• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.268-276
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• 2010

This study was to investigate the knee joint flexion angle and the foot pressure during climbing with different slope. The 24 healthy subjects were participated. And foot pressure was investigated using Parotec system. The knee joint flexion angle were filmed to using a video camera on each slope($0^{\circ},\;3^{\circ},\;6{\circ},\;9^{\circ}$). And knee joint angle was investigated by Dartfish. The data were analyzed ANOVAs. In conclusion, there was significantly different that knee joint flexion angle related on each slope angle. In foot pressure, there was significantly different in lateral heel area(1 cell), medial midfoot area(9 cell), medial forefoot area(15, 16 cell) of left foot, and in lateral heel area(3 cell) of right foot. There was significantly different of foot pressure in lateral and medial heel when knee joint flexion angle is between $10^{\circ}$ and $20^{\circ}$. There was change of gait cycle according to walking slop angle increasing, and the initial contact phase was shorter, the foot pressure in lateral heel was lower.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.9
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• pp.799-807
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• 2017

In this paper, a new method is proposed for estimating pedestrians' walking velocity based on lower-limb kinematics and wearable inertial measurement unit (IMU) sensors. While the soles and ground are not in contact during the walking cycle, the walking velocity can be estimated by integrating the acceleration output of the inertial sensor mounted on the pelvis. To minimize the effects of acceleration measurement errors caused by the tilt of the pelvis while walking, the estimated walking velocity based on lower-limb kinematics is imposed as the initial value in the acceleration signal integration process of the pelvis inertial sensor. In the experiment involving outdoor walking for six minutes, sensor drift due to error accumulation was not observed, and the RMS error in the walking velocity estimation was less than 0.08 m/s.

• The Journal of Korean Physical Therapy
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• v.30 no.1
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• pp.14-22
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• 2018

Purpose: This study examined the effects of the lower limb alignment on the pelvis, hip, and knee kinematics in people with genu varum during stair walking. Methods: Forty subjects were enrolled in this study. People who had intercondylar distance ${\geq}4cm$ were classified in the genu varum group, and people who had intercondylar distance <4cm and intermalleolar distance <4cm were placed in the control group. 3D motion analysis was used to collect the pelvis, hip, and knee kinematic data while subjects were walking stairs with three steps. Results: During stair ascent, the genu varum group had decreased pelvic lateral tilt and hip adduction at the early stance phase and decreased pelvic lateral tilt at the swing phase compared to the control group. At the same time, they had decreased minimal hip adduction ROM at the early stance and decreased maximum pelvic lateral tilt ROM and minimum hip rotation ROM at the swing phase. During stair descent, the genu varum group had decreased pelvic lateral tilt at the early stance and decreased pelvic lateral tilt and pelvic rotation at the swing phase. In addition, they had decreased pelvic frontal ROM during single limb support and increased knee sagittal ROM during the whole gait cycle. Conclusion: This study suggests that a genu varum deformity could affect the pelvis, hip and knee kinematics. In addition, the biomechanical risk factors that could result in the articular impairments by the excessive loads from lower limb malalignment were identified.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.7
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• pp.1242-1246
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• 2016

Heel rocking phase in gait cycle is from initial contact to forefoot contact. The purpose of this study was to investigate the effect of age on heel rocking time. Seven young women ($21.9{\pm}1.5yrs$) and seven elderly women ($74.1{\pm}6.7yrs$) participated in this study. Subjects wore the shoes equipped with pressure sensors and walked along 10 m walkway at comfortable speeds. Stride time, stance time, and heel rocking time were compared between groups. Stride time was not different between groups (p=0.087). Stance time was longer (p<0.001) but heel rocking time was shorter in the elderly than in the young (p<0.001). The shorter heel-rocking time in elderly women indicates less efficient shock-absorption in the heel-rocking phase, which might be related to the abnormal control and/or reduced performance of ankle dorsiflexors.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.6
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• pp.88-95
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• 2020

In this paper, we propose a new arm swing walking pattern-based walking safety system for safe walking of elderly pedestrians. The proposed system is a walking safety system for elderly pedestrians using haptic-based devices such as smart bands and smart watches, and arm swing-based walking patterns to solve the problem that it is difficult to recognize the fall situation of pedestrians with the existing walking patterns of lower limb movements. Use. The arm swing-based walking pattern recognizes the number of steps and the fall situation of pedestrians through the swing of the arm using the acceleration sensor of the device, and creates a database of the location of the fall situation to warn elderly pedestrians when walking near the expected fall location. It delivers a message to provide pedestrian safety to the elderly. This system is expected to improve the safe walking rights and environment of the elderly.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.519-530
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• 1998

In this paper, the basic study on the design of the flexible keel of the energy-storage prosthetic foot was performed in order to Improve the walking performance and Increase the activities of the below knee amputees. Based on the analysis of the anthropometric data and the normal gait on two dimensional sagittal plane available In the literature, we presented a model of the basic structure of the flexible keel of the prosthetic foot. The model of the basic structure was composed of the simple beams, and linear rotational spring and damper. Laminated carbon fiber-reinforced composites were selected as the material of the basic structure model of the flexible keel In order to apply the high strength and light weight materials to the basic structure of the flexible keel of the prosthetic foot. The recoverable strain energy In response to the change of beam shape was calculated bur the finite element analysis and it was suggested that the change of beam shape could be the design variable in flexible keel design. The simulation process was systematically designed by using orthogonal array table in order to design the flexible keel structure which could store the more recoverable strain energy. finite element analysis was carried but according to the design of simulations by using the finite element program ABAQUS and the flexible keel structure of the energy-storage prosthetic foot was obtained from the analysis of variance(ANOVA). The dynamic simulation model of the prosthetic walking using the flexible keel structure was made and the dynamic analysis was carried but during one walk cycle. Based on the above results, an effective design process was presented for the development of the prosthetic fool system.

• Reproductive and Developmental Biology
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• v.35 no.2
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• pp.151-157
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• 2011

Clinical arthritis is typically divided into rheumatoid arthritis (RA) and osteoarthritis (OA). Arthritis-induced muscle weakness is a major problem in aged people, leading to a disturbance of balance during the gait cycle and frequent falls. The purposes of the present study were to confirm fiber type-dependent expression of muscle atrophy markers induced by arthritis and to identify the relationship between clinical signs and expression of muscle atrophy markers. Mice were divided into four experimental groups as follows: (1) negative control (normal), (2) positive control (CFA+acetic acid), (3) RA group (CFA+acetic acid+type II collagen), and (4) aging-induced OA group. DBQA/1J mice (8 weeks of age) were injected with collagen (50 ${\mu}g/kg$), and physiological (body weight) and pathological (arthritis score and paw thickness) parameters were measured once per week. The gastrocnemius muscle from animals in each group was removed, and the expression of muscle atrophy markers (MAFbx and MuRF1) and myosin heavy chain isoforms were analyzed by reverse transcription-polymerase chain reaction. No significant change in body weight occurred between control groups and collagen-induced RA mice at week 10. However, bovine type II collagen induced a dramatic increase in clinical score or paw thickness at week 10 (p<0.01). Concomitantly, the expression of the muscle atrophy marker MAFbx was upregulated in the RA and OA groups (p<0.01). A dramatic reduction in myosin heavy chain (MHC)-$I{\beta}$ was seen in the gastrocnemius muscles from RA and OA mice, while only a slight decrease in MHC-IIb was seen. These results suggest that muscle atrophy gene expression occurred in a fiber type-specific manner in both RA- and OA-induced mice. The present study suggests evidence regarding why different therapeutic interventions are required between RA and OA.

• Clinical and Experimental Pediatrics
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• v.45 no.10
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• pp.1263-1272
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• 2002

Purpose : Rett syndrome(RTT) is an X-linked dominant neurodevelopmental disorder affecting 1 per 10,000-15,000 female births worldwide. It was initially described by Andreas Rett in 1966. RTT involves developmental regression characterized stereotypic hand movements, tremors, gait apraxia, seizures, deceleration of head growth after the age of 6-18 months. The disease-causing gene was identified as MECP2 on chromosome Xq28. We carried out mutational analysis of MECP2 genes in RTT patients. Methods : Whole blood(5 cc) of 34 sporadic RTT patients was collected in EDTA-anticoagulated tubes. Genomic DNA was extracted from peripheral blood using the E.Z.N.A. blood DNA kit. Four exons of the MECP2 gene were amplified by PCR in 34 Korean with RTT. We carried out PCR divided the exon three into two parts and the exon four into five parts. Primer sequences designed by Amir et al. in 1999 were almost used(AF030876). Sequencing primers used were the same as PCR. DNA sequencing reactions were performed using an ABI 377 DNA sequencer and ABI PRISM dye terminator cycle sequencing reaction kit(Perkin-elmer). The results were compared with the normal DNA sequence(X99686). To confirm the change of sequence on novel mutations, RFLP analysis was performed. Results : The MECP2 mutations were detected in 23(67.6%) of the 34 patients. The mutations consisted of 12 different types including nine missense and three nonsense mutations. Of these, three (L100V, G161E and T311M) mutations were newly identified. Most of the mutations discovered are located within MBD(39.1%) and TRD(39.1%). In this study, three(T158M, R270X, R306C) mutations were identified high frequency. Conclusion : MECP2 gene was also an important cause of Korean RTT patients. MECP2 gene study is an important tool for diagnosis of Korean RTT patients.