• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.3
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• pp.193-200
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• 2024

In this work, lipid nanovesicles (LNV) containing niacinamide were prepared by changing the concentration of lecithin, fatty acids (palmitic acid), and surfactant (polysorbate 60), and physicochemical characteristics analysis and skin permeability evaluation were performed. The present LNVs were measured with an average diameter of 77 ~ 160 nm, zeta potential -63 ~ -31 mV depending on the concentration of lecithin and polysorbate 60. As a result of observing the stability over time for 12 weeks, LNV1 showed much better colloidal stability than others. In addition, in vitro skin penetration using Franz cell was evaluated for LNV. In this work, niacinamide was selected as the model drug. As a result of skin penetration, it was confirmed that the skin penetration of fatty acid containing LNV1 was much superior than control. These results confirm that LNVs containing lecithin, fatty acids, and surfactants can support the skin absorption of active ingredients in cosmetics.

• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.766-778
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• 2019

In this study, Poria cocos bark were extracted by supercritical process, and anti-inflammatory, whitening, and antioxidant effects were measured in comparison with ethanol extract. Also, An effective percutaneous permeation method using a selected formulation of the extract and a drug delivery peptide was proposed. Pachymic acid, known as the anti-cancer and anti-inflammatory compound of the ventricle, is an indicator component and the HPLC analysis shows that the supercritical extract of the pericardium is more than twice that of the Poria cocos bark extract. In order to confirm antioxidative effect of Bombyx mori, DPPH scavenging ability and ABTS scavenging ability test showed that the ethanol extract of Poria cocos Back had lower concentration than the supercritical extract of Poria cocos back. However, RAW 264.7 Measurements of Nitric oxide (NO) production in cells showed lower NO production at the same concentration than the Poria cocos back ethanol extract. In addition, after 72 hours of processing of $20{\mu}g/mL$ of the Poria cocos back extract in B16 melanoma cells, both the intracellular and extracellular melanin extract were effective and the supercritical extract was lower melanin content. No toxicity was observed at the concentration of $800{\mu}g/mL$ in RAW 264.7 cells used in NO production experiments. However, in B16 melanoma cells, even at $50{\mu}g/mL$, both Poria cocos back ethanol extract and supercritical extract showed a survival rate of less than 60%. The liposome formulation and drug delivery peptides were shown to be useful for percutaneous permeation of Supercritical Extract of Poria cocos back using a liposome formulation and a drug delivery peptide. it is expected that there will be great potential for development as a variety of cosmetic materials for Poria cocos back.