• Journal of Audiology & Otology
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• 제24권3호
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• pp.149-156
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• 2020

Background and Objectives: The gap prepulse inhibition of the acoustic startle response has been used to screen tinnitus in an animal model. Here, we examined changes in the auditory late response under various conditions of gap prepulse inhibition. Subjects and Methods: We recruited 19 healthy adults (5 males, 14 females) and their auditory late responses were recorded after various stimuli with or without gap prepulsing. The N1 and P2 responses were selected for analysis. The gap prepulse inhibition was estimated to determine the optimal auditory late response in the gap prepulse paradigm. Results: We found that the gap per se generated a response that was very similar to the response elicited by sound stimuli. This critically affected the gap associated with the maximal inhibition of the stimulus response. Among the various gap-stimulus intervals (GSIs) between the gap and principal stimulus, the GSI of 150 ms maximally inhibited the response. However, after zero padding was used to minimize artifacts after a P2 response to a gap stimulus, the differences among the GSIs disappeared. Conclusions: Overall, the data suggest that both the prepulse inhibition and the gap per se should be considered when using the gap prepulse paradigm to assess tinnitus in humans.

• 대한청각학회지
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• 제24권3호
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• pp.149-156
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• 2020

Background and Objectives: The gap prepulse inhibition of the acoustic startle response has been used to screen tinnitus in an animal model. Here, we examined changes in the auditory late response under various conditions of gap prepulse inhibition. Subjects and Methods: We recruited 19 healthy adults (5 males, 14 females) and their auditory late responses were recorded after various stimuli with or without gap prepulsing. The N1 and P2 responses were selected for analysis. The gap prepulse inhibition was estimated to determine the optimal auditory late response in the gap prepulse paradigm. Results: We found that the gap per se generated a response that was very similar to the response elicited by sound stimuli. This critically affected the gap associated with the maximal inhibition of the stimulus response. Among the various gap-stimulus intervals (GSIs) between the gap and principal stimulus, the GSI of 150 ms maximally inhibited the response. However, after zero padding was used to minimize artifacts after a P2 response to a gap stimulus, the differences among the GSIs disappeared. Conclusions: Overall, the data suggest that both the prepulse inhibition and the gap per se should be considered when using the gap prepulse paradigm to assess tinnitus in humans.

• 재활복지공학회논문지
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• 제7권1호
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• pp.45-50
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• 2013

최근, 동물에 대한 객관적 이명 유무 검사인 GPIAS (gap prepulse inhibition of acoustic startling) 방법이 보고된바 있으나 동물과 달리 큰 자극음에 의한 놀람 반응 (startling response)을 사람에게서 측정하는 것은 어렵기 때문에, 청성 유발 반응과 같은 뇌파 신호를 측정하는 것이 사람 이명 검사법 연구에 보다 적합하다. 본 연구에서는 GPIAS 방법에서 사용하는 gap prepulse 기반의 소리 자극법을 자유롭게 적용할 수 있으며, 청각 심리학적 현상인 이명과 연관된 대뇌 피질 활동을 반영하는 청성 후기 반응 (auditory late latency response, ALLR) 뇌파를 간편하게 측정할 수 있는 청성 후기 반응 측정 시스템을 구현하였다. 또한, 구현된 시스템을 정상 청력을 가진 8인의 피험자에게 적용하는 실험을 통해 gap prepulse 기반의 소리자극에 의한 청성 후기 반응의 N1-P2 첨두치 크기를 측정하였고, gap prepulse에 의한 N1-P2 억제율 현상을 확인 및 평가하였다. 이를 통해, 구현된 청성 후기 반응 측정 시스템이 향후 gap prepulse 소리 자극법에 기반한 객관적 이명 검사법 연구 및 검증 도구로서 이용될 수 있음을 확인하였다.