• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.431-437
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• 2016

In this investigation, global DNA methylation patterns and the specific methylation status of 5 genes were studied in DNA from peripheral blood (PB) and impact on progression free survival (PFS) and overall-survival (OS) in patients with de novo or relapsed acute myeloid leukemia (AML) treated with decitabine-based regimens waas assessed. DNA was isolated from PB samples at the time of -1, 1, and 7 days of chemotherapy. Global methylation was determined by ELISA, and the CpG island DNA methylation profile of 5 genes using a DNA methylation PCR system. Our data demonstrated that patients with a high level of 5-mC had a poor prognosis after demethylation therapy and those who have low levels of 5-mC in PB achieved higher CR and better SO, but there was no significant correlation found between the 5-mC levels and other clinical features before treatment except the disease status. Higher methylation status of Sox2 and Oct4 genes was associated with differential response to demethylation therapy. A relatively low methylation percentage in one or both of these two genes was also associated with longer OS after decitabine based chemotherapy. We also suggest that global DNA and Oct-4/Sox2 methylation might impact on the pathogenesis of leukemia and play an important role in the initiation and progression. Moreover, dynamic analysis of 5-mC and Oct-4/Sox2 in peripheral blood nucleated cells of leukemia patients may provide clues to important molecular diagnostic and prognostic targets.

• Ocean and Polar Research
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• v.40 no.3
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• pp.99-114
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• 2018

In the present study, we assess the GloSea5 (Global Seasonal Forecasting System version 5) near-surface ocean current forecasts using globally observed surface drifter dataset. Annual mean surface current fields at 0-day forecast lead time are quite consistent with drifter-derived velocity fields, and low values of root mean square (RMS) errors distributes in global oceans, except for regions of high variability, such as the Antarctic Circumpolar Current, Kuroshio, and Gulf Stream. Moreover a comparison with the global high-resolution forecasting system, HYCOM (Hybrid Coordinate Ocean Model), signifies that GloSea5 performs well in terms of short-range surface-current forecasts. Predictions from 0-day to 4-week lead time are also validated for the global ocean and regions covering the main ocean basins. In general, the Indian Ocean and tropical regions yield relatively high RMS errors against all forecast lead times, whilst the Pacific and Atlantic Oceans show low values. RMS errors against forecast lead time ranging from 0-day to 4-week reveal the largest increase rate between 0-day and 1-week lead time in all regions. Correlation against forecast lead time also reveals similar results. In addition, a strong westward bias of about $0.2m\;s^{-1}$ is found along the Equator in the western Pacific on the initial forecast day, and it extends toward the Equator of the eastern Pacific as the lead time increases.

• Clinical and Experimental Reproductive Medicine
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• v.45 no.1
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• pp.17-24
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• 2018

Objective: To investigate sperm chromatin/DNA integrity, global DNA methylation, and DNMT mRNA transcription in men with oligoasthenoteratozoospermia (OAT) compared with normozoospermic men. Methods: Semen samples from 32 OAT patients who comprised the case group and 32 normozoospermic men who comprised the control group were isolated and purified using a standard gradient isolation procedure according to World Health Organization criteria. DNMT1, DNMT3A, and DNMT3B transcripts were then compared between groups using real-time quantitative reverse-transcription polymerase chain reaction. Global DNA methylation in sperm was determined by an enzyme-linked immunosorbent assay. Protamine deficiency and the proportion of apoptotic spermatozoa were evaluated using chromomycin A3 (CMA3), aniline blue (AB), and toluidine blue (TB) staining, as well as the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. The p-values < 0.05 were considered to indicate statistical significance. Results: Significantly higher proportions of AB+, TB+, CMA3+, and TUNEL+ spermatozoa, as well as DNMT3A and DNMT3B transcription, were found in the OAT group. Positive correlations were detected between sperm parameters, DNA/chromatin damage, and DNMT3A and DNMT3B transcripts. Global DNA methylation was significantly higher in the OAT patients and had a significant correlation with abnormal results of all sperm chromatin integrity tests, but was not associated with DNMT1, DNMT3A, or DNMT3B expression. Conclusion: Oligoasthenoteratozoospermic men showed abnormal sperm parameters, abnormal chromatin/DNA integrity, and a higher global DNA methylation rate, as well as overexpression of DNMT mRNA.

• Journal of the Korean Solar Energy Society
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• v.33 no.5
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• pp.9-17
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• 2013

Hourly horizontal global solar radiation has been used as one of significant parameters in a weather file for building energy simulations, which determines the quality of building thermal performance. However, as about twenty two weather stations in Korea have actually measured the horizontal global sola radiation, the weather files collected in other stations requires solar data simulation from the other meteorological parameters. Thus, finding the reliable complicated method that can be used in various weather conditions in Korea is critically important. In this paper, three solar simulation models were selected and evaluated through the reliability test with the simulated hourly horizontal global solar radiation against the actually measured solar data to find the most suitable model for the south east area of Korea. Three selected simulation models were CRM, ZHM, and MRM. The first two models are regression type models using site-fitted coefficients which are derived from the correlation between measured solar data and local meteorological parameters from the previous years, and the last model is a mechanistic type model using the meteorological data to calculate conditions of atmospheric constituents that cause absorption and scattering of the extraterrestrial radiation on the way to the surface on the Earth. The evaluation results show that ZHM is the most reliable model in this area, yet a complicated hybrid simulation methods applying the advantages of each simulation method with the monthly-based weather data is needed.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.63.1-63.1
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• 2010

Since the solar energy resource is the main input for sizing any solar photovoltaic system and solar thermal power system, it is essential to utilize the solar radiation data as a application and development of solar energy system increase. It will be necessary to understand and evaluate the insolation data. The Korea Institute of Energy Research(KIER) has begun collecting horizontal global insolation data since May, 1982 at 16 different locations in Korea and for the more detailed analysis, Images taken by geostationary satellite may be used to estimate solar irradiance fluxes at earth's surface. It is based on the empirical correlation between a satellite derived cloud index and the irradiance at the ground. From the results, the measured data has been collected at 16 different stations and estimated using satellite at 23 different stations over the South Korea from 1982 to 2009. The Result of analysis shows that the annual-average daily global radiation on the horizontal surface is $3.56kWh/m^2/day$.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.5035-5042
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• 2014

Background: Knowledge and individual perceptions about adverse effects of all forms of tobacco exert direct influence on the level of tobacco consumption in various socio-demographic groups. The objective of this study was to determine the nature, extent and demographic correlates of knowledge, attitudes and perceptions of use of tobacco among adults in low and middle income countries. Materials and Methods: The Global Adult Tobacco Survey, conducted in fourteen different countries from 2008-2010, was sourced for the data analyzed in this study. Descriptive statistical analyses were conducted to determine the prevalent knowledge and individual perceptions amongst adults about all forms of tobacco consumption. Results: There was relatively high awareness about the harmful effects of smoking tobacco with main awareness being about its relationship with lung cancer (>90% in most countries). In contrast, there was relatively low awareness about harmful effects of smokeless tobacco (< 90% in all countries except India and Bangladesh), and observed correlation of smoking tobacco with heart attack (40.6% in China, 65.1% in India) and stroke (28.2% in China, 50.5% in India). Conclusions: A large proportion of adults living in low and middle income countries possess adequate knowledge about smoking tobacco but have inadequate awareness as well as false perceptions about smokeless forms of tobacco. Popular beliefs of inverse relationships of tobacco consumption with knowledge, attitudes and perception of populations towards tobacco are challenged by the findings of this study.

• Journal of the Korean Solar Energy Society
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• v.32 no.2
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• pp.28-34
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• 2012

It is necessary to estimate the regression coefficients in order to predict the daily global radiation on a horizontal surface. Therefore many different equations have proposed to evaluate them for certain areas. In this work a new correlation has been made to predict the solar radiation for 16 different areas over Korea by estimating the regression coefficients taking into account cloud hours of bright sunshine. Particularly, the multiple linear regression model proposed shows reliable results for estimating the global radiation on a horizontal surface with monthly average deviation of-0.26 to +0.53% and each station annual average deviation of -1.61 to +1.7% from measured values.

• KIEAE Journal
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• v.11 no.1
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• pp.15-20
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• 2011

Computer simulation of buildings and solar energy systems is being used increasingly in energy assessments and design. For the six locations (Seoul, Incheon, Daejeon, Deagu, Gwangju and Busan) in South Korea where the global hourly solar irradiation (GHSI) is currently measured, GHSI was calculated using a comparatively simple cloud cover radiation model (CRM) and sunshine fraction radiation model (SFRM). The result was that the measured and calculated values of GHSI were similar for the six regions. Results of cloud cover and sunshine fraction models have been compared with the measured data using the coefficient of determination (R2), root-mean-square error (RMSE) and mean bias error (MBE). The strength of correlation R2 varied within similar ranges: 0.886-0.914 for CRM and 0.908-0.934 for SFRM. Average MBE for the CRM and SFRM were 6.67 and 14.02 W/m2, respectively, and average RMSE 104.36 and 92.15 W/m2. This showed that SFRM was slightly accurate and used many regions as compared to CRM for prediction of GHSI.

• Journal of Distribution Science
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• v.18 no.10
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• pp.39-52
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• 2020

Purpose: This study aims to find out the relationship between the impact of Korean crew on airline service quality in the global aviation market, which is the representative of the face-to-face sales and can help in the face-to-face market of aviation services. Research design, data: The survey was conducted for about a month from March 1 to April 6, 2020, and a total of 300 copies were used in the analysis of the results. To verify the hypothesis, data was analyzed using the statistical package program SPSS 18.0, and frequency analysis, exploratory factor analysis, correlation analysis, and multiple regression analysis were performed. Results: It is a study on the sales of face-to-face service of crews of global airlines. Non-verbal elements in airline service face-to-face sales have been shown to have a significant impact on service quality. Conclusions: In the face-to-face service sales of global airlines, communication has been shown to affect service quality. A face-to-face sale using mother tongue means important. The better the flight attendant's linguistic face-to-face selling ability, the more positive on the airline's quality of service. It suggests that the communication skills of managers in the aviation service market are important for repurchase.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.6
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• pp.940-953
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• 2006

The major source of carbon monoxide (CO) at the Earth's surface is the incomplete combustion of biomass and fossil fuels. Because the global lifetime of CO is about two months, it can be used as a tracer for pollution from anthropogenic activities and biomass hurtling. In this paper, we introduced the principle and algorithm of the Measurement of Pollution in the Troposphere (MOPITT) instrument for global CO monitoring. The MOPITT instrument, which was launched on the Satellite Terra in 1999, measures CO column and mixing ratio based on gas correlation radiometry. CO levels can be determined by a retrieval algorithm based on the maximum likelihood method minimizing the difference between observed and modeled radiances. MOPITT level 2 data (HDF format) can be downloaded through the Earth Observing System (EOS) data gateway of NASA. ASCII files of CO parameters can be extracted from HDF files, and then temporal and spatial distributions can be obtained. Finally, we showed an example of CO monitoring in April 2000. The locations of forest fires and distribution of MOPITT CO clearly indicated that not only anthropogenic emissions but also forest fires play an important role in CO levels and global CO distribution. Our introduction to MOPITT and the example of MOPITT data interpretation would be helpful for scientists who want to use the EOS data.