• 제목/요약/키워드: gastric ulceration

검색결과 71건 처리시간 0.033초

Expansion of Indication for Endoscopic SD in Early Gastric Cancer

  • Kim, Do-Hoon;Jung, Hwoon-Yong
    • Journal of Gastric Cancer
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    • 제10권2호
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    • pp.49-54
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    • 2010
  • Endoscopic resection is now accepted as curative treatment modalities for early gastric cancer without lymph node metastasis. However, based on large-scaled data about the risk of lymph node metastasis in early gastric cancer and as a result of the technical development of endoscopic devices, it was suggested that the criteria for endoscopic resection should be extended. According to the treatment guidelines for gastric cancer in Japan, the extended indications include the following: differentiated-type mucosal cancer without ulceration and greater than 2 cm in diameter, differentiated-type mucosal cancer with ulceration and up to 3 cm in diameter, undifferentiated-type mucosal cancer without ulceration and up to 2 cm in diameter, and, in the absence of lymphovascular invasion, a tumor not deeper than submucosal level 1 (less than $500\;{\mu}m$). In this review, we discuss the evidence of the application of expanded endoscopic indication based on analysis of biologic behavior and data of endoscopic resection.

H. pylori에 감염된 소화성궤양 치료에 관한 문헌고찰 -근래(近來) 중의잡지(中醫雜誌)를 중심(中心)으로- (A literature study on the treatment of H. pylori infected gastric ulceration. -Chinese medicine journal put first in importance-)

  • 서영철;임성우;이원철
    • 동국한의학연구소논문집
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    • 제7권1호
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    • pp.53-64
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    • 1998
  • 소화기 질환중 다수를 차지하고 있는 소화성궤양의 발병원인이 H. pylori로 많이 발생한다고 보고되는 현재, 부작용을 최소화 하고 치료율을 높이기 위한 변증치료를 최근 보고된 문헌을 통해 고찰하고 향후 H. pylori 감염에 의한 소화성궤양 치료의 연구 방향을 제시해 본다.

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Therapeutic Effect of Astaxanthin Isolated from Xanthophyllomyces dendrorhous Mutant Against Naproxen-Induced Gastric Antral Ulceration in Rats

  • KIM JEONG-HWAN;KIM SEUNG-WOOK;YUN CHEOL-WON;CHANG HYO-IHL
    • Journal of Microbiology and Biotechnology
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    • 제15권3호
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    • pp.633-639
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    • 2005
  • Frequently used for humans as a nonsteroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesions. The present study was undertaken to investigate the in vivo therapeutic effect of astaxanthin, isolated from a Xanthophyllomyces dendrorhous mutant, against naproxen-induced gastric antral ulceration in rats. The rats were treated with three doses of astaxanthin [1, 5, and 25 mg/kg body weight (B.W.), respectively] once daily for 2 weeks after pretreatment of 80 mg of naproxen/kg B.W. twice daily for 3 days, while the control rats received only 80 mg of naproxen/kg B.W. twice daily for 3 days. The oral administration of astaxanthin (1,5, and 25 mg/kg B.W.) showed a curative effect against naproxen (80 mg/kg B.W.)-induced gastric antral ulcer and reduced the elevated lipid peroxide level in gastric mucosa. In addition, astaxanthin treatment resulted in significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that acute gastric mucosal lesion induced by naproxen nearly disappeared after the astaxanthin treatment. These results suggest that astaxanthin eliminated the lipid peroxides and free radicals induced by naproxen and may be a potential candidate for remedy of gastric ulceration.

두릅나무 근피 추출물의 약물학적 연구 -흰쥐의 위염 및 웨궤양에 대한 효과- (Pharmacological Studies on Root Bark Extract of Aralia elata - Antigastritic and Antiulcerative Effects in Rats -)

  • 이은방;정춘식
    • 약학회지
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    • 제37권6호
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    • pp.581-590
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    • 1993
  • In a preliminary screening of the plant extracts for the antigastritic action in rats, the extract of Aralia elata(Araliaceae) showed positive activity in HCI plus ethanol induced gastric lesion. Systematic fractions with hexane, chloroform, ethyl acetate and butanol resulted in the most patent activity with the butanol fraction: This butanol fraction at the oral dose of 200 mg/kg exhibited significant inhibition of absolute alcohol induced gastric lesion which was more potent than 100 mg/kg of cimetidine and had significant stimulation of mucus secretion. The butanol fraction showed significant decreases in the ulcer indices of Shay ulcers and inhibition of gastric juice secretion with acid output in pylorus-ligated stomachs of rats. It also suppressed the acetic acid induced gastric ulcer. These results might suggest that the butanol fraction had inhibitory action in gastric lesion and ulceration through inhibition of gastric acid secretion and stimulation of mucin secretion in the stomachs of rats.

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느릅나무 수피 엑스가 흰쥐의 위염, 위궤양 및 발부종에 미치는 영향 (The Influence of Methanol Extract of Ulmus davidiana var. japonica Cortex on Gastric Erosion and Ulcer and Paw Edema in Rats)

  • 이은방;김옥경;정춘식;정기화
    • 약학회지
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    • 제39권6호
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    • pp.671-675
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    • 1995
  • The bark of Ulmus davidiana var. japonica(Ulmaceae) has been described in traditional books to have diuretic and laxative actions, to ameliorate edematous disease, and to be used in insomnia and gastointestinal disorders. Thus this study was carried out to elucidate some of the pharmacological activities of the plant extracts. The results obtained in tills experiment indicated that its methanol extract elicited remarkable inhibition of HCI.ethanol induced gastric lesion, Shay ulceration and gastric secretion. However, it showed no anti-inflammatory action. The acute toxicity of the extract was low, that is, the minimum lethal dose was more than 2000 mg/kg by oral administration in mice. The systematic fractionation of the methanol extract by hexane, ether, ethylacetate and butanol resulted in potent prevention of gastric erosion in butanol and water fractions.

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Creosote에 의해 발생한 위궤양 2례 (Two Cases of Creosote Induced Gastric Ulcer)

  • 김광렬;박재옥;신상만
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제3권1호
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    • pp.84-88
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    • 2000
  • Secondary peptic ulceration and gastritis have been known to be associated with stress, exogenous agents, drugs or infection. Salicylate (aspirin) ingestion has been known to be associated with increased incidence of gastric ulcer and more frequently as the cause of hemorrhagic gastric erosions and gastritis. Some medications such as tetracyclines and iron preparations have been associated with ulceration of the gastrointestinal tract. Chemotherapeutic agents including cytoxan and methotrexate also have been implicated in the development of mucosal and gastrointestinal ulcers. We have experienced two cases of hemorrhagic gastric ulcers due to creosote ingestion in a 13 month and a 5 year old boys. Creosote is a main component of one of the popular digestives, Jungrohwan in Japan and Korea.

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생강추출물의 항위염 . 항궤양 작용 (Antigastritic and Antiulcerative Action of the Extract of Zingiberis Rhizoma)

  • 양원경;정춘식;정기화;김재완;이은방
    • 약학회지
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    • 제36권2호
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    • pp.173-179
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    • 1992
  • The rhizoma of Zingiber officinale has been used as antiemetic, expectorants, stomachache relieving drugs and digestive accelerators. From the observation of antigastritic action of the methanol extract of the rhizoma, it was fractionated with hexane, chloroform, ethyl acetate and butanol, followed by bioassay on antigastritic and antiulcerative activity. The hexane and the chloroform fraction reduced significantly HCl ethanol induced gastric lesion at the dose of 370 and 210 mg/kg, p.o., respectively. On the gastric ulceration and gastric secretion in pylorus-ligated rats, the hexane fraction decreased the volume of gastric secretion and acid output, and also increased pH at the dose of 370 mg/kg, i.d.. It showed considerable curative ratio of acetic acid induced ulcer without inhibition of indomethacin induced gastric lesion. The methanol extract showed low acute toxicity with minimum lethal dose of more than 3000 mg/kg, p.o. in mice. In conclusion, Zingiberis rhizoma exhibited antigastric and antiulcerative activity which might be attributable to inhibition of gastric secretion. It is revealed that the active component may be present in the hexane fraction.

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Gastric Cancer and Concomitant Gastric Tuberculosis: A Case Report

  • Kang, Hyok-Jo;Lee, Young-Seok;Jang, You-Jin;Mok, Young-Jae
    • Journal of Gastric Cancer
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    • 제12권4호
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    • pp.254-257
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    • 2012
  • Gastric tuberculosis is rare even in the endemic areas of tuberculosis, and can mimic neoplasm by causing elevation of the mucosa with or without ulceration. Here, we report a case in which a 54-year-old female patient admitted for resection of early gastric cancer was found to have coexisting histopathologically and bacteriologically confirmed gastric cancer and tuberculosis.

Adenosine Triphosphate-Induced Gastric Cytoprotection Against Ulcerogenic Effects of Hypothermic Restraint Stress and Diclofenac in Rats

  • Eub shoka, Afaf A. Eub-Shoka
    • Archives of Pharmacal Research
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    • 제16권1호
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    • pp.71-74
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    • 1993
  • The protective effect of adenosine triphosphate (ATP) on gastic ulcer induced in rats has been studied. Gastic ulceration was induced by hypothemic restraint stress or dicolofenac sodium. Gastic acid secretion and mucosal injury produced by the hypothemic restraint stress was greater as compared with those produced by diclofenac sodifum. ATP significantly reduced area of injury, however, increased cyclic adenosine monophosphate (cATP) content. Administration of dipyridamole along with ATP did not change the total lesion area in both models when compared to ATP alone. Aminophyline antagonized antagonized the protective effect of ATP on the injured area. Famotidine was found to be effective in reducing gastric acid output as well as the total injured area without any change in cAMP content when given along with ATP.

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한국 전통약주의 위보호 효과 (Gastroprotective Effect of Korean Rice-Wine (Yakju))

  • 김승진;백지영;박찬구;김계원
    • 한국식품과학회지
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    • 제36권5호
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    • pp.818-822
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    • 2004
  • 본 실험은 랫드나 마우스에서 2가지 실험적 위궤양 유발 모델과 알코올 반복 투여를 이용하여 한국 전통약주의 위 보호효과를 확인하였다. 24시간 절식시킨 랫드에 전통약주를 250-1,000mg/kg를 경구 투여하고 30분 후에 150mM HCl-60% EtOH를 투여하거나 전통약주 62.5-1,000mg/kg를 투여하고 30분 후에 무수 에탄올을 경구 투여하였을 때, 대조군에 대해 유의성 있는 위병변 억제효과를 나타내었다. 또한 마우스에서 30% 알코올을 12시간 간격으로 7일간 반복투여 하였을 때, 대조군에 대해 육안으로 관찰 가능한 위병벽 억제 효과를 확인하였다.