• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4604-4611
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• 2012

The purpose of the research is to investigate the factors affecting the life quality of oral health according to the knowledge and behavior related with oral health. Total 272 people who work in Gyeong-Nam province participated in this survey. The research shows that major 4 factors are subjective whole body health, ages, dietary pattern and dry mouse. The subjective whole body health and dietary pattern have an positive effect on the life quality of oral health, whereas ages and dry mouse an negative effect on this. As a result, the health and the life quality of oral health should be improved by investigating the factors affecting oral health and thus developing the program enhancing the oral health to prevent oral disease.

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.851-857
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• 2000

SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(防風), Radix Cocculi or Stephaniae(防己), Semen Armeniacae(杏仁), Cortex Cinnamomi(肉桂), Radix Scutellariae(黃芩), Radix Paeoniae Lactiflorae(白芍藥), Radix Ginseng(人蔘), Rhizoma Cnidll(川芎), Herba Ephedrae(麻黃), Radix Glycyrrhizae(甘草), Radix Aconiti(附子?), Fructus Zizyphi Jujubae(大棗), Rhizoma Zingiberis(生薑) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.

• Journal of Korean Medical classics
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• v.22 no.2
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• pp.337-347
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• 2009

"Dong-uisusebowon("東醫壽世保元")", written by Ijema(李濟馬), is about the treatment and prevention of diseases according to the four constitutions, Soeum, Soyang, Taeeum and Taeyang. He presents a precise pathogenic mechanism along with specific treatment methods of the Ulgwang(鬱狂) Syndrome which are Seungbo(升補) and Ikgiseung-yang[益氣而升陽] in comparing Mang-yang(亡陽) and Ulgwang Syndromes. However, in the case of the Mang-yang Syndrome, he merely presents formulas without mentioning details of the treatment methods. In this study, the formulas of the Mang-yang Syndrome and Ulgwang Syndrome were thoroughly compared and analyzed, leading to the conclusion that the concept of the Ikgi(益氣) method matches that of the Bojung-ikgitang(補中益氣湯) of Idongwon(李東垣), consisted of ingredients such as Ginseng, Radix Astragali, Radix Angelicae Gigantis, Rhizoma Atractylodis Macrocephalae etc,, and the concept of Seung-yang matches that of Gyejitang(桂枝湯). Furthermore, we have examined the addition of Radix Aconti Lateralis Preparata[附子] to the Ikgiseung-yang[益氣而升陽] method to be aimed at restoring the Yanggi(陽氣). Lastly, through comparison of formulas according to the progress of the Mang-yang Syndrome and Ulgwang Syndrome, we have presented a more detailed explanation of the concept of each treatment methods: the Mang-yang Syndrome focuses more on Seung-yang(升陽), Ulgwang leans more towards Ikgi(益氣).

• Korean Journal of Soil Science and Fertilizer
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• v.23 no.2
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• pp.128-134
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• 1990

Croping pattern, fertilizer application, Soil chemical characteristics, plant nutritional condition and growth status were investigated in three major vinyl house farms near Yesan. Croping pattern changed from tomato to pumpkin due to tomato diseases such as wilting and blossom-end rot. Wilting seemed to be closely related with high EC, nitrogen and root cyst nematodes. Calcium deficiency seemed to be due to high potassium, EC in soil and high uptake of iron. Chinese cabbages in summer showed poor growth (80% inhibition) due to high EC(1.8mmho/cm) and easily got wenny root disease that might due to high phosphorus (1055ppm) in soil. Summer radish showed poor growth (50% inhibition) due to high EC(1.6mmho/cm), K and Mg resulting in base imbalance. Farmers used 5 kinds of compound fertilizer as basal application and one without P for top dressing. Urea and KCL were used for top dressing. Heavy application of livestock manure and chemical fertilizer for every crop made eutrophic even in subsoil.

• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.101-108
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• 2016

Objectives: This study introduces the history and types of Korean pharmacopuncture and reports trends of research on Korean pharmacopuncture. Methods: Pharmacopuncture studies were searched from the first year of each search engine to 2014 by using seven domestic and foreign search databases. Selected studies were divided into the history of pharmacopuncture, kinds and features of pharmacopuncture, research types, and experimental and clinic studies and were then classified by year of publication, type of pharmacopuncture, disease, and topic. Results: Pharmacopuncture can be classified into four large groups: meridian field pharmacopuncture (MFP), eight-principles pharmacopuncture (EPP), animal-based pharmacopuncture (ABP) and mountain-ginseng pharmacopuncture, which is a single-compound pharmacopuncture (SCP). The largest numbers of studies were reported from 1997 to 2006, after which the numbers decreased until 2014. Of experimental studies, 51.9%, 18.7%. 14.3%, 9% and 3.4% were on SCP, ABP, MFP, formula pharmacopuncture (FP), and EPP, respectively. Of clinical studies, 54.7%, 15.3%. 14.9% 10.0% and 1.5% were on ABP, MFP, EPP, SCP, and FP (1.5%), respectively. Among clinical studies, case reports and case series accounted for 76.5%, followed by randomized controlled trials (RCTs, 16.4%) and non-RCT (13.9%). Musculoskeletal diseases, toxicity and safety tests, anti-cancer effects, and nervous system diseases were mainly treated in experimental studies while musculoskeletal diseases, nervous system diseases, toxicity and safety tests, and autonomic nerve function tests were addressed in clinical studies. Bee venom (BV) was the most frequently-used pharmacopuncture in mechanism studies. Pharmacopuncture was mainly used to treat musculoskeletal diseases. Conclusion: Pharmacopuncture and studies of it have made great progress in Korea. Studies on BV pharmacopuncture and musculoskeletal diseases accounted for most of the studies reported during the review period. Research on the types of pharmacopuncture and diseases has to be expanded. Especially, studies on the use of MFP and EPP for treating patients with various diseases are needed.

• The Journal of Korean Medicine
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• v.27 no.2 s.66
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• pp.253-261
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• 2006

Backgrounds : Hyperlipidemia is a major cause of cardiovascular disease (CVD). Lowering serum cholesterol levels could reduce the risk of CVD. Insamsansa-eum (Renshenshanzha-yin, ISE), composed of Ginseng Radix and Crataegii Fructus, is a new medicine developed to treat hyperlipidemia and CVD. Objectives : In this study, we intended to explore the clinical effects of ISE on patients with hypercholesterolemia, and moreover we also compared its effects according to the pattern identification. Methods : Subjects were administered ISE with the dose of 600 mg three times a day for 4 weeks. Patterns of subjects were identified with diagnostic scoring system for Yin-Yang and the condition of Excess-Deficiency before treatment. Serum lipids were measured at baseline and after 4 weeks of medication. Results : ISE lowered total cholesterol(TC), triglyceride(TG), total lipid(TL), phospholipid(PL) and low density lipoprotein cholesterol(LDL) significantly. Compared with the data of our previous study, it was less effective than Atorvastatin but showed equal lipids-lowering effect to Chunghyul-dan (Qingxue-dan, CHD). In Yang pattern group, ISE was less effective in lowering TG and LDL than it was in not-Yang-not-Yinpattern group. On safety assessment, there was no adverse effect, hepatic or renal toxicity. Conclusions : We suggest that ISE is a safe and useful herbal medicine for hypercholesterolemia, and moreover it could be more useful when it is used for patients with not Yang pattern.

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.228-254
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• 2006

1. King Hyeonjong(1641-1674) mainly suffered from eye disease and abscess. He specially took a hot spring bath for cure of eye and skin problems. He probably died of septicemia and the following gastro-intestinal infection at the age of 34, quite early for his age. 2. King Sukjong(1661-1720) was not very well all through his life, but lived quite longer than other Kings in the Joseon Dynasty. He suffered from various diseases like heart-based heat, abscess, edema, upper respiratory infections, etc. He frequently took the treatments of acupuncture and moxibustion. He presumably died of dysfunction of liver and kidney at the age of 60. 3. King Gyeongjong(1688-1724) suffered from political problems from birth to death, so he may have had excessive mental stress for his poor health. He mainly suffered from heart-based heat and abscess. It is quite not sure why he died in only one month from the onset of his symptoms, so many people thought that he was poisoned to death. He probably died of septicemia and the following gastro-intestinal infection at the age of 37. 4. King Yeongjo(1694-1776) lived for 83 years, which is the longest of all the Kings in the Joseon Dynasty. He mainly suffered from hypofunction of gastro-intestinal system with cold symptoms, coughs, uneasiness. He took various kinds of herbal medicine, of which he took ginseng the most. He is supposed to be dead due to his old age at 83.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.2
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• pp.133-137
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• 2013

Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has been used for prevention of illness in Korea. In this study, we investigated the mechanism(s) by which ginsenoside Rg2 may inhibit VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS) in human umbilical vein endothelial cell (HUVEC). LPS increased VCAM-1 and ICAM-1 expression. Ginsenoside Rg2 prevented LPS-mediated increase of VCAM-1 and ICAM-1 expression. On the other hand, JSH, a nuclear factor kappa B (NF-${\kappa}B$) inhibitor, reduced both VCAM-1 and ICAM-1 expression stimulated with LPS. SB202190, inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and wortmannin, phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, reduced LPS-mediated VCAM-1 but not ICAM-1 expression. PD98059, inhibitor of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) did not affect VCAM-1 and ICAM-1 expression stimulated with LPS. SP600125, inhibitor of c-Jun N-terminal kinase (JNK), reduced LPS-mediated ICAM-1 but not VCAM-1 expression. LPS reduced IkappaB${\alpha}$ ($I{\kappa}B{\alpha}$) expression, in a time-dependent manner within 1 hr. Ginsenoside Rg2 prevented the decrease of $I{\kappa}B{\alpha}$ expression stimulated with LPS. Moreover, ginsenoside Rg2 reduced LPS-mediated THP-1 monocyte adhesion to HUVEC, in a concentration-dependent manner. These data provide a novel mechanism where the ginsenoside Rg2 may provide direct vascular benefits with inhibition of leukocyte adhesion into vascular wall thereby providing protection against vascular inflammatory disease.

• Korean journal of applied entomology
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• v.23 no.4 s.61
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• pp.209-214
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• 1984

Since 1980, burley tobacco plants grown mainly in the western hat of the Korea. have shown two new types of disease symptom. Both symptoms were found to be caused by two different PVY strains : the vein banding type by a PVY strain designated as PVY-VB and necrosis on leaf veins by a PVY strain designated as PVY-VN, Identification of the PVY strains was based on host range test. aphid( Myzus Persicae) transmission test, physical properties, serology, and observation of virus particle morphology. The virus particles were measured to be about 730 nm without any difference in shape or dimensions between the two strains. Both strains also gave a positive reaction to the PVY antiserum in SDS-agar gel double diffusion test. These strains, however, gave a negative reaction to the tobacco etch virus and tobacco vein mottling virus antisera.

• Herbal Formula Science
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• v.17 no.1
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• pp.45-59
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• 2009

To beef up natural immunity, we have used Bojoongikgitang which has been known to treat enervation in the oriental medicine. This study is analyzed out structure material and the chief virtue of a prescription through Literature Study on Bojoongikgitang and Clinical Application. And this study is investigated to make sure of the necessity and additional symptoms in using Bojoongikgitang. The results are as follows : 1. It is regarded that the structure materials of Bojoongikgitang consist of Astragali Radix one jeon(錢) five poon(分), Ginseng Radix, Atractylodis Macrocephalae Rhizoma, Glycyrrhizae Radix one jeon for each, Citri Pericarpium, Angelicae Gigantis Radix five poon for each, Cimicifugae Rhizoma, Bupleuri Radix three poon for each. 2. The necessity symptoms in using Bojoongikgitang are a pale complexion, drowsy eyes(目無精光), vigorless, lethargy, sluggish talk. 3. The fittest prescriptions prior to the necessity symptoms in using Bojoongikgitang are Bojoongikgitang added Paeoniae Radix Alba, Scutellariae Radix in fever, exterior heat, mild fever, Bojoongikgitang added Ephedrae Radix, Tritici Fructus Levis, Aconiti Iateralis Preparata Radix in spontaneous sweating, spontaneous sweating by yang deficiency, Bojoongikgitang added Paeoniae Radix Alba, Scutellariae Radix in feeling the pulse like a flood, largeness and weakness, scatter and largeness, flood and largeness for diagnosis respectively. Bojoongikgitang Entering the heart channel by culturing the blood prescription in vexation, vexation and anxiety, Soongihwajoongtang in headache, DossiBojoongikgitang in rigor, Bojoongikgitang annexed Saengmaecsan in thirst, Daninsamtang or Jojoongikgitang in asthma, asthma by congestion of the upwardness, Eeegongsan in light eating, eschewing food, losing one's appetite, Ikweeseungyangtang in deficiency failing to control blood and blood collapsey. 4. To treat a functional disease is superior to organic one in using Bojoongikgitang.