• Atmosphere
• /
• v.27 no.3
• /
• pp.359-370
• /
• 2017

In this study, the oceanic Total Precipitable Water (TPW) retrieval algorithm at 16 km altitude of High Altitude Long Endurance Unmanned Aerial Vehicle (HALE UAV) is described. Empirical equation based on Wentz method (1995) that uses the 18.7 and 22.235 GHz channels is developed using the simulated brightness temperature and SeeBor training dataset. To do radiative simulation, Satellite Data Simulator Unit (SDSU) Radiative Transfer Model (RTM) is used. The data of 60% (523) and 40% (349) in the SeeBor training dataset are used to develop and validate the TPW retrieval algorithm, respectively. The range of coefficients for the TPW retrieval at the altitude of 3~18 km with 3 km interval were 153.69~199.87 (${\alpha}$), 54.330~58.468 (${\beta}$), and 84.519~93.484 (${\gamma}$). The bias and RMSE at each altitude were found to be about $-0.81kg\;m^{-2}$ and $2.17kg\;m^{-2}$, respectively. Correlation coefficients were more than 0.9. Radiosonde observation has been generally operated over land. To validate the accuracy of the oceanic TPW retrieval algorithm, observation data from the Korea Meteorological Administration (KMA) Gisang 1 research vessel about six clear sky cases representing spring, autumn, and summer season is used. Difference between retrieved and observed TPW at 16 km altitude were in the range of $0.53{\sim}1.87kg\;m^{-2}$, which is reasonable for most applications. Difference in TPW between retrieval and observation at each altitude (3~15 km) is also presented. Differences of TPW at altitudes more than 6 km were $0.3{\sim}1.9kg\;m^{-2}$. Retrieved TPW at 3 km altitude was smaller than upper level with a difference of $-0.25{\sim}0.75kg\;m^{-2}$ compared to the observed TPW.

• Progress in Medical Physics
• /
• v.29 no.1
• /
• pp.8-15
• /
• 2018

This work reports the acceptance testing and commissioning experience of the Robotic Intensity-Modulated Radiation Therapy (IMRT) M6 system with a newly released $InCise^{TM}2$ Multileaf Collimator (MLC) installed at the Yonsei Cancer Center. Acceptance testing included a mechanical interdigitation test, leaf positional accuracy, leakage check, and End-to-End (E2E) tests. Beam data measurements included tissue-phantom ratios (TPRs), off-center ratios (OCRs), output factors collected at 11 field sizes (the smallest field size was $7.6mm{\times}7.7mm$ and largest field size was $115.0mm{\times}100.1mm$ at 800 mm source-to-axis distance), and open beam profiles. The beam model was verified by checking patient-specific quality assurance (QA) in four fiducial-inserted phantoms, using 10 intracranial and extracranial patient plans. All measurements for acceptance testing satisfied manufacturing specifications. Mean leaf position offsets using the Garden Fence test were found to be $0.01{\pm}0.06mm$ and $0.07{\pm}0.05mm$ for X1 and X2 leaf banks, respectively. Maximum and average leaf leakages were 0.20% and 0.18%, respectively. E2E tests for five tracking modes showed 0.26 mm (6D Skull), 0.3 mm (Fiducial), 0.26 mm (Xsight Spine), 0.62 mm (Xsight Lung), and 0.6 mm (Synchrony). TPRs, OCRs, output factors, and open beams measured under various conditions agreed with composite data provided from the manufacturer to within 2%. Patient-specific QA results were evaluated in two ways. Point dose measurements with an ion chamber were all within the 5% absolute-dose agreement, and relative-dose measurements using an array ion chamber detector all satisfied the 3%/3 mm gamma criterion for more than 90% of the measurement points. The Robotic IMRT M6 system equipped with the $InCise^{TM}2$ MLC was proven to be accurate and reliable.

• Korean Journal of Food Science and Technology
• /
• v.48 no.4
• /
• pp.384-391
• /
• 2016

In previous studies, we confirmed that the ethanol extract of Polygonatum sibiricum (ID1216) has anti-obesity effects on high-fat diet-fed mice. To identify the obesity-related genes affected by ID1216, we studied its effects both in vivo and in vitro. In mice, single administration of ID1216 increased the expression of obesity-related genes including sirtuin1 (SIRT1), peroxisome proliferator-activated receptor ${\gamma}$ coactivator $1{\alpha}$ ($PGC1{\alpha}$) and peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) compared to that in mice administered the vehicle; their downstream genes (uncoupling proteins, acyl-CoA oxidase, adipocyte protein 2, and hormone-sensitive lipase) were also increased by ID1216. In fully differentiated 3T3-L1 adipocytes, ID1216 showed the same effects on anti-obesity genes as those in the animal model. Based on these results, we propose that ID1216 has anti-obesity effects by regulating the $SIRT1-PGC1{\alpha}-PPAR{\alpha}$ pathway and their downstream genes, thereby controlling energy and lipid metabolisms.

• The Korean Journal of Physiology and Pharmacology
• /
• v.13 no.6
• /
• pp.449-454
• /
• 2009

5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic ($\alpha$) and two regulatory ($\beta$ and $\gamma$) subunits. Two isoforms are known for catalytic subunit (${\alpha}1$, ${\alpha}2$) and are encoded by different genes. To assess the metabolic effects of $AMPK{\alpha}1$, we examined the effects of overexpression of adenoviral-mediated $AMPK{\alpha}1$ in hyperlipidemic type 2 diabetic rats. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an established animal model of type 2 diabetes that exhibits chronic and slowly progressive hyperglycemia and hyperlipidemia. Thirty five-week-old overt type 2 diabetic rats (n=10) were administered intravenously with Ad.$AMPK{\alpha}1$. AMPK activity was measured by phosphorylation of acetyl CoA carboxlyase (ACC). To investigate the changes of gene expression related glucose and lipid metabolism, quantitative real-time PCR was performed with liver tissues. Overexpression of $AMPK{\alpha}1$ showed that blood glucose concentration was decreased but that glucose tolerance was not completely recovered on 7th day after treatment. Plasma triglyceride concentration was decreased slightly, and hepatic triglyceride content was markedly reduced by decreasing expression of hepatic lipogenic genes. Overexpression of $AMPK{\alpha}1$ markedly improved hepatic steatosis and it may have effective role for improving hepatic lipid metabolism in hyperlipidemic state.

• Journal of Acupuncture Research
• /
• v.29 no.1
• /
• pp.89-101
• /
• 2012

Objectives : The purpose of this study was find out the therapeutic effects of its exclusive use on the rat with allergic rhinitis. Materials and Methods : Thirty Sprague-Dawley rats were divided into three group : normal group, control group and sample group. To induce the allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalumin solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalumin solution 3 times at intervals of 2 days. After that time, rats in the sample group were administered by $Yonghyang$($LI_{20}$) subcutaneously to treat the inflammation. Results : 1. The anti-oxidant effects of $Hwangryunhaedok-tang$ extract was dose-dependantly increased. 2. The RAW 264.7 cells were treated with LPS for 1 hours prior to the addition of indicated concentrations ($0.4,-1.0mg/m{\ell}$) of HHT, and the cells were further incubated for 24 hours. The LPS-induced iNOS mRNA expression and NO production were dose-dependantly decreased in HHT treated RAW 264.7 cells. 3. The number of eosinophil in HP noticeably decreased than CON and this decrease had probability. The infiltration of eosinophil in HP noticeably decreased than CON. 4. The damaged mucosa as disruption of cilia in respiratory cell and vacant mucose secreting cell were increased CON, but HP same as normal configuration. Decrease of PAS positive cell were shown in CON, but goblet cell occupied with neutral mucous were shown in HP. Decrease of mucosal stress(HSP70). Decrease of perennial sign(PPAR-${\gamma}$). Decrease of icthing and sneezing intricate neurotransmitter-(substance P). 5. The anti-inflammation of HHT pharmacopuncture for AR caused mucosa comes to result as belows. Decrease of pre-inflammation cytokine(TNF-${\alpha}$). Decrease of transcription factor (NF-${\kappa}B$ p65). Decrease of transcription factor inhibitor(p-$I{\kappa}B$). Decrease of inflammation cytokine(iNOS). Conclusions : The results may suggest that administration treatment using $Hwangryunhaedok-tang$ pharmacopucnture decreases the inflammatory response on an animal model with allergic rhinitis.

• Journal of Acupuncture Research
• /
• v.29 no.1
• /
• pp.115-125
• /
• 2012

Objectives : The purpose of this study is to observe the inhibitory effects of $Chrthami$ semen oil pharmacopuncture(CSOP) on CIA (collagen-induced arthritis) mice. Materials and Methods : Two types of experiments were conducted: $in$ $vitro$ assay, inhibition of MIF mRNA and TNF-${\alpha}$ mRNA expressions in synovial membranes was observed, and $in$ $vivo$ assay, $1{\mu}{\ell}/kg$ CSOP was injected every day to the left $Weizhong$ ($BL_{40}$) from day 3 to 21 after induction of CIA, and changes in paw edema, apical surface morphology, neovascularization in synovial membranes, fibrosis, pro-inflammatory cytokines production, Th-1 differentiation, and anti-inflammatory effect were investigated. Results : 1. In synoviocytes of the CIA mice treated with CSOP, MIF mRNA and TNF-${\alpha}$ mRNA expressions were down-regulated in a dose-dependent manner. 2. Paw edema of the CIA mice treated with CSOP was diminished. 3. Tissue injury in the synovial membranes, capillary distribution and fibrosis were reduced in CSOP-treated mice. 4. MIF, TNF-${\alpha}$, IL-6, MMP-9 expressions were repressed in CSOP-treated mice during the experiment to observe the inhibitory effect on cytokines production in early stage RA. 5. IL-12 and CD28 were reduced in CSOP-treated mice during the observation of inhibitory effect on Th 1 differentiation. 6. PPAR-${\gamma}$ was increased during the experiment to observe the anti-inflammatory effect of CSOP. Conclusions : The results may suggest that administration treatment using $Chrthami$ semen oil pharmacopuncture decreases the inflammatory response on an Animal Model with CIA.

• Journal of Acupuncture Research
• /
• v.29 no.5
• /
• pp.1-16
• /
• 2012

Objectives : The purpose of this study was to examine the effects of manual acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ on Electroencephalogram(EEG) of patients with stroke. Methods : 32 channel EEG measurement was carried out in 35 Stroke patients(23 males and 12 females). EEG was measured for 21 minutes(made up of 7 sessions, 1 session means 3 minutes time interval) including 15 minutes(5 sessions) of acupuncture time. Power spectrum analysis was used as a measure of complexity. Statistical analysis was performed using Linear mixed model and DUNNETT's multiple comparison. Results : The results were as follows; 1. EEG amplitude was reduced during acupuncture except electrodes PG1 and PG2. 2. There was a notable change during 6~9 minutes after needling in ${\delta}{\cdot}{\beta}{\cdot}{\gamma}$ wave, and during 6~9 minutes after needling in ${\Theta}{\cdot}{\alpha}$ wave. Overall, during 6~9 minutes after needling. 3. TP8 is a common significant electrode among five wave forms. Conclusions : These results suggest that TP8 could be typical electrodes and change of EEG compared to baseline happens most often during 6~9 minutes after manipulated acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ of patients with stroke.

• Tuberculosis and Respiratory Diseases
• /
• v.78 no.3
• /
• pp.218-226
• /
• 2015

Background: Eph receptors and ephrin ligands have several functions including angiogenesis, cell migration, axon guidance, fluid homeostasis, oncogenesis, inflammation and injury repair. The EphA2 receptor potentially mediates the regulation of vascular permeability and inflammation in response to lung injury. Methods: Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS)-induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). Results: EphA2 and ephrinA1 were upregulated in LPS-induced lung injury. The lung injury score of the EphA2 mAb+LPS group was lower than that of the IgG+LPS group ($4.30{\pm}2.93$ vs. $11.45{\pm}1.20$, respectively; p=0.004). Cell counts (EphA2 mAb+LPS: $11.33{\times}10^4{\pm}8.84{\times}10^4$ vs. IgG+LPS: $208.0{\times}10^4{\pm}122.6{\times}10^4$; p=0.018) and total protein concentrations (EphA2 mAb+LPS: $0.52{\pm}0.41mg/mL$ vs. IgG+LPS: $1.38{\pm}1.08mg/mL$; p=0.192) were decreased in EphA2 mAb+LPS group, as compared to the IgG+LPS group. In addition, EphA2 antagonism reduced the expression of phospho-p85, phosphoinositide 3-kinase $110{\gamma}$, phospho-Akt, nuclear factor ${\kappa}B$, and proinflammatory cytokines. Conclusion: This results of the study indicated a role for EphA2-ephrinA1 signaling in the pathogenesis of LPS-induced lung injury. Furthermore, EphA2 antagonism inhibits the phosphoinositide 3-kinase-Akt pathway and attenuates inflammation.

• The Bulletin of The Korean Astronomical Society
• /
• v.41 no.2
• /
• pp.42.1-42.1
• /
• 2016

The formation process and the dynamical properties of a large-scale quasi-circular flare ribbon were investigated using the SDO AIA and HMI data along with data from RHESSI and SOT. Within one hour time interval, two subsequent M-class flares were detected from the NOAA 12371 that had a ${\beta}{\gamma}{\delta}$ configuration with one bipolar sunspot group in the east and one unipolar spot in the west embedded in a decayed magnetic field. Earlier M2.0 flare was associated with a coronal loop eruption, and a two-ribbon structure formed within the bipolar sunspot group. On the other hand, the later M2.6 flare was associated with a halo CME, and a quasi-circular ribbon developed encircling the full active region. The observed quasi-circular ribbon was strikingly large in size spanning 650" in north-south and 500" in east-west direction. It showed the well-known sequential brightening in the clockwise direction during the decay phase of the M2.6 flare at the estimated speed of 160.7 km s-1. The quasi-circular ribbon also showed the radial expansion, especially in the southern part. Interestingly, at the time of the later M2.6 flare, the third flare ribbon parallel to the early two-ribbon structure also developed near the unipolar sunspot, then showed a typical separation in pair with the eastern most ribbon of the early two ribbons. The potential field reconstruction based on the PFSS model showed a fan shaped magnetic configuration including fan-like field lines stemming from the unipolar spot and fanning out toward the background decayed field. This large-scale fan-like field overarched full active region, and the footpoints of fan-like field lines were co-spatial with the observed quasi-circular ribbon. From the NLFF magnetic field reconstruction, we confirmed the existence of a twisted flux rope structure in the bipolar spot group before the first M2.0 flare. Hard X-ray emission signatures were detected at the site of twisted flux rope during the pre-flare phase of the M2.0 flare. Based on the analysis of both two-ribbon structure and quasi-circular ribbon, we suggest that a tether-cutting reconnection between sheared arcade overarching the twisted flux rope embedded in a fan-like magnetic field may have triggered the first M2.0 flare, then secondary M2.6 flare was introduced by the fan-spine reconnection because of the interaction between the expanding field and the nearby quasi-null and formed the observed large-scale quasi-circular flare ribbon.

• Journal of the Korean Crystal Growth and Crystal Technology
• /
• v.13 no.3
• /
• pp.132-138
• /
• 2003

A stoichiometric mixture for $CdIn_2Te_4$ single crystal was prepared from horizontal electric furnace. The $CdIn_2Te_4$ single crystal was grown in the three-stage vertical electric furnace by using Bridgman method. The $CdIn_2Te_4$ single crystal was evaluated to be tetragonal by the power method. The (001) growth plane of oriented $CdIn_2Te_4$ single crystal was confirmed from back-reflection Laue patterns. The carrier density and mobility of $CdIn_2Te_4$ single crystal measured with Hall effect by van der Pauw method are $8.61\times 1016 \textrm {cm}^{-3}$ and 242 $\textrm{cm}^2$/V.s at 293 K, respectively. The temperature dependence of the energy band gap of the $CdIn_2Te_4$ single crystal obtained from the absorption spectra was well described by the Varshni's relation, $1.4750ev - (7.69\times10^{-3})\; ev/k)\;T^2$/(T + 2147k).The crystal field and the spin-orbit splitting energies for the valence band of the $CdIn_2Te_4$ single crystal have been estimated to be 0.2704 eV and 0.1465 eV, respectively, by means of the photocurrent spectra and the Hopfield quasicubic model. These results indicate that the splitting of the $\Delta$so definitely exists in the $\Gamma_7$ states of the valence band of the $CdIn_2Te_4$ single crystal. The three photocurrent peaks observed at 10 K are ascribed to the $A_{1-} B_{1-}$ and Cl-exciton peaks for n = 1.