• Animal cells and systems
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• v.7 no.3
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• pp.207-211
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• 2003

Caveolin-1 is a principal protein in the plasma membrane microdomains called caveolae. Caveolae play an important role in the transcytosis and pinocytosis. Therefore, caveolin-1 is most likely to work for the membrane dynamic events. In addition, caveolin-1 interacts with various signaling molecules. Although caveolin-1 possesses a variety of physiological functions, its structural properties were little construed. Here we analyzed the structural dynamics of the N-terminal caveolin-1 (residues 1-101), in order to better understand the structural properties in terms of its versatile functionality. We first analyzed its oligomeric form using GST-fused N-terminal domain, revealing that it equilibrates between a dimer and monomers in av concentration-dependent manner. The N-terminal domain of caveolin-1 was previously found to form a heptamer, so that our data suggest the dimeric form as an intermediate structure for the heptamer formation. Then, we obtained the folding profile, which indicated that $\DeltaG_{H2O}\;is\;about\;0.5\;\pm0.03$ kcal/mol. The stability of N-terminal domain is relatively low, indicating that N-terminal domain may not be crystalline. Conclusively, the dynamic and flexible structure of N-terminal domain appears more favorable to maintain the versatile functions of caveolin-1.

• Journal of Korean Society of Water and Wastewater
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• v.27 no.3
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• pp.383-394
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• 2013

A sedimentation basin is used to remove suspended sediments which can cause abrasive and erosive wear on hydraulic turbines of hydropower plants. This sediment erosion not only decreases efficiency of the turbine but also increases maintenance costs. In this study, the three-dimensional numerical simulations were carried out on the overseas hydropower project. The simulations of flow and suspended sediment concentration were obtained using FLOW-3D computational fluid dynamics code. The simulations provide removal efficiency of a sedimentation basin based on particle sizes. The influence of baffles on the flow field and the removal efficiency of suspended sediments in the sedimentation basin has been investigated. This paper also provides the numerical simulations for sediment-induced density currents that may occur in the sedimentation basin. The simulation results indicate that the formation of density currents decreases the removal efficiency. When a baffle is installed in the sedimentation basin, the baffle provides intensive settling zones resulting in increasing the sediments settling. Thus the enhanced removal efficiency can be achieved by installing the baffle inside the sedimentation basin.

• International Journal of Railway
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• v.4 no.4
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• pp.109-115
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• 2011

An analysis and design method for reducing aerodynamic noise in high-speed trains based on biomimetics of noiseless flight of owl is proposed. Five factors related to the morphology of the flight feather have been selected, and the candidate optimal shape of the flight feather is determined. The turbulent flow field analysis demonstrates that the optimal shape leads to diminished vortex formation by causing separation of the flow as well as allowing the fluid to climb up along the surface of the flight feather. To determine the effect of scaling of the owl's flight feather on the noise reduction, a two-fold and a four-fold scaled up model of the feather are constructed, and the numerical simulations are carried out to obtain the aerodynamic noise levels for each scale. Original model is found to reduce the noise level by 10 dBA, while two-fold increase in length dimensions reduces the noise by 12 dBA. Validation of numerical solution using wind tunnel experimental measurements is presented as well.

• International Journal of Railway
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• v.7 no.4
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• pp.100-108
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• 2014

A numerical analysis method for predicting aerodynamic noise at inter-coach space of high-speed trains, validated by wind-tunnel experiments for limited speed range, is proposed. The wind-tunnel testing measurements of the train aerodynamic sound pressure level for the new generation Korean high-speed train have suggested that the inter-coach space aerodynamic noise varies approximately to the 7.7th power of the train speed. The observed high sensitivity serves as a motivation for the present investigation on elucidating the characteristics of noise emission at inter-coach space. As train speed increases, the effect of turbulent flows and vortex shedding is amplified, with concomitant increase in the aerodynamic noise. The turbulent flow field analysis demonstrates that vortex formation indeed causes generation of aerodynamic sound. For validation, numerical simulation and wind tunnel measurements are performed under identical conditions. The results show close correlation between the numerically derived and measured values, and with some adjustment, the results are found to be in good agreement. Thus validated, the numerical analysis procedure is applied to predict the aerodynamic noise level at inter-coach space. As the train gains speed, numerical simulation predicts increase in the overall aerodynamic sound emission level accompanied by an upward shift in the main frequency components of the sound. A contour mapping of the aerodynamic sound for the region enclosing the inter-coach space is presented.

• Journal of ILASS-Korea
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• v.10 no.2
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• pp.10-17
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• 2005

The proposed research has been performed to know the characteristics of cutting fluid aerosol formation using Dual-PDA system in machining process. The cutting fluid aerosol size and concentration is common attributes that quantify the environmental intrusiveness or air quality contamination. The atomized cutting fluid aerosols can be affected to human health risk such as lung cancer and skin irritations. Even though cutting fluid can be improved the machining quality and productivity in a carefully. its use must be controlled and optimized carefully. This experimental works using Dual-PDA were performed to analyze the cutting fluid aerosol behaviors and characteristics in turning process using precise aerosol particle measuring system. The obtained experimental results profovide basic knowledge to develop the environmentally conscious machining process. This results cail be provided as a basis to estimate and control the hazardous cutting fluid aerosol in machining process.

• Bulletin of the Korean Chemical Society
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• v.28 no.11
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• pp.1967-1972
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• 2007

Photophysical properties of a newly-synthesized porphyrin derivative, trans-bis(ferrocene carboxylato)- (5,10,15,20-tetraphenylporphyrinato)tin(IV) [Sn(TPP)(FcCOO)2] were investigated by means of steady-state and fs-time resolved laser spectroscopic techniques, and compared with those of a standard molecule, trans-dichloro( 5,10,15,20-tetraphenyl-porphrinato)tin(IV) [Sn(TPP)Cl2]. The fluorescence spectrum of Sn(TPP)- (FcCOO)2 was observed to exhibit dual emission bands originating from the S2-state and the S1-state, which was greatly quenched as compared to those of Sn(TPP)Cl2. The fs-time resolved fluorescence and transient absorption spectroscopic measurements revealed that the fluorescence quenching is due to formation of the long-lived charge transfer state by intramolecular electron transfer from ferrocene to the S2-excited SnTPP in addition to the enhanced non-radiative deactivation processes.

• Nuclear Engineering and Technology
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• v.45 no.2
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• pp.191-202
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• 2013

A numerical analysis of thermal stratification in the upper plenum of the MONJU fast breeder reactor was performed. Calculations were performed for a 1/6 simplified model of the MONJU reactor using the commercial code, CFX-13. To better resolve the geometrically complex upper core structure of the MONJU reactor, the porous media approach was adopted for the simulation. First, a steady state solution was obtained and the transient solutions were then obtained for the turbine trip test conducted in December 1995. The time dependent inlet conditions for the mass flow rate and temperature were provided by JAEA. Good agreement with the experimental data was observed for steady state solution. The numerical solution of the transient analysis shows the formation of thermal stratification within the upper plenum of the reactor vessel during the turbine trip test. The temporal variations of temperature were predicted accurately by the present method in the initial rapid coastdown period (~300 seconds). However, transient numerical solutions show a faster thermal mixing than that observed in the experiment after the initial coastdown period. A nearly homogenization of the temperature field in the upper plenum is predicted after about 900 seconds, which is a much shorter-term thermal stratification than the experimental data indicates. This discrepancy may be due to the shortcoming of the turbulence models available in the CFX-13 code for a natural convection flow with thermal stratification.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.6
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• pp.581-591
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• 2011

This paper describes the air compressibility effect in the CFD simulation of water impact load prediction. In order to consider the air compressibility effect, two sets of governing equations are employed, namely the incompressible Navier-stokes equations and compressible Navier-Stokes equations that describe general compressible gas flow. In order to describe violent motion of free surface, volume-of-fluid method is utilized. The role of air compressibility is presented by the comparative study of water impact load obtained from two different air models, i.e. the compressible and incompressible air. For both cases, water is considered as incompressible media. Compressible air model shows oscillatory behavior of pressure on the solid surface that may attribute to the air-cushion effect. Incompressible air model showed no such oscillatory behavior in the pressure history. This study also showed that the CFD simulation can capture the formation of air pockets enclosed by water and solid surface, which may be the location where the air compressibility effect is dominant.

• Transactions of the Korean hydrogen and new energy society
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• v.30 no.6
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• pp.499-504
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• 2019

Due to the rapid spread and low minimum ignition energy of hydrogen, rupture is highly likely to cause fire, explosion and major accidents. The self-ignition of high-pressure hydrogen is highly likely to ignite immediately when it leaks from an open space, resulting in jet fire. Results of the diffusion and leakage simulation show that jet effect occurs from the leakage source to a certain distance. And at the end of location, the vapor cloud explosion can be occurred due to the formation of hydrogen vapor clouds by built-up. In the result, it is important that depending on the time of ignition, a jet fire or a vapor cloud explosion may occur. Therefore, it is necessary to take into account jet effect by location of leakage source and establish a damage minimizing plan for the possible jet fire or vapor cloud explosion. And it is required to any kind of measurements such as an interlock system to prevent hydrogen leakage or minimize the amount of leakage when detecting leakage of gas.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.2011-2016
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• 2018

In this study, we have been investigated pin to plate pulsed bi-polar discharges in saline solutions, where bubble generation occurs. We integrate basic I-V-t electrical characteristics with the ICCD shadowgraph images, and finally instant and time averaged I-V waveforms. We observed that the bubble formation phase dynamics is quite different corresponding to the polarity applied to the pin electrode. When the pin electrode is a cathode, the bubble tends to be periodically detached from the pin electrode and the numerous tiny voltage spikes occur related to the electron emission from a pin cathode casing via, we judge from, direct dissociation of water molecules by energetic electrons. On the contrary, the bubble tends to stick to the pin electrode, when the pin electrode is anode; the bubble grows in size throughout the pulse duration. The dynamic electrical characteristics relative to the applied polarity of a pin electrode are presented and discussed by analysis of time averaged I-V waveforms.