• Annals of Clinical Neurophysiology
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• v.10 no.2
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• pp.98-100
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• 2008

Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron, as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no direct evidence of pathogenic mechanisms of RLS.

• Journal of the Korean Arthroscopy Society
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• v.1 no.1
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• pp.1-8
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• 1997

The anterior cruciate ligament(ACL) is, perhaps, the most intriguing component of the knee joint. Initially referred to crucial ligament because of the cruciate or crossed arrangement or the anterior and posterior ligaments within the knee. the irony or the ACL being crucial to the well-being or the joint has only recently appreciated. The anterior cruciate ligament of human knee joint is a complex structure and its orientation, construct and biology arc directly related to the knee function as a constraint of knee joint motion. In addition to its functional role as a static stabilizer or the knee. the ACL has a unique neurovascular system. The vascular anatomy of the ACL plays a crucial role in the repair and reconstruction of the ligament, and the neuroreceptors found in its substance suggest a possible proprioceptive role for the ligament. The structural complexity of the ACL allows the ligament to function through the normal range of motion as a static stabilizer or the knee. hut it also makes the exact duplication of this structure very difficult. A comprehensive knowledge or the anatomy of the ACL can provide the orthopedic surgeon with a blueprint for the idealized repair and reconstruction of this most complex structure.

• Korean Institute of Interior Design Journal
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• v.15 no.1 s.54
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• pp.47-54
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• 2006

Stages, in the theatrical spaces, were space, which incorporates aspects of cities. Hence, the stages have been constituted to materialize sequence of city, which has exact number, proportion and order of ideal city. In addition, it has accomplished change, which depends on type of performance with the social condition and culture of generation, city has. However, the original form of theatrical space were forgotten on account of the various changes of theatrical form with modem movement since the end of 19th century, and theatrical space, which does not relate with its space of city, was started to constitute. Particularly in contemporary society, the theatre can give vitality to the citizens, and also theatrical architecture as a commercial code has been a general form, though it takes important role, which improves cultural value with technical improvement of cities development of society. Thus, this study analyzed urbanity ,which theatres have incorporated historically, and deduced a correlativity from to be based on constitution of space in visual, perceptual, spatial constitution and functional role. Focused on published SPAC international competition, it was interpreted by contemporary focus, therefore, this experiment suggests constitution of theatrical spaces of information, takes urbanity, through to analyze visual, perceptual, spatial constitution and functional role in context of contemporary city.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.4
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• pp.25-33
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• 2002

• Proceedings of the Korean Society of Potoscience Conference
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• 2006.06a
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• pp.64-64
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• 2006

• Journal of Marine Bioscience and Biotechnology
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• v.1 no.1
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• pp.34-39
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• 2006

Molecular biology and microalgal biotechnology have the potential to play a major role in improving the production efficiency of a vast variety of products including functional foods, industrial chemicals, compounds with therapeutic applications and bioremediation solutions from a virtually untapped source. Microalgae are a source of natural products and have been recently studied for biotechnological applications. Efficient genetic transformation systems in microalgae are necessary to enhance their potential to be used for human health. A microalga such as Chlarella is a eukaryotic organism sharing its metabolic pathways with higher plants. This microalga is capable of expressing, glycosylating, and correctly processing proteins which normally undergo post-translational modification. Moreover, it can be cultured inexpensively because it requires only limited amount of sunlight and carbon dioxide as energy sources. Because of these advantages, Chlarella may be of great potential interest in biotechnology as a good candidate for bioreactor in the production of pharmaceutical and industrial compounds for human functional foods. Here, we briefly discuss recent progress in microalgal transgenesis that has utilized molecular biology to produce functional proteins and bioactive compounds.

• Annals of Clinical Neurophysiology
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• v.10 no.1
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• pp.13-24
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• 2008

Functional neuroimaging, especially positron emission tomography (PET) and functional magnetic resonance imaging (MRI), is the main tool that allows the unveiling of the neurovascular events during a migraine attack. In migraine with aura, functional neuroimaging has contributed greatly to the understanding of the fundamental pathophysiology of the visual aura, whereas in migraine without aura, the PET findings of brainstem activation suggest a pivotal role of brainstem in the generation of migraine headache. In addition, voxel-based morphometry (VBM) method has provided an insight into the morphometric changes of the brain, which might be considered as a consequence of repeated migraine attacks. In this article, I will briefly discuss the main neuroimaging findings pertaining to the pathophysiology of migraine.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2000.11a
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• pp.45-52
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• 2000

Genomic approach produces massive amount of data within a short time period, New high-throughput automatic sequencers can generate over a million nucleotide sequence information overnight. A typical DNA chip experiment produces tens of thousands expression information, not to mention the tens of megabyte image files, These data must be handled automatically by computer and stored in electronic database, Thus there is a need for systematic approach of data collection, processing, and analysis. DNA sequence information is translated into amino acid sequence and is analyzed for key motif related to its biological and/or biochemical function. Functional genomics will play a significant role in identifying novel drug targets and diagnostic markers for serious diseases. As an enabling technology for functional genomics, bioinformatics is in great need worldwide, In Korea, a new functional genomics project has been recently launched and it focuses on identi☞ing genes associated with cancers prevalent in Korea, namely gastric and hepatic cancers, This involves gene discovery by high throughput sequencing of cancer cDNA libraries, gene expression profiling by DNA microarray and proteomics, and SNP profiling in Korea patient population, Our bioinformatics team will support all these activities by collecting, processing and analyzing these data.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.25 no.2
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• pp.86-89
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• 2014

Functional dysphonia (FD) is a voice disorder in the absence of structural or neurologic laryngeal pathology. FD is not a single disease but a disease entity. Therefore several voice disorders, which have completely different pathogenesis, are included in this category. The first step of treatment of FD is differentiating patient's voice symptoms from other organic voice disorders and other functional voice problems. Several different treatment modalities are included in the managements of FD. Voice therapy is in charge of the main role in treatment of FD. Medical treatment is also necessary when patient has general problems which would affect voice production. Vocal folds mucosal lesions can cause FD even the lesion is minor. In this case proper surgical intervention helps to improve the symptom of FD. Psychiatric consultation should be considered when the patient has psychological problems.

• Cross-Cultural Studies
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• v.25
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• pp.649-678
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• 2011

The purpose of this work is to explain categorial correlations between indirect evidentiality and epistemic modality on the basis of semantic, pragmatic usages of Russian so-called non-specialized lexical markers of evidentiality, such as kazhetsja, naverno, vidimo, poxozhe, dolzhno byt' etc. To do this, firstly I concentrated on the parameter of internal functional variation of a given parenthetic word. Secondly, I approached this topic from a typological perspective. Thirdly, I accepted Sweeter(1990)'s methodological assumption that etymological prototype of a given word plays a great role in grammatical, semantic, pragmatic changes. As a result, I could postulate general tendencies of grammaticalizations (or semantic, pragmatic, funtional changes) in the direction from epistemic modality to indirect evidentialty, which consists of inferentives, presumptives, and quotatives. For example, such a parenthetic word as kazhetsja can functions not only as a marker of epistemic modality of uncertainty, but also as inferentives. Besides, it is very interesting that this word lately has started to function as quotatives, too. This kind of functional variations are very characteristic in these spheres.