• 분석과학
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• 제37권1호
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• pp.25-38
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• 2024

The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) to separate, identify and characterize very nominal quantities of degradation products (DPs) of balsalazide along with its process related impurities without isolation from their reaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 ㎛) column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45 (v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. The method shows sensitive detection limit of 0.003 ㎍/mL, 0.015 ㎍/mL and 0.009 ㎍/mL respectively for impurity 1, 2 and 3 with calibration curve liner in the range of 50-300 ㎍/mL for balsalazide and 0.05-0.30 for its impurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products (DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC-MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl) diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoic acid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable for routine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicable for identification of known and unknown impurities of balsalazide.

• KEPCO Journal on Electric Power and Energy
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• 제2권3호
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• pp.461-467
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• 2016

부유 이송식 해상풍력 기초를 목표 지점에 설치하기 위해서는 내부의 중공부에 해수를 주입하여 착저 시키게 되는데, 그 과정에서 중량 및 무게 중심과 부력중심이 변하게 되어 부유식 기초가 불안정해 질 수 있다. 부유 이송식 기초의 동적안정성 해석은 기초 외부의 수력학적 하중과 6-자유도 운동을 하게 되는 기초에 작용하는 파도와 조류 하중 및 설치 과정에서 기초 내부의 중공부로 투입되는 해수의 무게중심 이동까지 동시에 고려해야 하는 복잡한 문제이다. 따라서 본 연구에서는 3차원 비정상 CFD 기법과 다물체 동역학 기법을 연성 (coupling)한 정밀 해석기법을 적용하여 부유 이송식 기초 내부 물의 슬로싱 운동까지 고려한 동적안정성 해석을 수행하고 특성을 분석하였다.

• 한국방재학회 논문집
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• 제8권2호
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• pp.111-117
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• 2008

지반 및 원형기초의 물성이 그 기초의 수직 동적거동에 미치는 영향이 해석적 해와 수치해석을 통해 연구되었다. 해석적 해로는 반무한체 지반 위 원형기초의 거동을 나타내는 간략 해가, 수치해석방법으로는 선대칭 유한요소법이 consistent transmitting 경계조건과 함께 사용되었다. 균일한 지반의 물성으로서의 전단파속도는 원형기초 동적거동의 공명진동수에 영향을 주었으나 공명진동시의 최대반응값에는 영향을 미치지 않았다. 같은 경우에 지반의 밀도는 공명진동수와 최대반응값에 모두 영향을 주었다. 균일한 지반 위 원형기초의 크기와 질량도 원형기초 동적거동의 공명진동수와 최대반응값 모두에 영향을 주었으나 균일 지반의 포아송비는 큰 영향을 미치지 않는 것으로 나타났다. 지반이 균일하지 않고 층이 존재할 경우에 각 층의 물성으로의 전단파속도들의 상관관계는 원형기초의 최대반응값에 영향을 주었다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 학회창립 10주년 기념 1999년도 가을 학술발표회 논문집
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• pp.345-348
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• 1999

Since the cement-water reaction is exothermic by nature, the temperature rise within a large concrete mass. Significant tensile stresses may develop from the volumn change associated with the increase and decrease of the temperature with the mass concrete. These thermal stresses will cause temperature-related cracking in mass concrete structures. These typical type of mass concrete include mat foundation, bridge piers, thich walls, box type walls, tunnel linings, etc. Crack control methods can be considered at such stages as designing, selecting the materials, and detailing the construction method. In this paper, the effect of placing of crack control joint or construction joint was analysed by a three dimensional finite element method. As a result, using this method, crack control can be easily performed for structures such as wall-type structures.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 봄 학술논문 발표대회
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• pp.229-230
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• 2023

In this study, the hydration heat differential method was applied to mass concrete structures, and the hydration heat analysis was compared and analyzed with on-site measurement results. The results showed that the temperature history measurements of mass concrete were managed at a difference of 8.4 ℃, and although there was some deviation in thermal stress, a similar trend was observed. Consequently, it was determined that the thermal stress on the surface of mass concrete is less than its tensile strength, which would prevent the occurrence of thermal cracks.

• 산업기술연구
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• 제17권
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• pp.199-204
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• 1997

In this paper, the result of application of vibration method to the orthotropic plates with free edges supported on elastic foundation and with a pair of opposite edges under axial forces is presented. Such plates represent the concrete highway slab and hybrid composite pavement of bridges. The reinforced concrete slab can be assumed as a special orthotropic plate, as a close approximation. The highway slab is supported on elastic foundation, with free boundaries. Sometimes, the pair of edges perpendicular to the traffic direction may be subject to the axial forces. The plate is subject to the concentrated load/loads, in the form of traffic loads, or the test equipments. Finite difference method is used to obtain the deflection influence surfaces needed for vibration analysis. The influence of the modulus of the foundation, the aspect ratio of the plate, and the magnitudes of the axial forces and the concentrated attached mass on the plate, under the natural frequency is thoroughly studied.

• 소음진동
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• 제10권3호
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• pp.493-499
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• 2000

Structural vibration analysis of the stationary power plant system employing a large two-stroke low speed diesel engine is performed to verify that the vibration characteristics of the system meet design requirements, The system consists of the diesel engine generator and concrete foundation including pile and soil. The system is modeled in the form of a mass-elastic system of 5 degrees of freedom for vibration analysis. Excitation moments and dynamic parameters including engine body stiffness soil stiffness and damping are identified for the analysis, Results of structural vibration analysis of the system are presented and compared with measurements in this paper.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2002년도 봄 학술발표회 논문집
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• pp.979-984
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• 2002

The mat foundation of Tower Palace III is designed as a massive structure which has a 3.5m depth. The purpose of this study is to determine the optimum mix design having good workability and to control the actual concrete quality in site. For this purpose, we select the Self Compacting Concrete. Recently, the Self Compacting Concrete has been applied to achieve workability improvement. As the result of actual application, we have finished placing the mass concrete of 8, 000m$^3$ during 14hours with good success and obtain the good quality concrete. All test results are satisfied with our specifications for mat foundation and cut cost as the reduction of placing hours.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2002년도 춘계학술대회 논문집
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• pp.98-103
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• 2002

In this paper, shock analysis was performed for coarse and fine mesh model using MSC/NASTRAN and ANSYS after substituting the foundation of deck mounted equipment of marine ship for mass-spring system. In order to determine input file in MSC/NASTRAN, dynamic response analysis was also performed using DDAM based on the calculation in the range of low frequency. It was confirmed that the coarse mesh model has the sufficient effective weight in a lower degree mode compared to fine mesh model.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.675-680
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• 2004

In this study, a turbine simuiator is designed and manufactured to investigate the transient response of an actual turbine. The rotor mass and bearing stiffness is reduced to 1/140 of its actual turbine. The dynamic characteristics of turbine simulator are similar to those of the actual turbine. The turbine simulator is excited by an electro-magnetic type exciter in the form of half sine wave. Duration time is con☞oiled by Sms, 10ms, and Isms, and maximum acceleration is applied by 3g. Foundation excitation test is performed in stationary condition and rotating condition(6000rpm). The test results can be used to verify the validif of the theoretical afproach for transient analysis of actual turbine.