• Journal of Korean Academy of Fundamentals of Nursing
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• v.4 no.1
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• pp.87-101
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• 1997

This Research is an attempt to find out what effects the resistance exercise program has on the rheumatoid arthritis patient's functional disability and biochemical parameters. The research took place from June to November 1996, and the target included an experimental group of 25 cases of rheumatoid arthritis and a control group of 26 cases of rheumatoid arthritis taken from the Anam Medical Center at Korea University. The resistance exercise program was executed on these patients five times a week during a period of eight weeks. Before and after the experiments, measurements of functional disability score, ESR, CRP, self-efficacy, and family support were taken and closely analysed. The results of this analysis are as follows : 1. After the experiment, the experimental group had less functional disabilities compared to the control group(t=9.11, P=0.0017). 2. After the experiment, the ESR of both the experimental and the control groups decrease, but there was not notable difference between the two groups(t=0.07, P=0.9546). 3. After the experiment, the CRP of both the experimental and the control groups decreased, with no significant different between them(t=0.53, P=0.6022). 4. After the experiment, the self-efficacy of the experimental group increased significantly compared to the control group(t=3.15, P=0.0042), but the self-efficacy had no effect on the actual practice of the program. 5. After the experiment, the family support of the experimental group was higher than of the control group(t=6.33, P=0.0013), but again the family support had no effect on the actual practice of the program. Judging from the results of these experiments, the resistance exercise program not only diminishes rheumatoid arthritis patients' functional disabilities, but also has a great influence on increasing their self-efficacy and family support. Concluding, in diminishing the functional disabilities of rheumatoid arthritis, the resistance exercise program would be appropriate nursing intervention.

• Investigative Magnetic Resonance Imaging
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• v.26 no.2
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• pp.117-124
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• 2022

Purpose: In this study, we provide a way to assess even a slight effect of exercise on trunk-muscle activity. Materials and Methods: Seven healthy male participants (mean age, 24.7 ± 3.2 years; height, 171.2 ± 9.8 cm; and weight, 63.8 ± 11.9 kg) performed 15 sets of an exercise with 20 repetitions of 90° hip and right-knee flexion while lying supine. The exercise intensity was measured using the 10-point Rating of Perceived Exertion Scale after the first and 15th sets of exercises. Although cross-sectional areas and functional T2 mapping using ultrafast imaging (fast-acquired muscle functional magnetic resonance imaging, fast-mfMRI) have been proposed for imaging to evaluate exercise-induced muscle activity in real time, no previous studies have reported on the evaluation of trunk-muscle activity using functional T2 mapping. As a method for assessing trunk-muscle activity, we compared functional T2 mapping using ultrafast imaging (fast-mfMRI) with cross-sectional areas. Results: Although the muscle cross-sectional areas were increased by the exercise, there was no significant difference at rest. On the other hand, for all sets, the changes in T2 were significant compared with those at rest (P < 0.01). These results demonstrate that T2, calculated from fast-mfMRI images can be used to detect even a small amount of muscle activity induced by acute exercise, which was impossible to do with cross-sectional areas. Conclusion: Fast-mfMRI, which can also display functional information with detailed forms, enabled non-invasive real-time imaging for identifying and evaluating the degree of deep trunk-muscle activity induced by exercise.

• PNF and Movement
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• v.19 no.3
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• pp.351-359
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• 2021

Purpose: This purpose of this study was to investigate the effects of initial cognitive status on the recovery of functional status in patients with subacute stroke. Methods: The participants were 111 patients with subacute stroke, divided into two groups: mini-mental state examination (MMSE) <20 (n=49) group and MMSE ≥20 (n=62) group. Clinical evaluation scores were collected before and after rehabilitation. The repeated measurements ANOVA was used to confirm the changes in functional status before and after intervention in the two groups. Changes in functional status within the group were examined through a paired test. A Pearson correlation coefficient analysis was performed to identify the correlation between MMSE change amount and functional status score. Results: In each of the two groups, according to the initial cognitive status, the clinical evaluation score increased statistically significantly, but there was no difference between the two groups in the degree of significant increase. When examining the correlation between the MMSE change amount, according to the initial cognitive state and the functional state score change amount, it was found, only in the group with MMSE <20, that the larger the change in the MMSE score, the greater the functional state change of Berg balance scale, Rivermead Mobility Index, and motor assessment scale. This did not apply to the group with MMSE ≥20. Conclusion: Initial cognitive status should be considered when setting the patient's goal, and considering cognitive improvement when constructing a rehabilitation program is thought to have a positive effect on rehabilitation services.

• Journal of Sport and Applied Science
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• v.7 no.3
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• pp.19-26
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• 2023

Purpose: This study attempted to investigate the effect of functional rehabilitation exercise for posture correction on physical strength factors and physical balance. Research design, data, and methodology: It consisted of 40 experimental groups that applied functional rehabilitation exercises to 80 people with posture imbalance and 40 comparative groups that performed general exercises, and was conducted four times a week, once for 40 minutes, and for 12 weeks. Results: D.S. (p<.o1) among F.M.S., a moving assessment. It increased significantly from the dictionary, and H.S. (p<.o5). I.L(p<.o5). S.M(p<.o5). A.S.L.R(p<.o5). T.S.P(p<.o01). It was confirmed that R.S. (p<.o5) decreased more after than before. In other words, Functional rehabilitation exercise was effective in improving physical balance. PAPS flexibility (bending forward) (p<.o1). Muscle strength (grip strength test) (p<.o1). Quickness (long jump) (p<.o1). Functional rehabilitation exercise was found to be effective in muscle strength, agility, and flexibility, but not in cardiopulmonary endurance. Pain: Based on the NRS scale (1-10 points). The experimental that there was a significant interaction between the groups.(F=38.583, P=.000). In the comparative group, there was no significant difference in the pre-post, and it was found that the pain level in the experimental group decreased after the pre-post (p<.001). Conclusion: As a result of the above study, it was confirmed that functional rehabilitation exercise improves physical strength factors and physical balance ability, and also affects physical pain reduction due to physical imbalance.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.169-179
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• 2017

Background: Ginsenosides are the main pharmacological components of Panax ginseng root, which are thought to be primarily responsible for the suppressing effect on oxidative stress. Methods: 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and oxygen radical absorption capacity were applied to evaluate the antioxidant activities of the ginsenosides. Human embryonic kidney 293 (HEK-293) cells were incubated with ginsenosides extracted by pulsed electric field (PEF) and solvent cold soak extraction (SCSE) for 24 h and then the injury was induced by $40{\mu}M$ $H_2O_2$. The cell viability and surface morphology of HEK-293 cells were studied using MTS assay and scanning electron microscopy, respectively. Dichloro-dihydro-fluorescein diacetate fluorescent probe assay was used to measure the level of intracellular reactive oxygen species. The intracellular antioxidant activities of ginsenosides were evaluated by cellular antioxidant activity assay in HepG2 cells. Results: The PEF extracts displayed the higher 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and stronger oxygen radical absorption capacity (with an oxygen radical absorption capacity value of $14.48{\pm}4.04{\mu}M\;TE\;per\;{\mu}g/mL$). The HEK-293 cell model also suggested that the protective effect of PEF extracts was dose-dependently greater than SCSE extracts. Dichloro-dihydro-fluorescein diacetate assay further proved that PEF extracts are more active (8% higher than SCSE extracts) in reducing intracellular reactive oxygen species accumulation. In addition, scanning electron microscopy images showed that the HEK-293 cells, which were treated with PEF extracts, maintained more intact surface morphology. Cellular antioxidant activity values indicated that ginsenosides extracted by PEF had stronger cellular antioxidant activity than SCSE ginsenosides extracts. Conclusion: The present study demonstrated the antioxidative effect of ginsenosides extracted by PEF in vitro. Furthermore, rather than SCSE, PEF may be more useful as an alternative extraction technique for the extraction of ginsenosides with enhanced antioxidant activity.

• Journal of Digital Convergence
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• v.10 no.3
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• pp.179-189
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• 2012

The purpose of this study examines the influence of brand concepts(symbolic vs. functional) and thinking styles(holistic vs. analytic) on the attitude toward extension ads.(rational/emotional) and product. The moderating effect of thinking styles was also tested. The results of this study are as follows: I) Brand concepts of parent brand had a significant effect on the attitude toward extension ads.(symbolic: no differences between rational and emotional ads., functional: rational ads. > emotional ads.) and extension product. 2) Thinking styles of consumers also did.(holistic: no differences between rational and emotional ads., analytic: rational > emotional ads.) and extension product. 3) The moderating effect of thinking styles was(rational ads.: symbolicfunctional).

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.329-336
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• 2003

Objective : We evaluated the therapeutic effect of Banwhasasimtang dry extract powder on gastrointestinal symptoms and its side effects in patients with functional dyspepsia. Methods : Patients with functional dyspepsia, defined as discomfort in the epigastrium. A total 45 patients participated in this study. Dyspeptic symptoms ratio was obtained by patients, total point of symptom score/total 21 points x 100(%). On each of symptom after 4 weeks administration of Banwhasashim-tang was made by variation of symptom score: If symptoms score of posttreatment is lower than that of pretreatment, it is improved ; Otherwise aggravated, and if there is no change between them, unchangeable. When a full health condition of normal control is assumed 100%, relative health condition of dyspeptic patient could be calculated from 'full health condition-dyspeptic symptoms ratio'. Therefore a whole satisfaction rate on symptom improvement was presented with variation of a relative health condition to dyspepsia between pretreatment and post. Results : Banwhasashimtang significantly improved symptoms in patients. The significance was shown in both all seven items(p<0.01, respectively) and 19.2% (p<0.01) of increase of a whole satisfaction rate on symptom improvement. There is no remarkable side-effect in all laboratory test, excepting 1 case of abdominal pain and another one case of recurred pain of chronic prostatitis. Conclusion : Banwhasashimtang extract provides symptomatic relief in functional dyspepsia and is no remarkable side-effect drug.

• BMB Reports
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• v.55 no.10
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• pp.506-511
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• 2022

Advanced hepatocellular carcinoma (HCC) is among the most challenging cancers to overcome, and there is a need for better therapeutic strategies. Among the different cancer drugs that have been used in clinics, sorafenib is considered the standard first-line drug for advanced HCC. Here, to identify a chemical compound displaying a synergistic effect with sorafenib in HCC, we screened a focused chemical library and found that MG149, a histone acetyltransferase inhibitor targeting the MYST family, exhibited the most synergistic anticancer effect with sorafenib on HCC cells. The combination of sorafenib and MG149 exerted a synergistic anti-proliferation effect on HCC cells by inducing apoptotic cell death. We revealed that cotreatment with sorafenib and MG149 aggravated endoplasmic reticulum (ER) stress to promote the death of HCC cells rather than adaptive cell survival. In addition, combined treatment with sorafenib and MG149 significantly increased the intracellular levels of unfolded proteins and reactive oxygen species, which upregulated ER stress. Collectively, these results suggest that MG149 has the potential to improve the efficacy of sorafenib in advanced HCC via the upregulation of cytotoxic ER stress.

• Journal of Korean Physical Therapy Science
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• v.15 no.1
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• pp.47-56
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• 2008

The purpose of this study was to seek for a performance level of functional independence of the long term care elderly people. This study questionnaires 160 elders with 80 in a large city and 80 in small－to－medium sized city in order to find out the functional independence of elderly people. The results of this study were as follows. 1. Functional independence level following health factor; The comparison of degrees of functional independence level between two groups showed significant difference in sanitation, drinking and smoking, eating habit, chronic disease, physical activities, and regular physical examination(P<.05). But the comparison between two groups was not showed significant difference in present treatment, regular exercise. 2. Functional independence level following Psychological factor; The comparison of degrees of functional independence level between two groups showed significant difference in health evaluation(P<.05). But the comparison between two groups was not showed significant difference in quality of life. In conclusion it is needed that stable housing, much physical activities, and diversified family members should be realized and stable livelihood security recipients to maintain and improve health of the aged and to be socially satisfied.

• Journal of the Korean Recycled Construction Resources Institute
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• v.2 no.2
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• pp.93-100
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• 2006

Building materials are trending toward environmental materials nowadays and the market share of those is growing. So those researches and developments for environmental property are proceeding now. The main properties of environmental products are far infrared emission, negative ion emission, electro magnetic wave shielding, and anti fungus, these products are used with shape of mortar, and spray on the finish material. But There are not much researches for the concrete, main material in construction field, with those functional properties. So in this research we evaluated slump, compressive strength and air content as basic properties for concrete using functional materials of sericite, wood pattern sand stone, carbon black and nanometric silver solution and functional properties like far infrared emission, negative ion emission, electro magnetic wave shielding, and anti fungus. The results were as follows. The most useful material in the functional materials was carbon black. Sericite and nanometric silver solution had a little effect on functional property, so it was difficult to apply to concrete, and wood pattern sand stone had a high functional property but low compressive strength, can be applied to a factory product. Anti fungus of the concrete using nanometric silver solution was not clear but if those specimens were aged in $CO_2$ gas for a long time it might apparent.