• BMB Reports
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• v.55 no.5
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• pp.213-219
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• 2022

The blood-brain barrier (BBB) is an interface between cerebral blood and the brain parenchyma. As a gate keeper, BBB regulates passage of nutrients and exogeneous compounds. Owing to this highly selective barrier, many drugs targeting brain diseases are not likely to pass through the BBB. Thus, a large amount of time and cost have been paid for the development of BBB targeted therapeutics. However, many drugs validated in in vitro models and animal models have failed in clinical trials primarily due to the lack of an appropriate BBB model. Human BBB has a unique cellular architecture. Different physiologies between human and animal BBB hinder the prediction of drug responses. Therefore, a more physiologically relevant alternative BBB model needs to be developed. In this review, we summarize major features of human BBB and current BBB models and describe organ-on-chip models for BBB modeling and their applications in neurological complications.

• Journal of Life Science
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• v.34 no.5
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• pp.356-364
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• 2024

Lymph nodes (LNs) are crucial sites where immune responses are initiated to combat invading pathogens in the body. LNs are organized into distinctive compartments by stromal cells. Stromal cell subsets constitute special niches supporting the trafficking, activation, differentiation, and crosstalk of immune cells in LNs. Fibroblastic reticular cells (FRC) are a type of stromal cell that form the three-dimensional structure networks of the T cell-rich zones in LNs, providing guidance paths for immigrating T lymphocytes. FRCs imprint immune responses by supporting LN architecture, recruiting immune cells, coordinating immune cell crosstalk, and presenting antigens. During inflammation, FRCs exert both spatial and molecular regulation on immune cells through their topological and secretory responses, thereby steering immune responses. Here, we propose a model in which FRCs regulate immune responses through a three-part scheme: setting up, supporting, or suppressing immune responses. FRCs engage in bidirectional interactions that enhance T cell biological efficiency. In addition, FRCs have profound effects on the innate immune response through phagocytosis. Thus, FRCs in LNs act as gatekeepers of immune responses. Overall, this study aims to highlight the emerging roles of FRCs in controlling both innate and adaptive immunity. This collaborative feedback loop mediated by FRCs may help maintain tissue function during inflammatory responses.

• The KIPS Transactions:PartD
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• v.10D no.7
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• pp.1177-1188
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• 2003

In this paper, a cyber space for multimedia conference is designed and implemented using gatekeeper and web service which satisfies H.323 standards. The implemented gatekeeper manages a registration and a call control for H.323 video conference terminals. The implemented gate-keeper can manage registered users efficiently with directory services using web service. Also, software maintenance of video conference system is established by service provider instead of users using control download on web. finally, we present the practical use of video conference through various applications of directory services.

• The Journal of Art Theory & Practice
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• no.2
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• pp.121-146
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• 2004

Compared to the influences of Korean art journalism, the researches on them are rarely conducted. This study aims to examine the influence of art journalism in art magazines in Korea. Although it is essential to consider media, journalism, public opinion altogether, I focused only on the media due to the absence of previous studies I have analyzed the current conditions of korean art journalism, types of feature articles, sponsors, their relations with articles and the comparison with foreign art journalism in terms of production conditions. There have been about one hundred art magazines published in previous sixty years and currently there are twenty three. Monthly periodicals are the majority: the publishers are sorted out as publishing houses, galleries, newspaper company in order specialized art magazines developed from the eighties. Through an examination of feature articles in these art magazines, I found that they repeated similar art issues and covered the same artists sponsors and articles. Moreover, when the magazines went through the conflicts between managers and editors, the ascendency of managers obstructed the development of art journalism regarding journal quality. These days, art journalism have been comparatively regressed compared to other art systems such as art museums, curatorship, international aft festivals, distributions and art promotion policies. The main causes for failure were the lack of professional management, the limited effort to diversify sponsors, and the repetition of the same informants and events without making an effort to be specialized Magazines are published media which contribute to the creation of culture, distribution, and preservation. Therefore art magazines can be said the most influential media in forming art culture and distributing it. It is quite necessary to reform the problems of repeating of information and the lack of speciality in conjunction with the commitment of management and editorialship.

• Journal of the Korea Convergence Society
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• v.8 no.11
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• pp.431-438
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• 2017

The purpose of the study was to identify the factors on Gatekeeper behavior of adolescents for suicide prevention. The participants were five high school students from D metropolitan city. The collected data were analysed using t-test, ANOVA, Multiple regression with SPSS 21.0 program. In the results of the study, Gatekeeper behavior showed significant difference by gender(t=2.85, p=.005), type of school(t=-2.81, p=.006), experience of significant others' suicide(t=-2.09, p=.038). Gatekeeper behavior had a positive relationship with the perception toward suicide prevention(r=.23, p=.006) and the knowledge about suicide prevention(r=.42, p<.001). In regression analysis, significant influencing factors on Gatekeeper behavior were the perception toward suicide prevention (${\beta}=.20$, p=.006) and the knowledge about suicide prevention(${\beta}=.35$, p<.001), and these variables showed 24.3% of variance. Therefore, it need to develop the intervention for improving positive perception and active knowledge about suicide prevention in adolescents. In addition, future study to identify various predictable variables is needed.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2017.11a
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• pp.515-534
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• 2017

본 연구는 Kingdon의 다중흐름모형(MSF: Multiple Stream Framework)을 통하여 정부연구개발예산 중 미래성장동력 부문에 대한 예산결정 과정을 살펴보았다. 연구 대상은 대통령 의지로 의제가 발기된 정책의제 국가전략프로젝트이며 비합리적 의사결정에 대한 견제수단으로 활용되는 예비타당성조사가 예산의 결정단계로 이어지는 일련의 과정을 살펴보았다. 연구의의는 3개 흐름에서 행해지는 비합리적 의사결정 케이스를 확인하고, 정부 R&D 사업의 예산결정과정에서 온-오프 스위치 역할을 하고 있는 게이트 키퍼(gate keeper)인 사업 평가자(PM), 구체적 사업계획안을 만드는 부처의 사업기획자, 그리고 자문역할을 하는 전문가집단을 정책혁신가로 바라볼 수 있다는 의의를 발견했다. 공공부문의 정책혁신가는 사업을 기획한 부처와 같이 자기(부처)이익을 추구하지는 않지만 공공가치를 추구하는 독립적인 위치에 있었고, 어느 일면에는 과학기술분야의 성장과 발전을 바라고 있었다. 다시 말해, 연구는 정책혁신가라는 존재가 특정한 개인 또는 집단일 뿐만 아니라 2개 집단 이상의 복수의 정책혁신가가 있을 수 있는 가능성을 확인하였다. 특히, 예비타당성조사에서 PM이 흐름 간의 중개를 상향적 직접적으로 수행하지 않지만, 하향적으로 사업기획자 등 주체들 간 의견을 조정하고 합의를 이끌어 내는 모습은 중요 활동을 하고 있음이 확인되었다. 연구는 정책혁신가의 새로운 형태를 발견하였지만, 정책결정의 전 주기가 아닌 정부예산 이후 국회예산이라는 특정 시기를 대상으로 하였는데, 분석 과정에서 예산과 시간의 제약으로 사업기획을 담당했던 부처 및 기재부공무원, 해당기술 분야 연구자, 국회 관계자 등 관련 주체들의 견해를 고루 담아내지 못한 아쉬움이 있다. 향후 다양한 참여자들의 의견을 수렴할 수 있다면 정책 결정 과정에 정책혁신가의 다층적(Multiple) 존재 여부와 특성을 면밀히 들여다 볼 수 있을 것이다.

• Korea Journal of Hospital Management
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• v.25 no.1
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• pp.13-20
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• 2020

Purposes: This study has the purpose to the improvement of health promotion for local residents through delivery of high-quality medical service by improving imbalance of medical use and seeking an improvement plan for accessibility of effective medical service by understanding the pattern of medical use by region. Methodology: As for the method, this study derived results at the significance level of p<0.05 through chi square test(χ² test) and Generalized Estimating Equation(GEE) SAS 9.4 version by using the data of the 7th Korean Longitudinal Study of Ageing 2018. Findings: Study results show that local residents use medical service such as hospitalization care and outpatient visit more as compared to the residents in Gyeonggi-do/large or medium-sized cities. The more the number of chronic disease, the more they select hospitalization care rather than outpatient visit. Results also show that patients engaged in labour tend to select outpatient treatment rather than hospitalization treatment. Meanwhile, severity of disease turned out to be higher amongst medical care beneficiaries than that of national health insurance patients when comparing the types of medical security. Practical Implications: In stead of solving the problem of the difference in medical use by region from the aspect of income and economic level, an integrative solution shall be provided putting viewpoint on the social phenomenon suited to the changes of the times. This study suggests a plan for using a health and medical community care center that acts as a gate keeper of regional medical service.

• The KIPS Transactions:PartD
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• v.9D no.3
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• pp.501-510
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• 2002

A various multimedia application services should be developed with techniques of high speed networks and computer. Among these, video-conference system over Internet is useful and important, and the standardization for it should be showed in ITU-T H.323. H.323 standardization consists of four components such as Terminal, MCU(Multipoint Control Unit), Gatekeeper, and Gateway. Among these, the functions of Gatekeeper are as follows, firstly the address translation service to translate the alias address into the IP address, secondary conference admission control service to control of conference start and termination, thirdly bandwidth management service for H.323 terminals. In this paper, we implemented the Gatekeeper for an efficient management of video-conference components in Internet environment, and will introduce our system. As the experimental results with CUSeeMe and Netmeeting which are well-known H.323 terminal, it is known that our gatekeeper should be satisfied with H.323 standardization.

• Korean Journal of Heritage: History & Science
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• v.43 no.1
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• pp.212-235
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• 2010

The purpose of this study is to examine the characteristics of the location and the spatial composition of Uireung that is located in Seokgwan-dong, Seongbuk-gu, Seoul, in order to understand the landscape architectural characteristics. The results are as follows. First, Uireung is 6.4km from Changdeokgung Palace and 5.5km from Heunginjimun Gate. It did not violate the distance standard (40km) for the royal tombs according to Joseon Dynasty Neung-won Myo-je. Second, Uireung is in harmony with the nature and shows the authoritative characteristics of the royal authority through the spatial composition and rank(Entrance Area, Ceremonial Area, Burial Area). Third, there are burial mound, stone sheep, stone tiger, stone table, stone watch pillars in the upper platform, and stone civil official, stone horse, stone lantern in the middle platform, and stone military official, stone horse in the lower platform, and T-shape shrine, worship road in the ceremonial area. There is no pond and a tomb keeper residence, but the position, size, and form can be approximated through historical research materials. There are a colony of pine trees around the burial mound and 64 species of trees such as pine tree, zelcova tree, and fir tree below the burial mound.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.12
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• pp.1903-1914
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• 2008

The purpose of this study was to propose an efficient and feasible global market entry strategy for the Korean apparel industry by analyzing the Italian fashion industry. In particular, the study investigated the role of foreign exhibitions and showrooms supported and organized by Italian fashion organizations. The methodology for this study was to analyze industrial reports, review previous studies and conduct in-depth interviews with 23 industry experts in Italy, Korea and LA. The results indicated that the most prominent factor in the Italian fashion industry was the fashion cluster, which is a strong and organic network of diverse fashion related areas No matter the size of the enterprise, firms can get practical, prompt and efficient support from diverse associations. The network operated by the associations provides strong support to each firm by organizing collections and exhibitions, and providing promotional activities. Showrooms and agents are another supportive "gate keeper", directly related to an enterprise's sales. However, Korean fashion firms did not have enough information or knowledge for foreign exhibitions, nor did they make aggressive promotional efforts in the global market. Despite the many fashion-related associations exist in Korea, their programs are too focused on visible accomplishments and are too oriented on "big company" and "big voice", rather than many "small firms". In conclusion, the Korean fashion industry-particularly the fashion industry in Seoul-has strong potential to become the center of the global fashion market in the future. However, the fashion support system that can act as the channel to promote firms and to meet global buyers needs to be supplemented. To feasibly create this system, government or industry associations should develop a strong and generous support system and network, and they must recognize the need for small firms to exist.