• 대한한의학방제학회지
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• 제25권4호
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• pp.499-508
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• 2017

Objectives : Skeletal muscle atrophy occurs in response to a variety of conditions. The unloading to muscle occurs clinically in limb immobilization, bed rest, spinal cord injury and peripheral nerve damage, resulting in significant loss of muscle mass and force production. Muscle disuse is accompanied by an increase in apoptotic signaling, which mediates some of the responses to unloading in the muscle. In this study we tested the hypothesis that Daeyeoung-jeon extract would improve muscle recovery after reloading following disuse. Method : Twenty young male Sprague-Dawley rats were used for the studies. The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. No intervention was performed on the right leg and used as intact region. The Rats in Daeyeoung-jeon treated group (DYJ) were orally administrated Daeyeoung-jeon water extract, and rats of Control group were given with saline only. After 2 weeks of immobilization, all animals were sacrificed, and the whole gastrocnemius muscles were dissected from both legs. The morphology of right and left gastrocnemius muscles in both DYJ and Control groups were assessed by hematoxylin and eosin staining. Moreover, to investigate the immobilization-induced muscular apoptosis, the immunohistochemical analysis of Bax and Bcl-2 was carried out. Results : Daeyeoung-jeon represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group. The treatment with Daeyeoung-jeon extract significantly reduced the immunoreactivity of BAX and increased the immunoreactivity of Bcl-2 in gastrocnemius muscle compared with Control group. Conclusion : Daeyeoung-jeon has protective effects against immobilization-induced muscle atrophy by regulating the activities of apoptosis-associated BAX/Bcl-2 proteins in gastrocnemius muscle.

• Preventive Nutrition and Food Science
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• 제8권4호
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• pp.377-382
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• 2003

This study investigated the effects of green tea on the muscle antioxidative defense system in the white & red gastrocnemius muscles of rats after aerobic exercise. Male Sprague-Dawley rats weighing 150 10 g were randomly assigned to a control group, non-exercise with green tea group (G group), and exercise training group. The exercise training group was then further classified as the training (T) group and training with green tea (TG) group, the latter of which was supplemented with green tea in the drinking water during the experimental period. The rats in the exercise training groups (T and TG) were subjected to aerobic exercise on a treadmill 30 min/day at a speed of 28 m/min (7% incline) 5 days/week, while the other groups (control and G group) were cage confined for 4 weeks. Thereafter, the rats were sacrificed with an injected overdose of pentobarbital just after running. In the white muscle, the xanthine oxidase (XOD) activities were 71 % higher in the T group compared to control group, whereas the TG group had the same activity as the control group. The XOD activities in the red gastrocnemius muscle exhibited the same tendency as in the white muscle. The superoxide dismutase (SOD) activity in the white muscle was lower in the T group compared with the control group, yet significantly higher in the TG group compared with the T group. The SOD activities in the red gastrocnemius muscle exhibited the same tendency as in the white gastrocnemius muscle. The glutathione peroxidase (GSHpx) activities in the white & red gastrocnemius muscles were 43 % lower in the T group compared with the control group, yet the activities in the TG group remained at control levels. The glutathione S-transferase (GST) activity in the white muscle was not significantly different among any of the three groups, but in the red gastrocnemius muscle, the TG group had the same activity as in the control group. The thiobarbituric acid reactive substance (TBARS) contents in the white & red gastrocnemius muscles were higher in the T group than in the control but the control and TG groups had the same concentrations of TBARS. In conclusion, the supplementation of green tea in rats subjected to aerobic exercise was found to reduce the peroxidation of muscle lipids by enhancing the antioxidative defense mechanism.

• 한방재활의학과학회지
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• 제27권4호
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• pp.1-9
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• 2017

Objectives Oxidative stress, in which antioxidant proteins and scavenger protection are overwhelmed by reactive oxygen species (ROS) production, is recognized as one of central causes of disuse muscle atrophy. In this study, the hypothesis that oral treatment with Dangguibohyul-tang (Dangguibuxuetang) could attenuate immobilization-induced skeletal muscle atrophy was tested. Methods The hindlimb immobilization was performed with casting tape to keep the left ankle joint in a fully extended position. The Rats in Dangguibohyul-tang treated group (DGBHT) (n=10) were orally administrated Dangguibohyul-tang water extract, and rats of Control group (n=10) were given with saline only. After 2 weeks of immobilization, the morphology of right and left gastrocnemius muscles in both DGBHT and Control groups were assessed by hematoxylin and eosin staining. Results Dangguibohyul-tang water extract represented the significant protective effects against the reductions of the left gastrocnemius muscles weight and average cross section area to compared with Control group. Moreover, the treatment with Dangguibohyul-tang extract significantly enhanced the Cu/Zn-SOD activities in gastrocnemius muscle compared with Control group. Conclusions Thses results suggest that Dangguibohyul-tang has protective effects against immobilization-induced muscle atrophy by increasing the Cu/Zn-SOD activities in gastrocnemius muscle.

• The Journal of Korean Physical Therapy
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• 제23권3호
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• pp.49-56
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• 2011

Purpose: To evaluate changes in lower extremity muscle activity caused by high heeled shoe wearing during normal, brisk, and upslope walking. Methods: Twenty healthy young women (age, $23.9{\pm}2.47$) participated in this study. Muscle activities of the tibialis anterior, peroneus longus, gastrocnemius lateralis, gastrocnemius medialis, soleus, hamstring, vastus lateralis, and vastus medialis while walking normally, walking briskly, and walking up a slope. Results: When walking normally, the peroneus longus, gastrocnemius lateralis, soleus, and vastus lateralis evidenced higher activity when high-heeled shoes were worn (p<0.05). During brisk walking, the peroneus longus and gastrocnemius lateralis exhibited higher activity (p<0.05). Although the peroneus longus and vastus lateralis exhibited higher activity when walking up an incline with high-heeled shoes, the activity levels of the tibialis anterior and gastrocnemius medialis were lower (p<0.05). Conclusion: The results of this study demonstrate that increased heel height substantially reduces muscle effort when walking up a slope. From a therapeutic perspective, it is possible that using high heeled shoes over a short period might enhance muscle activity of ankle evertor, although it can cause mediolateral muscle imbalances in the lower extremities.

• 대한간호학회지
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• 제34권1호
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• pp.150-159
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• 2004

Purpose: The purpose of this study was to determine the effect of DHEA on hindlimb muscles(soleus, plantaris and gastrocnemius) in a focal brain ischemia model rat. Method: Twenty-seven male Sprague-Dawley rats were randomly divided into three groups: CINS(cerebral ischemia + normal saline), CIDH(cerebral ischemia + DHEA), or SHNS(sham + normal saline). Both the CINS and CIDH groups underwent a transient right middle cerebral artery occlusion operation. In the SHNS group, a sham operation was done. 0.34mmol/kg DHEA was administered daily by an intraperitoneal injection for 7days. Results: The muscle weight, muscle fiber cross-sectional area of the Type I muscle fiber of soleus and Type II muscle fiber of plantaris and gastrocnemius, myofibrillar protein content of gastrocnemius, and muscle strength in the CINS group decreased compared with the SHNS group. The muscle weight, muscle fiber cross-sectional area of the Type II muscle fiber of plantaris and gastrocnemius, myofibrillar protein content of soleus, and muscle strength in the CIDH group increased compared with the CINS group. Conclusion: It was identified that muscle atrophy could be induced during 7 days after a cerebral infarction, and DHEA administration during the early stages of a cerebral infarction might attenuate muscle atrophy.

• PNF and Movement
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• 제22권2호
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• pp.223-231
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• 2024

Purpose: The aim of this study was to investigate changes in ankle muscle strength, range of motion (ROM) dorsiflexion, and gastrocnemius flexibility following gastrocnemius stretching with talus stability taping in subjects with limited ankle dorsiflexion. Methods: Fifteen subjects (all males) with limited ankle dorsiflexion participated in this study for six weeks. Ankle muscle strength, ankle passive dorsiflexion ROM, and gastrocnemius flexibility were assessed pre- and post-intervention. Results: Ankle dorsiflexion and plantarflexion strength and passive ankle dorsiflexion ROM were significantly increased post-intervention compared to pre-intervention (p < 0.05). Gastrocnemius flexibility was significantly improved post-intervention compared to pre-intervention (p < 0.05). Conclusion: Gastrocnemius stretching with talus stability taping can be recommended for subjects with limited ankle dorsiflexion to increase passive ankle dorsiflexion, flexibility, and ankle muscle strength.

• Korean Journal of Acupuncture
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• 제39권3호
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• pp.107-113
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• 2022

Gastrocnemius muscle partial rupture is a common muscle injury. This case is report on a patient with a gastrocnemius muscle partial rupture who was continuously observed with ultrasonography while receiving Korean medicine treatment. Acupuncture, pharmacoacupuncture, herbal medicine, physical therapy and rehabilitation treatment were performed on a patient diagnosed with gastrocnemius partial rupture. The improvement of symptoms was evaluated using Numeric Rating Scale (NRS), Range of Motion (ROM) of ankle, circumference of calf and size of hematoma by using ultrasonography. NRS decreased more than 90%, ROM of ankle joint gradually improved, calf circumference improved, and hematoma reduced by more than 90% when measured by ultrasonography. In this study, gastrocnemius muscle partial rupture was observed with ultrasonography, and it is considered that the Korean medical treatment is useful for gastrocnemius muscle partial rupture.

• 대한물리치료과학회지
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• 제24권3호
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• pp.30-38
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• 2017

Purpose: The purpose of this study was to find out changes in muscle activity and body heat of tibialis anterior and gastrocnemius muscles according to the area touching the ground through the areas of different heel heights using electromyography and infrared thermography. Method: This study was carried out for 15 healthy women. After walking for 30 minutes, the body temperature was measured in a standing state in front of the measuring instrument, and the distance between the treadmill and the thermography was about 50M, which may cause an error in measurement. Result: The results of the comparison of changes in muscle activity and body heat showed significant differences all in tibialis anterior, medial gastrocnemius muscle an lateral gastrocnemius muscle. The changes in body heat of tibialis anterior and medial gastrocnemius muscles according to the shape of the heel were lower as the area of the heel touching the ground was wider. Conclusion: This study was conducted to find out changes in muscle activity and body heat of tibialis anterior and gastrocnemius muscle depending on the area touching the ground through different heel areas.

• 대한간호학회지
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• 제36권7호
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• pp.1232-1241
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• 2006

Purpose: The purpose of this study was to examine the effects of cerebral ischemia on Type I(soleus) and Type II(plantaris, gastrocnemius) muscles, and to determine the effects of isometric contraction training by electro- stimulation on Type I and II muscles in cerebral ischemia model rats. Method: Twenty-five male Sprague-Dawley rats were randomly divided into four groups: ST(stroke), STES(stroke+electrostimulation), SH(sham) and SHES (sham+electrostimulation). The ST and STES groups received a transient right middle cerebral artery occlusion operation. The SH and SHES groups received a sham operation. The STES and SHES groups had daily isometric contraction training by electrostimulation(100Hz, 45mA, 7.5V) on hindlimb muscles for 7days. Result: Plantaris and gastrocenmius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the muscle fiber cross-sectional area of gastrocnemius in the ST group significantly decreased compared with the SH group. Soleus, plantaris, gastrocnemius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the Type I muscle fiber cross-sectional area of soleus and the Type II muscle fiber cross-sectional area of gastrocnemius in the STES group significantly increased compared with the 57 group. Conclusion: Hindlimb muscle atrophy occurs after acute stroke and isometric contraction training by electrostimulation during early stages of a stroke attenuates muscle atrophy of Type I and Type II muscles.

• 한국운동역학회지
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• 제25권1호
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• pp.77-84
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• 2015

Objective : The purpose of this study was to analyze the effects of lower limb muscle activity on postural stability and ground type in elderly women subjects. Method : Forty two subjects participated in the experiment (high group - age: $74.29{\pm}4.13yr$, height: $152.44{\pm}5.54cm$, weight: $57.43{\pm}6.16kg$, BMI: $24.77{\pm}2.99$, low group - age: $77.67{\pm}5.16yr$, height: $151.40{\pm}3.93cm$, weight: $60.92{\pm}6.40kg$, BMI: $26.59{\pm}2.57$). Wireless EMG with eight channels was used. Ground types were classified as flat and cushion. Results : In the double-support phase, left and right rectus femoris, left biceps femoris, left and right tibialis anterior, and left gastrocnemius did not show a significant difference in postural stability according to ground type. However right biceps femoris and gastrocnemius showed higher muscle activity in the elderly women group with lower postural stability. In the single-support phase, left and right rectus femoris, right biceps femoris, and left and right tibialis anterior did not show a significant difference in postural stability according to ground type. In addition, left biceps femoris had higher muscle activity in the elderly women group with lower postural stability. Left gastrocnemius had higher muscle activity in the elderly women group with higher postural stability and right gastrocnemius had higher muscle activity in the elderly women group on cushion ground. Conclusion : In a dynamic postural stability and cushion ground, biceps femoris and gastrocnemius muscle activity were high. As a result, biceps femoris and gastrocnemius muscle strengthening exercise on cushion ground could be beneficial in the prevention of falling.