• Biomolecules & Therapeutics
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• 제18권2호
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• pp.184-190
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• 2010

Clinical cases of pure red cell aplasia (PRCA) have been reported during the recombinant human erythropoietin (EPO) therapy for the anemia patients. PRCA is a rare hematological disorder leading to a severe anemia due to an almost complete stop of red blood cell production. Antibody (Ab)-associated PRCA is caused by the EPO-neutralizing Abs that eliminate the biological activity of EPO. In order to detect anti-EPO Abs in human sera, we performed conventional ELISA, directly coated bridging ELISA, and streptavidin coated bridging ELISA, and compared their sensitivity and specificity. Some false positive results were obtained in the conventional ELISA. One positive sample was detected successfully by streptavidin coated bridging ELISA, which was not appeared in the directly coated bridging ELISA. In conclusion, streptavidin coated bridging ELISA was substantially sensitive and specific format and one out of sixty-eight serum samples was proved to be anti-EPO positive.

• 한국융합학회논문지
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• 제7권1호
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• pp.137-143
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• 2016

본 연구는 쥐눈이콩을 주재료로 하는 당뇨의 식이요법에 활용할 수 있는 간편 편이식을 개발하고자 계획하였고 그 첫 단계로 고처방을 기초로 하여 미숫가루를 고안하였다. 동양의 기미론을 기본으로 그 효능을 분석하고 동시에 영양성분을 분석한 후 동 서 식품영양학적으로 그 효능을 비교, 고찰하여 당뇨의 식 의약 치료에 있어 활용가치를 판단해 보았다. 본 연구는 식품을 기미론(氣味論)적으로 분석하여 약선식료학 연구를 위한 기초자료를 확보하고 동시에 식품영양분야에서 식품효능 접근 방법과 원활한 접목을 위한 자료를 제시할 수 있을 것이라 사료된다. 또한 향후 식품의 효능이나 섭취방안에 대한 올바른 개념을 정립하여 식품 효능에 대한 인식 전환의 계기가 되어 동양에서 바라보는 식품의 섭취효능을 이해하는데 기초자료가 될 수 있으리라 판단된다. 한편, 본 연구자들은 본 연구에서 고안한 미숫가루의 보간익신(補肝益腎) 효능을 객관적으로 판단해 보고자 임상실험을 진행하여 당뇨의 식 의약치료에 활용할 수 있는 가치를 계속적으로 연구 보고하고자 한다.

• The Korean Journal of Physiology and Pharmacology
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• 제13권6호
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• pp.491-496
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• 2009

Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors. However, the cellular mechanisms of the atrophic process are poorly understood. In this study, we investigated the involvement of mitogen-activated protein kinase (MAPK) in the expression of muscle-specific RING finger 1 (MuRF1) during atrophy of the rat gastrocnemius muscle. Histological analysis revealed that cast immobilization induced the atrophy of the gastrocnemius muscle, with diminution of muscle weight and cross-sectional area after 14 days. Cast immobilization significantly elevated the expression of MuRF1 and the phosphorylation of p38 MAPK. The starvation of L6 rat skeletal myoblasts under serum-free conditions induced the phosphorylation of p38 MAPK and the characteristics typical of cast-immobilized gastrocnemius muscle. The expression of MuRF1 was also elevated in serum-starved L6 myoblasts, but was significantly attenuated by SB203580, an inhibitor of p38 MAPK. Changes in the sizes of L6 myoblasts in response to starvation were also reversed by their transfection with MuRF1 small interfering RNA or treatment with SB203580. From these results, we suggest that the expression of MuRF1 in cast-immobilized atrophy is regulated by p38 MAPK in rat gastrocnemius muscles.

• 대한영양사협회학술지
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• 제8권1호
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• pp.9-18
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• 2002

This study was reviewed databases and outcomes of national/international off-line and on-line(Internet) nutrition softwares to identify the present conditions of nutrition softwares, and investigated user's needs and determine which component should be included in nutrition software. The most frequently used databases for the national programs were the food composition table provided from the National Rural Living Science Institution in Rural Development Administration and the food composition table and the nutrient contents of foods provided from the Korean Nutrition Society. For international programs, the food composition table from the USDA was commonly used. The analysed outcomes included the degree of obesity, nutrient analysis and nutrient intake compared with RDA, food intake from each by food group, food habits and the frequency of food consumption. As to the result of needs assessment for the Internet nutrition softwares, it was suggested that the needs of the Internet nutrition softwares were high because most of the respondents replied that 3-point('it is needed') or 4-point('it is necessary') on 4-points likert scale. As to the databases, the needs of 'food composition analysis' and 'the suggestion of the Korean RDA' were high. For the basic information for foods, the respondents replied that 'the classification of foods', 'foods codes', 'the amount of ingredients' and 'nutrient analysis' should be included. The needs of 'nutrient analysis of meal', 'diet therapy' and 'meal plan by caloric requirements' were high. As for utilizing the Internet meal planning programs, the respondents replied that 'it should be easy to use' most and demand for 'data saving and the saved data should be usable later' and 'meal planning education tools' were high. In conclusion, the Internet nutrition software that satisfies various needs of users should be developed for policy making that promote public health, nutritional care and self-supporting of foods.

• Nutrition Research and Practice
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• 제14권3호
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• pp.242-251
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• 2020

BACKGROUND/OBJECTIVES: This study was conducted to examine disparities in food and nutrient intakes based on family types identified among 1,856 participants who were the Korean elderly people in the 6th Korea National Health and Nutrition Examination Survey (KNHNES) excluding those who were currently practicing the diet therapy. SUBJECTS/METHODS: We separated the subjects into two groups: living alone (LA, n = 638) and living with a spouse (LS, n = 1,218). We also examined the disparities of dietary quantity and quality of those two groups using complex sampling design general linear regression analyses (CS GLM). RESULTS: In the LA group, there was a higher percentage of females and average age in LA group was higher than the participants in the LS group. Household income and education level were significantly lower in LA compared to those of LS. The frequencies of skipping meals were higher in LA. LA's food and nutrient intakes showed lower consumption of vegetables, fruits, seaweeds, and of most nutrients. Even after adjusting for the confounding factors, the consumption of vegetables, seaweeds, carbohydrates, potassium, riboflavin, and vitamin C showed lower in LA than LS. Moreover, LA's nutrient intake ratios compared to the KDRIs were lower which turned out to be similar to their nutrient intakes. CONCLUSIONS: These results show that dietary behavior and food intake of the elderly are associated with family types. Frequently skipping meals and less dietary variety are more common with elderly persons who were living alone. Therefore, it is necessary to integrate the supplementary food programs and nutrition education programs for the elderly living alone.

• 재활치료과학
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• 제10권1호
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• pp.37-52
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• 2021

서론 : 구강 운동 기능은 태아기에서 유년기 발달로 이어지는 감각 탐색, 음식 섭취, 의사소통 표현의 기초가 되는 기능이다. 구강 운동 기능에 문제가 발행하면, 구강 내 음식 처리 어려움, 삼킴 및 섭식기능 저하, 의사소통 기능 감소, 구강 위생 능력 저하 등이 나타난다. 이러한 증상 치료를 위한 구강운동 치료는 구강 내 감각 정상화, 자세 조절, 구강 움직임 증진, 구강 운동 기능 향상을 목표로 제공되는 치료법이다. 본론 : 구강운동촉진기술(OMFT)은 1) 구강 및 안면 근육계의 해부생리학적 이해; 2) 감각·적응·행동·인지의 통합적 접근; 3) 도수적 접근을 통한 감각 및 운동 자극; 4) 운동 조절과 운동 학습 이론에 기초한 구강운동의 4가지 주요 특징을 바탕으로 전반적이고 통합적인 구강 기능 증진을 목적으로 개발되었다. OMFT는 근거 중심의 새로운 치료 프로토콜로써 아동 및 성인, 신경계 및 근골격계의 구강 기능에 문제를 보이는 모든 이들에게 적용이 가능한 치료 기법이다. 결론 : 본 논문은 OMFT의 개발에 따른 이론적 배경 및 OMFT의 실제적 적용에 따른 기초 요소를 소개하는 것이 목표로, 본 논문을 통해 임상 전문가들이 정확한 이론적 배경과 치료법을 바탕으로 대상자에 맞는 전문적인 치료 제공에 도움이 되기를 바란다.

• 재활간호학회지
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• 제18권1호
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• pp.46-56
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• 2015

Purpose: The purpose of this study was to identify health status and the use of complementary and alternative therapies in the community dwelling pre-elderly and elderly. Methods: A total of 193 subjects participated in this study. They were recruited from one senior welfare center, four senior citizen centers and subjects' home in two cities. Data were collected with self-reported questionnaires to measure health status and the use of complementary and alternative therapies. Data were analyzed by t-test, ANOVA using SPSS/WIN 22.0. Results: Health status in this subjects was different depending on their age, sex, education, religion, type of family, and average monthly living expenses. Most used items as complementary and alternative medicine are diet therapy, herbal medicine such as health supplement food therapy, vitamin therapy, and Korean folk remedies. There were statistically significant differences in using complementary and alternative therapies according to one's current health status (F=7.09, p<.001), comparing health status to peers (F=3.67, p=.013), and chronic disease having more than three months (t=-2.50, p=.013). Conclusion: This study suggest that individualized health care should be continued for the pre-elderly and elderly. Moreover, we need to prepare long term care plans such as educations for applying complementary and alternative therapies.

• 대한한의학원전학회지
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• 제27권4호
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• pp.15-20
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• 2014

Objectives : We search the contents about Bi disease in Huang Di Nei Jing(黃帝內經), to analyze the significance of Bi disease, etiopathogenisis and pathogenesis of Bi disease, treatment of Bi disease. Methods : We find that the key feature of Bi disease is joint pain induced by impatency of Qi and blood. Exterior and interior etiological factors are involved in, such as exogenous evil of cold and dampness, emotional disorders, intemperance of taking food, dysfunction of yingqi and weiqi, strong or weak constitution, etc. Results : The important pathogenesis are invaded by exogenous evil because of deficiency, disharmony of yingqi and weiqi and disharmony of five viscera. The key points of treatments are the individual concerned therapy and climate concerned therapy, selecting the acupoint according to the differentiation of symptoms and signs. Conclusions : The combined therapy should be used such as acupuncture and moxibustion, hot application of medicine, massage, Daoyin, outside apply, etc. These supply the theory foundation for etiological factor, pathogenesis, syndrome and treatment, and to direct the diagnosis and treatment of Bi disease later generations.

• 한국의사학회지
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• 제30권1호
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• pp.43-50
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• 2017

In the United States, California is well known for its rigorous education and licensing system regarding East Asian Medicine and acupuncture. As in most other states in America, the State government controls the practice of acupuncture, massage, acupressure therapy, food therapy, and natural therapy using a board established to set, maintain, and uphold licensing credentials for acupuncturists and practitioners of East Asian medicine. In California the system started in the 1970s when the State Legislature passed a bill to measure competency, and license acupuncturists. This study briefly describes the California Acupuncture Board (CAB), which is authorized to control the related education, examination, continuing education, and management of licenses already awarded. This study addresses the essential and minimum educational requirement established by the CAB for licensure, that is mandate classroom lecture with additional 950 hours clinic training, and the 50 hours of continuing education credits earned every two years, for maintaining the license.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.183-189
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• 2002

Tinnitus is usually due to insufficiency of Kidney-essence, asthenia of the Spleen and Stomach, diseases caused by exogenous pathogenic factor, Liver fire(肝火) by severe stress, Phlegm -fire(痰火) by surfeit of high caloric food and alcoholic liquor. I observed and treated four patients who had been diagnosed with tinnitus of Liver-fire(肝火) and Phlegm-fire(痰火). After I checked the Inyeong(人迎) and the chon spot(寸口), all of their Inyeong were stronger than chon spot. Unbalance of the Inyeong(人迎) and the chon spot(寸口), and symptoms of tinnitus were removed by Acupuncture therapy of three Yang meridians of the hand(手三陽) and three Yang meridians of the foot(足三陽).