서울시 글로벌센터를 중심으로 -)

  • Choi, Sung-Jin;Han, Sun-Sheng
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.35 no.6
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    • pp.81-92
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    • 2019
  • Globalization has diversified ethnic composition thus increased the risk of conflicts and socio-political instability in global cities. However, still the status of community facility in a global city is unclear despite its critical role to build sustainable community in global era. In Seoul, as a reaction of globalization, 19 community facilities known as the 'Seoul Global Center' have been established since 2007 by Seoul Metropolitan Government. These facilities have started to provide basic foreigner services but been transformed to foreigner service hub with multiple functions in terms of a living, a business, a labour, etc. This study explores the role of the community facility for foreigners by using the Seoul Global Center as a case study, conducting a site observation, an interview(13 staff) and a questionnaire(148 visitors). The findings are the community facility functions as a 'global platform' in forms of a policy tool for implementing the urban globalization strategy, a mediator connecting foreign migrants with local communities, an applicant for successful settlement of foreign residents, an incubator that grows human and social capital, and a base for collecting and aggregating information on foreign migrants and forming new local identities.

Methyl Donor Status Influences DNMT Expression and Global DNA Methylation in Cervical Cancer Cells

  • Poomipark, Natwadee;Flatley, Janet E;Hill, Marilyn H;Mangnall, Barbara;Azar, Elnaz;Grabowski, Peter;Powers, Hilary J
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.7
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    • pp.3213-3222
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    • 2016
  • Background: Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyl-donor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. Materials and Methods: The human cervical cancer cell line, C4-II, was grown in complete medium and medium depleted of folate (F-M+) and folate and methionine (F-M-). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT-PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. Results: Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant down-regulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. Conclusions: Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.

A Named Data Networking Testbed with Global NDN Connection

  • Ni, Alexander;Lim, Huhnkuk
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.40 no.12
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    • pp.2419-2426
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    • 2015
  • Named Data Networking (NDN) is one of the powerfully evolving future internet architectures. In this paper installation, configuration and several tests are addressed to show how well and properly our NDN testbed have been prepared and established using NDN platform, in order to have interoperability with global NDN testbed. Global NDN testbed status with our NDN node participation was addressed. To verify one reachability on the NDN connection to global NDN testbed, a latency result is presented using NDN ping test.

A Study on Global Compliance of Global Companies under the Circumstance of Export Control (전략물자 무역환경에 따른 글로벌기업의 글로벌 컴플라이언스에 관한 연구)

  • Choi, Choon-Ho
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.39
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    • pp.367-389
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    • 2008
  • On the stage of an international trade with well-developed transportation, communication system and proliferation of free trade, global companies who are eager to sustain business growth by cutting cost and pioneering new market are facing a new challenge named "Global Compliance" of business transparency, export and import regulations, and potential international business environment. The purpose of a global compliance is to monitor and regulate a company's trade activities to reduce the risk of transactions that might violate relevant countries' laws, regulations, or standards. After the 911, for strengthening the non-proliferation of the export control goods, UNSCR1540(United Nations Security Council Resolution 1540(2004)) was declared in order to enforce the members to adopt the rules in the resolution into their national laws and regulations. Companies does not realized that they need to get rid of the risks because they underestimate the importance of international security, caused by their careless management. That is why currently the export control program is not fully observed by the most. Lack of awareness for the export control and the poor system of each members could be the reason for this unstable operating status. With this background, this thesis will study on the meaning of export control, schemes for companies to recognize its importance and governmental guideline to support global companies.

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