• 사상체질의학회지
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• 제2권1호
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• pp.189-197
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• 1990

In order to study on the effect of Volume of Gastric Juice Free acid, Total acid, and Anti-Ulceration, Jo gi pyeong yoe san Extract were administered to the Pylorus-Ligated Rats induced Shay's Ulcer. The results were as follows. 1. The effect upon Volume of Gastric Juice, Free Acid, and Total Acid of experimenting group with medicine, in contrast with Control Group and Pyeong yoe san Group, there was decreasing that it reveled Significant Value. 2. In the effect upon Shay's Ulcerlation, Jo gi pyeong yoe san Extract were decrease to the Ulcer Index that it reveled Significant Value. 3. Control Group and Pyeong yoe san Group were similar. According to the above results, Jo gi pyeong yoe san is assumed to have Anti-Ulcerlation.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제5권1호
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• pp.68-72
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• 2002

비록 크기가 크지 않고, 가장자리가 뾰족하거나 날카롭지 않지만, 1개 이상의 자석을 삼킨 경우나 혹은 자석과 금속류를 함께 삼킨 경우에는 장의궤양, 천공, 누공 등의 합병증을 일으킬 수 있으므로 신속한 제거가 필요할 것으로 생각되며, 저자들은 3개의 팔찌자석을 삼킨 후 동반된 위궤양 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국수산과학회지
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• 제33권6호
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• pp.520-523
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• 2000

Alginate를 가열에 의해 저분자화하여 저분자화에 따른 위점막 보호작용을 검토하기 위해 랫드에 있어서 저분자 alginate인 HAG-10, HAG-50, HAG-100 및 alginate의 투여 가 $HCl{\cdot}ethanol$ 용액과 침수스트레스에 의해 유발되는 위손상과 위궤양의 억제효과에 미치는 영향을 광학현미경으로 점막의 형태를 관찰하면서 그 억제율과 조직학적 변화를 측정하였다. $HCl{\cdot}ethanol$ 용액과 침수스트레스에 의해 유발되는 위손상과 위궤양에 대한 억제효과에 미치는 저분자 alginate의 영향을 검토한 결과, 그 억제효과는 alginate에서 가장 높았고, 다음으로 HAG-50과 HAG-100 및 HAG-10의 순으로 HAG-50, HAG-100 및 alginate에서 현저한 효과를 보였으나, HAG-10은 아무런 효과를 나타내지 않았다. 위손상과 위궤양점막을 광학현미경으로 관찰해 볼 때, 대조군과 HAG-10에서는 위점막 전체에 걸친 출혈과 부식에 의한 응고괴사가 진행되었고 점막 (粘膜)과 점막근판 (粘膜筋板) 및 근육층 (筋肉層)에 부종의 발생과 조직의 파괴가 일어났으나 HAG-50, HAG-100 및 alginate에서는 가벼운 병변이 진행되어 위점막층에 약간의 출혈만 관찰되어 위손상억제 및 위궤양 억제효과를 뚜렷히 나타내었다.

• Journal of Nutrition and Health
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• 제27권7호
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• pp.699-708
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• 1994

This study aimed to verify the nutritional and curative effects of protein hydrolysate in rats with cysteamine-induced duodenal uncer. Duodenal ulcer rat model was established by intraperitoneal injections of cysteamine. Sprague-Dawley, female rats weighing approximately 200g were intraperitoneally injected twice cysteamine(13mg/100g BW) at intervals of 3h per day. This procedure was repeated 3$\times$at intervals of 3d. Animals fed on 10% casein diet for infection periods. After last injection, 4 kinds of diets(10% casein, 20% casein, 10% casein hydrolysate, 20% casein hydrolysate) were given. Gastric montility, trypsin activity in gastrointestinal content, retention rate of nitrogen, plasma total protein, albumin, amino-N, urinary urea nitrogen, creatinine and hydroxyproline were analyzed for nutritional effects of dietary nitrogen levels(10%, 20%) and sources(casein, casein hydrolysate). In duodenal ulcer rat model, there was no differences between 20% casein diet and 20% casein hydrolysate in the view of severeness of ulcer, gastric emptying rate, serum total protein, serum albumin, plasma $\alpha$-amino-N, UUN, creatinine excretion, GFR, nitrogen retention. On the other hand, rats on 10% casein hydrolysate diet group had more curative effect of the ulcer, higher plasma albumin concentration and nitrogen retention than 10% casein diet group. The casein hydrolysate diet group was lower trypsin activity in small intestinal content than the casein diet group, at both nitrogen levels(10%, 20%). The results suggest that protein hydrolysate be applied in diet therapy for the patients with gastrointestinal ulcer.

• Archives of Pharmacal Research
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• 제26권11호
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• pp.906-911
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• 2003

We previously reported that the butanol (BuOH) fraction of the head of Panax ginseng exhibited gastroprotective activity in peptic and chronic ulcer models. In order to identify the active constituent, an activity-guided isolation of the BuOH faction was conducted with a HCI$.$ethanol-induced gastric lesion model. The BuOH fraction was passed through a silica-gel column using a chloroform-methanol gradient solvent system, and six fractions (frs. 1-6) were obtained. The active fr. 5 was further separated by silica-gel column, to yield 6 subfractions (subfrs. a-f). Subfr. d was composed of ginsenosides Re, Rc and $Rb_1$. The most active constituent was ginsenoside $Rb_1$ ($GRb_1$), a protopanaxadiol glycoside, which was investigated for its anti-ulcer effect. Gastric injury induced by HCI$.$ethanol, indomethacin and pyloric ligation (Shay ulcer) was apparently reduced with oral $GRb_1$ doses of 150 and 300 mg/kg. $GRb_1$ at these dosage significantly increased the amount of mucus secretion in an ethanol-induced model. The anti-ulcer effects were consistent with the result of histological examination. These results suggest that the major active constituent in the head of Panax ginseng is $GRb_1$ and that anti-ulcer effect is produced through an increase in mucus secretion.

• 대한약리학회지
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• 제5권2호
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• pp.149-152
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• 1969

Anti-ulcer activity of licorice alkaloid fraction, separated from Glycyrrhiza glabra L. by fractionation according to general alkaloid purification procedure, were studied with various experimental gastric ulcers. In Shay ulcer, licorice alkaloid fraction inhibit significantly response rate and severity of ulcer. But there was no significant changes in volume and pH of gastric contents. A male rat was fixed on a board and immersed up to breast in water of $25^{\circ}C$ for 20 hrs. Hemorrhage and erosion develop in all the animals on the mucosa of the glandular portion of stomach. Licorice alkaloid fraction (5 mg/kg, 10 mg/kg) inhibit significantly in the severity of stress ulcer but there was no changes in the response rate. Chlorpromazine produce marked inhibition in the severity and response rate of ulcer It was suggested that at least the anti-ulcer activity of licorice alkaloid fraction was not mediated by central depression.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3021-3027
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• 2014

Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.

• Advances in Traditional Medicine
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• 제6권1호
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• pp.53-57
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• 2006

The plant Indigofera aspalathoides is used by a large number of tribes in India for the treatment of various hepatic disorders and abscesses. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its protective effects on gastric mucosal lesion in Wister albino rats against indomethacin, histamine and ethanol induced gastric mucosal damage. The response to MEIA was assessed using the ulcer index, thiobarbituric acid reactive substance (TBARS), and glutahione level. MEIA pretreatment showed protection against chemical induced gastric mucosal damage, a significant reduction in the ulcer index and TBARS activity and increase glutathione level as compared with that of standard drugs.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권1호
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• pp.23-28
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• 2012

Purpose: Interest in peptic ulcer in children has been relatively low because the disease is rarer in children than in adults and there were restrictions in the application of endoscopy to children, but the recent development of pediatric endoscopy is activating research on pediatric peptic ulcer. Thus, this study compared the $H.$ $pylori$ infection rate and clinical and endoscopic findings among pediatric patients diagnosed with peptic ulcer. Methods: We analyzed retrospectively 58 pediatric patients for whom whether to be infected with $H.$ $pylori$ was confirmed selected out of pediatric patients diagnosed with gastric ulcer or duodenal ulcer through upper gastrointestinal endoscopy at the Department of Pediatrics of Gachon University Gil Hospital during the period from January 2002 to December 2007. A case was considered $H.$ $pylori$ positive if $H.$ $pylori$ was detected in the Giemsa stain of tissue or the results of UBT (urea breath test) and CLO (rapid urease test) were both positive. Results: Of the pediatric patients, 37 were infected with $H.$ $pylori$ and 21 were not. The $H.$ $pylori$ infection rate increased with aging and the result was statistically significant ($p$<0.05). However, $H.$ $pylori$ infection was not in a statistically significant correlation with sex, chief complaint, and gastroduodenal ulcer ($p$>0.05). Conclusion: $H.$ $pylori$ infection increased with aging, but was not significantly correlated with gastroduodenal ulcer. Further research may need to examine prospectively the relation between $H.$ $pylori$ and gastroduodenal ulcer in the Incheon area.

• 대한한방내과학회지
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• 제19권2호
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• pp.185-207
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• 1998

In order to study the immunohistochemical effects of Opae-san on gastric ulcer induced by HCl-aspirin in rats, experiments were done by oral administration and measure histological features of ulcer lesion, scaning electron microscopic appearance, the changes of numbers of parietal cells, chief cells, gastrin and somatostatin-immunoreactive cells. The obtained results are as follows: 1. Ulcerative lesions were numerously detected in control groups especially in junction of cardiac-fundic gastric mucosa and histologically very severe injury to gastric epithelium were observed too but in the Opae-san administrated groups, no gross lesion of ulcer were detected and histologically minor injury of gastric mucosa were observed. Most slight injuries to gastric mucosa were observed in 5 days after treatment. 2. The numbers of parietal cells were remarkably increased in control group but in Opae-san administrated groups appeared significant decrease compared to control groups. Most remarkably decrease of the numbers of parietal cells compared to control groups were observed in 5 days after treatment. 3. The numbers of chief cells were remarkably decreased in control group but in Opae-san administrated groups appeared significant increase compared to control groups. Most remarkably increase of the numbers of chief cells compared to control groups were observed in 5 days after treatment. 4. The numbers of gastrin-immunoreactive cells were remarkably decreased in control group but in Opae-san administrated groups appeared significant increase compared to control groups. Most remarkably decrease of the numbers of gastrin-immunoreactive cells compared to control groups were observed in 5 days after treatment. 5. The numbers of somatostatin-immunoreactive cells were remarkably decreased in control group but in Opae-san administrated groups appeared significant increase compared to control groups. Most remarkably decrease of the numbers of somatostatin-immunoreactive cells compared to control groups were observed in 5 days after treatment. 6. Scaning electron microscopically, severe denude and degeneration of gastric mucosa were observed in control groups but in Opae-san administrated groups the lesions were remarkably decreased compared to control groups.