• Journal of Nutrition and Health
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• 제26권9호
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• pp.1085-1097
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• 1993

Recently, as korean eating habits have been westernized, the incidence of large intestinal disease, which has been recognized as western diseases until now, has been increasing. This study was conducted to find the association of fiber intake and large bowel function. This was a cross-sectional survey, the data were obtained by self-administering questionnaire and study population was adults aged more than 18 years old in Seoul(N=1200). The response rate was 81.8%. The results were summarized as followed: 1) The factors associated with bowel function was sex, habits of defecation such as regularity and frequencies of defecation, fecal form, gastrointestinal diseases, psychological scores, self-assessment of physical status, exercise and alcohol drinking. 2) The association between the amount of fiber intake and bowel function was significant. This association was still significant, when the confounders such as disease of upper digestive system and alcohol drinking were controlled.

• 한국식품영양과학회지
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• 제29권5호
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• pp.865-869
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• 2000

흰쥐에게 뽕잎을 4주동안 투여하여 장기능에 미치는 영향을 알아본 결과, 사료이용효율은 10% 투여구에서 14% 감소되었고, 장 통과시간은 1% 투여구에서 16%, 10% 투여구에서 21% 빨라졌다. 장의 길이는 1% 투여구에서 10%, 10% 투여구에서 11% 증가되었고, 장 통과속도는 1% 투여구에서 30%, 10% 투여구에서 40% 빨라졌다. 변의 pH는 대조구가 6.91인데 비해 1% 투여구는 6.07, 10% 투여구는 5.95로서 뽕잎 투여량이 증가함에 따라 변의 pH는 점차 낮아졌다. 변량은 1% 투여구에서 57%, 10% 투여구에서 91% 증가되었다. 변중의 무기성분 중에서 K의 함량이 50% 증가하였으나, 이는 뽕잎 중에 K함량이 많기 때문으로 생각된다.

• 한국잠사곤충학회지
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• 제41권1호
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• pp.29-35
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• 1999

누에분말, 쫑잎, 상백피의 투여가 흰쥐의 장관기능에 미치는 영향에 대해 알아본 결과, 시료이용효율은 대조구 0.1792, 뽕잎 투여구 0.1486, 누에분말 투여구 0.1543, 상백피 투여구 0.1573으로 잠상산물 투여가 사료이용효율을 떨어뜨렸다. 장통과시간은 대조구 644.0분, 뽕잎 투여구 512.2분, 누에분말 투여구 555.9분, 상백피 투여구 574.0분 이었다. 또한 잠상산물을 투여함에 따라 소장길이는 6~11% 증가하였으며, 대장길이는 0~11% 증가하였다. 장의 통과속도는 대조구 20.77 mm/분, 뽕잎 투여구 29.11 mm/분, 누에분말 투여구 26.07 mm/분, 상백피 투여구 25.05 mm/분으로 잠상산물의 투여에 따라 장의 통과속도가 21~61% 빨라졌다. 소장의 무게는 7.26~8.45g과 대장의 무게는 1.69~2.08g으로 잠상산물 투여로 유의성 있는 증가를 나타냈다. 변의 pH는 뽕잎 투여구가 가장 낮은 5.95이며, 변량 또한 5.42g/day으로 가장 많았다. 이상의 결과로부터 잠상산물을 투여함에 따라 장관 기능이 유의성 있게 개선됨을 알 수 있었다.

• Journal of Korean Biological Nursing Science
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• 제8권1호
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• pp.49-59
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• 2006

Purpose: The purpose of this study was to investigate the recovery time and its related factors after sedative gastroscopy. Method: The subjects of this study consisted of 103 clients. The data were collected from clients who visited a health care system at S national university hospital in Seoul. The sedative gastroscopy was performed by gastrointestinal endoscopists. Patients' demographics and medical characteristics were assessed by reviewing the patients' charts. Degree of sedation and recovery were assessed by the Ramsay's sedation scale and the Aldrete score, respectively. Result: The mean recovery time was $37.8{\pm}16.9$ minutes(range, 5 to 90 minutes). Hypoxia was resent in four clients during recovery. Alcohol intake(p=0.02) and pulmonary function(p=0.003) were significant factors affecting recovery time, whereas midazolam dose and sedation level were not. Conclusion: Current alcohol intake, pulmonary function were predicting factors on recovery time.

• 대한한의학회지
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• 제23권3호
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• pp.11-25
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• 2002

Objectives: This study was undertaken to investigate the effects of Yijin-tang and GamiYijin-tang on the gastrointestinal functions of rats Methods: Sprague-Dawley rats were used as experimental animals, and were administered Yijin-tang (Sample I group, 47.5 mg/ml) and GamiYijin-tang(Sample II group, 38.37 mg/ml, Sample ill group, 85.3 mg/ml) water extract once a day. Changes of gastric juice volume and intestinal mobility index were measured. The effects on colitis induced by dextran sulfate sodium in the rats were also observed. Results: 1. Gastric juice volume was decreased significantly in the sample I group (P<0.05) compared to the control group; there was not significant effect in the sample II and sample III groups. 2. The moving distance of carbon bolus was increased significantly in the sample n (p<0.05) and sample II (p<0.05) groups compared to the control group; there was not significant effect in the sample I group. 3. The intestinal mobility index was increased significantly only in the sample II group (P<0.05) compared to the control group. 4. The feces consistency was increased significantly on the 3rd and 5th day of the sample I group (P<0.05), on 3rd, 4th, and 5th day of the sample II (p<0.05) and the sample III (p<0.05) groups compared to the control group. 5. The feces property index was increased significantly only on the 5th day of the sample III group (p<0.05) compared to the control group. 6. The number of WBC and RBC, levels of hemoglobin and hematocrit were not changed in all sample groups compared to the control group. 7. The number of the type B Goblet cells were increased significantly in the sample II (p<0.05) and the sample III (P<0.05) groups, but the number of the type C Goblet cells were decreased significantly only in the sample ill group (P<0.05) compared to the control group. Conclusions: According to the above results, GamiYijin-tang compared to the Yijin-tang were decreased hight significantly in gastrointestinal mucose and histological antidiarrheal function with protection of the goblet cell more excellently were observed.

• Journal of Gastric Cancer
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• 제4권4호
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• pp.268-271
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• 2004

Purpose: Most gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of the KIT or the platelet-derived growth factor receptor alpha (PDGFRA) genes, but approximately $10\%$ of the GISTs are wild types for both the KIT and the PDGFRA genes. The purpose of this study was to investigate the possibility that epidermal growth factor receptor (EGFR) gene mutation might be responsible for the pathogenesis of GIST. Materials and Methods: We analyzed the EGFR gene in 60 GISTs for the detection of somatic mutations by using the polymerase chain reaction (PCR), the single strand conformation polymorphism (SSCP), and DNA sequencing in exon 18, 19, and 21 encoding the kinase domain. Results: The SSCP analysis revealed no evidence of EGFR mutations in exon 18, 19, and 21 in GISTs. Conclusion: The data indicate that the EGFR gene may not be mutated in human GIST and suggest that therapies targeting the mutated EGFR gene products might not be useful in the treatment of GISTs.

• 대한한방내과학회지
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• 제21권1호
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• pp.162-168
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• 2000

Irritable Bowel Syndrome(IBS) is the most common disease in the western male, and it is founded in $70{\sim}80%$ patient who has Gastrointestinal trouble. It is characterized by the formation of disorders of Gastrointestinal tract, for example, constipation, diarrhea, abdominal pain& discomfort, stool urgency, and so on. The etiology of IBS is uncertain, but the majority of patients has emotional problems. The aims of this study are to investigate and summarize the current trends of treatment for IBS so as to suggest the effective and available way to treat this disease. In Oriental Medicine, the IBS is recognized as Stagnation of the Iiver-qi(肝氣鬱結), Incoordination between the liver and the stomach(肝胃不和). So the point of treatment of IBS is Invigorating the spleen and relieving the depression of Iiver-qi(疏肝健脾), Regulating the function of the liver and the flow of qi(調肝理氣), Regulating the stomach and lowering the adverse flow(和胃降逆), and the treatment can be approached in several ways through herb drugs, acupuncture. Some of the herb drugs have substances which promote gastric and small intestinal emptying. Acupuncture and moxibustion therapies stimulate the meridian points of LR(足厥陰肝經), ST(足陽明胃經), LI(手陽明腸經), SI(手太陽小腸經) and is reported to be effective for releafing syndromes. Anal therapy, attachment of herb drug to umbilicus are annunced as the effective treatments. So, this study of the approach and application of these treatments on IBS would be necessary.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3233-3238
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• 2012

Esophageal carcinoma (EC) is one of the most aggressive cancers with a poor prognosis. Understanding the molecular mechanisms underlying esophageal cancer progression is a high priority for improved EC diagnosis and prognosis. Recently, MSP58 was shown to behave as an oncogene in colorectal carcinomas and gliomas. However, little is known about its function in esophageal carcinomas. We therefore examined the effects of MSP58 knockdown on the growth of esophageal squamous cell carcinoma (ESCC) cells in vitro and in vivo in order to gain a better understanding of its potential as a tumor therapeutic target. We employed lentiviral-mediated small hairpin RNA (shRNA) to knock down the expression of MSP58 in the ESCC cell lines Eca-109 and EC9706 and demonstrated inhibition of ESCC cell proliferation and colony formation in vitro. Furthermore, flow cytometry and western blot analyses revealed that MSP58 depletion induced cell cycle arrest by regulating the expression of P21, CDK4 and cyclin D1. Notably, the downregulation of MSP58 significantly inhibited the growth of ESCC xenografts in nude mice. Our results suggest that MSP58 may play an important role in ESCC progression.

• 대한영양사협회학술지
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• 제10권4호
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• pp.442-451
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• 2004

Protein-calories malnutrition is common among patients in the hospital. In particular, elderly patients with neurologic disorders has more risk of nutritional deficiency due to swallowing difficulty. Enteral tube feeding is more economical, physiological and immunological than parenteral nutrition for patients who have adequate gastrointestinal function. This study was conducted patients with neurologic disorders who received enteral nutrition at Asan Medical Center from February 1 to October 10, 2002. The control group (48 patients) were given traditional feeding methods 4 times a day while the treatment group (45 patients) were given improved feeding methods 3 times a day. We assessed nutritional status of patients and compared to both groups. We investigated body weight, serum albumin, hemoglobin, total lymphocyte count by means of nutrition markers. The objectives of this study is to reduce the time needed for nutritional requirement of patients without an increase in gastrointestinal intolerances. The results of this study are as follows: 1. Nutritional status of many patients in both groups were either malnourished or at risk for malnutrition. 2. The time to arrive to the nutritional requirements were 6.21 $\pm$ 0.35 days for the control group and 4.24 $\pm$ 0.52 days for the treatment group. The treatment group showed a significantly shorter amount of time. 3. The changes of the nutritional marker in the control group showed a significant drop in body weight, serum albumin and serum hemoglobin while the treatment group experienced a significant increase in body weight, serum albumin and total lymphocyte count. 4. Feeding intolerane such as diarrhea, high residual volume, ileus, nausea and vomiting were investigated. Diarrhea found in 25.1% (12 patients) of the control group and 22.2% (10 patients) of the treatment group and these findings are not significant.

• The Korean Journal of Pain
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• 제32권2호
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• pp.69-78
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• 2019

Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to as high as 81%. This can lead to a significant impairment in quality of life, often resulting in discontinuation of opioid therapy. In this regard, a good doctor-patient relationship is especially pivotal when initiating opioid therapy. In addition to a detailed history of bowel habits, patient education regarding the possible gastrointestinal side effects of the drugs is crucial. In addition, the bowel function must be regularly evaluated for the entire duration of treatment with opioids. Furthermore, if the patient has preexisting constipation that is well under control, continuation of that treatment is important. In the absence of such history, general recommendations should include sufficient fluid intake, physical activity, and regular intake of dietary fiber. In patients of OIC with ongoing opioid therapy, the necessity of opioid use should be critically reevaluated in terms of an with acceptable quality of life, particularly in cases of non-cancer pain. If opioids must be continued, lowering the dose may help, as well as changing the type of opioid. If these measures do not suffice, the next step for persistent OIC is the administration of laxatives. If these are ineffective as well, treatment with peripherally active ${\mu}$-opioid receptor antagonists should be considered. Enemas and irrigation are emergency measures, often used as a last resort.