• 대한한의학회지
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• 제39권4호
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• pp.86-113
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• 2018

Objectives: We examined the effects of a mixed formula consisting of dried pomegranate concentrate powder (PCP) and the aqueous extracts of Eucommiae cortex (EC) and Achyranthis radix (AR) in rats with surgically induced osteoarthritis (OA). Methods: Two weeks after OA-inducing surgery, a PCP:EC:AR 5:4:1 (g/g) combination or single formula was orally administered. Changes in body weight, knee thickness, maximum knee extension angle, bone mineral density of the knee joints, femoral and tibial articular surfaces, and compressive strength of the femoral and tibial articular cartilage (AC) were assessed, along with the prostaglandin E2 level, 5-lipoxygenase, matrix metalloproteinase (MMP)-2 and MMP-9 activity, and chondrogenic gene mRNA expression in the femoral and tibial AC with the synovial membrane (SM). In addition, the number of cleaved poly(ADP-ribose) polymerase, cyclooxygenase and tumor necrosis factor-${\alpha}$-immunoreactive cells in the femoral and tibial AC with SM were monitored, and the rate of cell proliferation was determined with a 5-bromo-2'-deoxyuridine uptake assay. Results : The signs of surgically induced OA in rats were significantly inhibited by both PCP, EC and AR combined and single formulas. In particular, the combination formula-treated OA model rats showed dose-dependent, significantly increased inhibitory activity against all tested criteria compared with single formula-treated rats. Conclusions: Taken together, our results suggest that the combination formula synergistically increased the anti-OA effects of its components through anti-inflammatory and chondrogenic activity in rats with surgically induced OA. In addition, 200, 100 and 50 mg/kg combination formula treatments showed dose-dependent inhibitory activity against all of the tested criteria.

• 산업경영시스템학회지
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• 제42권3호
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• pp.206-216
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• 2019

The present study identified several antecedents that create perceived resistance to supply chain management (SCM) change. This work particularly emphasizes SCM change, which is notable given its central role in reacting market orientation and varied environmental and managerial conditions. A careful case study on a small and medium sized food production company in South Korea leads to the formulation of our framework including one second-order construct of 'resistance' as well as eight first-order constructs of 'implementing the payment terms', 'balancing of business process', 'fear of responsibility', 'business sustainability transparency', 'past experience of failure', 'competence of work personnel', 'cooperation with third parties' and 'sharing personnel information with partner'. The hypothesized relation of first- and second-order construct was validated using survey sample data collected from 350 respondents who completed their questionnaire instrument. Results from confirmatory factor analysis revealed that nomological validity was established at statistical significance level by identifying six first order constructs of 'implementing the payment terms', 'fear of responsibility', 'business sustainability transparency', 'past experience of failure', a conbined construct of 'competence of work personnel/cooperation with third parties' and 'sharing personnel information with partner'. The findings from our work are expected to provide important insights to the strategy for SCM risk management for small and medium sized company.

• 한국구조물진단유지관리공학회 논문집
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• 제24권5호
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• pp.1-8
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• 2020

이 연구에서는 철근콘크리트 부재의 전단파괴가 휨-전단 메커니즘에 지배된다는 가정을 바탕으로 인장측과 압축측에 대한 2개의 전단요구곡선들과 이에 대응되는 잠재전단강도곡선들을 각각 도출하였으며, 이를 기반으로 전단강도 산정모델을 제안하였다. 제안모델에서는 철근과 콘크리트의 부착거동을 고려하여 휨균열폭과 철근의 국부응력증가분을 산정하였다. 또한, 휨균열로부터 발전되는 지배전단균열의 생성과 균열진전거동을 이론적으로 모사하기 위하여 균열집중계수를 도입하였으며, 이를 통해 단면높이가 큰 철근콘크리트 부재에서 관측되는 크기효과를 반영하였다. 또한, 기존의 해석모델과는 다르게 전단철근과 콘크리트의 전단기여분 사이의 상호작용을 고려할 수 있는 새로운 형태의 수식을 개발하였다. 제안모델의 검증을 위하여 방대한 전단실험체들을 기존문헌으로부터 수집하였으며, 이를 통해 해석모델을 검증한 결과는 제안모델이 실험체들의 재료, 크기 및 철근의 부착특성에 관계없이 실험결과를 정확하게 평가할 수 있음을 보여주었다.

• International Journal of Naval Architecture and Ocean Engineering
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• 제12권1호
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• pp.755-767
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• 2020

A significant development has been made on a new fatigue damage model applicable to Gaussian wide band stress response spectra using numerical approximation methods such as data processing, time simulation, and regression analysis. So far, most of the alternative approximate models provide slightly underestimated or overestimated damage results compared with the rain-flow counting distribution. A more reliable approximate model that can minimize the damage differences between exact and approximate solutions is required for the practical design of ships and offshore structures. The present paper provides a detailed description of the development process of a new fatigue damage model. Based on the principle of the Gaussian wide band model, this study aims to develop the best approximate fatigue damage model. To obtain highly accurate damage distributions, this study deals with some prominent research findings, i.e., the moment of rain-flow range distribution MRR(n), the special bandwidth parameter μk, the empirical closed form model consisting of four probability density functions, and the correction factor QC. Sequential prerequisite data processes, such as creation of various stress spectra, extraction of stress time history, and the rain-flow counting stress process, are conducted so that these research findings provide much better results. Through comparison studies, the proposed model shows more reliable and accurate damage distributions, very close to those of the rain-flow counting solution. Several significant achievements and findings obtained from this study are suggested. Further work is needed to apply the new developed model to crack growth prediction under a random stress process in view of the engineering critical assessment of offshore structures. The present developed formulation and procedure also need to be extended to non-Gaussian wide band processes.

• Nuclear Engineering and Technology
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• 제54권8호
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• pp.3059-3072
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• 2022

A Jacobian-Free Newton Krylov Two-Nodal Coarse Mesh Finite Difference algorithm based on Nodal Expansion Method (NEM_TNCMFD_JFNK) is successfully developed and proposed to solve the three-dimensional (3D) and multi-group reactor physics models. In the NEM_TNCMFD_JFNK method, the efficient JFNK method with the Modified Incomplete LU (MILU) preconditioner is integrated and applied into the discrete systems of the NEM-based two-node CMFD method by constructing the residual functions of only the nodal average fluxes and the eigenvalue. All the nonlinear corrective nodal coupling coefficients are updated on the basis of two-nodal NEM formulation including the discontinuity factor in every few newton steps. All the expansion coefficients and interface currents of the two-node NEM need not be chosen as the solution variables to evaluate the residual functions of the NEM_TNCMFD_JFNK method, therefore, the NEM_TNCMFD_JFNK method can greatly reduce the number of solution variables and the computational cost compared with the JFNK based on the conventional NEM. Finally the NEM_TNCMFD_JFNK code is developed and then analyzed by simulating the representative PWR MOX/UO₂ core benchmark, the popular NEACRP 3D core benchmark and the complicated full-core pin-by-pin homogenous core model. Numerical solutions show that the proposed NEM_TNCMFD_JFNK method with the MILU preconditioner has the good numerical accuracy and can obtain higher computational efficiency than the NEM-based two-node CMFD algorithm with the power method in the outer iteration and the Krylov method using the MILU preconditioner in the inner iteration, which indicates the NEM_TNCMFD_JFNK method can serve as a potential and efficient numerical tool for reactor neutron diffusion analysis module in the JFNK-based multiphysics coupling application.

• Journal of Veterinary Science
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• 제23권3호
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• pp.48.1-48.12
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• 2022

Background: The poor intracellular concentration of enrofloxacin might lead to treatment failure of cow mastitis caused by Staphylococcus aureus small colony variants (SASCVs). Objectives: In this study, enrofloxacin composite nanogels were developed to increase the intracellular therapeutic drug concentrations and enhance the efficacy of enrofloxacin against cow mastitis caused by intracellular SASCVs. Methods: Enrofloxacin composite nanogels were formulated by an electrostatic interaction between gelatin (positive charge) and sodium alginate (SA; negative charge) with the help of CaCl₂ (ionic crosslinkers) and optimized by a single factor test using the particle diameter, zeta potential (ZP), polydispersity index (PDI), loading capacity (LC), and encapsulation efficiency (EE) as indexes. The formation mechanism, structural characteristics, bioadhesion ability, cellular uptake, and the antibacterial activity of the enrofloxacin composite nanogels against intracellular SASCVs strain were studied systematically. Results: The optimized formulation was comprised of 10 mg/mL (gelatin), 5 mg/mL (SA), and 0.25 mg/mL (CaCl₂). The size, LC, EE, PDI, and ZP of the optimized enrofloxacin composite nanogels were 323.2 ± 4.3 nm, 15.4% ± 0.2%, 69.6% ± 1.3%, 0.11 ± 0.02, and -34.4 ± 0.8 mV, respectively. Transmission electron microscopy showed that the enrofloxacin composite nanogels were spherical with a smooth surface and good particle size distributions. In addition, the enrofloxacin composite nanogels could enhance the bioadhesion capacity of enrofloxacin for the SASCVs strain by adhesive studies. The minimum inhibitory concentration, minimum bactericidal concentration, minimum biofilm inhibitory concentration, and minimum biofilm eradication concentration were 2, 4, 4, and 8 ㎍/mL, respectively. The killing rate curve had a concentration-dependent bactericidal effect as increasing drug concentrations induced swifter and more radical killing effects. Conclusions: This study provides a good tendency for developing enrofloxacin composite nanogels for treating cow mastitis caused by intracellular SASCVs and other intracellular bacterial infections.

• 한국안전학회지
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• 제37권4호
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• pp.44-50
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• 2022

This study examines the relationship between safety factors and health management systems based on accident statistics in the construction industry stipulated in the Serious Disaster Punishment Act. To determine the level of safety achieved by companies through their health management system, the top 1000 construction firms in the country were surveyed online. Four hundred sixty companies responded to the survey by providing their statistics on major accidents (mortality, accidental mortality, and injury rates). Statistical tests showed that companies with a team dedicated to the oversight of safety and health management had fewer accidents than those without one. Factor and regression analyses revealed that three factors affected the mortality and accident rates: safety and health plan, safety and health professionals, and safety and health activities. Moreover, two factors significantly influenced the injury rate: safety management supported by a cooperative company and implementation of on-site safety and health activities. The findings of this study can be used as a fundamental reference for further research and consultation on the formulation of safety and health management systems for construction companies.

• Steel and Composite Structures
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• 제46권4호
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• pp.471-483
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• 2023

This paper presents an analytical hyperbolic theory based on the refined shear deformation theory for mechanical stability analysis of the simply supported advanced composites plates (exponentially, sigmoidal and power-law graded) under triangular, trapezoidal and uniform uniaxial and biaxial loading. The developed model ensures the boundary condition of the zero transverse stresses at the top and bottom surfaces without using the correction factor as first order shear deformation theory. The mathematical formulation of displacement contains only four unknowns in which the transverse deflection is divided to shear and bending components. The current study includes the effect of the geometric imperfection of the material. The modeling of the micro-void presence in the structure is based on the both true and apparent density formulas in which the porosity will be dense in the mid-plane and zero in the upper and lower surfaces (free surface) according to a logarithmic function. The analytical solutions of the uniaxial and biaxial critical buckling load are determined by solving the differential equilibrium equations of the system with the help of the Navier's method. The correctness and the effectiveness of the proposed HyRPT is confirmed by comparing the results with those found in the open literature which shows the high performance of this model to predict the stability characteristics of the FG structures employed in various fields. Several parametric analyses are performed to extract the most influenced parameters on the mechanical stability of this type of advanced composites plates.

• Structural Engineering and Mechanics
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• 제86권4호
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• pp.443-459
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• 2023

This study investigates the theoretical thermal buckling analyses of thick porous rectangular functionally graded (FG) plates with different geometrical boundary conditions resting on a Winkler-Pasternak elastic foundation using a new higher-order shear deformation theory (HSDT). This new theory has only four unknowns and involves indeterminate integral variables in which no shear correction factor is required. The variation of material properties across the plate's thickness is considered continuous and varied following a simple power law as a function of volume fractions of the constituents. The effect of porosity with two different types of distribution is also included. The current formulation considers the Von Karman nonlinearity, and the stability equations are developed using the virtual works principle. The thermal gradients are involved and assumed to change across the FG plate's thickness according to nonlinear, linear, and uniform distributions. The accuracy of the newly proposed theory has been validated by comparing the present results with the results obtained from the previously published theories. The effects of porosity, boundary conditions, foundation parameters, power index, plate aspect ratio, and side-to-thickness ratio on the critical buckling temperature are studied and discussed in detail.

• Steel and Composite Structures
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• 제44권4호
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• pp.503-517
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• 2022

This paper presents the mechanical buckling of bi-directional functionally graded sandwich beams (BFGSW) with various boundary conditions employing a quasi-3D beam theory, including an integral term in the displacement field, which reduces the number of unknowns and governing equations. The beams are composed of three layers. The core is made from two constituents and varies across the thickness; however, the covering layers of the beams are made of bidirectional functionally graded material (BFGSW) and vary smoothly along the beam length and thickness directions. The power gradation model is considered to estimate the variation of material properties. The used formulation reflects the transverse shear effect and uses only three variables without including the correction factor used in the first shear deformation theory (FSDT) proposed by Timoshenko. The principle of virtual forces is used to obtain stability equations. Moreover, the impacts of the control of the power-law index, layer thickness ratio, length-to-depth ratio, and boundary conditions on buckling response are demonstrated. Our contribution in the present work is applying an analytical solution to investigate the stability behavior of bidirectional FG sandwich beams under various boundary conditions.