• Structural Engineering and Mechanics
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• v.26 no.6
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• pp.725-739
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• 2007

In recent years there are many plate bending elements that emerged for solving both thin and thick plates. The main features of these elements are that they are based on mix formulation interpolation with discrete collocation constraints. These elements passed the patch test for mix formulation and performed well for linear analysis of thin and thick plates. In this paper a member of this family of elements, namely, the Discrete Reissner-Mindlin (DRM) is further extended and developed to analyze both thin and thick plates with geometric nonlinearity. The Von K$\acute{a}$rm$\acute{a}$n's large displacement plate theory based on Lagrangian coordinate system is used. The Hu-Washizu variational principle is employed to formulate the stiffness matrix of the geometrically Nonlinear Discrete Reissner-Mindlin (NDRM). An iterative-incremental procedure is implemented to solve the nonlinear equations. The element is then tested for plates with simply supported and clamped edges under uniformly distributed transverse loads. The results obtained using the geometrically NDRM element is then compared with the results of available analytical solutions. It has been observed that the NDRM results agreed well with the analytical solutions results. Therefore, it is concluded that the NDRM element is both reliable and efficient in analyzing thin and thick plates with geometric non-linearity.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.709-714
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• 2000

A splitting method for the direct numerical simulation of solid-liquid mixtures is presented, where a symmetric pressure equation is newly proposed. Through numerical experiment, it is found that the newly proposed splitting method works well with a matrix-free formulation fer some bench mark problems avoiding an erroneous pressure field which appears when using the conventional pressure equation of a splitting method. When deriving a typical pressure equation of a splitting method, the motion of a solid particle has to be approximated by the 'intermediate velocity' instead of treating it as unknowns since it is necessary as a boundary condition. Therefore, the motion of a solid particle is treated in such an explicit way that a particle moves by the known form drag (pressure drag) that is calculated from the pressure equation in the previous step. From the numerical experiment, it was shown that this method gives an erroneous pressure field even for the very small time step size as a particle velocity increases. In this paper, coupling the unknowns of particle velocities in the pressure equation is proposed, where the resulting matrix is reduced to the symmetric one by applying the projector of the combined formulation. It has been tested over some bench mark problems and gives reasonable pressure fields.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.104-110
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• 2009

Phenylketonuria (PKU) is an inherited metabolic disorder caused by mutations in the phenylalanine catabolic enzyme, phenylalanine hydroxylase (PAH). The use of phenylalanine ammonia-lase (PAL) by oral and parenteral routes as a therapeutic drug for PKU has been severely limited due to inactivation by intestinal proteolysis and immune reactions. PEGylation was applied to PAL to reduce the degrees of antigenicity and proteolytic inactivation. Kinetic experiments with native PAL and pegylated PALs were performed, and pH stability, temperature stability, and protease susceptibility were evaluated. Enzyme linked immunosorbent assay (ELISA) was carried out to measure the immune complex between pegylated PALs and antiserum that had been extracted from a PAL-immunized mouse. Pegylated PAL, especially branched pegylated PAL (10 kDa, 1:32), was more active for phenylalanine and more stable in pancreatic proteases than native PAL. Native PAL was optimal at pH 8.5, corresponding to the average pH range of the small intestine; the same finding was noted for pegylated PALs. All linear and branched pegylated PALs had low reactivity with mouse antiserum, especially the 1:16 formulation with linear 5-kDa PEG and the 1:32 formulation with branched 10-kDa PEG. Therefore, we suggest the 1:32 formulation with branched 10-kDa PEG as the most promising formulation for enzyme replacement therapy.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.46 no.3
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• pp.73-80
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• 2014

In this study, in order to investigate the influence of insolubilizer on the double coating structure, we carried out basic research related to the double coating formulation with four insolubilizers having various chemical types such as amino aldehyde, glyoxal and two metallic salts. It was found that although the four insolubilizers showed similar results on optical and surface properties of the coated papers, they gave different results in the printabilities of the coated papers since coating structure was significantly influenced by different reacting mechanism of the insolubilizers. Three of the insolubilizers (glyoxal, two metallic salts) showed better results than amino aldehyde type one when they were applied to top coating formulation. Metallic salts type insolubilizers showed good results in the print gloss when it was applied to top coating formulation. It was believed that amino aldehyde type insolubilizer applied top coating formulation showed good both of dry-pick and wet-pick strength.

• Applied Chemistry for Engineering
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• v.10 no.6
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• pp.848-851
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• 1999

In order to increase the stability of Ginkgo Biloba extract, we investigated the effect of three different fill formulations(SBO, PEG400, and PEG600 fill types) on the stability of Ginkgo Biloba extract in three different shell formulations (ssmb, smb and gmb shell types). The stabilities of each types were evaluated by testing their disintegration time sunder the condition of $40^{\circ}C$, 75% relative humidity(RH) for 8 weeks. The formulation of Ginkgo Biloba extract with ssmb and PEG600 formulation type showed the best stability among them.

• Journal of Korean Society of Steel Construction
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• v.10 no.2 s.35
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• pp.317-326
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• 1998

This paper describes a reduced finite element formulation for nonlinear transient heat transfer analysis based on Lanczos Algorithm. In the proposed reduced formulation all material nonlinearities of irradiation boundary element are included using the pseudo force method and numerical time integration of the reduced formulation is conducted by Galerkin method. The results of numerical examples demonstrate the applicability and the accuracy of the proposed method for the nonlinear transient heat transfer analysis.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2001.04a
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• pp.78-78
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• 2001

현재 Lab Coating은 실험의 정확성 및 재현성을 위해 기존의 Hand Coating에서 탈피하여 Mayor Coater나 CLC(Cylindrical Laboratory Coated) 등을 사용하여 주로 진행된다. Lab Coater로는 현재 가장 진보된 장비라고 할 수 있는 CLC의 경우 속도와 metering 방식 등에서 현장과 유사한 조건을 재현할 수 있다. 그러나 CLC를 사용하여 Multi Layer C Coating을 실시할 경우 원하는 도공량을 얻기 위해서는 상당한 시간과 노력이 필요하며 특히 Triple Coating의 경 우는 더 힘 든 과정 을 거 쳐 야 한다. 그래서 본 연구에서는 도공량 변화 및 Color Formulation 변경에 의한 물성변화를 측정 하여 Triple Coating에서 두 인자가 각각의 품질에 미치는 영향을 비교 분석하여 어느 정도 도공량 변화가 Color Formulation 변화에 상응하는 영향을 주는지를 파악하고자 하였다.코팅은 CLC 6000을 이용하여 실시하였으며, rod와 blade를 사용한 Triple coating을 5가 지 경우의 Color Formulation에 대하여 실시하였다. 변화시켜 코팅한 후 도공량에 따른 백지물성 관계를 분석한 결과 백색도, 평활도, 거칠음도, 투 기도,2도 trap, Set-Off, Dr${\gamma}$ pick은 총도공량과 강한 상관관계를 보였고, 광택도와 K&N은 총도공량보다는 Top 코팅량과 강한 상관 관계를 보였다. 동일한 코팅칼라를 이용하여 인쇄물성을 고찰하였다. 도공량과 물성의 그러나 동일한 코팅칼라를 사용하여 얻어진 일련의 상관성은 Color Formulation이 변경 되었을 경우 전혀 발견할 수 없었다. 즉 Triple Coating에서 코팅칼라 변경이 품질에 미치는 영향은 도공량 변화에 비해 절대적이어서 몇십%의 현을 억제하지는 못한다는 결론을 도출할 수 있었다.

• Journal of Pharmaceutical Investigation
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• v.28 no.4
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• pp.267-274
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• 1998

Biphenyl dimethyl dicarboxylate (DDB) has been used for the treatment of acute and chronic hepatitis. However, its poor solubility in water, $2.5\;{\mu}g/ml$, caused low bioavailability of the drug after its oral administration. In order to increase the dissolution of DDB in gastrointestinal tracts, consequently to increase the bioavailability of the drug, DDB tablet was prepared with solid dispersion of DDB with poloxamer 338 or 407 using a direct compression method. To improve the flowability of the solid dispersion, Aerosil was used as an adsorbent. The effect of formulation variables (poloxamer and Aerosil contents) on the dissolution rate of DDB from tablets was investigated using an analysis of variance. The dissolution rate of DDB from tablets was evaluated with KP II (paddle) method. The dissolution patterns of the drug from the tablet prepared with poloxamer 407 were affected significantly by the contents of poloxamers and Aerosil over the range employed, but those of the drug from the tablet prepared with poloxamer 338 were not. The optimum formulation of the DDB tablet, showed the same dissolution pattern as that of the reference, was obtained after polynomial equations of drug dissolution profiles for each formula were fitted to contour plots. The optimum formulation ratios of DDB:poloxamer 407:Aerosil were 1:2.5:2.5 and 1:5:5.

• The Journal of Natural Sciences
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• v.8 no.1
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• pp.5-15
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• 1995

The equation error formulation in the adaptive IIR filtering provides convergence to a global minimum regardless a local minimum with a large stability margin. However, the equation error formulation suffers from the bias in the coefficient estimates. In this paper, a new algorithm, which does not require a prespecification of the noise variance, is proposed for the equation error formulation. This algorithm is based on the equation error smoothing and provides an unbiased parameter estimate in the presence of white noise. Through simulations, it is demonstrated that the algorithm eliminates the bias in the parameter estimate while retaining good properties of the equation error formulation such as fast convergence speed and the large stability margin.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.80-86
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• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).